Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJQ7_LEIMU

TriTrypDb:

LmxM.03.0220

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.550
CLV_NRD_NRD_1	105	107	PF00675	0.369
CLV_NRD_NRD_1	18	20	PF00675	0.421
CLV_NRD_NRD_1	209	211	PF00675	0.427
CLV_NRD_NRD_1	265	267	PF00675	0.530
CLV_NRD_NRD_1	279	281	PF00675	0.388
CLV_PCSK_FUR_1	263	267	PF00082	0.528
CLV_PCSK_KEX2_1	105	107	PF00082	0.369
CLV_PCSK_KEX2_1	17	19	PF00082	0.434
CLV_PCSK_KEX2_1	209	211	PF00082	0.420
CLV_PCSK_KEX2_1	263	265	PF00082	0.540
CLV_PCSK_KEX2_1	279	281	PF00082	0.386
CLV_PCSK_KEX2_1	67	69	PF00082	0.520
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.424
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.507
CLV_PCSK_SKI1_1	11	15	PF00082	0.467
CLV_PCSK_SKI1_1	161	165	PF00082	0.344
CLV_PCSK_SKI1_1	243	247	PF00082	0.524
CLV_PCSK_SKI1_1	279	283	PF00082	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.460
DOC_CKS1_1	25	30	PF01111	0.473
DOC_MAPK_gen_1	17	24	PF00069	0.376
DOC_MAPK_MEF2A_6	17	24	PF00069	0.376
DOC_MAPK_MEF2A_6	243	252	PF00069	0.379
DOC_MAPK_MEF2A_6	293	301	PF00069	0.388
DOC_PP1_RVXF_1	247	253	PF00149	0.374
DOC_PP1_RVXF_1	277	284	PF00149	0.378
DOC_PP4_FxxP_1	282	285	PF00568	0.369
DOC_PP4_FxxP_1	294	297	PF00568	0.354
DOC_USP7_MATH_1	152	156	PF00917	0.464
DOC_USP7_MATH_1	211	215	PF00917	0.385
DOC_USP7_UBL2_3	109	113	PF12436	0.479
DOC_USP7_UBL2_3	45	49	PF12436	0.417
DOC_WW_Pin1_4	170	175	PF00397	0.360
DOC_WW_Pin1_4	227	232	PF00397	0.392
DOC_WW_Pin1_4	24	29	PF00397	0.385
DOC_WW_Pin1_4	268	273	PF00397	0.507
DOC_WW_Pin1_4	303	308	PF00397	0.439
LIG_14-3-3_CanoR_1	209	219	PF00244	0.402
LIG_14-3-3_CanoR_1	3	8	PF00244	0.551
LIG_14-3-3_CanoR_1	51	59	PF00244	0.427
LIG_AP_GAE_1	83	89	PF02883	0.496
LIG_BRCT_BRCA1_1	212	216	PF00533	0.413
LIG_Clathr_ClatBox_1	237	241	PF01394	0.350
LIG_CSL_BTD_1	282	285	PF09270	0.369
LIG_FHA_1	2	8	PF00498	0.509
LIG_FHA_1	39	45	PF00498	0.385
LIG_Integrin_RGD_1	81	83	PF01839	0.387
LIG_LIR_Apic_2	230	235	PF02991	0.374
LIG_LIR_Gen_1	118	129	PF02991	0.351
LIG_LIR_Gen_1	217	223	PF02991	0.335
LIG_LIR_Gen_1	83	93	PF02991	0.350
LIG_LIR_Gen_1	97	102	PF02991	0.363
LIG_LIR_Nem_3	118	124	PF02991	0.314
LIG_LIR_Nem_3	162	167	PF02991	0.342
LIG_LIR_Nem_3	173	179	PF02991	0.376
LIG_LIR_Nem_3	213	219	PF02991	0.343
LIG_LIR_Nem_3	83	89	PF02991	0.351
LIG_LIR_Nem_3	97	101	PF02991	0.362
LIG_LYPXL_S_1	301	305	PF13949	0.418
LIG_LYPXL_yS_3	302	305	PF13949	0.421
LIG_MLH1_MIPbox_1	212	216	PF16413	0.413
LIG_MYND_1	303	307	PF01753	0.480
