zf-C2H2_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of acetyl-transferase ESCO, putative

Species:

Leishmania mexicana

UniProt:

E9AJQ3_LEIMU

TriTrypDb:

LmxM.03.0180

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.656
CLV_C14_Caspase3-7	289	293	PF00656	0.560
CLV_C14_Caspase3-7	491	495	PF00656	0.639
CLV_NRD_NRD_1	103	105	PF00675	0.552
CLV_NRD_NRD_1	13	15	PF00675	0.658
CLV_NRD_NRD_1	171	173	PF00675	0.726
CLV_NRD_NRD_1	177	179	PF00675	0.823
CLV_NRD_NRD_1	321	323	PF00675	0.513
CLV_NRD_NRD_1	332	334	PF00675	0.471
CLV_NRD_NRD_1	343	345	PF00675	0.416
CLV_NRD_NRD_1	48	50	PF00675	0.711
CLV_NRD_NRD_1	93	95	PF00675	0.275
CLV_PCSK_FUR_1	100	104	PF00082	0.511
CLV_PCSK_FUR_1	46	50	PF00082	0.606
CLV_PCSK_KEX2_1	102	104	PF00082	0.550
CLV_PCSK_KEX2_1	13	15	PF00082	0.658
CLV_PCSK_KEX2_1	171	173	PF00082	0.727
CLV_PCSK_KEX2_1	176	178	PF00082	0.797
CLV_PCSK_KEX2_1	320	322	PF00082	0.502
CLV_PCSK_KEX2_1	332	334	PF00082	0.464
CLV_PCSK_KEX2_1	343	345	PF00082	0.416
CLV_PCSK_KEX2_1	43	45	PF00082	0.625
CLV_PCSK_KEX2_1	48	50	PF00082	0.707
CLV_PCSK_KEX2_1	93	95	PF00082	0.275
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.518
CLV_PCSK_PC7_1	172	178	PF00082	0.711
CLV_PCSK_PC7_1	44	50	PF00082	0.529
CLV_PCSK_SKI1_1	309	313	PF00082	0.424
CLV_PCSK_SKI1_1	344	348	PF00082	0.426
CLV_PCSK_SKI1_1	381	385	PF00082	0.477
DEG_APCC_DBOX_1	308	316	PF00400	0.426
DEG_APCC_DBOX_1	380	388	PF00400	0.372
DEG_COP1_1	282	290	PF00400	0.458
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DEG_SPOP_SBC_1	216	220	PF00917	0.515
DOC_ANK_TNKS_1	262	269	PF00023	0.434
DOC_CYCLIN_RxL_1	247	258	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.478
DOC_MAPK_gen_1	13	20	PF00069	0.484
DOC_MAPK_MEF2A_6	138	146	PF00069	0.383
DOC_MAPK_MEF2A_6	321	330	PF00069	0.478
DOC_USP7_MATH_1	118	122	PF00917	0.677
DOC_USP7_MATH_1	132	136	PF00917	0.619
DOC_USP7_MATH_1	202	206	PF00917	0.725
DOC_USP7_MATH_1	216	220	PF00917	0.495
DOC_USP7_MATH_1	27	31	PF00917	0.559
DOC_USP7_MATH_1	275	279	PF00917	0.640
DOC_USP7_MATH_1	376	380	PF00917	0.459
DOC_USP7_MATH_1	396	400	PF00917	0.517
DOC_USP7_MATH_1	465	469	PF00917	0.538
DOC_USP7_UBL2_3	367	371	PF12436	0.421
DOC_WW_Pin1_4	128	133	PF00397	0.638
DOC_WW_Pin1_4	157	162	PF00397	0.637
DOC_WW_Pin1_4	192	197	PF00397	0.598
DOC_WW_Pin1_4	212	217	PF00397	0.495
