Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJP6_LEIMU

TriTrypDb:

LmxM.03.0110

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.482
CLV_C14_Caspase3-7	639	643	PF00656	0.810
CLV_NRD_NRD_1	16	18	PF00675	0.459
CLV_NRD_NRD_1	199	201	PF00675	0.765
CLV_NRD_NRD_1	214	216	PF00675	0.587
CLV_NRD_NRD_1	30	32	PF00675	0.425
CLV_NRD_NRD_1	302	304	PF00675	0.699
CLV_NRD_NRD_1	558	560	PF00675	0.631
CLV_NRD_NRD_1	692	694	PF00675	0.647
CLV_NRD_NRD_1	80	82	PF00675	0.557
CLV_NRD_NRD_1	841	843	PF00675	0.812
CLV_PCSK_KEX2_1	198	200	PF00082	0.765
CLV_PCSK_KEX2_1	214	216	PF00082	0.571
CLV_PCSK_KEX2_1	30	32	PF00082	0.533
CLV_PCSK_KEX2_1	302	304	PF00082	0.699
CLV_PCSK_KEX2_1	485	487	PF00082	0.765
CLV_PCSK_KEX2_1	692	694	PF00082	0.647
CLV_PCSK_KEX2_1	80	82	PF00082	0.557
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.692
CLV_PCSK_PC7_1	26	32	PF00082	0.536
CLV_PCSK_SKI1_1	18	22	PF00082	0.591
CLV_PCSK_SKI1_1	193	197	PF00082	0.675
CLV_PCSK_SKI1_1	486	490	PF00082	0.665
CLV_PCSK_SKI1_1	511	515	PF00082	0.697
CLV_PCSK_SKI1_1	790	794	PF00082	0.497
CLV_PCSK_SKI1_1	878	882	PF00082	0.848
CLV_Separin_Metazoa	787	791	PF03568	0.597
DEG_SPOP_SBC_1	236	240	PF00917	0.779
DEG_SPOP_SBC_1	243	247	PF00917	0.771
DEG_SPOP_SBC_1	853	857	PF00917	0.760
DOC_CYCLIN_yClb5_NLxxxL_5	540	547	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.578
DOC_MAPK_gen_1	80	91	PF00069	0.455
DOC_MAPK_MEF2A_6	80	89	PF00069	0.567
DOC_MAPK_NFAT4_5	84	92	PF00069	0.577
DOC_MIT_MIM_1	76	85	PF04212	0.561
DOC_PP2B_LxvP_1	85	88	PF13499	0.568
DOC_PP4_FxxP_1	91	94	PF00568	0.566
DOC_USP7_MATH_1	236	240	PF00917	0.802
DOC_USP7_MATH_1	243	247	PF00917	0.747
DOC_USP7_MATH_1	328	332	PF00917	0.820
DOC_USP7_MATH_1	364	368	PF00917	0.731
DOC_USP7_MATH_1	374	378	PF00917	0.580
DOC_USP7_MATH_1	381	385	PF00917	0.562
DOC_USP7_MATH_1	395	399	PF00917	0.467
DOC_USP7_MATH_1	605	609	PF00917	0.820
DOC_USP7_MATH_1	618	622	PF00917	0.607
DOC_USP7_MATH_1	653	657	PF00917	0.613
DOC_USP7_MATH_1	770	774	PF00917	0.751
DOC_USP7_MATH_1	798	802	PF00917	0.628
DOC_USP7_MATH_1	820	824	PF00917	0.779
DOC_USP7_MATH_1	853	857	PF00917	0.743
DOC_USP7_MATH_1	96	100	PF00917	0.301
DOC_WW_Pin1_4	237	242	PF00397	0.824
DOC_WW_Pin1_4	245	250	PF00397	0.696
DOC_WW_Pin1_4	254	259	PF00397	0.557
DOC_WW_Pin1_4	435	440	PF00397	0.832
DOC_WW_Pin1_4	488	493	PF00397	0.834
DOC_WW_Pin1_4	630	635	PF00397	0.782
DOC_WW_Pin1_4	764	769	PF00397	0.711
DOC_WW_Pin1_4	867	872	PF00397	0.684
DOC_WW_Pin1_4	873	878	PF00397	0.622
LIG_14-3-3_CanoR_1	190	196	PF00244	0.561
LIG_14-3-3_CanoR_1	26	32	PF00244	0.614
LIG_14-3-3_CanoR_1	273	279	PF00244	0.854
LIG_14-3-3_CanoR_1	302	312	PF00244	0.803
LIG_14-3-3_CanoR_1	316	325	PF00244	0.647
LIG_14-3-3_CanoR_1	366	372	PF00244	0.732
LIG_14-3-3_CanoR_1	486	492	PF00244	0.678
LIG_14-3-3_CanoR_1	588	595	PF00244	0.703
LIG_14-3-3_CanoR_1	620	626	PF00244	0.819
LIG_14-3-3_CanoR_1	695	701	PF00244	0.625
LIG_14-3-3_CanoR_1	772	778	PF00244	0.655
LIG_14-3-3_CanoR_1	806	811	PF00244	0.490
LIG_14-3-3_CanoR_1	878	884	PF00244	0.804
LIG_Actin_WH2_2	774	792	PF00022	0.618
LIG_Actin_WH2_2	85	100	PF00022	0.465
LIG_BRCT_BRCA1_1	124	128	PF00533	0.624
LIG_BRCT_BRCA1_1	287	291	PF00533	0.595
LIG_CaM_IQ_9	684	700	PF13499	0.657
LIG_CaM_NSCaTE_8	565	572	PF13499	0.671
LIG_FHA_1	10	16	PF00498	0.577
LIG_FHA_1	106	112	PF00498	0.443
LIG_FHA_1	135	141	PF00498	0.569
LIG_FHA_1	146	152	PF00498	0.403
LIG_FHA_1	165	171	PF00498	0.324
LIG_FHA_1	246	252	PF00498	0.556
LIG_FHA_1	274	280	PF00498	0.852
LIG_FHA_1	353	359	PF00498	0.560
LIG_FHA_1	456	462	PF00498	0.626
LIG_FHA_1	520	526	PF00498	0.701
LIG_FHA_1	530	536	PF00498	0.571
LIG_FHA_1	739	745	PF00498	0.654
LIG_FHA_1	879	885	PF00498	0.848
LIG_FHA_2	174	180	PF00498	0.656
LIG_FHA_2	531	537	PF00498	0.729
LIG_FHA_2	717	723	PF00498	0.547
LIG_GBD_Chelix_1	736	744	PF00786	0.571
LIG_Integrin_RGD_1	449	451	PF01839	0.810
LIG_LIR_Apic_2	90	94	PF02991	0.481
LIG_LIR_Gen_1	103	114	PF02991	0.551
LIG_LIR_Gen_1	33	43	PF02991	0.488
LIG_LIR_Gen_1	656	667	PF02991	0.498
LIG_LIR_Nem_3	103	109	PF02991	0.555
LIG_LIR_Nem_3	288	294	PF02991	0.599
LIG_LIR_Nem_3	33	38	PF02991	0.521
LIG_LIR_Nem_3	656	662	PF02991	0.502
LIG_LIR_Nem_3	694	700	PF02991	0.626
LIG_LIR_Nem_3	731	737	PF02991	0.649
LIG_LIR_Nem_3	76	82	PF02991	0.451
LIG_NRBOX	412	418	PF00104	0.673
LIG_NRBOX	879	885	PF00104	0.848
LIG_PCNA_yPIPBox_3	407	421	PF02747	0.655
LIG_PDZ_Class_2	889	894	PF00595	0.744
LIG_Pex14_1	75	79	PF04695	0.562
LIG_Pex14_2	124	128	PF04695	0.624
LIG_Pex14_2	48	52	PF04695	0.524
LIG_PTB_Apo_2	46	53	PF02174	0.559
LIG_SH2_CRK	35	39	PF00017	0.571
LIG_SH2_NCK_1	797	801	PF00017	0.400
LIG_SH2_STAP1	35	39	PF00017	0.493
LIG_SH2_STAP1	465	469	PF00017	0.664
LIG_SH2_STAP1	827	831	PF00017	0.730
LIG_SH2_STAT5	113	116	PF00017	0.507
LIG_SH2_STAT5	139	142	PF00017	0.489
LIG_SH2_STAT5	237	240	PF00017	0.549
LIG_SH3_2	260	265	PF14604	0.735
LIG_SH3_3	157	163	PF00018	0.643
LIG_SH3_3	256	262	PF00018	0.842
LIG_SH3_3	309	315	PF00018	0.768
LIG_SH3_3	354	360	PF00018	0.706
LIG_SH3_3	433	439	PF00018	0.711
LIG_SH3_3	493	499	PF00018	0.811
LIG_SH3_3	622	628	PF00018	0.697
LIG_SH3_3	812	818	PF00018	0.608
LIG_Sin3_3	147	154	PF02671	0.572
LIG_SUMO_SIM_par_1	532	539	PF11976	0.641
LIG_TRAF2_1	183	186	PF00917	0.648
LIG_TRAF2_1	719	722	PF00917	0.670
LIG_TRAF2_1	801	804	PF00917	0.422
LIG_WRC_WIRS_1	20	25	PF05994	0.564
LIG_WW_3	258	262	PF00397	0.821
MOD_CDC14_SPxK_1	633	636	PF00782	0.510
MOD_CDK_SPK_2	437	442	PF00069	0.820
MOD_CDK_SPK_2	873	878	PF00069	0.552
MOD_CDK_SPxK_1	630	636	PF00069	0.517
MOD_CDK_SPxxK_3	245	252	PF00069	0.769
MOD_CDK_SPxxK_3	254	261	PF00069	0.660
MOD_CDK_SPxxK_3	435	442	PF00069	0.830
MOD_CK1_1	203	209	PF00069	0.812
MOD_CK1_1	218	224	PF00069	0.591
MOD_CK1_1	239	245	PF00069	0.819
MOD_CK1_1	268	274	PF00069	0.847
MOD_CK1_1	277	283	PF00069	0.703
MOD_CK1_1	319	325	PF00069	0.789
MOD_CK1_1	327	333	PF00069	0.717
MOD_CK1_1	33	39	PF00069	0.554
MOD_CK1_1	334	340	PF00069	0.647
MOD_CK1_1	346	352	PF00069	0.556
MOD_CK1_1	367	373	PF00069	0.637
MOD_CK1_1	377	383	PF00069	0.646
MOD_CK1_1	427	433	PF00069	0.717
MOD_CK1_1	490	496	PF00069	0.820
MOD_CK1_1	505	511	PF00069	0.545
MOD_CK1_1	621	627	PF00069	0.790
MOD_CK1_1	630	636	PF00069	0.683
MOD_CK1_1	773	779	PF00069	0.657
MOD_CK1_1	823	829	PF00069	0.699
MOD_CK1_1	865	871	PF00069	0.860
MOD_CK2_1	173	179	PF00069	0.649
MOD_CK2_1	716	722	PF00069	0.669
MOD_CK2_1	798	804	PF00069	0.413
MOD_Cter_Amidation	15	18	PF01082	0.597
MOD_DYRK1A_RPxSP_1	437	441	PF00069	0.648
MOD_GlcNHglycan	123	127	PF01048	0.534
MOD_GlcNHglycan	202	205	PF01048	0.795
MOD_GlcNHglycan	224	227	PF01048	0.770
MOD_GlcNHglycan	241	244	PF01048	0.616
MOD_GlcNHglycan	267	270	PF01048	0.577
MOD_GlcNHglycan	305	308	PF01048	0.778
MOD_GlcNHglycan	326	329	PF01048	0.855
MOD_GlcNHglycan	333	336	PF01048	0.724
MOD_GlcNHglycan	349	352	PF01048	0.601
MOD_GlcNHglycan	366	369	PF01048	0.581
MOD_GlcNHglycan	371	374	PF01048	0.756
MOD_GlcNHglycan	379	382	PF01048	0.626
MOD_GlcNHglycan	426	429	PF01048	0.763
MOD_GlcNHglycan	504	507	PF01048	0.835
MOD_GlcNHglycan	607	610	PF01048	0.715
MOD_GlcNHglycan	629	632	PF01048	0.794
MOD_GlcNHglycan	655	658	PF01048	0.530
MOD_GlcNHglycan	764	767	PF01048	0.507
MOD_GlcNHglycan	843	846	PF01048	0.663
MOD_GlcNHglycan	98	101	PF01048	0.382
MOD_GSK3_1	135	142	PF00069	0.596
MOD_GSK3_1	218	225	PF00069	0.766
MOD_GSK3_1	235	242	PF00069	0.616
MOD_GSK3_1	26	33	PF00069	0.461
MOD_GSK3_1	264	271	PF00069	0.840
MOD_GSK3_1	273	280	PF00069	0.733
MOD_GSK3_1	297	304	PF00069	0.769
MOD_GSK3_1	316	323	PF00069	0.530
MOD_GSK3_1	324	331	PF00069	0.763
MOD_GSK3_1	334	341	PF00069	0.588
MOD_GSK3_1	343	350	PF00069	0.585
MOD_GSK3_1	377	384	PF00069	0.757
MOD_GSK3_1	427	434	PF00069	0.755
MOD_GSK3_1	61	68	PF00069	0.683
MOD_GSK3_1	649	656	PF00069	0.565
MOD_GSK3_1	696	703	PF00069	0.616
MOD_GSK3_1	708	715	PF00069	0.430
MOD_GSK3_1	822	829	PF00069	0.692
MOD_GSK3_1	863	870	PF00069	0.692
MOD_N-GLC_1	265	270	PF02516	0.773
MOD_N-GLC_1	605	610	PF02516	0.687
MOD_NEK2_1	164	169	PF00069	0.632
MOD_NEK2_1	235	240	PF00069	0.551
MOD_NEK2_1	264	269	PF00069	0.578
MOD_NEK2_1	417	422	PF00069	0.683
MOD_NEK2_1	589	594	PF00069	0.544
MOD_NEK2_1	696	701	PF00069	0.619
MOD_PIKK_1	310	316	PF00454	0.846
MOD_PIKK_1	374	380	PF00454	0.537
MOD_PIKK_1	471	477	PF00454	0.668
MOD_PIKK_1	618	624	PF00454	0.820
MOD_PIKK_1	65	71	PF00454	0.626
MOD_PIKK_1	738	744	PF00454	0.654
MOD_PIKK_1	753	759	PF00454	0.535
MOD_PK_1	98	104	PF00069	0.486
MOD_PKA_1	198	204	PF00069	0.697
MOD_PKA_1	30	36	PF00069	0.525
MOD_PKA_2	198	204	PF00069	0.697
MOD_PKA_2	25	31	PF00069	0.616
MOD_PKA_2	264	270	PF00069	0.754
MOD_PKA_2	272	278	PF00069	0.840
MOD_PKA_2	301	307	PF00069	0.710
MOD_PKA_2	320	326	PF00069	0.648
MOD_PKA_2	331	337	PF00069	0.663
MOD_PKA_2	805	811	PF00069	0.543
MOD_PKA_2	841	847	PF00069	0.739
MOD_PKB_1	198	206	PF00069	0.784
MOD_Plk_1	134	140	PF00069	0.597
MOD_Plk_1	285	291	PF00069	0.515
MOD_Plk_1	33	39	PF00069	0.505
MOD_Plk_1	612	618	PF00069	0.626
MOD_Plk_1	649	655	PF00069	0.708
MOD_Plk_1	790	796	PF00069	0.582
MOD_Plk_2-3	19	25	PF00069	0.569
MOD_Plk_2-3	34	40	PF00069	0.495
MOD_Plk_4	105	111	PF00069	0.329
MOD_Plk_4	135	141	PF00069	0.598
MOD_Plk_4	145	151	PF00069	0.397
MOD_Plk_4	412	418	PF00069	0.673
MOD_Plk_4	530	536	PF00069	0.658
MOD_Plk_4	700	706	PF00069	0.610
MOD_Plk_4	773	779	PF00069	0.646
MOD_Plk_4	87	93	PF00069	0.492
MOD_Plk_4	879	885	PF00069	0.848
MOD_Plk_4	9	15	PF00069	0.500
MOD_ProDKin_1	237	243	PF00069	0.824
MOD_ProDKin_1	245	251	PF00069	0.699
MOD_ProDKin_1	254	260	PF00069	0.556
MOD_ProDKin_1	435	441	PF00069	0.826
MOD_ProDKin_1	488	494	PF00069	0.836
MOD_ProDKin_1	630	636	PF00069	0.785
MOD_ProDKin_1	764	770	PF00069	0.704
MOD_ProDKin_1	867	873	PF00069	0.681
MOD_SUMO_rev_2	639	646	PF00179	0.571
TRG_DiLeu_BaEn_1	539	544	PF01217	0.663
TRG_DiLeu_BaEn_1	784	789	PF01217	0.590
TRG_DiLeu_BaEn_4	649	655	PF01217	0.610
TRG_ENDOCYTIC_2	192	195	PF00928	0.653
TRG_ENDOCYTIC_2	35	38	PF00928	0.572
TRG_ENDOCYTIC_2	659	662	PF00928	0.579
TRG_ENDOCYTIC_2	734	737	PF00928	0.640
TRG_ER_diArg_1	198	200	PF00400	0.761
TRG_ER_diArg_1	30	32	PF00400	0.533
TRG_ER_diArg_1	302	305	PF00400	0.821
TRG_ER_diArg_1	55	58	PF00400	0.609
TRG_ER_diArg_1	556	559	PF00400	0.729
TRG_ER_diArg_1	691	693	PF00400	0.652
TRG_ER_diArg_1	727	730	PF00400	0.651
TRG_ER_diArg_1	79	81	PF00400	0.559
TRG_NES_CRM1_1	6	19	PF08389	0.396
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H523	Leishmania donovani	87%	100%
A4H3I3	Leishmania braziliensis	76%	100%
E9ACF8	Leishmania major	86%	100%
E9AG30	Leishmania infantum	87%	100%