LIG_Pex14_2	234	238	PF04695	0.379
LIG_REV1ctd_RIR_1	250	259	PF16727	0.398
LIG_SH2_CRK	219	223	PF00017	0.354
LIG_SH2_CRK	98	102	PF00017	0.379
LIG_SH2_STAP1	98	102	PF00017	0.384
LIG_SH2_STAT5	215	218	PF00017	0.378
LIG_SH3_3	128	134	PF00018	0.324
LIG_SH3_3	168	174	PF00018	0.377
LIG_SH3_3	17	23	PF00018	0.399
LIG_SH3_3	25	31	PF00018	0.381
MOD_CDK_SPxxK_3	170	177	PF00069	0.363
MOD_CK1_1	268	274	PF00069	0.503
MOD_CK1_1	38	44	PF00069	0.428
MOD_CK2_1	211	217	PF00069	0.356
MOD_CK2_1	71	77	PF00069	0.441
MOD_Cter_Amidation	103	106	PF01082	0.363
MOD_Cter_Amidation	277	280	PF01082	0.393
MOD_GlcNHglycan	102	105	PF01048	0.380
MOD_GlcNHglycan	154	157	PF01048	0.430
MOD_GlcNHglycan	168	171	PF01048	0.312
MOD_GlcNHglycan	53	56	PF01048	0.427
MOD_GSK3_1	152	159	PF00069	0.424
MOD_GSK3_1	166	173	PF00069	0.386
MOD_GSK3_1	183	190	PF00069	0.260
MOD_GSK3_1	223	230	PF00069	0.387
MOD_NEK2_1	1	6	PF00069	0.584
MOD_NEK2_1	124	129	PF00069	0.353
MOD_NEK2_1	166	171	PF00069	0.369
MOD_NEK2_1	205	210	PF00069	0.363
MOD_NEK2_1	9	14	PF00069	0.536
MOD_PIKK_1	156	162	PF00454	0.407
MOD_PK_1	265	271	PF00069	0.630
MOD_PK_1	3	9	PF00069	0.501
MOD_PKA_1	265	271	PF00069	0.650
MOD_PKA_2	2	8	PF00069	0.520
MOD_PKA_2	265	271	PF00069	0.595
MOD_PKA_2	50	56	PF00069	0.435
MOD_PKB_1	263	271	PF00069	0.634
MOD_Plk_1	9	15	PF00069	0.469
MOD_Plk_2-3	112	118	PF00069	0.388
MOD_Plk_4	211	217	PF00069	0.372
MOD_Plk_4	265	271	PF00069	0.593
MOD_Plk_4	3	9	PF00069	0.551
MOD_ProDKin_1	170	176	PF00069	0.356
MOD_ProDKin_1	227	233	PF00069	0.391
MOD_ProDKin_1	24	30	PF00069	0.378
MOD_ProDKin_1	268	274	PF00069	0.495
TRG_DiLeu_BaEn_4	241	247	PF01217	0.377
TRG_ENDOCYTIC_2	111	114	PF00928	0.396
TRG_ENDOCYTIC_2	176	179	PF00928	0.380
TRG_ENDOCYTIC_2	215	218	PF00928	0.341
TRG_ENDOCYTIC_2	219	222	PF00928	0.336
TRG_ENDOCYTIC_2	302	305	PF00928	0.421
TRG_ENDOCYTIC_2	98	101	PF00928	0.379
TRG_ER_diArg_1	105	107	PF00400	0.369
TRG_ER_diArg_1	137	140	PF00400	0.379
TRG_ER_diArg_1	18	20	PF00400	0.422
TRG_ER_diArg_1	209	211	PF00400	0.424
TRG_ER_diArg_1	263	266	PF00400	0.523
TRG_ER_diArg_1	279	281	PF00400	0.386
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I233	Leptomonas seymouri	91%	100%
A0A0S4JMI7	Bodo saltans	75%	100%
A0A1X0P9J8	Trypanosomatidae	85%	100%
A0A3R7MT70	Trypanosoma rangeli	85%	100%
A0A451EJM6	Leishmania donovani	100%	98%
A4H3J4	Leishmania braziliensis	97%	100%
A4HRT3	Leishmania infantum	100%	98%
D0A232	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
E9ACG9	Leishmania major	100%	100%
V5AIL9	Trypanosoma cruzi	84%	100%