Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJP2_LEIMU

TriTrypDb:

LmxM.03.0070

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	607	611	PF00656	0.536
CLV_NRD_NRD_1	361	363	PF00675	0.489
CLV_NRD_NRD_1	375	377	PF00675	0.536
CLV_NRD_NRD_1	430	432	PF00675	0.602
CLV_NRD_NRD_1	484	486	PF00675	0.554
CLV_NRD_NRD_1	705	707	PF00675	0.665
CLV_NRD_NRD_1	768	770	PF00675	0.587
CLV_PCSK_KEX2_1	375	377	PF00082	0.536
CLV_PCSK_KEX2_1	430	432	PF00082	0.602
CLV_PCSK_KEX2_1	483	485	PF00082	0.558
CLV_PCSK_KEX2_1	705	707	PF00082	0.665
CLV_PCSK_KEX2_1	770	772	PF00082	0.676
CLV_PCSK_PC1ET2_1	770	772	PF00082	0.676
CLV_PCSK_PC7_1	426	432	PF00082	0.577
CLV_PCSK_SKI1_1	176	180	PF00082	0.714
CLV_PCSK_SKI1_1	187	191	PF00082	0.575
CLV_PCSK_SKI1_1	270	274	PF00082	0.498
CLV_PCSK_SKI1_1	287	291	PF00082	0.385
CLV_PCSK_SKI1_1	315	319	PF00082	0.397
CLV_PCSK_SKI1_1	362	366	PF00082	0.427
CLV_PCSK_SKI1_1	526	530	PF00082	0.457
CLV_PCSK_SKI1_1	545	549	PF00082	0.260
CLV_PCSK_SKI1_1	598	602	PF00082	0.474
CLV_PCSK_SKI1_1	691	695	PF00082	0.386
CLV_PCSK_SKI1_1	714	718	PF00082	0.544
CLV_Separin_Metazoa	427	431	PF03568	0.576
DEG_APCC_DBOX_1	14	22	PF00400	0.645
DEG_APCC_DBOX_1	361	369	PF00400	0.481
DEG_APCC_DBOX_1	597	605	PF00400	0.503
DEG_APCC_DBOX_1	690	698	PF00400	0.417
DOC_ANK_TNKS_1	429	436	PF00023	0.584
DOC_CDC14_PxL_1	191	199	PF14671	0.496
DOC_CYCLIN_RxL_1	312	322	PF00134	0.534
DOC_CYCLIN_RxL_1	550	560	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	717	723	PF00134	0.507
DOC_MAPK_gen_1	362	370	PF00069	0.481
DOC_MAPK_gen_1	445	452	PF00069	0.510
DOC_MAPK_gen_1	689	698	PF00069	0.392
DOC_MAPK_MEF2A_6	402	409	PF00069	0.517
DOC_MAPK_MEF2A_6	445	454	PF00069	0.533
DOC_MAPK_MEF2A_6	598	605	PF00069	0.473
DOC_MAPK_MEF2A_6	689	698	PF00069	0.392
DOC_MAPK_NFAT4_5	691	699	PF00069	0.489
DOC_PP1_RVXF_1	285	291	PF00149	0.481
DOC_PP1_RVXF_1	524	530	PF00149	0.511
DOC_PP1_RVXF_1	551	558	PF00149	0.564
DOC_PP1_RVXF_1	668	674	PF00149	0.390
DOC_PP2B_LxvP_1	293	296	PF13499	0.481
DOC_PP2B_LxvP_1	628	631	PF13499	0.568
DOC_USP7_MATH_1	27	31	PF00917	0.560
DOC_USP7_MATH_1	382	386	PF00917	0.500
DOC_USP7_MATH_1	528	532	PF00917	0.503
DOC_USP7_MATH_1	58	62	PF00917	0.690
DOC_USP7_MATH_1	631	635	PF00917	0.641
DOC_USP7_MATH_2	49	55	PF00917	0.651
DOC_USP7_UBL2_3	22	26	PF12436	0.629
DOC_USP7_UBL2_3	766	770	PF12436	0.668
DOC_WW_Pin1_4	355	360	PF00397	0.496
DOC_WW_Pin1_4	586	591	PF00397	0.522
DOC_WW_Pin1_4	76	81	PF00397	0.690
LIG_14-3-3_CanoR_1	110	117	PF00244	0.521
LIG_14-3-3_CanoR_1	354	359	PF00244	0.434
LIG_14-3-3_CanoR_1	533	540	PF00244	0.491
LIG_14-3-3_CanoR_1	545	552	PF00244	0.466
LIG_14-3-3_CanoR_1	633	637	PF00244	0.651
LIG_14-3-3_CanoR_1	711	717	PF00244	0.557
LIG_Actin_WH2_2	30	48	PF00022	0.610
LIG_BRCT_BRCA1_1	405	409	PF00533	0.470
LIG_BRCT_BRCA1_1	576	580	PF00533	0.530
LIG_Clathr_ClatBox_1	131	135	PF01394	0.673
LIG_Clathr_ClatBox_1	404	408	PF01394	0.527
LIG_DCNL_PONY_1	1	4	PF03556	0.409
LIG_deltaCOP1_diTrp_1	408	414	PF00928	0.504
LIG_eIF4E_1	721	727	PF01652	0.403
LIG_FAT_LD_1	455	463	PF03623	0.553
LIG_FHA_1	234	240	PF00498	0.478
LIG_FHA_1	486	492	PF00498	0.544
LIG_FHA_1	502	508	PF00498	0.429
LIG_FHA_1	546	552	PF00498	0.431
LIG_FHA_2	597	603	PF00498	0.502
LIG_FHA_2	638	644	PF00498	0.580
LIG_FHA_2	742	748	PF00498	0.656
LIG_Integrin_RGD_1	608	610	PF01839	0.615
LIG_LIR_Gen_1	114	125	PF02991	0.598
LIG_LIR_Gen_1	202	213	PF02991	0.485
LIG_LIR_Gen_1	242	250	PF02991	0.427
LIG_LIR_Gen_1	304	314	PF02991	0.490
LIG_LIR_Gen_1	335	346	PF02991	0.561
LIG_LIR_Gen_1	447	455	PF02991	0.530
LIG_LIR_Gen_1	626	631	PF02991	0.569
LIG_LIR_Gen_1	67	77	PF02991	0.627
LIG_LIR_LC3C_4	329	333	PF02991	0.547
LIG_LIR_Nem_3	114	120	PF02991	0.561
LIG_LIR_Nem_3	127	132	PF02991	0.576
LIG_LIR_Nem_3	202	208	PF02991	0.460
LIG_LIR_Nem_3	242	248	PF02991	0.425
LIG_LIR_Nem_3	304	309	PF02991	0.498
LIG_LIR_Nem_3	335	341	PF02991	0.481
LIG_LIR_Nem_3	406	412	PF02991	0.526
LIG_LIR_Nem_3	447	451	PF02991	0.549
LIG_LIR_Nem_3	596	600	PF02991	0.417
LIG_LIR_Nem_3	626	630	PF02991	0.561
LIG_LIR_Nem_3	67	72	PF02991	0.657
LIG_LIR_Nem_3	712	716	PF02991	0.444
LIG_LIR_Nem_3	718	724	PF02991	0.425
LIG_LIR_Nem_3	751	756	PF02991	0.677
LIG_LYPXL_yS_3	721	724	PF13949	0.429
LIG_NRBOX	364	370	PF00104	0.476
LIG_NRBOX	493	499	PF00104	0.501
LIG_NRBOX	693	699	PF00104	0.492
LIG_Pex14_1	121	125	PF04695	0.604
LIG_Pex14_1	525	529	PF04695	0.439
LIG_Pex14_1	534	538	PF04695	0.452
LIG_Pex14_2	410	414	PF04695	0.474
LIG_PTB_Apo_2	207	214	PF02174	0.517
LIG_PTB_Apo_2	551	558	PF02174	0.564
LIG_PTB_Phospho_1	207	213	PF10480	0.512
LIG_Rb_LxCxE_1	127	147	PF01857	0.693
LIG_REV1ctd_RIR_1	162	171	PF16727	0.587
LIG_SH2_CRK	213	217	PF00017	0.455
LIG_SH2_PTP2	412	415	PF00017	0.550
LIG_SH2_STAP1	112	116	PF00017	0.673
LIG_SH2_STAP1	213	217	PF00017	0.440
LIG_SH2_STAP1	65	69	PF00017	0.648
LIG_SH2_STAT3	125	128	PF00017	0.560
LIG_SH2_STAT5	125	128	PF00017	0.572
LIG_SH2_STAT5	173	176	PF00017	0.539
LIG_SH2_STAT5	193	196	PF00017	0.476
LIG_SH2_STAT5	205	208	PF00017	0.394
LIG_SH2_STAT5	412	415	PF00017	0.476
LIG_SH2_STAT5	471	474	PF00017	0.528
LIG_SH2_STAT5	538	541	PF00017	0.454
LIG_SH2_STAT5	627	630	PF00017	0.554
LIG_SH2_STAT5	7	10	PF00017	0.588
LIG_SH3_3	117	123	PF00018	0.685
LIG_SH3_3	272	278	PF00018	0.501
LIG_SH3_3	447	453	PF00018	0.537
LIG_SH3_3	717	723	PF00018	0.381
LIG_Sin3_3	366	373	PF02671	0.476
LIG_SUMO_SIM_anti_2	581	586	PF11976	0.431
LIG_SUMO_SIM_anti_2	599	605	PF11976	0.509
LIG_SUMO_SIM_anti_2	645	651	PF11976	0.355
LIG_SUMO_SIM_par_1	246	251	PF11976	0.483
LIG_SUMO_SIM_par_1	503	510	PF11976	0.558
LIG_TYR_ITIM	115	120	PF00017	0.595
LIG_TYR_ITIM	625	630	PF00017	0.491
LIG_UBA3_1	163	167	PF00899	0.632
LIG_WRC_WIRS_1	145	150	PF05994	0.562
LIG_WW_1	277	280	PF00397	0.549
MOD_CDK_SPxxK_3	355	362	PF00069	0.492
MOD_CK1_1	146	152	PF00069	0.659
MOD_CK1_1	172	178	PF00069	0.526
MOD_CK1_1	316	322	PF00069	0.533
MOD_CK1_1	344	350	PF00069	0.541
MOD_CK1_1	645	651	PF00069	0.513
MOD_CK1_1	76	82	PF00069	0.655
MOD_CK2_1	133	139	PF00069	0.572
MOD_CK2_1	596	602	PF00069	0.503
MOD_CK2_1	741	747	PF00069	0.702
MOD_GlcNHglycan	148	151	PF01048	0.656
MOD_GlcNHglycan	29	32	PF01048	0.614
MOD_GlcNHglycan	343	346	PF01048	0.562
MOD_GlcNHglycan	384	387	PF01048	0.696
MOD_GlcNHglycan	388	391	PF01048	0.670
MOD_GlcNHglycan	534	537	PF01048	0.484
MOD_GlcNHglycan	660	663	PF01048	0.378
MOD_GlcNHglycan	74	78	PF01048	0.706
MOD_GlcNHglycan	81	84	PF01048	0.717
MOD_GSK3_1	27	34	PF00069	0.335
MOD_GSK3_1	340	347	PF00069	0.564
MOD_GSK3_1	382	389	PF00069	0.634
MOD_GSK3_1	515	522	PF00069	0.620
MOD_GSK3_1	528	535	PF00069	0.380
MOD_GSK3_1	53	60	PF00069	0.712
MOD_GSK3_1	574	581	PF00069	0.524
MOD_GSK3_1	675	682	PF00069	0.509
MOD_GSK3_1	7	14	PF00069	0.561
MOD_GSK3_1	84	91	PF00069	0.684
MOD_LATS_1	185	191	PF00433	0.664
MOD_NEK2_1	159	164	PF00069	0.583
MOD_NEK2_1	169	174	PF00069	0.600
MOD_NEK2_1	246	251	PF00069	0.408
MOD_NEK2_1	313	318	PF00069	0.449
MOD_NEK2_1	341	346	PF00069	0.553
MOD_NEK2_1	420	425	PF00069	0.491
MOD_NEK2_1	441	446	PF00069	0.619
