Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJN8_LEIMU

TriTrypDb:

LmxM.03.0020

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.495
CLV_NRD_NRD_1	235	237	PF00675	0.544
CLV_NRD_NRD_1	91	93	PF00675	0.613
CLV_PCSK_KEX2_1	207	209	PF00082	0.479
CLV_PCSK_KEX2_1	235	237	PF00082	0.565
CLV_PCSK_KEX2_1	34	36	PF00082	0.558
CLV_PCSK_KEX2_1	93	95	PF00082	0.587
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.627
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.586
CLV_PCSK_SKI1_1	207	211	PF00082	0.476
DEG_APCC_DBOX_1	197	205	PF00400	0.524
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.563
DOC_MAPK_DCC_7	8	17	PF00069	0.505
DOC_MAPK_gen_1	239	248	PF00069	0.601
DOC_MAPK_gen_1	8	14	PF00069	0.513
DOC_MAPK_MEF2A_6	8	17	PF00069	0.494
DOC_PP4_FxxP_1	210	213	PF00568	0.477
DOC_USP7_MATH_1	169	173	PF00917	0.534
DOC_USP7_MATH_1	46	50	PF00917	0.640
DOC_USP7_MATH_1	67	71	PF00917	0.641
DOC_USP7_MATH_1	75	79	PF00917	0.692
DOC_USP7_UBL2_3	153	157	PF12436	0.540
DOC_USP7_UBL2_3	59	63	PF12436	0.437
DOC_WW_Pin1_4	189	194	PF00397	0.489
DOC_WW_Pin1_4	237	242	PF00397	0.555
DOC_WW_Pin1_4	254	259	PF00397	0.555
DOC_WW_Pin1_4	71	76	PF00397	0.631
LIG_14-3-3_CanoR_1	19	27	PF00244	0.635
LIG_14-3-3_CanoR_1	94	101	PF00244	0.631
LIG_BRCT_BRCA1_1	127	131	PF00533	0.571
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.476
LIG_EH1_1	224	232	PF00400	0.460
LIG_eIF4E_1	130	136	PF01652	0.524
LIG_FHA_1	150	156	PF00498	0.478
LIG_FHA_1	169	175	PF00498	0.390
LIG_FHA_1	186	192	PF00498	0.388
LIG_LIR_Gen_1	132	141	PF02991	0.431
LIG_LIR_Gen_1	16	21	PF02991	0.456
LIG_LIR_Gen_1	202	210	PF02991	0.400
LIG_LIR_Nem_3	127	133	PF02991	0.457
LIG_LIR_Nem_3	16	20	PF02991	0.457
LIG_LIR_Nem_3	202	206	PF02991	0.376
LIG_LIR_Nem_3	240	246	PF02991	0.603
LIG_LIR_Nem_3	65	71	PF02991	0.670
LIG_MLH1_MIPbox_1	127	131	PF16413	0.571
LIG_MYND_3	12	16	PF01753	0.577
LIG_PDZ_Class_3	262	267	PF00595	0.658
LIG_SH2_PTP2	166	169	PF00017	0.501
LIG_SH2_STAT5	130	133	PF00017	0.438
LIG_SH2_STAT5	166	169	PF00017	0.374
LIG_SH3_3	255	261	PF00018	0.641
LIG_SH3_3	81	87	PF00018	0.567
LIG_SUMO_SIM_par_1	178	183	PF11976	0.475
LIG_SUMO_SIM_par_1	185	192	PF11976	0.487
MOD_CDC14_SPxK_1	192	195	PF00782	0.523
MOD_CDK_SPK_2	237	242	PF00069	0.599
MOD_CDK_SPxK_1	189	195	PF00069	0.501
MOD_CK1_1	118	124	PF00069	0.608
MOD_CK1_1	183	189	PF00069	0.525
MOD_CK1_1	257	263	PF00069	0.656
MOD_CK1_1	70	76	PF00069	0.673
MOD_CK1_1	78	84	PF00069	0.666
MOD_CK2_1	46	52	PF00069	0.732
MOD_CK2_1	94	100	PF00069	0.706
MOD_GlcNHglycan	108	111	PF01048	0.580
MOD_GlcNHglycan	48	51	PF01048	0.711
MOD_GlcNHglycan	75	78	PF01048	0.703
MOD_GSK3_1	169	176	PF00069	0.467
MOD_GSK3_1	185	192	PF00069	0.337
MOD_GSK3_1	237	244	PF00069	0.632
MOD_GSK3_1	253	260	PF00069	0.511
MOD_GSK3_1	66	73	PF00069	0.734
MOD_NEK2_1	131	136	PF00069	0.501
MOD_PKA_1	92	98	PF00069	0.639
MOD_PKA_2	78	84	PF00069	0.653
MOD_PKB_1	92	100	PF00069	0.606
MOD_Plk_1	131	137	PF00069	0.519
MOD_Plk_1	180	186	PF00069	0.540
MOD_Plk_4	169	175	PF00069	0.452
MOD_Plk_4	185	191	PF00069	0.468
MOD_ProDKin_1	189	195	PF00069	0.503
MOD_ProDKin_1	237	243	PF00069	0.553
MOD_ProDKin_1	254	260	PF00069	0.557
MOD_ProDKin_1	71	77	PF00069	0.632
MOD_SUMO_for_1	42	45	PF00179	0.733
MOD_SUMO_for_1	58	61	PF00179	0.523
MOD_SUMO_for_1	62	65	PF00179	0.405
TRG_DiLeu_BaEn_2	15	21	PF01217	0.550
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.536
TRG_ENDOCYTIC_2	130	133	PF00928	0.438
TRG_ER_diArg_1	206	208	PF00400	0.512
TRG_ER_diArg_1	24	27	PF00400	0.388
TRG_ER_diArg_1	91	94	PF00400	0.600
TRG_NLS_MonoExtC_3	91	96	PF00514	0.705
TRG_NLS_MonoExtN_4	92	97	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W5	Leptomonas seymouri	47%	100%
A0A1X0P8M5	Trypanosomatidae	30%	100%
A0A3R7KU56	Trypanosoma rangeli	28%	100%
A0A3S5H519	Leishmania donovani	90%	100%
A4H3H5	Leishmania braziliensis	72%	100%
E9ACF0	Leishmania major	87%	100%
E9AG22	Leishmania infantum	88%	100%
V5ANT9	Trypanosoma cruzi	30%	100%