Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJR1_LEIMU

TriTrypDb:

LmxM.03.0260

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AJR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.685
CLV_C14_Caspase3-7	80	84	PF00656	0.597
CLV_NRD_NRD_1	123	125	PF00675	0.425
CLV_PCSK_KEX2_1	123	125	PF00082	0.425
CLV_PCSK_SKI1_1	124	128	PF00082	0.427
DOC_MAPK_gen_1	290	296	PF00069	0.446
DOC_WW_Pin1_4	143	148	PF00397	0.644
DOC_WW_Pin1_4	152	157	PF00397	0.608
DOC_WW_Pin1_4	74	79	PF00397	0.676
LIG_14-3-3_CanoR_1	136	142	PF00244	0.646
LIG_14-3-3_CanoR_1	177	185	PF00244	0.563
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	71	75	PF00653	0.692
LIG_EVH1_2	150	154	PF00568	0.641
LIG_FHA_1	226	232	PF00498	0.310
LIG_FHA_1	68	74	PF00498	0.620
LIG_FHA_2	45	51	PF00498	0.622
LIG_FHA_2	78	84	PF00498	0.584
LIG_LIR_Apic_2	166	171	PF02991	0.582
LIG_LIR_Gen_1	224	235	PF02991	0.310
LIG_LIR_Nem_3	116	122	PF02991	0.625
LIG_LIR_Nem_3	155	161	PF02991	0.636
LIG_LIR_Nem_3	224	230	PF02991	0.310
LIG_LIR_Nem_3	88	93	PF02991	0.645
LIG_LYPXL_yS_3	158	161	PF13949	0.632
LIG_PCNA_PIPBox_1	214	223	PF02747	0.566
LIG_Pex14_2	52	56	PF04695	0.645
LIG_Pex14_2	86	90	PF04695	0.649
LIG_SH2_CRK	168	172	PF00017	0.563
LIG_SH2_SRC	168	171	PF00017	0.572
LIG_SH2_SRC	262	265	PF00017	0.391
LIG_SH2_STAP1	262	266	PF00017	0.392
LIG_SH3_1	153	159	PF00018	0.595
LIG_SH3_3	144	150	PF00018	0.640
LIG_SH3_3	153	159	PF00018	0.606
LIG_SH3_3	167	173	PF00018	0.582
LIG_SH3_3	228	234	PF00018	0.310
LIG_SH3_3	31	37	PF00018	0.654
LIG_SH3_CIN85_PxpxPR_1	74	79	PF14604	0.609
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.403
MOD_CDK_SPK_2	74	79	PF00069	0.609
MOD_CK1_1	108	114	PF00069	0.641
MOD_CK1_1	77	83	PF00069	0.589
MOD_CK2_1	27	33	PF00069	0.643
MOD_GlcNHglycan	10	13	PF01048	0.455
MOD_GlcNHglycan	115	118	PF01048	0.439
MOD_GlcNHglycan	133	136	PF01048	0.390
MOD_GlcNHglycan	164	168	PF01048	0.455
MOD_GlcNHglycan	66	70	PF01048	0.477
MOD_GSK3_1	105	112	PF00069	0.636
MOD_GSK3_1	127	134	PF00069	0.595
MOD_GSK3_1	221	228	PF00069	0.479
MOD_GSK3_1	40	47	PF00069	0.810
MOD_GSK3_1	51	58	PF00069	0.654
MOD_GSK3_1	8	15	PF00069	0.627
MOD_NEK2_1	184	189	PF00069	0.563
MOD_NEK2_1	221	226	PF00069	0.552
MOD_NEK2_1	40	45	PF00069	0.677
MOD_NEK2_1	56	61	PF00069	0.587
MOD_PIKK_1	111	117	PF00454	0.653
MOD_PIKK_1	12	18	PF00454	0.624
MOD_PIKK_1	40	46	PF00454	0.673
MOD_PKA_2	64	70	PF00069	0.679
MOD_PKB_1	129	137	PF00069	0.655
MOD_Plk_4	195	201	PF00069	0.503
MOD_Plk_4	56	62	PF00069	0.591
MOD_ProDKin_1	143	149	PF00069	0.644
MOD_ProDKin_1	152	158	PF00069	0.608
MOD_ProDKin_1	74	80	PF00069	0.672
TRG_DiLeu_BaEn_2	254	260	PF01217	0.405
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.310
TRG_ENDOCYTIC_2	158	161	PF00928	0.632
TRG_ENDOCYTIC_2	222	225	PF00928	0.540
TRG_ENDOCYTIC_2	226	229	PF00928	0.307
TRG_ER_diArg_1	122	124	PF00400	0.621
TRG_ER_diArg_1	128	131	PF00400	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H529	Leishmania donovani	85%	98%
A4HRT7	Leishmania infantum	85%	98%
E9ACH3	Leishmania major	82%	100%