Flagellar associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJR6_LEIMU

TriTrypDb:

LmxM.03.0320

Length:

1010

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AJR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.532
CLV_C14_Caspase3-7	748	752	PF00656	0.437
CLV_C14_Caspase3-7	893	897	PF00656	0.542
CLV_C14_Caspase3-7	957	961	PF00656	0.569
CLV_NRD_NRD_1	122	124	PF00675	0.294
CLV_NRD_NRD_1	263	265	PF00675	0.513
CLV_NRD_NRD_1	410	412	PF00675	0.678
CLV_NRD_NRD_1	441	443	PF00675	0.610
CLV_NRD_NRD_1	457	459	PF00675	0.411
CLV_NRD_NRD_1	492	494	PF00675	0.466
CLV_NRD_NRD_1	764	766	PF00675	0.533
CLV_NRD_NRD_1	914	916	PF00675	0.711
CLV_NRD_NRD_1	969	971	PF00675	0.669
CLV_PCSK_FUR_1	490	494	PF00082	0.565
CLV_PCSK_KEX2_1	122	124	PF00082	0.372
CLV_PCSK_KEX2_1	263	265	PF00082	0.555
CLV_PCSK_KEX2_1	343	345	PF00082	0.586
CLV_PCSK_KEX2_1	369	371	PF00082	0.558
CLV_PCSK_KEX2_1	441	443	PF00082	0.560
CLV_PCSK_KEX2_1	492	494	PF00082	0.587
CLV_PCSK_KEX2_1	914	916	PF00082	0.711
CLV_PCSK_KEX2_1	968	970	PF00082	0.670
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.586
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.596
CLV_PCSK_PC7_1	965	971	PF00082	0.593
CLV_PCSK_SKI1_1	143	147	PF00082	0.510
CLV_PCSK_SKI1_1	175	179	PF00082	0.510
CLV_PCSK_SKI1_1	244	248	PF00082	0.629
CLV_PCSK_SKI1_1	281	285	PF00082	0.534
CLV_PCSK_SKI1_1	369	373	PF00082	0.611
CLV_PCSK_SKI1_1	398	402	PF00082	0.679
CLV_PCSK_SKI1_1	508	512	PF00082	0.433
CLV_PCSK_SKI1_1	673	677	PF00082	0.398
CLV_PCSK_SKI1_1	682	686	PF00082	0.370
CLV_PCSK_SKI1_1	693	697	PF00082	0.261
CLV_PCSK_SKI1_1	74	78	PF00082	0.420
CLV_Separin_Metazoa	448	452	PF03568	0.580
CLV_Separin_Metazoa	51	55	PF03568	0.468
DEG_APCC_DBOX_1	142	150	PF00400	0.507
DEG_APCC_DBOX_1	397	405	PF00400	0.407
DEG_APCC_DBOX_1	692	700	PF00400	0.377
DEG_APCC_DBOX_1	787	795	PF00400	0.467
DEG_SPOP_SBC_1	14	18	PF00917	0.764
DEG_SPOP_SBC_1	953	957	PF00917	0.591
DOC_CYCLIN_RxL_1	140	148	PF00134	0.456
DOC_CYCLIN_RxL_1	670	683	PF00134	0.391
DOC_CYCLIN_RxL_1	71	81	PF00134	0.539
DOC_MAPK_gen_1	181	191	PF00069	0.568
DOC_MAPK_gen_1	343	351	PF00069	0.614
DOC_MAPK_gen_1	439	449	PF00069	0.645
DOC_MAPK_gen_1	689	696	PF00069	0.352
DOC_PP1_RVXF_1	584	590	PF00149	0.529
DOC_USP7_MATH_1	15	19	PF00917	0.699
DOC_USP7_MATH_1	423	427	PF00917	0.641
DOC_USP7_MATH_1	603	607	PF00917	0.485
DOC_USP7_MATH_1	663	667	PF00917	0.375
DOC_USP7_MATH_1	890	894	PF00917	0.623
DOC_USP7_MATH_1	904	908	PF00917	0.769
DOC_USP7_MATH_1	934	938	PF00917	0.621
DOC_USP7_MATH_1	948	952	PF00917	0.680
DOC_USP7_MATH_1	954	958	PF00917	0.674
DOC_USP7_UBL2_3	280	284	PF12436	0.533
DOC_USP7_UBL2_3	343	347	PF12436	0.547
DOC_USP7_UBL2_3	762	766	PF12436	0.526
DOC_WW_Pin1_4	19	24	PF00397	0.692
DOC_WW_Pin1_4	35	40	PF00397	0.529
DOC_WW_Pin1_4	919	924	PF00397	0.707
DOC_WW_Pin1_4	960	965	PF00397	0.685
LIG_14-3-3_CanoR_1	150	160	PF00244	0.540
LIG_14-3-3_CanoR_1	370	377	PF00244	0.579
LIG_14-3-3_CanoR_1	380	385	PF00244	0.538
LIG_14-3-3_CanoR_1	490	499	PF00244	0.568
LIG_14-3-3_CanoR_1	524	531	PF00244	0.409
LIG_14-3-3_CanoR_1	54	62	PF00244	0.575
LIG_14-3-3_CanoR_1	936	941	PF00244	0.627
LIG_Actin_WH2_2	597	614	PF00022	0.510
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_CaM_IQ_9	290	306	PF13499	0.560
LIG_FHA_1	104	110	PF00498	0.330
LIG_FHA_1	161	167	PF00498	0.633
LIG_FHA_1	20	26	PF00498	0.536
LIG_FHA_1	255	261	PF00498	0.518
LIG_FHA_1	323	329	PF00498	0.522
LIG_FHA_1	416	422	PF00498	0.561
LIG_FHA_1	555	561	PF00498	0.539
LIG_FHA_1	639	645	PF00498	0.349
LIG_FHA_1	772	778	PF00498	0.447
LIG_FHA_1	819	825	PF00498	0.556
LIG_FHA_2	132	138	PF00498	0.581
LIG_FHA_2	152	158	PF00498	0.535
LIG_FHA_2	196	202	PF00498	0.544
LIG_FHA_2	233	239	PF00498	0.480
LIG_FHA_2	287	293	PF00498	0.636
LIG_FHA_2	450	456	PF00498	0.624
LIG_FHA_2	532	538	PF00498	0.481
LIG_GBD_Chelix_1	973	981	PF00786	0.520
LIG_Integrin_isoDGR_2	966	968	PF01839	0.605
LIG_LIR_Gen_1	46	56	PF02991	0.419
LIG_LIR_Gen_1	68	77	PF02991	0.401
LIG_LIR_Gen_1	781	792	PF02991	0.447
LIG_LIR_Gen_1	857	866	PF02991	0.313
LIG_LIR_Nem_3	46	52	PF02991	0.417
LIG_LIR_Nem_3	68	72	PF02991	0.404
LIG_LIR_Nem_3	781	787	PF02991	0.430
LIG_LIR_Nem_3	857	862	PF02991	0.303
LIG_MYND_1	60	64	PF01753	0.531
LIG_NRBOX	173	179	PF00104	0.517
LIG_NRBOX	71	77	PF00104	0.544
LIG_PCNA_yPIPBox_3	354	367	PF02747	0.499
LIG_PCNA_yPIPBox_3	670	679	PF02747	0.521
LIG_RPA_C_Fungi	192	204	PF08784	0.415
LIG_RPA_C_Fungi	715	727	PF08784	0.539
LIG_SH2_CRK	784	788	PF00017	0.487
LIG_SH2_CRK	859	863	PF00017	0.568
LIG_SH2_STAP1	618	622	PF00017	0.437
LIG_SH2_STAT3	463	466	PF00017	0.610
LIG_SH2_STAT5	173	176	PF00017	0.480
LIG_SH2_STAT5	701	704	PF00017	0.508
LIG_SH3_3	9	15	PF00018	0.540
LIG_SH3_3	938	944	PF00018	0.709
LIG_SH3_3	982	988	PF00018	0.726
LIG_SUMO_SIM_anti_2	537	542	PF11976	0.391
LIG_SUMO_SIM_anti_2	647	655	PF11976	0.483
LIG_SUMO_SIM_par_1	38	43	PF11976	0.445
LIG_TRAF2_1	236	239	PF00917	0.362
LIG_TRAF2_1	289	292	PF00917	0.487
LIG_TRAF2_1	392	395	PF00917	0.547
LIG_TRAF2_1	498	501	PF00917	0.629
LIG_TRAF2_1	547	550	PF00917	0.511
LIG_TRAF2_1	799	802	PF00917	0.649
LIG_TRAF2_1	827	830	PF00917	0.519
MOD_CDK_SPK_2	960	965	PF00069	0.463
MOD_CK1_1	18	24	PF00069	0.778
MOD_CK1_1	488	494	PF00069	0.311
MOD_CK1_1	518	524	PF00069	0.503
MOD_CK1_1	554	560	PF00069	0.524
MOD_CK1_1	666	672	PF00069	0.403
MOD_CK1_1	741	747	PF00069	0.534
MOD_CK1_1	907	913	PF00069	0.726
MOD_CK2_1	131	137	PF00069	0.586
MOD_CK2_1	232	238	PF00069	0.550
MOD_CK2_1	286	292	PF00069	0.560
MOD_CK2_1	35	41	PF00069	0.616
MOD_CK2_1	424	430	PF00069	0.688
MOD_CK2_1	449	455	PF00069	0.592
MOD_CK2_1	531	537	PF00069	0.394
MOD_CK2_1	544	550	PF00069	0.380
MOD_CK2_1	596	602	PF00069	0.417
MOD_CK2_1	820	826	PF00069	0.557
MOD_Cter_Amidation	966	969	PF01082	0.604
MOD_GlcNHglycan	2	5	PF01048	0.665
MOD_GlcNHglycan	205	208	PF01048	0.377
MOD_GlcNHglycan	353	357	PF01048	0.488
MOD_GlcNHglycan	56	59	PF01048	0.628
MOD_GlcNHglycan	665	668	PF01048	0.506
MOD_GlcNHglycan	887	890	PF01048	0.661
MOD_GlcNHglycan	906	909	PF01048	0.749
MOD_GlcNHglycan	923	926	PF01048	0.719
MOD_GlcNHglycan	929	932	PF01048	0.702
MOD_GlcNHglycan	936	939	PF01048	0.599
MOD_GlcNHglycan	950	953	PF01048	0.597
MOD_GSK3_1	14	21	PF00069	0.679
MOD_GSK3_1	160	167	PF00069	0.558
MOD_GSK3_1	29	36	PF00069	0.541
MOD_GSK3_1	376	383	PF00069	0.566
MOD_GSK3_1	417	424	PF00069	0.650
MOD_GSK3_1	478	485	PF00069	0.348
MOD_GSK3_1	885	892	PF00069	0.687
MOD_GSK3_1	915	922	PF00069	0.727
MOD_GSK3_1	948	955	PF00069	0.743
MOD_N-GLC_1	195	200	PF02516	0.561
MOD_N-GLC_1	27	32	PF02516	0.445
MOD_N-GLC_1	958	963	PF02516	0.670
MOD_NEK2_1	145	150	PF00069	0.521
MOD_NEK2_1	352	357	PF00069	0.578
MOD_NEK2_1	415	420	PF00069	0.634
MOD_NEK2_1	457	462	PF00069	0.506
MOD_NEK2_1	516	521	PF00069	0.541
MOD_NEK2_1	716	721	PF00069	0.531
MOD_NEK2_1	75	80	PF00069	0.555
MOD_NEK2_1	820	825	PF00069	0.513
MOD_PIKK_1	108	114	PF00454	0.454
MOD_PIKK_1	30	36	PF00454	0.634
MOD_PIKK_1	638	644	PF00454	0.349
MOD_PIKK_1	714	720	PF00454	0.514
MOD_PIKK_1	936	942	PF00454	0.653
MOD_PK_1	247	253	PF00069	0.496
MOD_PK_1	380	386	PF00069	0.538
MOD_PKA_1	369	375	PF00069	0.533
MOD_PKA_2	18	24	PF00069	0.673
MOD_PKA_2	254	260	PF00069	0.480
MOD_PKA_2	369	375	PF00069	0.571
MOD_PKA_2	410	416	PF00069	0.682
MOD_PKA_2	457	463	PF00069	0.456
MOD_PKA_2	491	497	PF00069	0.564
MOD_PKA_2	531	537	PF00069	0.530
MOD_PKA_2	663	669	PF00069	0.419
MOD_PKA_2	913	919	PF00069	0.612
MOD_PKB_1	542	550	PF00069	0.460
MOD_Plk_1	247	253	PF00069	0.629
MOD_Plk_1	319	325	PF00069	0.614
MOD_Plk_1	958	964	PF00069	0.462
MOD_Plk_4	319	325	PF00069	0.581
MOD_Plk_4	457	463	PF00069	0.509
MOD_ProDKin_1	19	25	PF00069	0.692
MOD_ProDKin_1	35	41	PF00069	0.525
MOD_ProDKin_1	919	925	PF00069	0.710
MOD_ProDKin_1	960	966	PF00069	0.685
MOD_SUMO_for_1	342	345	PF00179	0.588
MOD_SUMO_for_1	555	558	PF00179	0.531
MOD_SUMO_rev_2	273	283	PF00179	0.466
MOD_SUMO_rev_2	340	349	PF00179	0.563
MOD_SUMO_rev_2	494	499	PF00179	0.538
MOD_SUMO_rev_2	843	850	PF00179	0.371
TRG_DiLeu_BaEn_1	186	191	PF01217	0.549
TRG_DiLeu_BaEn_1	362	367	PF01217	0.584
TRG_DiLeu_BaEn_1	535	540	PF01217	0.518
TRG_DiLeu_BaEn_1	648	653	PF01217	0.352
TRG_DiLeu_BaEn_1	680	685	PF01217	0.376
TRG_DiLeu_BaEn_4	186	192	PF01217	0.564
TRG_DiLeu_BaEn_4	500	506	PF01217	0.428
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.413
TRG_DiLeu_BaLyEn_6	813	818	PF01217	0.333
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.383
TRG_ENDOCYTIC_2	230	233	PF00928	0.438
TRG_ENDOCYTIC_2	69	72	PF00928	0.537
TRG_ENDOCYTIC_2	784	787	PF00928	0.439
TRG_ENDOCYTIC_2	859	862	PF00928	0.441
TRG_ER_diArg_1	121	123	PF00400	0.370
TRG_ER_diArg_1	262	264	PF00400	0.492
TRG_ER_diArg_1	441	443	PF00400	0.670
TRG_ER_diArg_1	489	492	PF00400	0.581
TRG_ER_diArg_1	541	544	PF00400	0.495
TRG_ER_diArg_1	586	589	PF00400	0.527
TRG_ER_diArg_1	628	631	PF00400	0.373
TRG_ER_diArg_1	690	693	PF00400	0.366
TRG_ER_diArg_1	697	700	PF00400	0.383
TRG_ER_diArg_1	720	723	PF00400	0.513
TRG_ER_diArg_1	968	970	PF00400	0.705
TRG_NES_CRM1_1	688	703	PF08389	0.491
TRG_NES_CRM1_1	748	760	PF08389	0.548
TRG_NLS_Bipartite_1	492	512	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	119	124	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	574	579	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	682	687	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	724	728	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ56	Leptomonas seymouri	25%	100%
A0A0N1I2V1	Leptomonas seymouri	63%	98%
A0A0S4JMK5	Bodo saltans	33%	100%
A0A0S4KGN1	Bodo saltans	24%	100%
A0A1X0P9K9	Trypanosomatidae	38%	100%
A0A381MLP4	Leishmania infantum	24%	100%
A0A3Q8IAS8	Leishmania donovani	24%	100%
A0A3R7L4Y2	Trypanosoma rangeli	37%	100%
A0A3S5H534	Leishmania donovani	89%	97%
A0A451EJK4	Leishmania donovani	24%	100%
A4H3K2	Leishmania braziliensis	76%	97%
A4HG33	Leishmania braziliensis	25%	100%
A4HRU2	Leishmania infantum	89%	97%
A8HUA1	Chlamydomonas reinhardtii	27%	100%
B2RW38	Mus musculus	27%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	98%
D0A240	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ACH7	Leishmania major	89%	100%
Q5T655	Homo sapiens	27%	100%
V5BCD1	Trypanosoma cruzi	37%	96%