Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJP7_LEIMU

TriTrypDb:

LmxM.03.0120

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AJP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJP7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.531
CLV_C14_Caspase3-7	616	620	PF00656	0.439
CLV_C14_Caspase3-7	683	687	PF00656	0.469
CLV_C14_Caspase3-7	747	751	PF00656	0.545
CLV_C14_Caspase3-7	80	84	PF00656	0.434
CLV_NRD_NRD_1	339	341	PF00675	0.640
CLV_NRD_NRD_1	415	417	PF00675	0.530
CLV_NRD_NRD_1	503	505	PF00675	0.508
CLV_NRD_NRD_1	517	519	PF00675	0.453
CLV_NRD_NRD_1	588	590	PF00675	0.473
CLV_NRD_NRD_1	610	612	PF00675	0.572
CLV_NRD_NRD_1	723	725	PF00675	0.728
CLV_NRD_NRD_1	764	766	PF00675	0.537
CLV_PCSK_KEX2_1	339	341	PF00082	0.662
CLV_PCSK_KEX2_1	415	417	PF00082	0.530
CLV_PCSK_KEX2_1	503	505	PF00082	0.508
CLV_PCSK_KEX2_1	507	509	PF00082	0.519
CLV_PCSK_KEX2_1	517	519	PF00082	0.376
CLV_PCSK_KEX2_1	552	554	PF00082	0.544
CLV_PCSK_KEX2_1	588	590	PF00082	0.473
CLV_PCSK_KEX2_1	610	612	PF00082	0.572
CLV_PCSK_KEX2_1	723	725	PF00082	0.728
CLV_PCSK_KEX2_1	764	766	PF00082	0.609
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.545
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.544
CLV_PCSK_PC7_1	503	509	PF00082	0.546
CLV_PCSK_PC7_1	606	612	PF00082	0.511
CLV_PCSK_SKI1_1	258	262	PF00082	0.664
CLV_PCSK_SKI1_1	534	538	PF00082	0.460
CLV_PCSK_SKI1_1	67	71	PF00082	0.528
CLV_PCSK_SKI1_1	724	728	PF00082	0.578
CLV_PCSK_SKI1_1	764	768	PF00082	0.525
CLV_PCSK_SKI1_1	913	917	PF00082	0.516
CLV_Separin_Metazoa	134	138	PF03568	0.459
CLV_Separin_Metazoa	381	385	PF03568	0.581
DEG_APCC_DBOX_1	129	137	PF00400	0.406
DEG_APCC_DBOX_1	196	204	PF00400	0.511
DEG_APCC_DBOX_1	268	276	PF00400	0.671
DEG_APCC_DBOX_1	53	61	PF00400	0.392
DEG_APCC_DBOX_1	594	602	PF00400	0.499
DEG_SCF_FBW7_2	246	252	PF00400	0.533
DOC_CKS1_1	246	251	PF01111	0.690
DOC_CKS1_1	35	40	PF01111	0.434
DOC_CKS1_1	425	430	PF01111	0.691
DOC_CYCLIN_RxL_1	594	604	PF00134	0.506
DOC_CYCLIN_RxL_1	721	731	PF00134	0.655
DOC_MAPK_gen_1	22	31	PF00069	0.401
DOC_PP2B_LxvP_1	894	897	PF13499	0.630
DOC_PP4_FxxP_1	35	38	PF00568	0.435
DOC_PP4_FxxP_1	462	465	PF00568	0.644
DOC_USP7_MATH_1	225	229	PF00917	0.619
DOC_USP7_MATH_1	279	283	PF00917	0.574
DOC_USP7_MATH_1	305	309	PF00917	0.780
DOC_USP7_MATH_1	311	315	PF00917	0.721
DOC_USP7_MATH_1	360	364	PF00917	0.612
DOC_USP7_MATH_1	421	425	PF00917	0.681
DOC_USP7_MATH_1	445	449	PF00917	0.534
DOC_USP7_MATH_1	5	9	PF00917	0.551
DOC_USP7_MATH_1	649	653	PF00917	0.643
DOC_USP7_MATH_1	65	69	PF00917	0.406
