LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E9AJS4_LEIMU
TriTrypDb:
LmxM.03.0410
Length:
657

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 17
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

E9AJS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJS4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 19
GO:0022857 transmembrane transporter activity 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 314 318 PF00656 0.670
CLV_C14_Caspase3-7 379 383 PF00656 0.728
CLV_NRD_NRD_1 10 12 PF00675 0.584
CLV_NRD_NRD_1 275 277 PF00675 0.310
CLV_NRD_NRD_1 295 297 PF00675 0.468
CLV_NRD_NRD_1 478 480 PF00675 0.265
CLV_NRD_NRD_1 626 628 PF00675 0.427
CLV_PCSK_KEX2_1 10 12 PF00082 0.490
CLV_PCSK_KEX2_1 249 251 PF00082 0.383
CLV_PCSK_KEX2_1 295 297 PF00082 0.416
CLV_PCSK_KEX2_1 478 480 PF00082 0.275
CLV_PCSK_KEX2_1 612 614 PF00082 0.277
CLV_PCSK_KEX2_1 618 620 PF00082 0.280
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.362
CLV_PCSK_PC1ET2_1 612 614 PF00082 0.332
CLV_PCSK_PC1ET2_1 618 620 PF00082 0.333
CLV_PCSK_SKI1_1 481 485 PF00082 0.248
CLV_PCSK_SKI1_1 608 612 PF00082 0.322
DEG_MDM2_SWIB_1 410 418 PF02201 0.480
DEG_SCF_FBW7_1 26 32 PF00400 0.652
DEG_SPOP_SBC_1 550 554 PF00917 0.473
DOC_CKS1_1 200 205 PF01111 0.312
DOC_CKS1_1 26 31 PF01111 0.630
DOC_CYCLIN_RxL_1 475 488 PF00134 0.549
DOC_MAPK_DCC_7 389 399 PF00069 0.596
DOC_MAPK_FxFP_2 272 275 PF00069 0.428
DOC_MAPK_gen_1 475 484 PF00069 0.458
DOC_MAPK_MEF2A_6 478 486 PF00069 0.420
DOC_MAPK_NFAT4_5 479 487 PF00069 0.398
DOC_MAPK_RevD_3 263 277 PF00069 0.428
DOC_PP4_FxxP_1 241 244 PF00568 0.262
DOC_PP4_FxxP_1 272 275 PF00568 0.321
DOC_PP4_FxxP_1 468 471 PF00568 0.354
DOC_PP4_FxxP_1 533 536 PF00568 0.303
DOC_SPAK_OSR1_1 88 92 PF12202 0.473
DOC_USP7_MATH_1 18 22 PF00917 0.652
DOC_USP7_MATH_1 188 192 PF00917 0.389
DOC_USP7_MATH_1 2 6 PF00917 0.620
DOC_USP7_MATH_1 360 364 PF00917 0.576
DOC_USP7_UBL2_3 608 612 PF12436 0.549
DOC_WW_Pin1_4 107 112 PF00397 0.311
DOC_WW_Pin1_4 199 204 PF00397 0.312
DOC_WW_Pin1_4 25 30 PF00397 0.772
DOC_WW_Pin1_4 577 582 PF00397 0.319
LIG_14-3-3_CanoR_1 123 130 PF00244 0.162
LIG_14-3-3_CanoR_1 411 417 PF00244 0.565
LIG_14-3-3_CanoR_1 585 591 PF00244 0.162
LIG_14-3-3_CanoR_1 630 639 PF00244 0.675
LIG_AP2alpha_2 85 87 PF02296 0.561
LIG_BIR_III_2 15 19 PF00653 0.668
LIG_BRCT_BRCA1_1 190 194 PF00533 0.487
LIG_deltaCOP1_diTrp_1 85 89 PF00928 0.569
LIG_FHA_1 130 136 PF00498 0.309
LIG_FHA_1 193 199 PF00498 0.301
LIG_FHA_1 200 206 PF00498 0.287
LIG_FHA_1 237 243 PF00498 0.312
LIG_FHA_1 497 503 PF00498 0.398
