Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJR3_LEIMU

TriTrypDb:

LmxM.03.0280

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJR3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0035091	phosphatidylinositol binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.592
CLV_C14_Caspase3-7	387	391	PF00656	0.660
CLV_C14_Caspase3-7	502	506	PF00656	0.583
CLV_C14_Caspase3-7	781	785	PF00656	0.613
CLV_NRD_NRD_1	182	184	PF00675	0.693
CLV_NRD_NRD_1	292	294	PF00675	0.446
CLV_NRD_NRD_1	322	324	PF00675	0.669
CLV_NRD_NRD_1	473	475	PF00675	0.530
CLV_NRD_NRD_1	495	497	PF00675	0.650
CLV_NRD_NRD_1	5	7	PF00675	0.509
CLV_NRD_NRD_1	596	598	PF00675	0.677
CLV_NRD_NRD_1	729	731	PF00675	0.391
CLV_NRD_NRD_1	76	78	PF00675	0.558
CLV_NRD_NRD_1	858	860	PF00675	0.617
CLV_PCSK_FUR_1	727	731	PF00082	0.383
CLV_PCSK_KEX2_1	182	184	PF00082	0.693
CLV_PCSK_KEX2_1	292	294	PF00082	0.446
CLV_PCSK_KEX2_1	321	323	PF00082	0.678
CLV_PCSK_KEX2_1	494	496	PF00082	0.658
CLV_PCSK_KEX2_1	5	7	PF00082	0.509
CLV_PCSK_KEX2_1	596	598	PF00082	0.673
CLV_PCSK_KEX2_1	729	731	PF00082	0.391
CLV_PCSK_KEX2_1	75	77	PF00082	0.573
CLV_PCSK_KEX2_1	857	859	PF00082	0.625
CLV_PCSK_SKI1_1	259	263	PF00082	0.494
CLV_PCSK_SKI1_1	5	9	PF00082	0.535
CLV_PCSK_SKI1_1	510	514	PF00082	0.661
CLV_PCSK_SKI1_1	76	80	PF00082	0.599
DEG_APCC_DBOX_1	237	245	PF00400	0.674
DEG_APCC_DBOX_1	4	12	PF00400	0.498
DEG_APCC_DBOX_1	74	82	PF00400	0.603
DEG_MDM2_SWIB_1	80	88	PF02201	0.583
DEG_SCF_FBW7_1	539	544	PF00400	0.546
DEG_SCF_FBW7_1	876	882	PF00400	0.626
DEG_SPOP_SBC_1	25	29	PF00917	0.691
DEG_SPOP_SBC_1	482	486	PF00917	0.574
DEG_SPOP_SBC_1	879	883	PF00917	0.656
DOC_ANK_TNKS_1	632	639	PF00023	0.619
DOC_CDC14_PxL_1	665	673	PF14671	0.687
DOC_CDC14_PxL_1	682	690	PF14671	0.552
DOC_CDC14_PxL_1	699	707	PF14671	0.421
DOC_CKS1_1	232	237	PF01111	0.580
DOC_CKS1_1	252	257	PF01111	0.436
DOC_CKS1_1	845	850	PF01111	0.570
DOC_CKS1_1	876	881	PF01111	0.622
DOC_CYCLIN_RxL_1	74	83	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	930	936	PF00134	0.470
DOC_MAPK_gen_1	710	717	PF00069	0.575
DOC_MAPK_gen_1	75	81	PF00069	0.592
DOC_MAPK_MEF2A_6	41	50	PF00069	0.513
DOC_MAPK_MEF2A_6	927	934	PF00069	0.593
DOC_PP1_RVXF_1	74	81	PF00149	0.602
DOC_PP2B_LxvP_1	210	213	PF13499	0.651
DOC_PP2B_LxvP_1	374	377	PF13499	0.711
DOC_PP2B_LxvP_1	46	49	PF13499	0.511
DOC_PP2B_LxvP_1	788	791	PF13499	0.506
DOC_PP2B_LxvP_1	846	849	PF13499	0.682
DOC_PP2B_LxvP_1	930	933	PF13499	0.603
DOC_PP4_FxxP_1	249	252	PF00568	0.656
DOC_PP4_FxxP_1	445	448	PF00568	0.637
DOC_USP7_MATH_1	103	107	PF00917	0.548
DOC_USP7_MATH_1	122	126	PF00917	0.551
DOC_USP7_MATH_1	176	180	PF00917	0.531
DOC_USP7_MATH_1	221	225	PF00917	0.664
DOC_USP7_MATH_1	426	430	PF00917	0.625
DOC_USP7_MATH_1	476	480	PF00917	0.598
DOC_USP7_MATH_1	482	486	PF00917	0.551
DOC_USP7_MATH_1	504	508	PF00917	0.573
DOC_USP7_MATH_1	51	55	PF00917	0.593
DOC_USP7_MATH_1	512	516	PF00917	0.572
DOC_USP7_MATH_1	541	545	PF00917	0.566
DOC_USP7_MATH_1	612	616	PF00917	0.685
DOC_USP7_MATH_1	704	708	PF00917	0.519
DOC_USP7_MATH_1	759	763	PF00917	0.702
DOC_USP7_MATH_1	782	786	PF00917	0.609
DOC_USP7_MATH_1	799	803	PF00917	0.567
DOC_USP7_MATH_1	806	810	PF00917	0.640
DOC_USP7_MATH_1	827	831	PF00917	0.591
DOC_USP7_MATH_1	836	840	PF00917	0.517
DOC_USP7_MATH_1	879	883	PF00917	0.648
DOC_USP7_MATH_1	888	892	PF00917	0.562
DOC_WW_Pin1_4	127	132	PF00397	0.651
DOC_WW_Pin1_4	225	230	PF00397	0.721
DOC_WW_Pin1_4	231	236	PF00397	0.642
DOC_WW_Pin1_4	251	256	PF00397	0.441
DOC_WW_Pin1_4	316	321	PF00397	0.573
DOC_WW_Pin1_4	530	535	PF00397	0.709
DOC_WW_Pin1_4	537	542	PF00397	0.597
DOC_WW_Pin1_4	561	566	PF00397	0.675
DOC_WW_Pin1_4	608	613	PF00397	0.677
DOC_WW_Pin1_4	62	67	PF00397	0.631
DOC_WW_Pin1_4	636	641	PF00397	0.672
DOC_WW_Pin1_4	656	661	PF00397	0.529
DOC_WW_Pin1_4	771	776	PF00397	0.651
DOC_WW_Pin1_4	813	818	PF00397	0.711
DOC_WW_Pin1_4	844	849	PF00397	0.589
DOC_WW_Pin1_4	875	880	PF00397	0.630
DOC_WW_Pin1_4	889	894	PF00397	0.544
LIG_14-3-3_CanoR_1	111	118	PF00244	0.563
LIG_14-3-3_CanoR_1	174	179	PF00244	0.642
LIG_14-3-3_CanoR_1	182	187	PF00244	0.583
LIG_14-3-3_CanoR_1	20	26	PF00244	0.520
LIG_14-3-3_CanoR_1	225	229	PF00244	0.614
LIG_14-3-3_CanoR_1	41	49	PF00244	0.609
LIG_14-3-3_CanoR_1	623	627	PF00244	0.699
LIG_14-3-3_CanoR_1	651	657	PF00244	0.642
LIG_14-3-3_CanoR_1	712	718	PF00244	0.569
LIG_14-3-3_CanoR_1	810	817	PF00244	0.709
LIG_14-3-3_CanoR_1	875	879	PF00244	0.582
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BIR_III_2	152	156	PF00653	0.502
LIG_BRCT_BRCA1_1	159	163	PF00533	0.524
LIG_BRCT_BRCA1_1	428	432	PF00533	0.614
LIG_BRCT_BRCA1_1	455	459	PF00533	0.510
LIG_BRCT_BRCA1_1	484	488	PF00533	0.578
LIG_BRCT_BRCA1_1	638	642	PF00533	0.544
LIG_FHA_1	289	295	PF00498	0.628
LIG_FHA_1	313	319	PF00498	0.613
LIG_FHA_1	426	432	PF00498	0.489
LIG_FHA_1	524	530	PF00498	0.495
LIG_FHA_1	790	796	PF00498	0.622
LIG_FHA_2	203	209	PF00498	0.646
LIG_FHA_2	252	258	PF00498	0.539
LIG_FHA_2	27	33	PF00498	0.707
LIG_FHA_2	62	68	PF00498	0.653
LIG_LIR_Apic_2	247	252	PF02991	0.614
LIG_LIR_Gen_1	436	447	PF02991	0.574
LIG_LIR_Gen_1	697	706	PF02991	0.598
LIG_LIR_Gen_1	850	856	PF02991	0.468
LIG_LIR_Gen_1	902	911	PF02991	0.538
LIG_LIR_LC3C_4	106	110	PF02991	0.490
LIG_LIR_Nem_3	436	442	PF02991	0.616
LIG_LIR_Nem_3	697	702	PF02991	0.610
LIG_LIR_Nem_3	850	854	PF02991	0.479
LIG_MLH1_MIPbox_1	159	163	PF16413	0.524
LIG_Pex14_1	724	728	PF04695	0.561
LIG_Pex14_2	80	84	PF04695	0.584
LIG_Rb_pABgroove_1	683	691	PF01858	0.674
LIG_Rb_pABgroove_1	898	906	PF01858	0.509
LIG_SH2_NCK_1	699	703	PF00017	0.434
LIG_SH2_PTP2	92	95	PF00017	0.461
LIG_SH2_SRC	92	95	PF00017	0.594
LIG_SH2_STAP1	689	693	PF00017	0.634
LIG_SH2_STAT3	552	555	PF00017	0.556
LIG_SH2_STAT5	439	442	PF00017	0.615
LIG_SH2_STAT5	670	673	PF00017	0.652
LIG_SH2_STAT5	789	792	PF00017	0.693
LIG_SH2_STAT5	860	863	PF00017	0.604
LIG_SH2_STAT5	92	95	PF00017	0.509
LIG_SH3_3	106	112	PF00018	0.521
LIG_SH3_3	226	232	PF00018	0.717
LIG_SH3_3	242	248	PF00018	0.511
LIG_SH3_3	249	255	PF00018	0.549
LIG_SH3_3	271	277	PF00018	0.613
LIG_SH3_3	526	532	PF00018	0.572
LIG_SH3_3	559	565	PF00018	0.544
LIG_SH3_3	654	660	PF00018	0.732
LIG_SH3_3	680	686	PF00018	0.664
LIG_SH3_3	690	696	PF00018	0.549
LIG_SH3_3	755	761	PF00018	0.676
LIG_SH3_3	766	772	PF00018	0.585
LIG_SH3_3	842	848	PF00018	0.584
LIG_SH3_3	91	97	PF00018	0.639
LIG_SH3_3	923	929	PF00018	0.607
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.493
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.632
LIG_SUMO_SIM_anti_2	690	695	PF11976	0.505
LIG_SUMO_SIM_par_1	891	899	PF11976	0.596
LIG_TRAF2_1	470	473	PF00917	0.636
LIG_WW_1	848	851	PF00397	0.488
MOD_CDC14_SPxK_1	319	322	PF00782	0.573
MOD_CDK_SPK_2	231	236	PF00069	0.583
MOD_CDK_SPK_2	316	321	PF00069	0.573
MOD_CDK_SPxK_1	316	322	PF00069	0.575
MOD_CDK_SPxxK_3	231	238	PF00069	0.579
MOD_CDK_SPxxK_3	316	323	PF00069	0.492
MOD_CK1_1	114	120	PF00069	0.512
MOD_CK1_1	202	208	PF00069	0.648
MOD_CK1_1	224	230	PF00069	0.718
MOD_CK1_1	26	32	PF00069	0.703
MOD_CK1_1	288	294	PF00069	0.627
MOD_CK1_1	333	339	PF00069	0.643
MOD_CK1_1	414	420	PF00069	0.734
MOD_CK1_1	480	486	PF00069	0.763
MOD_CK1_1	602	608	PF00069	0.636
MOD_CK1_1	632	638	PF00069	0.618
MOD_CK1_1	65	71	PF00069	0.598
MOD_CK1_1	813	819	PF00069	0.667
MOD_CK1_1	839	845	PF00069	0.524
MOD_CK1_1	880	886	PF00069	0.662
MOD_CK2_1	251	257	PF00069	0.596
MOD_CK2_1	26	32	PF00069	0.703
MOD_CK2_1	334	340	PF00069	0.703
MOD_CK2_1	612	618	PF00069	0.681
MOD_CK2_1	694	700	PF00069	0.433
MOD_CK2_1	734	740	PF00069	0.579
MOD_CK2_1	760	766	PF00069	0.619
MOD_GlcNHglycan	124	127	PF01048	0.644
MOD_GlcNHglycan	158	162	PF01048	0.659
MOD_GlcNHglycan	201	204	PF01048	0.596
MOD_GlcNHglycan	287	290	PF01048	0.679
MOD_GlcNHglycan	337	340	PF01048	0.675
MOD_GlcNHglycan	36	39	PF01048	0.693
MOD_GlcNHglycan	362	365	PF01048	0.668
MOD_GlcNHglycan	42	45	PF01048	0.652
MOD_GlcNHglycan	455	458	PF01048	0.615
MOD_GlcNHglycan	507	510	PF01048	0.614
MOD_GlcNHglycan	514	517	PF01048	0.565
MOD_GlcNHglycan	547	550	PF01048	0.708
MOD_GlcNHglycan	586	589	PF01048	0.653
MOD_GlcNHglycan	601	604	PF01048	0.538
MOD_GlcNHglycan	634	637	PF01048	0.707
MOD_GlcNHglycan	654	657	PF01048	0.589
MOD_GlcNHglycan	706	709	PF01048	0.474
MOD_GlcNHglycan	736	739	PF01048	0.590
MOD_GlcNHglycan	780	783	PF01048	0.684
MOD_GlcNHglycan	784	787	PF01048	0.648
MOD_GlcNHglycan	812	815	PF01048	0.646
MOD_GlcNHglycan	822	825	PF01048	0.617
MOD_GlcNHglycan	838	841	PF01048	0.531
MOD_GlcNHglycan	885	888	PF01048	0.651
MOD_GlcNHglycan	914	917	PF01048	0.484
MOD_GlcNHglycan	97	100	PF01048	0.590
MOD_GSK3_1	122	129	PF00069	0.645
MOD_GSK3_1	21	28	PF00069	0.544
MOD_GSK3_1	221	228	PF00069	0.667
MOD_GSK3_1	281	288	PF00069	0.629
MOD_GSK3_1	312	319	PF00069	0.597
MOD_GSK3_1	329	336	PF00069	0.600
MOD_GSK3_1	344	351	PF00069	0.585
MOD_GSK3_1	353	360	PF00069	0.692
MOD_GSK3_1	396	403	PF00069	0.685
MOD_GSK3_1	476	483	PF00069	0.675
MOD_GSK3_1	51	58	PF00069	0.569
MOD_GSK3_1	535	542	PF00069	0.695
MOD_GSK3_1	608	615	PF00069	0.680
MOD_GSK3_1	61	68	PF00069	0.568
MOD_GSK3_1	632	639	PF00069	0.706
MOD_GSK3_1	652	659	PF00069	0.538
MOD_GSK3_1	761	768	PF00069	0.595
MOD_GSK3_1	778	785	PF00069	0.618
MOD_GSK3_1	806	813	PF00069	0.665
MOD_GSK3_1	874	881	PF00069	0.654
MOD_N-GLC_1	579	584	PF02516	0.484
MOD_N-GLC_1	912	917	PF02516	0.507
MOD_N-GLC_2	912	914	PF02516	0.504
MOD_NEK2_1	330	335	PF00069	0.744
MOD_NEK2_1	490	495	PF00069	0.572
MOD_OFUCOSY	52	57	PF10250	0.501
MOD_PIKK_1	353	359	PF00454	0.653
MOD_PIKK_1	789	795	PF00454	0.624
MOD_PK_1	174	180	PF00069	0.688
MOD_PKA_1	182	188	PF00069	0.589
