LeishMANIAdb
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FYVE-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE-type domain-containing protein
Gene product:
FYVE zinc finger/Apolipoprotein A1/A4/E domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9AJR2_LEIMU
TriTrypDb:
LmxM.03.0270
Length:
1372

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 5
GO:0110165 cellular anatomical entity 1 5
GO:0000795 synaptonemal complex 3 1
GO:0099086 synaptonemal structure 2 1

Expansion

Sequence features

E9AJR2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 5
GO:0006810 transport 3 5
GO:0006869 lipid transport 5 5
GO:0008152 metabolic process 1 5
GO:0019538 protein metabolic process 3 5
GO:0042157 lipoprotein metabolic process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0044238 primary metabolic process 2 5
GO:0051179 localization 1 5
GO:0051234 establishment of localization 2 5
GO:0071702 organic substance transport 4 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:0006996 organelle organization 4 1
GO:0007130 synaptonemal complex assembly 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022414 reproductive process 1 1
GO:0022607 cellular component assembly 4 1
GO:0051276 chromosome organization 5 1
GO:0070192 chromosome organization involved in meiotic cell cycle 3 1
GO:0070193 synaptonemal complex organization 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1903046 meiotic cell cycle process 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 5
GO:0008289 lipid binding 2 5
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1180 1184 PF00656 0.577
CLV_C14_Caspase3-7 149 153 PF00656 0.474
CLV_C14_Caspase3-7 954 958 PF00656 0.506
CLV_NRD_NRD_1 1122 1124 PF00675 0.510
CLV_NRD_NRD_1 1356 1358 PF00675 0.385
CLV_NRD_NRD_1 707 709 PF00675 0.473
CLV_NRD_NRD_1 816 818 PF00675 0.481
CLV_NRD_NRD_1 887 889 PF00675 0.476
CLV_NRD_NRD_1 960 962 PF00675 0.497
CLV_PCSK_KEX2_1 1122 1124 PF00082 0.510
CLV_PCSK_KEX2_1 1356 1358 PF00082 0.385
CLV_PCSK_KEX2_1 816 818 PF00082 0.481
CLV_PCSK_KEX2_1 887 889 PF00082 0.476
CLV_PCSK_KEX2_1 940 942 PF00082 0.416
CLV_PCSK_KEX2_1 960 962 PF00082 0.465
CLV_PCSK_PC1ET2_1 940 942 PF00082 0.416
CLV_PCSK_PC7_1 883 889 PF00082 0.465
CLV_PCSK_PC7_1 956 962 PF00082 0.493
CLV_PCSK_SKI1_1 1143 1147 PF00082 0.663
CLV_PCSK_SKI1_1 1276 1280 PF00082 0.474
CLV_PCSK_SKI1_1 1323 1327 PF00082 0.497
CLV_PCSK_SKI1_1 708 712 PF00082 0.473
CLV_Separin_Metazoa 1234 1238 PF03568 0.605
DEG_APCC_DBOX_1 1322 1330 PF00400 0.495
DEG_SCF_FBW7_1 98 105 PF00400 0.532
