Putative 60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P2, putative

Species:

Leishmania mexicana

UniProt:

E9AJS6_LEIMU

TriTrypDb:

LmxM.03.0430

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

E9AJS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJS6

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	1
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	25	33	PF00400	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.377
DOC_MAPK_MEF2A_6	26	33	PF00069	0.478
DOC_USP7_UBL2_3	75	79	PF12436	0.528
DOC_WW_Pin1_4	58	63	PF00397	0.487
LIG_FHA_1	26	32	PF00498	0.480
LIG_FHA_2	7	13	PF00498	0.385
LIG_LIR_Nem_3	90	96	PF02991	0.472
LIG_SH3_3	24	30	PF00018	0.559
LIG_TRAF2_1	83	86	PF00917	0.482
MOD_CK1_1	41	47	PF00069	0.496
MOD_CK1_1	58	64	PF00069	0.496
MOD_CK2_1	6	12	PF00069	0.579
MOD_GlcNHglycan	57	60	PF01048	0.337
MOD_GlcNHglycan	67	70	PF01048	0.369
MOD_GlcNHglycan	9	12	PF01048	0.431
MOD_GSK3_1	54	61	PF00069	0.489
MOD_PKA_2	25	31	PF00069	0.483
MOD_Plk_2-3	38	44	PF00069	0.535
MOD_Plk_4	41	47	PF00069	0.429
MOD_ProDKin_1	58	64	PF00069	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IV06	Bodo saltans	51%	91%
A0A1X0P9L8	Trypanosomatidae	58%	84%
A0A3R7NK96	Trypanosoma rangeli	58%	85%
A0A451EJP5	Leishmania donovani	96%	87%
A4H3L0	Leishmania braziliensis	73%	100%
A4H3L1	Leishmania braziliensis	73%	91%
A4HRV3	Leishmania infantum	60%	87%
A4HRV4	Leishmania infantum	97%	87%
E9ACI8	Leishmania major	95%	100%
E9AJS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	88%
O01359	Oscheius tipulae	36%	87%
O23095	Arabidopsis thaliana	43%	86%
O44010	Leishmania braziliensis	39%	92%
O46313	Leishmania peruviana	73%	91%
P52855	Zea mays	46%	89%
P91913	Caenorhabditis elegans	41%	87%
Q8LCW9	Arabidopsis thaliana	44%	87%
Q8LEQ0	Arabidopsis thaliana	41%	86%