DOC_WW_Pin1_4	222	227	PF00397	0.488
DOC_WW_Pin1_4	255	260	PF00397	0.463
DOC_WW_Pin1_4	355	360	PF00397	0.460
DOC_WW_Pin1_4	473	478	PF00397	0.756
LIG_14-3-3_CanoR_1	123	132	PF00244	0.688
LIG_14-3-3_CanoR_1	13	21	PF00244	0.484
LIG_14-3-3_CanoR_1	231	235	PF00244	0.349
LIG_14-3-3_CanoR_1	343	351	PF00244	0.414
LIG_14-3-3_CanoR_1	440	445	PF00244	0.384
LIG_Actin_WH2_2	247	265	PF00022	0.429
LIG_FAT_LD_1	304	312	PF03623	0.255
LIG_FHA_1	201	207	PF00498	0.560
LIG_FHA_1	256	262	PF00498	0.401
LIG_FHA_1	281	287	PF00498	0.615
LIG_FHA_1	295	301	PF00498	0.367
LIG_FHA_1	58	64	PF00498	0.475
LIG_FHA_2	196	202	PF00498	0.587
LIG_FHA_2	287	293	PF00498	0.501
LIG_FHA_2	345	351	PF00498	0.394
LIG_FHA_2	476	482	PF00498	0.614
LIG_FHA_2	489	495	PF00498	0.641
LIG_FHA_2	57	63	PF00498	0.312
LIG_GBD_Chelix_1	303	311	PF00786	0.254
LIG_LIR_Nem_3	428	432	PF02991	0.325
LIG_NRBOX	2	8	PF00104	0.644
LIG_NRBOX	250	256	PF00104	0.405
LIG_NRBOX	306	312	PF00104	0.433
LIG_SH2_CRK	109	113	PF00017	0.623
LIG_SH2_NCK_1	109	113	PF00017	0.623
LIG_SH2_NCK_1	444	448	PF00017	0.486
LIG_SH2_STAP1	444	448	PF00017	0.410
LIG_SH2_STAT5	190	193	PF00017	0.650
LIG_SH2_STAT5	429	432	PF00017	0.457
LIG_SH2_STAT5	490	493	PF00017	0.601
LIG_SH2_STAT5	81	84	PF00017	0.503
LIG_SH3_3	18	24	PF00018	0.615
LIG_SH3_3	207	213	PF00018	0.546
LIG_SH3_3	353	359	PF00018	0.399
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.459
LIG_SUMO_SIM_par_1	201	208	PF11976	0.558
MOD_CDK_SPK_2	475	480	PF00069	0.637
MOD_CDK_SPxxK_3	473	480	PF00069	0.634
MOD_CK1_1	113	119	PF00069	0.739
MOD_CK1_1	151	157	PF00069	0.482
MOD_CK1_1	205	211	PF00069	0.515
MOD_CK1_1	215	221	PF00069	0.703
MOD_CK1_1	293	299	PF00069	0.467
MOD_CK1_1	399	405	PF00069	0.601
MOD_CK2_1	355	361	PF00069	0.439
MOD_CK2_1	475	481	PF00069	0.639
MOD_Cter_Amidation	11	14	PF01082	0.610
MOD_Cter_Amidation	169	172	PF01082	0.529
MOD_DYRK1A_RPxSP_1	212	216	PF00069	0.410
MOD_GlcNHglycan	14	17	PF01048	0.507
MOD_GlcNHglycan	148	153	PF01048	0.602
MOD_GlcNHglycan	179	182	PF01048	0.669
MOD_GlcNHglycan	29	32	PF01048	0.633
MOD_GlcNHglycan	292	295	PF01048	0.522
MOD_GlcNHglycan	361	365	PF01048	0.422
MOD_GlcNHglycan	39	42	PF01048	0.706
MOD_GlcNHglycan	398	401	PF01048	0.619
MOD_GlcNHglycan	456	459	PF01048	0.327
MOD_GlcNHglycan	512	515	PF01048	0.565
MOD_GSK3_1	12	19	PF00069	0.563
MOD_GSK3_1	128	135	PF00069	0.633