DEG_SCF_TRCP1_1 1180 1185 PF00400 0.550
DOC_ANK_TNKS_1 698 705 PF00023 0.272
DOC_CKS1_1 1187 1192 PF01111 0.626
DOC_CKS1_1 119 124 PF01111 0.630
DOC_CKS1_1 1308 1313 PF01111 0.601
DOC_CYCLIN_yCln2_LP_2 1201 1207 PF00134 0.533
DOC_MAPK_gen_1 1065 1073 PF00069 0.440
DOC_MAPK_gen_1 1139 1148 PF00069 0.512
DOC_MAPK_gen_1 1155 1164 PF00069 0.409
DOC_MAPK_gen_1 1356 1364 PF00069 0.351
DOC_MAPK_gen_1 841 848 PF00069 0.415
DOC_MIT_MIM_1 859 867 PF04212 0.486
DOC_USP7_MATH_1 102 106 PF00917 0.571
DOC_USP7_MATH_1 1025 1029 PF00917 0.514
DOC_USP7_MATH_1 1035 1039 PF00917 0.576
DOC_USP7_MATH_1 1108 1112 PF00917 0.553
DOC_USP7_MATH_1 111 115 PF00917 0.626
DOC_USP7_MATH_1 1118 1122 PF00917 0.522
DOC_USP7_MATH_1 1207 1211 PF00917 0.567
DOC_USP7_MATH_1 1221 1225 PF00917 0.643
DOC_USP7_MATH_1 1248 1252 PF00917 0.561
DOC_USP7_MATH_1 179 183 PF00917 0.563
DOC_USP7_MATH_1 767 771 PF00917 0.429
DOC_USP7_MATH_1 83 87 PF00917 0.436
DOC_USP7_UBL2_3 709 713 PF12436 0.272
DOC_WW_Pin1_4 118 123 PF00397 0.562
DOC_WW_Pin1_4 1186 1191 PF00397 0.622
DOC_WW_Pin1_4 1196 1201 PF00397 0.587
DOC_WW_Pin1_4 1226 1231 PF00397 0.647
DOC_WW_Pin1_4 128 133 PF00397 0.534
DOC_WW_Pin1_4 1307 1312 PF00397 0.598
DOC_WW_Pin1_4 85 90 PF00397 0.618
DOC_WW_Pin1_4 98 103 PF00397 0.580
LIG_14-3-3_CanoR_1 1010 1019 PF00244 0.494
LIG_14-3-3_CanoR_1 1267 1275 PF00244 0.527
LIG_14-3-3_CanoR_1 1301 1308 PF00244 0.565
LIG_14-3-3_CanoR_1 916 926 PF00244 0.421
LIG_Actin_WH2_2 995 1012 PF00022 0.506
LIG_APCC_ABBA_1 672 677 PF00400 0.272
LIG_APCC_ABBA_1 924 929 PF00400 0.428
LIG_BIR_II_1 1 5 PF00653 0.414
LIG_BRCT_BRCA1_1 30 34 PF00533 0.313
LIG_CtBP_PxDLS_1 1077 1083 PF00389 0.438
LIG_eIF4E_1 1051 1057 PF01652 0.507
LIG_FHA_1 1171 1177 PF00498 0.483
LIG_FHA_1 1308 1314 PF00498 0.738
LIG_FHA_1 53 59 PF00498 0.393
LIG_FHA_1 720 726 PF00498 0.444
LIG_FHA_1 802 808 PF00498 0.440
LIG_FHA_2 1256 1262 PF00498 0.582
LIG_FHA_2 187 193 PF00498 0.570
LIG_FHA_2 788 794 PF00498 0.452
LIG_FHA_2 941 947 PF00498 0.487
LIG_LIR_Gen_1 1277 1284 PF02991 0.473
LIG_LIR_Nem_3 1272 1278 PF02991 0.530
LIG_LIR_Nem_3 1353 1358 PF02991 0.403
LIG_LIR_Nem_3 31 35 PF02991 0.313
LIG_PDZ_Class_1 1367 1372 PF00595 0.327
LIG_RPA_C_Fungi 1118 1130 PF08784 0.498
LIG_SH2_GRB2like 63 66 PF00017 0.327
LIG_SH2_SRC 1280 1283 PF00017 0.475
LIG_SH2_STAP1 1215 1219 PF00017 0.718
LIG_SH2_STAP1 1280 1284 PF00017 0.473
LIG_SH2_STAP1 63 67 PF00017 0.297
LIG_SH2_STAT5 1163 1166 PF00017 0.434
LIG_SH2_STAT5 1298 1301 PF00017 0.675
LIG_SH2_STAT5 91 94 PF00017 0.491
LIG_SH3_1 104 110 PF00018 0.595
LIG_SH3_2 1232 1237 PF14604 0.607
LIG_SH3_3 104 110 PF00018 0.627
LIG_SH3_3 116 122 PF00018 0.646
LIG_SH3_3 1184 1190 PF00018 0.611
LIG_SH3_3 1201 1207 PF00018 0.509
LIG_SH3_3 1224 1230 PF00018 0.636
LIG_SH3_3 1242 1248 PF00018 0.542
LIG_SH3_3 1305 1311 PF00018 0.587
LIG_SxIP_EBH_1 51 65 PF03271 0.327
LIG_TRAF2_1 1328 1331 PF00917 0.455
LIG_TRAF2_1 1346 1349 PF00917 0.400
LIG_TRAF2_1 190 193 PF00917 0.568
LIG_TRAF2_1 232 235 PF00917 0.281
LIG_TRAF2_1 271 274 PF00917 0.281
LIG_TRAF2_1 310 313 PF00917 0.281
LIG_TRAF2_1 349 352 PF00917 0.281
LIG_TRAF2_1 388 391 PF00917 0.281
LIG_TRAF2_1 427 430 PF00917 0.281
LIG_TRAF2_1 466 469 PF00917 0.281
LIG_TRAF2_1 505 508 PF00917 0.281
LIG_TRAF2_1 544 547 PF00917 0.281
LIG_TRAF2_1 583 586 PF00917 0.281
LIG_TRAF2_1 622 625 PF00917 0.281
LIG_TRAF2_1 791 794 PF00917 0.459
LIG_TRAF2_1 931 934 PF00917 0.454
LIG_TRAF2_1 977 980 PF00917 0.517
LIG_TYR_ITIM 1278 1283 PF00017 0.474
LIG_WW_3 1234 1238 PF00397 0.605
MOD_CDK_SPK_2 1307 1312 PF00069 0.598
MOD_CDK_SPxK_1 1196 1202 PF00069 0.606
MOD_CDK_SPxK_1 98 104 PF00069 0.588
MOD_CDK_SPxxK_3 1226 1233 PF00069 0.645
MOD_CK1_1 1024 1030 PF00069 0.597
MOD_CK1_1 1185 1191 PF00069 0.601
MOD_CK1_1 145 151 PF00069 0.498
MOD_CK1_1 182 188 PF00069 0.558
MOD_CK1_1 951 957 PF00069 0.471
MOD_CK2_1 1031 1037 PF00069 0.516
MOD_CK2_1 1039 1045 PF00069 0.524
MOD_CK2_1 1248 1254 PF00069 0.615
MOD_CK2_1 1255 1261 PF00069 0.567
MOD_CK2_1 1365 1371 PF00069 0.331
MOD_CK2_1 186 192 PF00069 0.572
MOD_CK2_1 787 793 PF00069 0.449
MOD_CK2_1 940 946 PF00069 0.484
MOD_GlcNHglycan 1023 1026 PF01048 0.649
MOD_GlcNHglycan 1027 1030 PF01048 0.569
MOD_GlcNHglycan 1033 1036 PF01048 0.554
MOD_GlcNHglycan 1042 1045 PF01048 0.539
MOD_GlcNHglycan 1180 1183 PF01048 0.556
MOD_GlcNHglycan 1209 1212 PF01048 0.497
MOD_GlcNHglycan 1224 1227 PF01048 0.592
MOD_GlcNHglycan 1303 1306 PF01048 0.586
MOD_GlcNHglycan 181 184 PF01048 0.615
MOD_GlcNHglycan 722 725 PF01048 0.449
MOD_GlcNHglycan 919 922 PF01048 0.402
MOD_GlcNHglycan 963 966 PF01048 0.497
MOD_GlcNHglycan 98 101 PF01048 0.539
MOD_GSK3_1 1010 1017 PF00069 0.693
MOD_GSK3_1 1021 1028 PF00069 0.544
MOD_GSK3_1 1031 1038 PF00069 0.593
MOD_GSK3_1 1171 1178 PF00069 0.489
MOD_GSK3_1 1182 1189 PF00069 0.568
MOD_GSK3_1 1215 1222 PF00069 0.598
MOD_GSK3_1 1313 1320 PF00069 0.550
MOD_GSK3_1 142 149 PF00069 0.512
MOD_GSK3_1 175 182 PF00069 0.556
MOD_GSK3_1 193 200 PF00069 0.558
MOD_GSK3_1 92 99 PF00069 0.535
MOD_GSK3_1 961 968 PF00069 0.494
MOD_N-GLC_1 193 198 PF02516 0.569
MOD_NEK2_1 1021 1026 PF00069 0.511