MOD_PKA_2	156	162	PF00069	0.513
MOD_PKA_2	182	188	PF00069	0.589
MOD_PKA_2	224	230	PF00069	0.611
MOD_PKA_2	333	339	PF00069	0.691
MOD_PKA_2	34	40	PF00069	0.662
MOD_PKA_2	400	406	PF00069	0.605
MOD_PKA_2	605	611	PF00069	0.693
MOD_PKA_2	622	628	PF00069	0.740
MOD_PKA_2	632	638	PF00069	0.583
MOD_PKA_2	713	719	PF00069	0.512
MOD_PKA_2	874	880	PF00069	0.540
MOD_Plk_1	157	163	PF00069	0.524
MOD_Plk_1	426	432	PF00069	0.622
MOD_Plk_1	579	585	PF00069	0.667
MOD_Plk_1	689	695	PF00069	0.630
MOD_Plk_1	765	771	PF00069	0.545
MOD_Plk_2-3	866	872	PF00069	0.625
MOD_Plk_2-3	899	905	PF00069	0.504
MOD_Plk_4	103	109	PF00069	0.552
MOD_Plk_4	426	432	PF00069	0.622
MOD_Plk_4	455	461	PF00069	0.629
MOD_Plk_4	638	644	PF00069	0.544
MOD_Plk_4	689	695	PF00069	0.600
MOD_Plk_4	713	719	PF00069	0.445
MOD_Plk_4	899	905	PF00069	0.553
MOD_ProDKin_1	127	133	PF00069	0.652
MOD_ProDKin_1	225	231	PF00069	0.720
MOD_ProDKin_1	251	257	PF00069	0.463
MOD_ProDKin_1	316	322	PF00069	0.575
MOD_ProDKin_1	530	536	PF00069	0.711
MOD_ProDKin_1	537	543	PF00069	0.595
MOD_ProDKin_1	561	567	PF00069	0.673
MOD_ProDKin_1	608	614	PF00069	0.679
MOD_ProDKin_1	62	68	PF00069	0.626
MOD_ProDKin_1	636	642	PF00069	0.675
MOD_ProDKin_1	656	662	PF00069	0.527
MOD_ProDKin_1	771	777	PF00069	0.651
MOD_ProDKin_1	813	819	PF00069	0.713
MOD_ProDKin_1	844	850	PF00069	0.585
MOD_ProDKin_1	875	881	PF00069	0.637
MOD_ProDKin_1	889	895	PF00069	0.538
MOD_SUMO_rev_2	472	476	PF00179	0.532
TRG_DiLeu_BaEn_1	388	393	PF01217	0.714
TRG_DiLeu_BaEn_1	74	79	PF01217	0.610
TRG_DiLeu_BaLyEn_6	891	896	PF01217	0.582
TRG_DiLeu_LyEn_5	74	79	PF01217	0.610
TRG_ENDOCYTIC_2	439	442	PF00928	0.567
TRG_ENDOCYTIC_2	699	702	PF00928	0.613
TRG_ENDOCYTIC_2	851	854	PF00928	0.480
TRG_ENDOCYTIC_2	92	95	PF00928	0.642
TRG_ER_diArg_1	182	184	PF00400	0.693
TRG_ER_diArg_1	235	238	PF00400	0.596
TRG_ER_diArg_1	292	294	PF00400	0.445
TRG_ER_diArg_1	320	323	PF00400	0.667
TRG_ER_diArg_1	4	6	PF00400	0.438
TRG_ER_diArg_1	494	496	PF00400	0.654
TRG_ER_diArg_1	630	633	PF00400	0.629
TRG_ER_diArg_1	709	712	PF00400	0.530
TRG_ER_diArg_1	728	730	PF00400	0.353
TRG_ER_diArg_1	75	77	PF00400	0.621
TRG_ER_diArg_1	857	859	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	859	863	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H531	Leishmania donovani	80%	94%
A4H3K0	Leishmania braziliensis	53%	99%
A4HRT9	Leishmania infantum	80%	94%
E9ACH5	Leishmania major	74%	100%