MOD_GSK3_1	151	158	PF00069	0.467
MOD_GSK3_1	162	169	PF00069	0.578
MOD_GSK3_1	186	193	PF00069	0.655
MOD_GSK3_1	212	219	PF00069	0.641
MOD_GSK3_1	271	278	PF00069	0.608
MOD_GSK3_1	282	289	PF00069	0.527
MOD_GSK3_1	290	297	PF00069	0.386
MOD_GSK3_1	335	342	PF00069	0.494
MOD_GSK3_1	383	390	PF00069	0.514
MOD_GSK3_1	395	402	PF00069	0.637
MOD_GSK3_1	432	439	PF00069	0.500
MOD_N-GLC_2	235	237	PF02516	0.531
MOD_NEK2_1	155	160	PF00069	0.509
MOD_NEK2_1	162	167	PF00069	0.640
MOD_NEK2_1	230	235	PF00069	0.418
MOD_NEK2_1	280	285	PF00069	0.732
MOD_NEK2_1	377	382	PF00069	0.534
MOD_NEK2_1	383	388	PF00069	0.495
MOD_NEK2_1	442	447	PF00069	0.436
MOD_NEK2_1	460	465	PF00069	0.287
MOD_NEK2_1	47	52	PF00069	0.666
MOD_NEK2_1	56	61	PF00069	0.285
MOD_NEK2_2	294	299	PF00069	0.452
MOD_PIKK_1	118	124	PF00454	0.592
MOD_PIKK_1	442	448	PF00454	0.430
MOD_PIKK_1	54	60	PF00454	0.619
MOD_PKA_1	177	183	PF00069	0.585
MOD_PKA_2	12	18	PF00069	0.554
MOD_PKA_2	177	183	PF00069	0.609
MOD_PKA_2	230	236	PF00069	0.326
MOD_PKA_2	290	296	PF00069	0.509
MOD_PKA_2	47	53	PF00069	0.725
MOD_PKB_1	123	131	PF00069	0.648
MOD_Plk_1	16	22	PF00069	0.539
MOD_Plk_1	200	206	PF00069	0.631
MOD_Plk_1	244	250	PF00069	0.333
MOD_Plk_1	460	466	PF00069	0.344
MOD_Plk_2-3	497	503	PF00069	0.691
MOD_Plk_4	275	281	PF00069	0.632
MOD_Plk_4	282	288	PF00069	0.536
MOD_Plk_4	303	309	PF00069	0.361
MOD_Plk_4	383	389	PF00069	0.661
MOD_ProDKin_1	128	134	PF00069	0.634
MOD_ProDKin_1	157	163	PF00069	0.640
MOD_ProDKin_1	192	198	PF00069	0.598
MOD_ProDKin_1	212	218	PF00069	0.505
MOD_ProDKin_1	222	228	PF00069	0.471
MOD_ProDKin_1	255	261	PF00069	0.462
MOD_ProDKin_1	355	361	PF00069	0.464
MOD_ProDKin_1	473	479	PF00069	0.759
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.595
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.466
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.399
TRG_ER_diArg_1	100	103	PF00400	0.536
TRG_ER_diArg_1	175	178	PF00400	0.794
TRG_ER_diArg_1	320	322	PF00400	0.502
TRG_ER_diArg_1	44	47	PF00400	0.693
TRG_ER_diArg_1	48	51	PF00400	0.681
TRG_ER_diArg_1	93	95	PF00400	0.312
TRG_NLS_MonoCore_2	42	47	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD4	Leptomonas seymouri	35%	73%
A0A3S5H526	Leishmania donovani	85%	71%
A4H3J0	Leishmania braziliensis	64%	99%
A4HRS9	Leishmania infantum	85%	71%
E9ACG5	Leishmania major	84%	100%