MOD_NEK2_1 1319 1324 PF00069 0.629
MOD_NEK2_1 1333 1338 PF00069 0.443
MOD_NEK2_1 1365 1370 PF00069 0.332
MOD_NEK2_1 197 202 PF00069 0.596
MOD_NEK2_1 34 39 PF00069 0.329
MOD_NEK2_1 786 791 PF00069 0.444
MOD_NEK2_1 917 922 PF00069 0.494
MOD_NEK2_1 93 98 PF00069 0.516
MOD_PIKK_1 1109 1115 PF00454 0.525
MOD_PIKK_1 111 117 PF00454 0.682
MOD_PIKK_1 209 215 PF00454 0.332
MOD_PIKK_1 248 254 PF00454 0.281
MOD_PIKK_1 287 293 PF00454 0.281
MOD_PIKK_1 326 332 PF00454 0.281
MOD_PIKK_1 365 371 PF00454 0.281
MOD_PIKK_1 404 410 PF00454 0.281
MOD_PIKK_1 443 449 PF00454 0.281
MOD_PIKK_1 482 488 PF00454 0.297
MOD_PIKK_1 521 527 PF00454 0.281
MOD_PIKK_1 560 566 PF00454 0.281
MOD_PIKK_1 599 605 PF00454 0.297
MOD_PIKK_1 638 644 PF00454 0.281
MOD_PKA_1 940 946 PF00069 0.421
MOD_PKA_2 1021 1027 PF00069 0.556
MOD_PKA_2 1266 1272 PF00069 0.556
MOD_PKA_2 1300 1306 PF00069 0.595
MOD_PKA_2 83 89 PF00069 0.423
MOD_PKA_2 865 871 PF00069 0.483
MOD_PKA_2 940 946 PF00069 0.421
MOD_Plk_1 1182 1188 PF00069 0.583
MOD_Plk_1 193 199 PF00069 0.600
MOD_Plk_1 871 877 PF00069 0.516
MOD_Plk_2-3 663 669 PF00069 0.281
MOD_Plk_4 1015 1021 PF00069 0.544
MOD_Plk_4 1171 1177 PF00069 0.483
MOD_Plk_4 54 60 PF00069 0.329
MOD_Plk_4 940 946 PF00069 0.545
MOD_Plk_4 948 954 PF00069 0.639
MOD_ProDKin_1 118 124 PF00069 0.560
MOD_ProDKin_1 1186 1192 PF00069 0.623
MOD_ProDKin_1 1196 1202 PF00069 0.582
MOD_ProDKin_1 1226 1232 PF00069 0.646
MOD_ProDKin_1 128 134 PF00069 0.526
MOD_ProDKin_1 1307 1313 PF00069 0.598
MOD_ProDKin_1 85 91 PF00069 0.621
MOD_ProDKin_1 98 104 PF00069 0.588
MOD_SUMO_rev_2 657 667 PF00179 0.297
MOD_SUMO_rev_2 844 848 PF00179 0.463
MOD_SUMO_rev_2 854 862 PF00179 0.499
TRG_DiLeu_BaEn_1 809 814 PF01217 0.405
TRG_DiLeu_BaEn_4 192 198 PF01217 0.622
TRG_DiLeu_BaLyEn_6 1069 1074 PF01217 0.430
TRG_ENDOCYTIC_2 1275 1278 PF00928 0.474
TRG_ENDOCYTIC_2 1280 1283 PF00928 0.455
TRG_ENDOCYTIC_2 927 930 PF00928 0.441
TRG_ER_diArg_1 1083 1086 PF00400 0.426
TRG_ER_diArg_1 1099 1102 PF00400 0.463
TRG_ER_diArg_1 1122 1124 PF00400 0.510
TRG_ER_diArg_1 1355 1357 PF00400 0.394
TRG_ER_diArg_1 887 889 PF00400 0.476
TRG_ER_diArg_1 913 916 PF00400 0.500
TRG_NES_CRM1_1 838 851 PF08389 0.440
TRG_Pf-PMV_PEXEL_1 1089 1093 PF00026 0.460
TRG_Pf-PMV_PEXEL_1 1327 1331 PF00026 0.499
TRG_Pf-PMV_PEXEL_1 928 933 PF00026 0.493
TRG_Pf-PMV_PEXEL_1 972 976 PF00026 0.517

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H530 Leishmania donovani 80% 86%
A4H3J9 Leishmania braziliensis 55% 97%
A4H3R9 Leishmania braziliensis 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS