Glycerol-3-phosphate acyl transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate acyl transferase

Species:

Leishmania mexicana

UniProt:

E9AJP3_LEIMU

TriTrypDb:

LmxM.03.0080

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AJP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJP3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0004366	glycerol-3-phosphate O-acyltransferase activity	6	5
GO:0008374	O-acyltransferase activity	5	5
GO:0016287	glycerone-phosphate O-acyltransferase activity	7	2
GO:0016407	acetyltransferase activity	5	2
GO:0016413	O-acetyltransferase activity	6	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	5
GO:0043772	acyl-phosphate glycerol-3-phosphate acyltransferase activity	5	1
GO:0102420	sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	531	535	PF00656	0.526
CLV_NRD_NRD_1	257	259	PF00675	0.540
CLV_NRD_NRD_1	312	314	PF00675	0.452
CLV_NRD_NRD_1	372	374	PF00675	0.455
CLV_NRD_NRD_1	503	505	PF00675	0.308
CLV_NRD_NRD_1	554	556	PF00675	0.400
CLV_PCSK_KEX2_1	257	259	PF00082	0.516
CLV_PCSK_KEX2_1	312	314	PF00082	0.452
CLV_PCSK_KEX2_1	372	374	PF00082	0.440
CLV_PCSK_KEX2_1	407	409	PF00082	0.352
CLV_PCSK_KEX2_1	503	505	PF00082	0.300
CLV_PCSK_KEX2_1	553	555	PF00082	0.395
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.492
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.389
CLV_PCSK_PC7_1	549	555	PF00082	0.417
CLV_PCSK_SKI1_1	10	14	PF00082	0.454
CLV_PCSK_SKI1_1	258	262	PF00082	0.457
CLV_PCSK_SKI1_1	273	277	PF00082	0.447
CLV_PCSK_SKI1_1	355	359	PF00082	0.599
CLV_PCSK_SKI1_1	372	376	PF00082	0.424
CLV_PCSK_SKI1_1	407	411	PF00082	0.285
CLV_PCSK_SKI1_1	427	431	PF00082	0.118
CLV_PCSK_SKI1_1	453	457	PF00082	0.415
CLV_PCSK_SKI1_1	481	485	PF00082	0.290
CLV_PCSK_SKI1_1	555	559	PF00082	0.465
DEG_APCC_DBOX_1	452	460	PF00400	0.272
DEG_APCC_DBOX_1	480	488	PF00400	0.593
DEG_Nend_Nbox_1	1	3	PF02207	0.215
DOC_CKS1_1	150	155	PF01111	0.301
DOC_CYCLIN_RxL_1	352	361	PF00134	0.407
DOC_CYCLIN_RxL_1	396	406	PF00134	0.331
DOC_MAPK_gen_1	108	116	PF00069	0.291
DOC_MAPK_gen_1	230	239	PF00069	0.246
DOC_MAPK_gen_1	257	265	PF00069	0.267
DOC_MAPK_gen_1	372	379	PF00069	0.205
DOC_MAPK_gen_1	90	100	PF00069	0.291
DOC_MAPK_MEF2A_6	453	460	PF00069	0.215
DOC_MAPK_MEF2A_6	481	488	PF00069	0.497
DOC_MAPK_NFAT4_5	481	489	PF00069	0.500
DOC_PP1_RVXF_1	281	288	PF00149	0.357
DOC_PP1_RVXF_1	3	10	PF00149	0.359
DOC_PP1_RVXF_1	425	431	PF00149	0.451
DOC_PP1_RVXF_1	46	53	PF00149	0.205
DOC_PP4_FxxP_1	243	246	PF00568	0.255
DOC_PP4_FxxP_1	460	463	PF00568	0.273
DOC_PP4_FxxP_1	536	539	PF00568	0.501
DOC_PP4_FxxP_1	59	62	PF00568	0.215
DOC_USP7_MATH_1	127	131	PF00917	0.323
DOC_USP7_MATH_1	532	536	PF00917	0.523
DOC_USP7_MATH_1	55	59	PF00917	0.205
DOC_WW_Pin1_4	149	154	PF00397	0.243
DOC_WW_Pin1_4	241	246	PF00397	0.261
LIG_14-3-3_CanoR_1	131	138	PF00244	0.272
LIG_14-3-3_CanoR_1	212	217	PF00244	0.229
LIG_14-3-3_CanoR_1	408	417	PF00244	0.570
LIG_14-3-3_CanoR_1	69	75	PF00244	0.272
LIG_Actin_WH2_2	390	406	PF00022	0.453
LIG_Actin_WH2_2	465	483	PF00022	0.336
LIG_APCC_ABBA_1	181	186	PF00400	0.205
LIG_APCC_ABBA_1	446	451	PF00400	0.408
LIG_APCC_ABBA_1	526	531	PF00400	0.572
LIG_BRCT_BRCA1_1	5	9	PF00533	0.356
LIG_DLG_GKlike_1	541	548	PF00625	0.557
LIG_EH1_1	377	385	PF00400	0.254
LIG_FHA_1	139	145	PF00498	0.248
LIG_FHA_1	191	197	PF00498	0.205
LIG_FHA_1	21	27	PF00498	0.200
LIG_FHA_1	274	280	PF00498	0.266
LIG_FHA_1	441	447	PF00498	0.375
LIG_FHA_1	452	458	PF00498	0.265
LIG_FHA_2	131	137	PF00498	0.296
LIG_LIR_Apic_2	241	246	PF02991	0.260
LIG_LIR_Apic_2	534	539	PF02991	0.499
LIG_LIR_Apic_2	56	62	PF02991	0.215
LIG_LIR_Gen_1	104	114	PF02991	0.323
LIG_LIR_Gen_1	165	175	PF02991	0.222
LIG_LIR_Gen_1	233	243	PF02991	0.309
LIG_LIR_Gen_1	306	314	PF02991	0.257
LIG_LIR_Gen_1	325	334	PF02991	0.193
LIG_LIR_Gen_1	335	345	PF02991	0.270
LIG_LIR_Gen_1	443	449	PF02991	0.323
LIG_LIR_Nem_3	104	109	PF02991	0.323
LIG_LIR_Nem_3	165	171	PF02991	0.222
LIG_LIR_Nem_3	233	239	PF02991	0.304
LIG_LIR_Nem_3	281	285	PF02991	0.325
LIG_LIR_Nem_3	290	294	PF02991	0.298
LIG_LIR_Nem_3	306	310	PF02991	0.192
LIG_LIR_Nem_3	325	330	PF02991	0.199
LIG_LIR_Nem_3	335	340	PF02991	0.248
LIG_LIR_Nem_3	423	429	PF02991	0.451
LIG_LIR_Nem_3	443	447	PF02991	0.416
LIG_LIR_Nem_3	6	12	PF02991	0.303
LIG_MLH1_MIPbox_1	5	9	PF16413	0.356
LIG_NRBOX	353	359	PF00104	0.405
LIG_Pex14_2	239	243	PF04695	0.293
LIG_Pex14_2	287	291	PF04695	0.229
LIG_Pex14_2	426	430	PF04695	0.451
LIG_Rb_pABgroove_1	247	255	PF01858	0.376
LIG_SH2_CRK	168	172	PF00017	0.207
LIG_SH2_CRK	282	286	PF00017	0.333
LIG_SH2_CRK	295	299	PF00017	0.270
LIG_SH2_NCK_1	168	172	PF00017	0.205
LIG_SH2_PTP2	467	470	PF00017	0.239
LIG_SH2_SRC	225	228	PF00017	0.363
LIG_SH2_SRC	295	298	PF00017	0.306
LIG_SH2_SRC	518	521	PF00017	0.396
LIG_SH2_STAP1	158	162	PF00017	0.247
LIG_SH2_STAP1	168	172	PF00017	0.170
LIG_SH2_STAT5	225	228	PF00017	0.278
LIG_SH2_STAT5	236	239	PF00017	0.238
LIG_SH2_STAT5	307	310	PF00017	0.268
LIG_SH2_STAT5	378	381	PF00017	0.385
LIG_SH2_STAT5	400	403	PF00017	0.522
LIG_SH2_STAT5	467	470	PF00017	0.239
LIG_SH2_STAT5	8	11	PF00017	0.275
LIG_SH3_3	137	143	PF00018	0.245
LIG_SH3_3	147	153	PF00018	0.192
LIG_SH3_3	387	393	PF00018	0.244
LIG_SH3_3	73	79	PF00018	0.205
LIG_Sin3_3	431	438	PF02671	0.184
LIG_SUMO_SIM_anti_2	11	16	PF11976	0.205
LIG_SUMO_SIM_anti_2	454	461	PF11976	0.287
LIG_SUMO_SIM_anti_2	469	475	PF11976	0.161
LIG_SUMO_SIM_par_1	454	461	PF11976	0.314
LIG_SUMO_SIM_par_1	469	475	PF11976	0.152
LIG_TRAF2_1	134	137	PF00917	0.251
LIG_TYR_ITIM	398	403	PF00017	0.453
LIG_UBA3_1	195	199	PF00899	0.239
LIG_UBA3_1	397	404	PF00899	0.333
LIG_WRC_WIRS_1	288	293	PF05994	0.429
LIG_WRC_WIRS_1	441	446	PF05994	0.329
MOD_CK1_1	107	113	PF00069	0.452
MOD_CK1_1	130	136	PF00069	0.304
MOD_CK1_1	411	417	PF00069	0.453
MOD_CK1_1	489	495	PF00069	0.374
MOD_CK1_1	544	550	PF00069	0.477
MOD_CK2_1	130	136	PF00069	0.278
MOD_GlcNHglycan	302	305	PF01048	0.477
MOD_GSK3_1	127	134	PF00069	0.356
MOD_GSK3_1	152	159	PF00069	0.327
MOD_GSK3_1	186	193	PF00069	0.287
MOD_GSK3_1	346	353	PF00069	0.380
MOD_GSK3_1	447	454	PF00069	0.330
MOD_N-GLC_1	335	340	PF02516	0.420
MOD_N-GLC_2	178	180	PF02516	0.254
MOD_NEK2_1	156	161	PF00069	0.354
MOD_NEK2_1	287	292	PF00069	0.450
MOD_NEK2_1	403	408	PF00069	0.357
MOD_NEK2_1	41	46	PF00069	0.385
MOD_NEK2_1	410	415	PF00069	0.394
MOD_NEK2_1	440	445	PF00069	0.298
MOD_NEK2_1	466	471	PF00069	0.276
MOD_NEK2_1	486	491	PF00069	0.344
MOD_NEK2_2	55	60	PF00069	0.227
MOD_PIKK_1	346	352	PF00454	0.335
MOD_PIKK_1	489	495	PF00454	0.439
MOD_PK_1	212	218	PF00069	0.273
MOD_PKA_1	258	264	PF00069	0.341
MOD_PKA_2	107	113	PF00069	0.378
MOD_PKA_2	130	136	PF00069	0.409
MOD_PKA_2	346	352	PF00069	0.348
MOD_Plk_1	10	16	PF00069	0.260
MOD_Plk_1	138	144	PF00069	0.275
MOD_Plk_1	190	196	PF00069	0.239
MOD_Plk_1	411	417	PF00069	0.448
MOD_Plk_1	55	61	PF00069	0.239
MOD_Plk_4	10	16	PF00069	0.285
MOD_Plk_4	191	197	PF00069	0.282
MOD_Plk_4	221	227	PF00069	0.283
MOD_Plk_4	440	446	PF00069	0.254
MOD_Plk_4	466	472	PF00069	0.280
MOD_Plk_4	486	492	PF00069	0.323
MOD_Plk_4	541	547	PF00069	0.450
MOD_ProDKin_1	149	155	PF00069	0.292
MOD_ProDKin_1	241	247	PF00069	0.326
MOD_SUMO_rev_2	519	528	PF00179	0.410
MOD_SUMO_rev_2	86	92	PF00179	0.260
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.435
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.385
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.379
TRG_ENDOCYTIC_2	168	171	PF00928	0.239
TRG_ENDOCYTIC_2	172	175	PF00928	0.239
TRG_ENDOCYTIC_2	236	239	PF00928	0.371
TRG_ENDOCYTIC_2	282	285	PF00928	0.457
TRG_ENDOCYTIC_2	307	310	PF00928	0.306
TRG_ENDOCYTIC_2	337	340	PF00928	0.450
TRG_ENDOCYTIC_2	400	403	PF00928	0.455
TRG_ENDOCYTIC_2	467	470	PF00928	0.287
TRG_ER_diArg_1	231	234	PF00400	0.351
TRG_ER_diArg_1	311	313	PF00400	0.315
TRG_ER_diArg_1	371	373	PF00400	0.315
TRG_ER_diArg_1	552	555	PF00400	0.485
TRG_NES_CRM1_1	266	281	PF08389	0.434
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I239	Leptomonas seymouri	81%	77%
A0A0S4JH62	Bodo saltans	57%	77%
A0A1X0P8Y7	Trypanosomatidae	63%	80%
A0A3R7K7V0	Trypanosoma rangeli	63%	80%
A0A3S5H521	Leishmania donovani	96%	89%
A4H3I0	Leishmania braziliensis	92%	100%
D0A214	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	80%
E9ACF5	Leishmania major	96%	100%
E9AG27	Leishmania infantum	96%	89%
P32784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	74%
P36148	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	75%
Q9P7P0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	83%
V5B455	Trypanosoma cruzi	64%	80%