MOD_NEK2_1	53	58	PF00069	0.648
MOD_NEK2_1	532	537	PF00069	0.508
MOD_NEK2_1	574	579	PF00069	0.530
MOD_NEK2_1	580	585	PF00069	0.483
MOD_NEK2_1	657	662	PF00069	0.562
MOD_NEK2_1	679	684	PF00069	0.491
MOD_NEK2_1	99	104	PF00069	0.523
MOD_NEK2_2	17	22	PF00069	0.643
MOD_NEK2_2	528	533	PF00069	0.475
MOD_PIKK_1	248	254	PF00454	0.250
MOD_PIKK_1	31	37	PF00454	0.620
MOD_PIKK_1	469	475	PF00454	0.573
MOD_PIKK_1	679	685	PF00454	0.545
MOD_PKA_2	382	388	PF00069	0.659
MOD_PKA_2	532	538	PF00069	0.412
MOD_PKA_2	58	64	PF00069	0.654
MOD_PKA_2	632	638	PF00069	0.636
MOD_PKB_1	483	491	PF00069	0.501
MOD_Plk_1	134	140	PF00069	0.649
MOD_Plk_1	260	266	PF00069	0.550
MOD_Plk_1	485	491	PF00069	0.508
MOD_Plk_1	645	651	PF00069	0.417
MOD_Plk_2-3	403	409	PF00069	0.524
MOD_Plk_4	159	165	PF00069	0.560
MOD_Plk_4	169	175	PF00069	0.537
MOD_Plk_4	348	354	PF00069	0.506
MOD_Plk_4	574	580	PF00069	0.491
MOD_ProDKin_1	355	361	PF00069	0.493
MOD_ProDKin_1	586	592	PF00069	0.523
MOD_ProDKin_1	76	82	PF00069	0.694
MOD_SUMO_rev_2	514	520	PF00179	0.623
MOD_SUMO_rev_2	765	772	PF00179	0.671
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.671
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.532
TRG_DiLeu_LyEn_5	503	508	PF01217	0.369
TRG_ENDOCYTIC_2	112	115	PF00928	0.597
TRG_ENDOCYTIC_2	117	120	PF00928	0.555
TRG_ENDOCYTIC_2	193	196	PF00928	0.515
TRG_ENDOCYTIC_2	205	208	PF00928	0.362
TRG_ENDOCYTIC_2	213	216	PF00928	0.252
TRG_ENDOCYTIC_2	280	283	PF00928	0.462
TRG_ENDOCYTIC_2	621	624	PF00928	0.398
TRG_ENDOCYTIC_2	627	630	PF00928	0.429
TRG_ENDOCYTIC_2	676	679	PF00928	0.388
TRG_ENDOCYTIC_2	721	724	PF00928	0.429
TRG_ER_diArg_1	429	431	PF00400	0.592
TRG_ER_diArg_1	482	485	PF00400	0.547
TRG_ER_diArg_1	568	571	PF00400	0.587
TRG_ER_diArg_1	769	772	PF00400	0.704
TRG_NES_CRM1_1	214	227	PF08389	0.465
TRG_NES_CRM1_1	237	252	PF08389	0.579
TRG_NES_CRM1_1	495	510	PF08389	0.561
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	677	681	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX1	Leptomonas seymouri	66%	86%
A0A0S4JH32	Bodo saltans	28%	89%
A0A1X0PA13	Trypanosomatidae	33%	93%
A0A422N7I6	Trypanosoma rangeli	34%	93%
A0A451EJL3	Leishmania donovani	95%	93%
A4H3H9	Leishmania braziliensis	89%	100%
D0A213	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
E9ACF4	Leishmania major	95%	100%
E9AG26	Leishmania infantum	95%	93%