GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family, putative

Species:

Leishmania mexicana

UniProt:

E9AJS3_LEIMU

TriTrypDb:

LmxM.03.0400

Length:

294

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0005886	plasma membrane	3	2

Expansion

Sequence features

E9AJS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJS3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0006835	dicarboxylic acid transport	7	2
GO:0006846	acetate transport	6	2
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015718	monocarboxylic acid transport	7	2
GO:0015740	C4-dicarboxylate transport	8	2
GO:0015744	succinate transport	6	2
GO:0015849	organic acid transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0035433	acetate transmembrane transport	5	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071422	succinate transmembrane transport	5	2
GO:0071702	organic substance transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015123	acetate transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015293	symporter activity	5	2
GO:0015294	solute:monoatomic cation symporter activity	5	2
GO:0015295	solute:proton symporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	2
GO:0015360	acetate:proton symporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043893	acetate:monoatomic cation symporter activity	6	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	57	59	PF00675	0.389
CLV_NRD_NRD_1	76	78	PF00675	0.277
CLV_PCSK_KEX2_1	57	59	PF00082	0.437
CLV_PCSK_KEX2_1	76	78	PF00082	0.221
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.417
CLV_PCSK_SKI1_1	256	260	PF00082	0.377
DEG_APCC_DBOX_1	255	263	PF00400	0.577
DEG_APCC_DBOX_1	57	65	PF00400	0.573
DEG_ODPH_VHL_1	73	86	PF01847	0.381
DOC_MAPK_DCC_7	256	264	PF00069	0.524
DOC_MAPK_DCC_7	76	86	PF00069	0.477
DOC_MAPK_MEF2A_6	196	205	PF00069	0.467
DOC_MAPK_MEF2A_6	256	264	PF00069	0.577
DOC_USP7_MATH_1	15	19	PF00917	0.718
DOC_USP7_UBL2_3	47	51	PF12436	0.617
DOC_USP7_UBL2_3	55	59	PF12436	0.576
DOC_WW_Pin1_4	271	276	PF00397	0.632
LIG_14-3-3_CanoR_1	132	137	PF00244	0.507
LIG_Actin_RPEL_3	249	268	PF02755	0.476
LIG_APCC_ABBA_1	26	31	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BRCT_BRCA1_1	171	175	PF00533	0.333
LIG_deltaCOP1_diTrp_1	129	136	PF00928	0.530
LIG_FHA_1	106	112	PF00498	0.277
LIG_FHA_1	190	196	PF00498	0.353
LIG_FHA_1	205	211	PF00498	0.305
LIG_FHA_1	263	269	PF00498	0.558
LIG_FHA_1	91	97	PF00498	0.317
LIG_FHA_2	1	7	PF00498	0.599
LIG_FHA_2	164	170	PF00498	0.169
LIG_FHA_2	20	26	PF00498	0.553
LIG_FHA_2	271	277	PF00498	0.599
LIG_FHA_2	280	286	PF00498	0.618
LIG_LIR_Gen_1	135	146	PF02991	0.318
LIG_LIR_Gen_1	187	195	PF02991	0.323
LIG_LIR_Gen_1	209	220	PF02991	0.475
LIG_LIR_Nem_3	135	141	PF02991	0.313
LIG_LIR_Nem_3	142	147	PF02991	0.318
LIG_LIR_Nem_3	172	178	PF02991	0.254
LIG_LIR_Nem_3	187	191	PF02991	0.269
LIG_LIR_Nem_3	209	215	PF02991	0.392
LIG_MLH1_MIPbox_1	171	175	PF16413	0.330
LIG_SH2_STAT5	174	177	PF00017	0.313
LIG_SH2_STAT5	179	182	PF00017	0.296
LIG_SH2_STAT5	243	246	PF00017	0.315
LIG_SH3_3	257	263	PF00018	0.477
LIG_SH3_3	272	278	PF00018	0.513
LIG_SH3_3	9	15	PF00018	0.591
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.334
LIG_WRC_WIRS_1	185	190	PF05994	0.329
MOD_CDK_SPxK_1	271	277	PF00069	0.549
MOD_CK1_1	162	168	PF00069	0.219
MOD_CK1_1	279	285	PF00069	0.579
MOD_CK2_1	279	285	PF00069	0.579
MOD_GlcNHglycan	222	225	PF01048	0.517
MOD_GSK3_1	100	107	PF00069	0.356
MOD_GSK3_1	15	22	PF00069	0.718
MOD_GSK3_1	159	166	PF00069	0.278
MOD_GSK3_1	216	223	PF00069	0.434
MOD_N-GLC_1	163	168	PF02516	0.428
MOD_N-GLC_1	36	41	PF02516	0.416
MOD_NEK2_1	147	152	PF00069	0.345
MOD_NEK2_1	191	196	PF00069	0.323
MOD_NEK2_1	206	211	PF00069	0.432
MOD_NEK2_1	215	220	PF00069	0.361
MOD_NEK2_1	49	54	PF00069	0.578
MOD_NEK2_1	89	94	PF00069	0.332
MOD_NEK2_1	98	103	PF00069	0.298
MOD_PIKK_1	262	268	PF00454	0.530
MOD_PIKK_1	36	42	PF00454	0.600
MOD_PKA_2	276	282	PF00069	0.543
MOD_Plk_1	163	169	PF00069	0.288
MOD_Plk_1	254	260	PF00069	0.482
MOD_Plk_4	105	111	PF00069	0.267
MOD_Plk_4	147	153	PF00069	0.316
MOD_Plk_4	163	169	PF00069	0.265
MOD_Plk_4	206	212	PF00069	0.353
MOD_Plk_4	90	96	PF00069	0.326
MOD_ProDKin_1	271	277	PF00069	0.637
TRG_ENDOCYTIC_2	144	147	PF00928	0.315
TRG_ENDOCYTIC_2	179	182	PF00928	0.316
TRG_ENDOCYTIC_2	232	235	PF00928	0.373
TRG_ENDOCYTIC_2	243	246	PF00928	0.309
TRG_ER_diArg_1	75	77	PF00400	0.533
TRG_NLS_MonoExtN_4	55	61	PF00514	0.496
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I5	Leptomonas seymouri	50%	74%
A0A0N1PAF6	Leptomonas seymouri	69%	81%
A0A1X0P8X4	Trypanosomatidae	42%	100%
A0A1X0P9Q6	Trypanosomatidae	51%	100%
A0A3R7M294	Trypanosoma rangeli	36%	100%
A0A3S5H538	Leishmania donovani	85%	79%
A0A3S5H540	Leishmania donovani	82%	97%
A4H3K6	Leishmania braziliensis	71%	100%
A4H3K7	Leishmania braziliensis	65%	100%
A4HRU8	Leishmania infantum	85%	79%
A4HRV0	Leishmania infantum	82%	97%
B0YBR5	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	28%	100%
E9ACI2	Leishmania major	26%	100%
E9ACI3	Leishmania major	84%	79%
E9ACI5	Leishmania major	79%	100%
E9AJS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AJS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	79%
O14201	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	97%
O26317	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	41%	100%
P32907	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P41943	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q24JP1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q460G9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5B2K4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	99%