DOC_USP7_MATH_1	662	666	PF00917	0.624
DOC_USP7_MATH_1	717	721	PF00917	0.660
DOC_USP7_MATH_1	730	734	PF00917	0.558
DOC_USP7_MATH_1	742	746	PF00917	0.596
DOC_USP7_MATH_1	752	756	PF00917	0.536
DOC_USP7_MATH_1	786	790	PF00917	0.534
DOC_USP7_MATH_1	844	848	PF00917	0.640
DOC_USP7_UBL2_3	913	917	PF12436	0.516
DOC_WW_Pin1_4	174	179	PF00397	0.397
DOC_WW_Pin1_4	239	244	PF00397	0.707
DOC_WW_Pin1_4	245	250	PF00397	0.636
DOC_WW_Pin1_4	322	327	PF00397	0.689
DOC_WW_Pin1_4	34	39	PF00397	0.440
DOC_WW_Pin1_4	386	391	PF00397	0.798
DOC_WW_Pin1_4	424	429	PF00397	0.733
DOC_WW_Pin1_4	440	445	PF00397	0.685
DOC_WW_Pin1_4	461	466	PF00397	0.644
DOC_WW_Pin1_4	624	629	PF00397	0.713
DOC_WW_Pin1_4	657	662	PF00397	0.795
DOC_WW_Pin1_4	840	845	PF00397	0.625
DOC_WW_Pin1_4	872	877	PF00397	0.746
LIG_14-3-3_CanoR_1	120	125	PF00244	0.385
LIG_14-3-3_CanoR_1	145	152	PF00244	0.392
LIG_14-3-3_CanoR_1	156	161	PF00244	0.438
LIG_14-3-3_CanoR_1	197	201	PF00244	0.424
LIG_14-3-3_CanoR_1	258	267	PF00244	0.583
LIG_14-3-3_CanoR_1	339	346	PF00244	0.581
LIG_14-3-3_CanoR_1	470	478	PF00244	0.607
LIG_14-3-3_CanoR_1	517	527	PF00244	0.442
LIG_14-3-3_CanoR_1	556	566	PF00244	0.736
LIG_14-3-3_CanoR_1	575	580	PF00244	0.421
LIG_14-3-3_CanoR_1	664	671	PF00244	0.748
LIG_14-3-3_CanoR_1	71	77	PF00244	0.394
LIG_14-3-3_CanoR_1	723	727	PF00244	0.754
LIG_14-3-3_CanoR_1	78	82	PF00244	0.388
LIG_14-3-3_CanoR_1	845	854	PF00244	0.695
LIG_14-3-3_CanoR_1	88	94	PF00244	0.320
LIG_14-3-3_CanoR_1	908	916	PF00244	0.525
LIG_Actin_WH2_2	523	540	PF00022	0.453
LIG_Actin_WH2_2	75	90	PF00022	0.328
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_Clathr_ClatBox_1	207	211	PF01394	0.409
LIG_CtBP_PxDLS_1	243	247	PF00389	0.537
LIG_DLG_GKlike_1	120	127	PF00625	0.386
LIG_eIF4E_1	76	82	PF01652	0.462
LIG_EVH1_1	894	898	PF00568	0.631
LIG_FHA_1	144	150	PF00498	0.436
LIG_FHA_1	175	181	PF00498	0.411
LIG_FHA_1	480	486	PF00498	0.669
LIG_FHA_1	642	648	PF00498	0.663
LIG_FHA_1	683	689	PF00498	0.558
LIG_FHA_1	691	697	PF00498	0.546
LIG_FHA_1	714	720	PF00498	0.623
LIG_FHA_1	869	875	PF00498	0.730
LIG_FHA_2	197	203	PF00498	0.539
LIG_FHA_2	35	41	PF00498	0.436
LIG_FHA_2	401	407	PF00498	0.716
LIG_FHA_2	46	52	PF00498	0.376
LIG_FHA_2	541	547	PF00498	0.500
LIG_FHA_2	576	582	PF00498	0.441
LIG_FHA_2	585	591	PF00498	0.415
LIG_FHA_2	862	868	PF00498	0.704
LIG_GBD_Chelix_1	688	696	PF00786	0.614
LIG_GBD_Chelix_1	718	726	PF00786	0.630
LIG_LIR_Gen_1	115	125	PF02991	0.369
LIG_LIR_Gen_1	75	82	PF02991	0.396
LIG_LIR_Nem_3	115	121	PF02991	0.368
LIG_LIR_Nem_3	694	700	PF02991	0.581
LIG_LIR_Nem_3	75	79	PF02991	0.385
LIG_NRBOX	167	173	PF00104	0.303
LIG_PCNA_TLS_4	764	771	PF02747	0.524
LIG_RPA_C_Fungi	513	525	PF08784	0.474
LIG_RPA_C_Fungi	584	596	PF08784	0.457
LIG_RPA_C_Fungi	731	743	PF08784	0.525
LIG_SH2_CRK	323	327	PF00017	0.532
LIG_SH2_CRK	697	701	PF00017	0.584
LIG_SH2_CRK	76	80	PF00017	0.503
LIG_SH2_GRB2like	221	224	PF00017	0.648
LIG_SH2_NCK_1	221	225	PF00017	0.575
LIG_SH2_NCK_1	323	327	PF00017	0.532
LIG_SH2_NCK_1	76	80	PF00017	0.385
LIG_SH2_PTP2	437	440	PF00017	0.525
LIG_SH2_SRC	221	224	PF00017	0.648
LIG_SH2_STAP1	221	225	PF00017	0.647
LIG_SH2_STAP1	580	584	PF00017	0.455
LIG_SH2_STAT3	580	583	PF00017	0.461
LIG_SH2_STAT5	164	167	PF00017	0.445
LIG_SH2_STAT5	437	440	PF00017	0.525
LIG_SH3_1	331	337	PF00018	0.613
LIG_SH3_1	359	365	PF00018	0.536
LIG_SH3_2	264	269	PF14604	0.531
LIG_SH3_2	334	339	PF14604	0.709
LIG_SH3_2	465	470	PF14604	0.579
LIG_SH3_3	183	189	PF00018	0.502
LIG_SH3_3	261	267	PF00018	0.615
LIG_SH3_3	272	278	PF00018	0.698
LIG_SH3_3	331	337	PF00018	0.669
LIG_SH3_3	347	353	PF00018	0.503
LIG_SH3_3	359	365	PF00018	0.567
LIG_SH3_3	380	386	PF00018	0.670
LIG_SH3_3	422	428	PF00018	0.679
LIG_SH3_3	462	468	PF00018	0.626
LIG_SH3_3	799	805	PF00018	0.577
LIG_SH3_3	838	844	PF00018	0.601
LIG_SH3_3	892	898	PF00018	0.565
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.534
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.403
LIG_SUMO_SIM_anti_2	859	875	PF11976	0.527
LIG_SUMO_SIM_anti_2	918	925	PF11976	0.408
LIG_SUMO_SIM_par_1	206	211	PF11976	0.414
LIG_SUMO_SIM_par_1	242	248	PF11976	0.583
LIG_SUMO_SIM_par_1	42	48	PF11976	0.403
LIG_SUMO_SIM_par_1	865	875	PF11976	0.694
LIG_TRAF2_1	37	40	PF00917	0.434
LIG_TRAF2_2	782	787	PF00917	0.715
LIG_TYR_ITIM	435	440	PF00017	0.704
LIG_UBA3_1	544	552	PF00899	0.594
LIG_WRC_WIRS_1	576	581	PF05994	0.461
LIG_WRC_WIRS_1	767	772	PF05994	0.551
LIG_WW_3	381	385	PF00397	0.581
MOD_CDC14_SPxK_1	467	470	PF00782	0.595
MOD_CDK_SPK_2	245	250	PF00069	0.691
MOD_CDK_SPK_2	840	845	PF00069	0.625
MOD_CDK_SPxK_1	464	470	PF00069	0.603
MOD_CDK_SPxxK_3	322	329	PF00069	0.789
MOD_CDK_SPxxK_3	657	664	PF00069	0.774
MOD_CK1_1	206	212	PF00069	0.616
MOD_CK1_1	228	234	PF00069	0.629
MOD_CK1_1	245	251	PF00069	0.647
MOD_CK1_1	290	296	PF00069	0.669
MOD_CK1_1	424	430	PF00069	0.638
MOD_CK1_1	45	51	PF00069	0.334
MOD_CK1_1	464	470	PF00069	0.634
MOD_CK1_1	540	546	PF00069	0.513
MOD_CK1_1	554	560	PF00069	0.548
MOD_CK1_1	660	666	PF00069	0.787
MOD_CK1_1	731	737	PF00069	0.707
MOD_CK1_1	745	751	PF00069	0.524
MOD_CK1_1	755	761	PF00069	0.695
MOD_CK1_1	8	14	PF00069	0.557
MOD_CK1_1	813	819	PF00069	0.654
MOD_CK2_1	196	202	PF00069	0.527
MOD_CK2_1	322	328	PF00069	0.666
MOD_CK2_1	34	40	PF00069	0.445
MOD_CK2_1	445	451	PF00069	0.517
MOD_CK2_1	50	56	PF00069	0.370
MOD_CK2_1	540	546	PF00069	0.492
MOD_CK2_1	575	581	PF00069	0.444
MOD_CK2_1	584	590	PF00069	0.416
MOD_CK2_1	863	869	PF00069	0.683
MOD_GlcNHglycan	10	13	PF01048	0.599
MOD_GlcNHglycan	281	284	PF01048	0.657
MOD_GlcNHglycan	362	365	PF01048	0.790
MOD_GlcNHglycan	366	369	PF01048	0.726
MOD_GlcNHglycan	376	379	PF01048	0.636
MOD_GlcNHglycan	447	450	PF01048	0.531
MOD_GlcNHglycan	454	457	PF01048	0.709
MOD_GlcNHglycan	553	556	PF01048	0.629
MOD_GlcNHglycan	603	606	PF01048	0.579
MOD_GlcNHglycan	651	654	PF01048	0.719
MOD_GlcNHglycan	664	667	PF01048	0.713
MOD_GlcNHglycan	702	705	PF01048	0.480
MOD_GlcNHglycan	710	714	PF01048	0.461
MOD_GlcNHglycan	729	733	PF01048	0.689
MOD_GlcNHglycan	747	750	PF01048	0.515
MOD_GlcNHglycan	787	791	PF01048	0.593
MOD_GlcNHglycan	812	815	PF01048	0.593
MOD_GlcNHglycan	847	850	PF01048	0.730
MOD_GlcNHglycan	902	905	PF01048	0.591
MOD_GlcNHglycan	909	912	PF01048	0.508
MOD_GSK3_1	1	8	PF00069	0.525
MOD_GSK3_1	224	231	PF00069	0.609
MOD_GSK3_1	284	291	PF00069	0.678
MOD_GSK3_1	311	318	PF00069	0.720
MOD_GSK3_1	360	367	PF00069	0.779
MOD_GSK3_1	436	443	PF00069	0.659
MOD_GSK3_1	575	582	PF00069	0.540
MOD_GSK3_1	660	667	PF00069	0.741
MOD_GSK3_1	696	703	PF00069	0.494
MOD_GSK3_1	709	716	PF00069	0.620
MOD_GSK3_1	835	842	PF00069	0.697
MOD_GSK3_1	861	868	PF00069	0.649
MOD_GSK3_1	872	879	PF00069	0.688
MOD_GSK3_1	900	907	PF00069	0.492
MOD_N-GLC_1	311	316	PF02516	0.583
MOD_N-GLC_1	374	379	PF02516	0.683
MOD_N-GLC_1	641	646	PF02516	0.597
MOD_N-GLC_1	72	77	PF02516	0.365
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	114	119	PF00069	0.347
MOD_NEK2_1	172	177	PF00069	0.478
MOD_NEK2_1	288	293	PF00069	0.530
MOD_NEK2_1	355	360	PF00069	0.725
MOD_NEK2_1	478	483	PF00069	0.585
MOD_NEK2_1	485	490	PF00069	0.421
MOD_NEK2_1	50	55	PF00069	0.367
MOD_NEK2_1	579	584	PF00069	0.508
MOD_NEK2_1	599	604	PF00069	0.364
MOD_NEK2_1	696	701	PF00069	0.627
MOD_NEK2_1	72	77	PF00069	0.365
MOD_NEK2_1	722	727	PF00069	0.730
MOD_NEK2_1	87	92	PF00069	0.389
MOD_NEK2_2	421	426	PF00069	0.727
MOD_NEK2_2	436	441	PF00069	0.573
MOD_OFUCOSY	880	886	PF10250	0.480
MOD_PIKK_1	103	109	PF00454	0.445
MOD_PIKK_1	253	259	PF00454	0.748
MOD_PIKK_1	471	477	PF00454	0.542
MOD_PIKK_1	518	524	PF00454	0.440
MOD_PIKK_1	525	531	PF00454	0.444
MOD_PIKK_1	579	585	PF00454	0.459
MOD_PIKK_1	742	748	PF00454	0.622
MOD_PIKK_1	803	809	PF00454	0.660
MOD_PIKK_1	813	819	PF00454	0.651
MOD_PIKK_1	87	93	PF00454	0.419
MOD_PKA_2	119	125	PF00069	0.380
MOD_PKA_2	144	150	PF00069	0.447
MOD_PKA_2	196	202	PF00069	0.418
MOD_PKA_2	228	234	PF00069	0.661
MOD_PKA_2	338	344	PF00069	0.768
MOD_PKA_2	537	543	PF00069	0.474
MOD_PKA_2	557	563	PF00069	0.630
MOD_PKA_2	599	605	PF00069	0.573
MOD_PKA_2	722	728	PF00069	0.649
MOD_PKA_2	77	83	PF00069	0.438
MOD_PKA_2	8	14	PF00069	0.557
MOD_PKA_2	844	850	PF00069	0.688
MOD_PKA_2	87	93	PF00069	0.331
MOD_PKA_2	907	913	PF00069	0.501
MOD_Plk_1	114	120	PF00069	0.355
MOD_Plk_1	311	317	PF00069	0.629
MOD_Plk_1	421	427	PF00069	0.705
MOD_Plk_1	525	531	PF00069	0.520
MOD_Plk_1	58	64	PF00069	0.492
MOD_Plk_1	709	715	PF00069	0.613
MOD_Plk_1	72	78	PF00069	0.390
MOD_Plk_1	868	874	PF00069	0.646
MOD_Plk_2-3	394	400	PF00069	0.602
MOD_Plk_2-3	861	867	PF00069	0.704
MOD_Plk_4	203	209	PF00069	0.508
MOD_Plk_4	242	248	PF00069	0.534
MOD_Plk_4	42	48	PF00069	0.374
MOD_Plk_4	485	491	PF00069	0.594
MOD_Plk_4	540	546	PF00069	0.492
MOD_Plk_4	575	581	PF00069	0.464
MOD_Plk_4	691	697	PF00069	0.568
MOD_Plk_4	766	772	PF00069	0.523
MOD_Plk_4	868	874	PF00069	0.732
MOD_ProDKin_1	174	180	PF00069	0.391
MOD_ProDKin_1	239	245	PF00069	0.708
MOD_ProDKin_1	322	328	PF00069	0.691
MOD_ProDKin_1	34	40	PF00069	0.437
MOD_ProDKin_1	386	392	PF00069	0.801
MOD_ProDKin_1	424	430	PF00069	0.733
MOD_ProDKin_1	440	446	PF00069	0.686
MOD_ProDKin_1	461	467	PF00069	0.640
MOD_ProDKin_1	624	630	PF00069	0.710
MOD_ProDKin_1	657	663	PF00069	0.794
MOD_ProDKin_1	840	846	PF00069	0.626
MOD_ProDKin_1	872	878	PF00069	0.744
MOD_SUMO_for_1	249	252	PF00179	0.536
MOD_SUMO_for_1	671	674	PF00179	0.546
MOD_SUMO_rev_2	144	152	PF00179	0.313
TRG_DiLeu_BaEn_1	594	599	PF01217	0.465
TRG_DiLeu_BaEn_1	918	923	PF01217	0.401
TRG_DiLeu_LyEn_5	594	599	PF01217	0.465
TRG_ENDOCYTIC_2	437	440	PF00928	0.630
TRG_ENDOCYTIC_2	573	576	PF00928	0.462
TRG_ENDOCYTIC_2	697	700	PF00928	0.591
TRG_ENDOCYTIC_2	76	79	PF00928	0.392
TRG_ER_diArg_1	338	340	PF00400	0.636
TRG_ER_diArg_1	458	461	PF00400	0.703
TRG_ER_diArg_1	502	504	PF00400	0.518
TRG_ER_diArg_1	517	519	PF00400	0.369
TRG_ER_diArg_1	595	598	PF00400	0.465
TRG_ER_diArg_1	722	724	PF00400	0.725
TRG_ER_diArg_1	763	765	PF00400	0.710
TRG_NES_CRM1_1	100	115	PF08389	0.415
TRG_NES_CRM1_1	42	56	PF08389	0.380
TRG_NES_CRM1_1	522	535	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q0	Leptomonas seymouri	50%	91%
A0A3S5H524	Leishmania donovani	88%	100%
A4H3I4	Leishmania braziliensis	71%	98%
E9ACF9	Leishmania major	87%	100%
E9AG31	Leishmania infantum	88%	100%