LeishMANIAdb
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GPR1/FUN34/YaaH-class plasma membrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/YaaH-class plasma membrane protein
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania mexicana
UniProt:
E9AJS2_LEIMU
TriTrypDb:
LmxM.03.0380
Length:
372

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005886 plasma membrane 3 3

Expansion

Sequence features

E9AJS2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJS2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006811 monoatomic ion transport 4 3
GO:0006820 monoatomic anion transport 5 3
GO:0006835 dicarboxylic acid transport 7 3
GO:0006846 acetate transport 6 3
GO:0009987 cellular process 1 3
GO:0015711 organic anion transport 5 3
GO:0015718 monocarboxylic acid transport 7 3
GO:0015740 C4-dicarboxylate transport 8 3
GO:0015744 succinate transport 6 3
GO:0015849 organic acid transport 5 3
GO:0034220 monoatomic ion transmembrane transport 3 3
GO:0035433 acetate transmembrane transport 5 3
GO:0046942 carboxylic acid transport 6 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071422 succinate transmembrane transport 5 3
GO:0071702 organic substance transport 4 3
GO:0098656 monoatomic anion transmembrane transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0008509 monoatomic anion transmembrane transporter activity 4 3
GO:0008514 organic anion transmembrane transporter activity 5 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015078 proton transmembrane transporter activity 5 3
GO:0015123 acetate transmembrane transporter activity 6 3
GO:0015291 secondary active transmembrane transporter activity 4 3
GO:0015293 symporter activity 5 3
GO:0015294 solute:monoatomic cation symporter activity 5 3
GO:0015295 solute:proton symporter activity 6 3
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 3
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 3
GO:0015360 acetate:proton symporter activity 7 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022853 active monoatomic ion transmembrane transporter activity 4 3
GO:0022857 transmembrane transporter activity 2 3
GO:0022890 inorganic cation transmembrane transporter activity 4 3
GO:0043893 acetate:monoatomic cation symporter activity 6 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 144 146 PF00675 0.304
CLV_NRD_NRD_1 359 361 PF00675 0.423
CLV_NRD_NRD_1 366 368 PF00675 0.426
CLV_NRD_NRD_1 369 371 PF00675 0.422
CLV_NRD_NRD_1 51 53 PF00675 0.462
CLV_NRD_NRD_1 82 84 PF00675 0.451
CLV_PCSK_FUR_1 49 53 PF00082 0.400
CLV_PCSK_KEX2_1 359 361 PF00082 0.409
CLV_PCSK_KEX2_1 366 368 PF00082 0.413
CLV_PCSK_KEX2_1 51 53 PF00082 0.437
CLV_PCSK_KEX2_1 82 84 PF00082 0.399
CLV_PCSK_SKI1_1 32 36 PF00082 0.431
CLV_PCSK_SKI1_1 325 329 PF00082 0.377
DEG_APCC_DBOX_1 324 332 PF00400 0.577
DOC_MAPK_DCC_7 145 155 PF00069 0.530
DOC_MAPK_DCC_7 325 333 PF00069 0.522
DOC_MAPK_MEF2A_6 265 274 PF00069 0.516
DOC_MAPK_MEF2A_6 325 333 PF00069 0.577
DOC_USP7_MATH_1 141 145 PF00917 0.441
DOC_USP7_MATH_1 50 54 PF00917 0.615
DOC_USP7_MATH_1 70 74 PF00917 0.702
DOC_WW_Pin1_4 361 366 PF00397 0.604
LIG_14-3-3_CanoR_1 201 206 PF00244 0.536
LIG_14-3-3_CanoR_1 32 40 PF00244 0.807
LIG_14-3-3_CanoR_1 49 59 PF00244 0.648
LIG_14-3-3_CanoR_1 99 104 PF00244 0.726
LIG_Actin_RPEL_3 318 337 PF02755 0.486
LIG_BIR_II_1 1 5 PF00653 0.698
LIG_BRCT_BRCA1_1 240 244 PF00533 0.316
LIG_BRCT_BRCA1_1 72 76 PF00533 0.636
LIG_deltaCOP1_diTrp_1 198 205 PF00928 0.516
LIG_FHA_1 1 7 PF00498 0.677
LIG_FHA_1 160 166 PF00498 0.346
LIG_FHA_1 175 181 PF00498 0.344
LIG_FHA_1 259 265 PF00498 0.405
LIG_FHA_1 274 280 PF00498 0.359
LIG_FHA_1 332 338 PF00498 0.583
LIG_FHA_1 35 41 PF00498 0.658
LIG_FHA_2 21 27 PF00498 0.617
LIG_FHA_2 233 239 PF00498 0.245
LIG_LIR_Gen_1 204 215 PF02991 0.309
LIG_LIR_Gen_1 256 264 PF02991 0.383
LIG_LIR_Gen_1 278 289 PF02991 0.391
LIG_LIR_Gen_1 56 63 PF02991 0.610
LIG_LIR_Nem_3 204 210 PF02991 0.330
LIG_LIR_Nem_3 211 216 PF02991 0.348
LIG_LIR_Nem_3 241 247 PF02991 0.316
LIG_LIR_Nem_3 256 260 PF02991 0.372
LIG_LIR_Nem_3 278 284 PF02991 0.317
LIG_LIR_Nem_3 342 346 PF02991 0.555
LIG_LIR_Nem_3 56 60 PF02991 0.609
LIG_LYPXL_S_1 14 18 PF13949 0.419
LIG_LYPXL_yS_3 15 18 PF13949 0.617
LIG_MLH1_MIPbox_1 240 244 PF16413 0.316
LIG_Pex14_1 339 343 PF04695 0.510
LIG_SH2_CRK 57 61 PF00017 0.647
LIG_SH2_STAP1 57 61 PF00017 0.629
LIG_SH2_STAT5 243 246 PF00017 0.395
LIG_SH2_STAT5 248 251 PF00017 0.391
LIG_SH2_STAT5 312 315 PF00017 0.370
LIG_SH2_STAT5 59 62 PF00017 0.689
LIG_SH2_STAT5 92 95 PF00017 0.697
LIG_SH3_3 326 332 PF00018 0.490
LIG_SUMO_SIM_anti_2 276 281 PF11976 0.369
LIG_WRC_WIRS_1 254 259 PF05994 0.369
LIG_WRC_WIRS_1 340 345 PF05994 0.524
MOD_CDC14_SPxK_1 364 367 PF00782 0.605
MOD_CDK_SPK_2 361 366 PF00069 0.604
MOD_CDK_SPxK_1 361 367 PF00069 0.605
MOD_CK1_1 231 237 PF00069 0.204
MOD_CK1_1 53 59 PF00069 0.771
MOD_CK2_1 118 124 PF00069 0.585
MOD_CK2_1 22 28 PF00069 0.676
MOD_GlcNHglycan 291 294 PF01048 0.527
MOD_GlcNHglycan 356 359 PF01048 0.455
MOD_GlcNHglycan 72 75 PF01048 0.446
MOD_GSK3_1 169 176 PF00069 0.250
MOD_GSK3_1 228 235 PF00069 0.309
MOD_GSK3_1 285 292 PF00069 0.374
MOD_GSK3_1 34 41 PF00069 0.610
MOD_GSK3_1 78 85 PF00069 0.703
MOD_N-GLC_1 232 237 PF02516 0.478
MOD_N-GLC_1 352 357 PF02516 0.457
MOD_N-GLC_1 70 75 PF02516 0.429
MOD_N-GLC_1 97 102 PF02516 0.528
MOD_NEK2_1 158 163 PF00069 0.332
MOD_NEK2_1 167 172 PF00069 0.337
MOD_NEK2_1 216 221 PF00069 0.323
MOD_NEK2_1 260 265 PF00069 0.340
MOD_NEK2_1 275 280 PF00069 0.378
MOD_NEK2_1 284 289 PF00069 0.386
MOD_PIKK_1 331 337 PF00454 0.516
MOD_PIKK_1 346 352 PF00454 0.624
MOD_PIKK_1 359 365 PF00454 0.643
MOD_PIKK_1 65 71 PF00454 0.615
MOD_PKA_1 359 365 PF00069 0.605
MOD_PKA_1 82 88 PF00069 0.681
MOD_PKA_2 359 365 PF00069 0.606
MOD_PKA_2 50 56 PF00069 0.706
MOD_PKA_2 82 88 PF00069 0.630
MOD_PKA_2 98 104 PF00069 0.698
MOD_Plk_1 232 238 PF00069 0.275
MOD_Plk_1 323 329 PF00069 0.491
MOD_Plk_2-3 118 124 PF00069 0.562
MOD_Plk_4 10 16 PF00069 0.613
MOD_Plk_4 159 165 PF00069 0.340
MOD_Plk_4 174 180 PF00069 0.329
MOD_Plk_4 216 222 PF00069 0.310
MOD_Plk_4 232 238 PF00069 0.321
MOD_Plk_4 275 281 PF00069 0.373
MOD_ProDKin_1 361 367 PF00069 0.605
TRG_ENDOCYTIC_2 15 18 PF00928 0.617
TRG_ENDOCYTIC_2 213 216 PF00928 0.326
TRG_ENDOCYTIC_2 248 251 PF00928 0.309
TRG_ENDOCYTIC_2 301 304 PF00928 0.405
TRG_ENDOCYTIC_2 312 315 PF00928 0.428
TRG_ENDOCYTIC_2 57 60 PF00928 0.650
TRG_ER_diArg_1 365 367 PF00400 0.640
TRG_ER_diArg_1 48 51 PF00400 0.643
TRG_ER_diArg_1 82 84 PF00400 0.605

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAF6 Leptomonas seymouri 59% 100%
A0A3S5H538 Leishmania donovani 80% 100%
A0A3S5H540 Leishmania donovani 89% 100%
A0A451EJN9 Leishmania donovani 25% 100%
A4H3K6 Leishmania braziliensis 75% 100%
A4H3K7 Leishmania braziliensis 67% 100%
A4HRU8 Leishmania infantum 80% 100%
A4HRV0 Leishmania infantum 89% 100%
E9ACI2 Leishmania major 28% 100%
E9ACI3 Leishmania major 78% 100%
E9ACI5 Leishmania major 78% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BCC6 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS