GPR1/FUN34/YaaH-class plasma membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family, putative

Species:

Leishmania mexicana

UniProt:

E9AJS1_LEIMU

TriTrypDb:

LmxM.03.0370

Length:

291

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0005886	plasma membrane	3	2

Expansion

Sequence features

E9AJS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJS1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0006835	dicarboxylic acid transport	7	2
GO:0006846	acetate transport	6	2
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015718	monocarboxylic acid transport	7	2
GO:0015740	C4-dicarboxylate transport	8	2
GO:0015744	succinate transport	6	2
GO:0015849	organic acid transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0035433	acetate transmembrane transport	5	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071422	succinate transmembrane transport	5	2
GO:0071702	organic substance transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015123	acetate transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015293	symporter activity	5	2
GO:0015294	solute:monoatomic cation symporter activity	5	2
GO:0015295	solute:proton symporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	2
GO:0015360	acetate:proton symporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043893	acetate:monoatomic cation symporter activity	6	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.747
CLV_NRD_NRD_1	28	30	PF00675	0.496
CLV_PCSK_SKI1_1	275	279	PF00082	0.373
CLV_Separin_Metazoa	19	23	PF03568	0.548
DEG_APCC_DBOX_1	274	282	PF00400	0.618
DOC_MAPK_DCC_7	101	110	PF00069	0.484
DOC_MAPK_gen_1	24	33	PF00069	0.681
DOC_MAPK_MEF2A_6	275	282	PF00069	0.614
DOC_PP4_FxxP_1	179	182	PF00568	0.369
DOC_PP4_FxxP_1	214	217	PF00568	0.518
DOC_PP4_FxxP_1	225	228	PF00568	0.429
DOC_PP4_FxxP_1	25	28	PF00568	0.528
DOC_USP7_MATH_1	182	186	PF00917	0.300
DOC_USP7_MATH_1	204	208	PF00917	0.352
DOC_USP7_UBL2_3	12	16	PF12436	0.557
DOC_WW_Pin1_4	101	106	PF00397	0.472
DOC_WW_Pin1_4	213	218	PF00397	0.510
DOC_WW_Pin1_4	93	98	PF00397	0.676
LIG_14-3-3_CanoR_1	157	161	PF00244	0.483
LIG_14-3-3_CanoR_1	186	195	PF00244	0.170
LIG_14-3-3_CanoR_1	215	225	PF00244	0.436
LIG_14-3-3_CanoR_1	87	95	PF00244	0.655
LIG_Actin_WH2_2	256	272	PF00022	0.369
LIG_BRCT_BRCA1_1	206	210	PF00533	0.431
LIG_BRCT_BRCA1_1	234	238	PF00533	0.423
LIG_EH1_1	132	140	PF00400	0.152
LIG_FHA_1	114	120	PF00498	0.289
LIG_FHA_1	132	138	PF00498	0.340
LIG_FHA_2	266	272	PF00498	0.506
LIG_FHA_2	56	62	PF00498	0.612
LIG_LIR_Apic_2	212	217	PF02991	0.251
LIG_LIR_Apic_2	222	228	PF02991	0.238
LIG_LIR_Gen_1	216	226	PF02991	0.467
LIG_LIR_Nem_3	165	171	PF02991	0.297
LIG_LIR_Nem_3	222	227	PF02991	0.198
LIG_Pex14_2	198	202	PF04695	0.287
LIG_Pex14_2	210	214	PF04695	0.283
LIG_SH2_STAT5	251	254	PF00017	0.298
LIG_SH2_STAT5	262	265	PF00017	0.288
LIG_SH2_STAT5	288	291	PF00017	0.656
LIG_SH2_STAT5	35	38	PF00017	0.660
LIG_SH3_3	69	75	PF00018	0.681
LIG_SH3_3	91	97	PF00018	0.690
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.152
LIG_TRFH_1	224	228	PF08558	0.219
LIG_UBA3_1	119	126	PF00899	0.152
LIG_UBA3_1	277	285	PF00899	0.545
LIG_Vh1_VBS_1	245	263	PF01044	0.184
LIG_WRC_WIRS_1	115	120	PF05994	0.152
MOD_CK1_1	213	219	PF00069	0.537
MOD_CK1_1	54	60	PF00069	0.717
MOD_CK2_1	35	41	PF00069	0.565
MOD_CK2_1	55	61	PF00069	0.729
MOD_CK2_1	64	70	PF00069	0.668
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.540
MOD_GlcNHglycan	89	92	PF01048	0.446
MOD_GlcNHglycan	9	12	PF01048	0.492
MOD_GSK3_1	156	163	PF00069	0.453
MOD_GSK3_1	205	212	PF00069	0.400
MOD_GSK3_1	51	58	PF00069	0.781
MOD_N-GLC_1	51	56	PF02516	0.461
MOD_NEK2_1	113	118	PF00069	0.302
MOD_NEK2_1	160	165	PF00069	0.327
MOD_NEK2_1	205	210	PF00069	0.300
MOD_NEK2_1	232	237	PF00069	0.343
MOD_NEK2_1	239	244	PF00069	0.254
MOD_NEK2_1	265	270	PF00069	0.335
MOD_PIKK_1	55	61	PF00454	0.628
MOD_PKA_2	156	162	PF00069	0.438
MOD_Plk_4	114	120	PF00069	0.297
MOD_Plk_4	205	211	PF00069	0.284
MOD_Plk_4	219	225	PF00069	0.308
MOD_Plk_4	258	264	PF00069	0.378
MOD_ProDKin_1	101	107	PF00069	0.472
MOD_ProDKin_1	213	219	PF00069	0.510
MOD_ProDKin_1	93	99	PF00069	0.674
MOD_SUMO_rev_2	61	66	PF00179	0.571
TRG_DiLeu_BaEn_4	61	67	PF01217	0.608
TRG_ENDOCYTIC_2	168	171	PF00928	0.319
TRG_ENDOCYTIC_2	251	254	PF00928	0.318
TRG_ENDOCYTIC_2	262	265	PF00928	0.277
TRG_ER_diArg_1	21	24	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C8	Leptomonas seymouri	54%	91%
A0A0N1I1I5	Leptomonas seymouri	26%	74%
A0A0N1PAF6	Leptomonas seymouri	30%	80%
A0A1X0P9Q6	Trypanosomatidae	35%	100%
A0A3R7M294	Trypanosoma rangeli	35%	100%
A0A3R7MT82	Trypanosoma rangeli	30%	100%
A0A3S5H538	Leishmania donovani	27%	79%
A0A3S5H540	Leishmania donovani	27%	100%
A0A451EJN9	Leishmania donovani	78%	94%
A4H3K6	Leishmania braziliensis	31%	98%
A4H3K7	Leishmania braziliensis	31%	81%
A4HRU7	Leishmania infantum	79%	94%
A4HRU8	Leishmania infantum	28%	79%
A4HRV0	Leishmania infantum	27%	100%
E9ACI2	Leishmania major	78%	100%
E9ACI3	Leishmania major	27%	79%
E9AJS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AJS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
Q12359	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
V5BCC6	Trypanosoma cruzi	27%	100%
V5DU51	Trypanosoma cruzi	38%	90%