Putative acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AJP8_LEIMU

TriTrypDb:

LmxM.03.0130

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031415	NatA complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

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Expansion

Sequence features

E9AJP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJP8

Function

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Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0007062	sister chromatid cohesion	3	1
GO:0007064	mitotic sister chromatid cohesion	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016570	histone modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008080	N-acetyltransferase activity	6	1
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	1
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.388
CLV_NRD_NRD_1	167	169	PF00675	0.415
CLV_PCSK_KEX2_1	167	169	PF00082	0.478
CLV_PCSK_SKI1_1	78	82	PF00082	0.454
DOC_CYCLIN_yClb1_LxF_4	58	64	PF00134	0.382
DOC_MAPK_gen_1	120	128	PF00069	0.352
DOC_MAPK_MEF2A_6	120	128	PF00069	0.357
DOC_USP7_MATH_1	80	84	PF00917	0.162
DOC_WW_Pin1_4	131	136	PF00397	0.352
LIG_14-3-3_CanoR_1	106	112	PF00244	0.353

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L1	Leptomonas seymouri	79%	100%
A0A0S4JJ81	Bodo saltans	49%	100%
A0A1X0P8P4	Trypanosomatidae	56%	88%
A0A422N7F8	Trypanosoma rangeli	55%	90%
A0A451EJL8	Leishmania donovani	96%	100%
A3KPA3	Danio rerio	28%	75%
A4H3I5	Leishmania braziliensis	92%	100%
A8E5V7	Xenopus tropicalis	27%	75%
D0A220	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	89%
E9ACG0	Leishmania major	94%	100%

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