LIG_FHA_1 559 565 PF00498 0.372
LIG_FHA_1 605 611 PF00498 0.427
LIG_FHA_1 66 72 PF00498 0.704
LIG_FHA_2 50 56 PF00498 0.576
LIG_FHA_2 578 584 PF00498 0.280
LIG_FHA_2 612 618 PF00498 0.555
LIG_GBD_Chelix_1 265 273 PF00786 0.302
LIG_GBD_Chelix_1 492 500 PF00786 0.374
LIG_Integrin_RGD_1 83 85 PF01839 0.335
LIG_IRF3_LxIS_1 416 422 PF10401 0.428
LIG_IRF3_LxIS_1 94 101 PF10401 0.349
LIG_LIR_Apic_2 239 244 PF02991 0.259
LIG_LIR_Gen_1 191 201 PF02991 0.412
LIG_LIR_Gen_1 412 421 PF02991 0.462
LIG_LIR_Nem_3 191 197 PF02991 0.436
LIG_LIR_Nem_3 405 410 PF02991 0.520
LIG_LIR_Nem_3 412 417 PF02991 0.493
LIG_LIR_Nem_3 570 576 PF02991 0.348
LIG_MYND_1 61 65 PF01753 0.719
LIG_NRBOX 166 172 PF00104 0.387
LIG_NRBOX 496 502 PF00104 0.417
LIG_Pex14_2 252 256 PF04695 0.267
LIG_Pex14_2 410 414 PF04695 0.604
LIG_PTB_Apo_2 205 212 PF02174 0.459
LIG_SH2_CRK 262 266 PF00017 0.428
LIG_SH2_CRK 480 484 PF00017 0.462
LIG_SH2_GRB2like 119 122 PF00017 0.204
LIG_SH2_PTP2 138 141 PF00017 0.323
LIG_SH2_SRC 134 137 PF00017 0.266
LIG_SH2_STAP1 262 266 PF00017 0.428
LIG_SH2_STAT3 186 189 PF00017 0.303
LIG_SH2_STAT5 119 122 PF00017 0.254
LIG_SH2_STAT5 134 137 PF00017 0.269
LIG_SH2_STAT5 138 141 PF00017 0.290
LIG_SH2_STAT5 186 189 PF00017 0.349
LIG_SH2_STAT5 515 518 PF00017 0.335
LIG_SH2_STAT5 541 544 PF00017 0.549
LIG_SH3_3 23 29 PF00018 0.783
LIG_SH3_3 232 238 PF00018 0.309
LIG_SH3_3 272 278 PF00018 0.267
LIG_SH3_3 461 467 PF00018 0.348
LIG_SH3_4 608 615 PF00018 0.549
LIG_SUMO_SIM_anti_2 488 494 PF11976 0.374
LIG_SUMO_SIM_par_1 195 202 PF11976 0.303
LIG_SUMO_SIM_par_1 417 423 PF11976 0.456
LIG_SUMO_SIM_par_1 494 499 PF11976 0.362
LIG_SUMO_SIM_par_1 540 546 PF11976 0.466
LIG_SUMO_SIM_par_1 96 101 PF11976 0.303
LIG_TRAF2_1 388 391 PF00917 0.727
LIG_TYR_ITIM 136 141 PF00017 0.299
LIG_Vh1_VBS_1 482 500 PF01044 0.302
LIG_WRC_WIRS_1 237 242 PF05994 0.348
LIG_WRC_WIRS_1 587 592 PF05994 0.428
MOD_CK1_1 20 26 PF00069 0.592
MOD_CK1_1 412 418 PF00069 0.517
MOD_CK1_1 420 426 PF00069 0.350
MOD_CK2_1 190 196 PF00069 0.288
MOD_CK2_1 330 336 PF00069 0.823
MOD_CK2_1 384 390 PF00069 0.718
MOD_CK2_1 420 426 PF00069 0.296
MOD_CK2_1 577 583 PF00069 0.321
MOD_CK2_1 611 617 PF00069 0.549
MOD_CK2_1 69 75 PF00069 0.651
MOD_Cter_Amidation 476 479 PF01082 0.349
MOD_GlcNHglycan 20 23 PF01048 0.560
MOD_GlcNHglycan 224 227 PF01048 0.322
MOD_GlcNHglycan 348 352 PF01048 0.504
MOD_GlcNHglycan 386 389 PF01048 0.387
MOD_GlcNHglycan 422 425 PF01048 0.312
MOD_GlcNHglycan 553 556 PF01048 0.271
MOD_GlcNHglycan 632 635 PF01048 0.500
MOD_GSK3_1 188 195 PF00069 0.323
MOD_GSK3_1 218 225 PF00069 0.270
MOD_GSK3_1 25 32 PF00069 0.753
MOD_GSK3_1 360 367 PF00069 0.747
MOD_GSK3_1 558 565 PF00069 0.379
MOD_GSK3_1 575 582 PF00069 0.290
MOD_GSK3_1 591 598 PF00069 0.355
MOD_GSK3_1 604 611 PF00069 0.436
MOD_GSK3_1 65 72 PF00069 0.692
MOD_N-GLC_1 412 417 PF02516 0.334
MOD_NEK2_1 122 127 PF00069 0.290
MOD_NEK2_1 129 134 PF00069 0.339
MOD_NEK2_1 419 424 PF00069 0.326
MOD_NEK2_1 496 501 PF00069 0.281
MOD_NEK2_1 549 554 PF00069 0.479
MOD_NEK2_1 558 563 PF00069 0.297
MOD_NEK2_1 567 572 PF00069 0.239
MOD_NEK2_1 604 609 PF00069 0.370
MOD_NEK2_1 98 103 PF00069 0.291
MOD_PIKK_1 122 128 PF00454 0.316
MOD_PIKK_1 315 321 PF00454 0.660
MOD_PIKK_1 360 366 PF00454 0.685
MOD_PKA_2 122 128 PF00069 0.162
MOD_PKA_2 306 312 PF00069 0.720
MOD_Plk_1 412 418 PF00069 0.492
MOD_Plk_1 543 549 PF00069 0.467
MOD_Plk_4 130 136 PF00069 0.302
MOD_Plk_4 218 224 PF00069 0.320
MOD_Plk_4 236 242 PF00069 0.226
MOD_Plk_4 29 35 PF00069 0.698
MOD_Plk_4 432 438 PF00069 0.346
MOD_Plk_4 460 466 PF00069 0.335
MOD_Plk_4 485 491 PF00069 0.346
MOD_Plk_4 496 502 PF00069 0.359
MOD_Plk_4 567 573 PF00069 0.319
MOD_Plk_4 591 597 PF00069 0.287
MOD_ProDKin_1 107 113 PF00069 0.311
MOD_ProDKin_1 199 205 PF00069 0.312
MOD_ProDKin_1 25 31 PF00069 0.768
MOD_ProDKin_1 577 583 PF00069 0.319
MOD_SUMO_for_1 388 391 PF00179 0.565
TRG_DiLeu_BaLyEn_6 201 206 PF01217 0.323
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.719
TRG_ENDOCYTIC_2 119 122 PF00928 0.273
TRG_ENDOCYTIC_2 138 141 PF00928 0.295
TRG_ENDOCYTIC_2 262 265 PF00928 0.428
TRG_ENDOCYTIC_2 480 483 PF00928 0.475
TRG_ER_diArg_1 10 12 PF00400 0.619
TRG_ER_diArg_1 295 298 PF00400 0.646
TRG_ER_diArg_1 478 480 PF00400 0.481
TRG_NLS_Bipartite_1 612 631 PF00514 0.669
TRG_NLS_MonoCore_2 275 280 PF00514 0.533
TRG_NLS_MonoExtN_4 275 280 PF00514 0.533

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 28% 93%
A0A0N1IHM9 Leptomonas seymouri 71% 93%
A0A0S4J2T0 Bodo saltans 34% 100%
A0A1X0NWR8 Trypanosomatidae 28% 100%
A0A1X0PA49 Trypanosomatidae 51% 100%
A0A3Q8IBI9 Leishmania donovani 27% 90%
A0A3R7LY82 Trypanosoma rangeli 28% 100%
A0A3S5H541 Leishmania donovani 91% 97%
A0A422NQJ7 Trypanosoma rangeli 52% 100%
A4H3K8 Leishmania braziliensis 83% 100%
A4HRV1 Leishmania infantum 91% 97%
A4HYN7 Leishmania infantum 26% 90%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9ACI6 Leishmania major 92% 100%
E9AUH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 90%
Q4QD06 Leishmania major 26% 100%
V5BCB7 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS