RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJN7_LEIMU

TriTrypDb:

LmxM.03.0010

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 13
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15
GO:0016020	membrane	2	2

Expansion

Sequence features

E9AJN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJN7

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.533
CLV_C14_Caspase3-7	519	523	PF00656	0.354
CLV_C14_Caspase3-7	78	82	PF00656	0.376
CLV_C14_Caspase3-7	798	802	PF00656	0.311
CLV_C14_Caspase3-7	890	894	PF00656	0.283
CLV_NRD_NRD_1	189	191	PF00675	0.514
CLV_NRD_NRD_1	788	790	PF00675	0.422
CLV_NRD_NRD_1	838	840	PF00675	0.353
CLV_PCSK_FUR_1	786	790	PF00082	0.297
CLV_PCSK_KEX2_1	189	191	PF00082	0.505
CLV_PCSK_KEX2_1	788	790	PF00082	0.425
CLV_PCSK_SKI1_1	385	389	PF00082	0.458
CLV_PCSK_SKI1_1	80	84	PF00082	0.357
CLV_PCSK_SKI1_1	850	854	PF00082	0.549
CLV_PCSK_SKI1_1	926	930	PF00082	0.218
CLV_Separin_Metazoa	444	448	PF03568	0.180
DEG_Nend_UBRbox_2	1	3	PF02207	0.454
DEG_ODPH_VHL_1	594	605	PF01847	0.258
DOC_CDC14_PxL_1	173	181	PF14671	0.292
DOC_CDC14_PxL_1	202	210	PF14671	0.343
DOC_CYCLIN_RxL_1	395	406	PF00134	0.286
DOC_MAPK_DCC_7	590	599	PF00069	0.305
DOC_MAPK_gen_1	189	196	PF00069	0.403
DOC_MAPK_gen_1	465	473	PF00069	0.255
DOC_MAPK_MEF2A_6	465	473	PF00069	0.245
DOC_SPAK_OSR1_1	115	119	PF12202	0.332
DOC_SPAK_OSR1_1	620	624	PF12202	0.319
DOC_USP7_MATH_1	275	279	PF00917	0.369
DOC_USP7_MATH_1	4	8	PF00917	0.600
DOC_USP7_MATH_1	461	465	PF00917	0.378
DOC_USP7_MATH_1	658	662	PF00917	0.339
DOC_USP7_MATH_1	66	70	PF00917	0.559
DOC_USP7_MATH_1	704	708	PF00917	0.506
DOC_USP7_MATH_1	756	760	PF00917	0.438
DOC_USP7_MATH_1	894	898	PF00917	0.291
DOC_USP7_MATH_1	918	922	PF00917	0.430
DOC_WW_Pin1_4	230	235	PF00397	0.362
DOC_WW_Pin1_4	271	276	PF00397	0.309
DOC_WW_Pin1_4	385	390	PF00397	0.274
DOC_WW_Pin1_4	455	460	PF00397	0.393
DOC_WW_Pin1_4	500	505	PF00397	0.275
DOC_WW_Pin1_4	6	11	PF00397	0.535
DOC_WW_Pin1_4	684	689	PF00397	0.313
LIG_14-3-3_CanoR_1	115	119	PF00244	0.570
LIG_14-3-3_CanoR_1	166	173	PF00244	0.330
LIG_14-3-3_CanoR_1	200	206	PF00244	0.368
LIG_14-3-3_CanoR_1	358	366	PF00244	0.448
LIG_14-3-3_CanoR_1	391	400	PF00244	0.283
LIG_14-3-3_CanoR_1	437	445	PF00244	0.432
LIG_14-3-3_CanoR_1	47	51	PF00244	0.593
LIG_14-3-3_CanoR_1	483	491	PF00244	0.508
LIG_14-3-3_CanoR_1	515	524	PF00244	0.477
LIG_14-3-3_CanoR_1	528	532	PF00244	0.392
LIG_14-3-3_CanoR_1	590	598	PF00244	0.390
LIG_14-3-3_CanoR_1	620	629	PF00244	0.437
LIG_14-3-3_CanoR_1	636	644	PF00244	0.326
LIG_14-3-3_CanoR_1	653	662	PF00244	0.419
LIG_14-3-3_CanoR_1	712	721	PF00244	0.477
LIG_14-3-3_CanoR_1	934	939	PF00244	0.460
LIG_14-3-3_CanoR_1	95	103	PF00244	0.351
LIG_Actin_WH2_2	407	423	PF00022	0.301
LIG_Actin_WH2_2	469	485	PF00022	0.188
LIG_Actin_WH2_2	637	652	PF00022	0.341
LIG_Actin_WH2_2	728	744	PF00022	0.410
LIG_Actin_WH2_2	76	94	PF00022	0.477
LIG_Actin_WH2_2	774	790	PF00022	0.303
LIG_Actin_WH2_2	834	852	PF00022	0.324
LIG_Actin_WH2_2	912	928	PF00022	0.280
LIG_Actin_WH2_2	944	962	PF00022	0.304
LIG_BRCT_BRCA1_1	477	481	PF00533	0.238
LIG_BRCT_BRCA1_1	808	812	PF00533	0.454
LIG_DLG_GKlike_1	842	849	PF00625	0.310
LIG_FHA_1	115	121	PF00498	0.585
LIG_FHA_1	167	173	PF00498	0.493
LIG_FHA_1	21	27	PF00498	0.395
LIG_FHA_1	334	340	PF00498	0.430
LIG_FHA_1	348	354	PF00498	0.428
LIG_FHA_1	394	400	PF00498	0.220
LIG_FHA_1	440	446	PF00498	0.416
LIG_FHA_1	486	492	PF00498	0.263
LIG_FHA_1	577	583	PF00498	0.442
LIG_FHA_1	851	857	PF00498	0.414
LIG_FHA_1	960	966	PF00498	0.372
LIG_FHA_2	100	106	PF00498	0.548
LIG_FHA_2	138	144	PF00498	0.620
LIG_FHA_2	315	321	PF00498	0.451
LIG_FHA_2	350	356	PF00498	0.491
LIG_FHA_2	517	523	PF00498	0.362
LIG_FHA_2	65	71	PF00498	0.416
LIG_FHA_2	796	802	PF00498	0.287
LIG_FHA_2	885	891	PF00498	0.332
LIG_FHA_2	912	918	PF00498	0.454
LIG_LIR_Gen_1	673	678	PF02991	0.325
LIG_LIR_Gen_1	809	820	PF02991	0.311
LIG_LIR_Nem_3	147	153	PF02991	0.363
LIG_LIR_Nem_3	186	191	PF02991	0.465
LIG_LIR_Nem_3	470	476	PF02991	0.180
LIG_LIR_Nem_3	673	677	PF02991	0.324
LIG_LIR_Nem_3	809	815	PF02991	0.457
LIG_LIR_Nem_3	822	827	PF02991	0.310
LIG_SH2_PTP2	43	46	PF00017	0.432
LIG_SH2_STAP1	133	137	PF00017	0.394
LIG_SH2_STAP1	22	26	PF00017	0.398
LIG_SH2_STAT5	150	153	PF00017	0.319
LIG_SH2_STAT5	22	25	PF00017	0.472
LIG_SH2_STAT5	378	381	PF00017	0.289
LIG_SH2_STAT5	43	46	PF00017	0.670
LIG_SH2_STAT5	561	564	PF00017	0.425
LIG_SH2_STAT5	607	610	PF00017	0.371
LIG_SH2_STAT5	699	702	PF00017	0.441
LIG_SH2_STAT5	745	748	PF00017	0.456
LIG_SH3_3	27	33	PF00018	0.580
LIG_SH3_3	386	392	PF00018	0.282
LIG_SH3_3	802	808	PF00018	0.222
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.291
LIG_SUMO_SIM_anti_2	350	355	PF11976	0.284
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.291
LIG_SUMO_SIM_anti_2	488	493	PF11976	0.254
LIG_SUMO_SIM_anti_2	547	552	PF11976	0.472
LIG_SUMO_SIM_anti_2	579	584	PF11976	0.267
LIG_SUMO_SIM_anti_2	624	630	PF11976	0.281
LIG_SUMO_SIM_anti_2	673	679	PF11976	0.215
LIG_SUMO_SIM_anti_2	716	722	PF11976	0.288
LIG_SUMO_SIM_anti_2	776	782	PF11976	0.385
LIG_SUMO_SIM_par_1	268	274	PF11976	0.424
LIG_SUMO_SIM_par_1	336	343	PF11976	0.285
LIG_SUMO_SIM_par_1	349	355	PF11976	0.220
LIG_SUMO_SIM_par_1	595	601	PF11976	0.338
LIG_SUMO_SIM_par_1	765	770	PF11976	0.325
LIG_SUMO_SIM_par_1	949	954	PF11976	0.293
MOD_CDC14_SPxK_1	503	506	PF00782	0.276
MOD_CDK_SPxK_1	385	391	PF00069	0.255
MOD_CDK_SPxK_1	500	506	PF00069	0.283
MOD_CDK_SPxxK_3	6	13	PF00069	0.555
MOD_CK1_1	180	186	PF00069	0.397
MOD_CK1_1	274	280	PF00069	0.432
MOD_CK1_1	291	297	PF00069	0.380
MOD_CK1_1	301	307	PF00069	0.343
MOD_CK1_1	347	353	PF00069	0.434
MOD_CK1_1	415	421	PF00069	0.410
MOD_CK1_1	439	445	PF00069	0.408
MOD_CK1_1	485	491	PF00069	0.285
MOD_CK1_1	500	506	PF00069	0.220
MOD_CK1_1	530	536	PF00069	0.463
MOD_CK1_1	549	555	PF00069	0.259
MOD_CK1_1	576	582	PF00069	0.365
MOD_CK1_1	6	12	PF00069	0.496
MOD_CK1_1	622	628	PF00069	0.369
MOD_CK1_1	638	644	PF00069	0.387
MOD_CK1_1	684	690	PF00069	0.515
MOD_CK1_1	69	75	PF00069	0.582
MOD_CK1_1	714	720	PF00069	0.297
MOD_CK1_1	760	766	PF00069	0.370
MOD_CK1_1	776	782	PF00069	0.246
MOD_CK1_1	888	894	PF00069	0.435
MOD_CK1_1	99	105	PF00069	0.505
MOD_CK2_1	119	125	PF00069	0.292
MOD_CK2_1	137	143	PF00069	0.569
MOD_CK2_1	370	376	PF00069	0.354
MOD_CK2_1	403	409	PF00069	0.282
MOD_CK2_1	565	571	PF00069	0.345
MOD_CK2_1	621	627	PF00069	0.486
MOD_CK2_1	713	719	PF00069	0.233
MOD_CK2_1	868	874	PF00069	0.327
MOD_CK2_1	884	890	PF00069	0.213
MOD_CK2_1	911	917	PF00069	0.463
MOD_GlcNHglycan	185	188	PF01048	0.448
MOD_GlcNHglycan	277	280	PF01048	0.507
MOD_GlcNHglycan	300	303	PF01048	0.302
MOD_GlcNHglycan	308	311	PF01048	0.364
MOD_GlcNHglycan	405	408	PF01048	0.469
MOD_GlcNHglycan	417	420	PF01048	0.410
MOD_GlcNHglycan	438	441	PF01048	0.346
MOD_GlcNHglycan	484	487	PF01048	0.297
MOD_GlcNHglycan	575	578	PF01048	0.379
MOD_GlcNHglycan	667	670	PF01048	0.358
MOD_GlcNHglycan	713	716	PF01048	0.490
MOD_GlcNHglycan	731	735	PF01048	0.187
MOD_GlcNHglycan	781	784	PF01048	0.397
MOD_GlcNHglycan	815	818	PF01048	0.264
MOD_GlcNHglycan	860	864	PF01048	0.370
MOD_GlcNHglycan	869	873	PF01048	0.388
MOD_GlcNHglycan	897	900	PF01048	0.484
MOD_GlcNHglycan	920	923	PF01048	0.451
MOD_GlcNHglycan	943	946	PF01048	0.448
MOD_GlcNHglycan	952	956	PF01048	0.418
MOD_GlcNHglycan	98	101	PF01048	0.448
MOD_GSK3_1	133	140	PF00069	0.374
MOD_GSK3_1	162	169	PF00069	0.525
MOD_GSK3_1	2	9	PF00069	0.589
MOD_GSK3_1	271	278	PF00069	0.301
MOD_GSK3_1	283	290	PF00069	0.287
MOD_GSK3_1	311	318	PF00069	0.476
MOD_GSK3_1	340	347	PF00069	0.266
MOD_GSK3_1	357	364	PF00069	0.383
MOD_GSK3_1	366	373	PF00069	0.437
MOD_GSK3_1	455	462	PF00069	0.335
MOD_GSK3_1	471	478	PF00069	0.285
MOD_GSK3_1	516	523	PF00069	0.426
MOD_GSK3_1	635	642	PF00069	0.417
MOD_GSK3_1	654	661	PF00069	0.357
MOD_GSK3_1	684	691	PF00069	0.397
MOD_GSK3_1	700	707	PF00069	0.367
MOD_GSK3_1	730	737	PF00069	0.240
MOD_GSK3_1	746	753	PF00069	0.334
MOD_GSK3_1	756	763	PF00069	0.319
MOD_GSK3_1	792	799	PF00069	0.346
MOD_GSK3_1	828	835	PF00069	0.393
MOD_GSK3_1	880	887	PF00069	0.262
MOD_GSK3_1	90	97	PF00069	0.444
MOD_GSK3_1	930	937	PF00069	0.520
MOD_N-GLC_1	257	262	PF02516	0.292
MOD_N-GLC_1	423	428	PF02516	0.251
MOD_N-GLC_1	644	649	PF02516	0.425
MOD_N-GLC_1	773	778	PF02516	0.325
MOD_N-GLC_1	813	818	PF02516	0.332
MOD_N-GLC_1	885	890	PF02516	0.421
MOD_N-GLC_1	911	916	PF02516	0.303
MOD_N-GLC_1	960	965	PF02516	0.434
MOD_N-GLC_2	38	40	PF02516	0.385
MOD_N-GLC_2	794	796	PF02516	0.206
MOD_N-GLC_2	908	910	PF02516	0.247
MOD_NEK2_1	111	116	PF00069	0.509
MOD_NEK2_1	172	177	PF00069	0.304
MOD_NEK2_1	265	270	PF00069	0.347
MOD_NEK2_1	287	292	PF00069	0.331
MOD_NEK2_1	298	303	PF00069	0.296
MOD_NEK2_1	333	338	PF00069	0.457
MOD_NEK2_1	344	349	PF00069	0.326
MOD_NEK2_1	366	371	PF00069	0.444
MOD_NEK2_1	425	430	PF00069	0.484
MOD_NEK2_1	46	51	PF00069	0.651
MOD_NEK2_1	482	487	PF00069	0.371
MOD_NEK2_1	516	521	PF00069	0.453
MOD_NEK2_1	527	532	PF00069	0.405
MOD_NEK2_1	562	567	PF00069	0.306
MOD_NEK2_1	598	603	PF00069	0.381
MOD_NEK2_1	608	613	PF00069	0.289
MOD_NEK2_1	621	626	PF00069	0.365
MOD_NEK2_1	644	649	PF00069	0.492
MOD_NEK2_1	654	659	PF00069	0.396
MOD_NEK2_1	700	705	PF00069	0.275
MOD_NEK2_1	71	76	PF00069	0.588
MOD_NEK2_1	711	716	PF00069	0.318
MOD_NEK2_1	730	735	PF00069	0.324
MOD_NEK2_1	746	751	PF00069	0.350
MOD_NEK2_1	757	762	PF00069	0.370
MOD_NEK2_1	767	772	PF00069	0.375
MOD_NEK2_1	792	797	PF00069	0.292
MOD_NEK2_1	884	889	PF00069	0.360
MOD_NEK2_1	895	900	PF00069	0.346
MOD_NEK2_1	930	935	PF00069	0.465
MOD_NEK2_1	941	946	PF00069	0.346
MOD_NEK2_1	959	964	PF00069	0.324
MOD_PIKK_1	153	159	PF00454	0.304
MOD_PIKK_1	311	317	PF00454	0.450
MOD_PIKK_1	412	418	PF00454	0.413
MOD_PIKK_1	549	555	PF00454	0.427
MOD_PK_1	288	294	PF00069	0.298
MOD_PK_1	750	756	PF00069	0.279
MOD_PK_1	90	96	PF00069	0.375
MOD_PKA_2	114	120	PF00069	0.377
MOD_PKA_2	12	18	PF00069	0.401
MOD_PKA_2	183	189	PF00069	0.299
MOD_PKA_2	20	26	PF00069	0.412
MOD_PKA_2	357	363	PF00069	0.496
MOD_PKA_2	436	442	PF00069	0.417
MOD_PKA_2	46	52	PF00069	0.478
MOD_PKA_2	482	488	PF00069	0.274
MOD_PKA_2	527	533	PF00069	0.297
MOD_PKA_2	589	595	PF00069	0.469
MOD_PKA_2	619	625	PF00069	0.478
MOD_PKA_2	635	641	PF00069	0.218
MOD_PKA_2	665	671	PF00069	0.459
MOD_PKA_2	711	717	PF00069	0.483
MOD_PKA_2	770	776	PF00069	0.245
MOD_PKA_2	933	939	PF00069	0.443
MOD_PKA_2	94	100	PF00069	0.339
MOD_PKA_2	941	947	PF00069	0.370
MOD_PKB_1	544	552	PF00069	0.204
MOD_Plk_1	111	117	PF00069	0.503
MOD_Plk_1	133	139	PF00069	0.574
MOD_Plk_1	257	263	PF00069	0.290
MOD_Plk_1	339	345	PF00069	0.308
MOD_Plk_1	546	552	PF00069	0.315
MOD_Plk_1	638	644	PF00069	0.414
MOD_Plk_1	730	736	PF00069	0.266
MOD_Plk_1	776	782	PF00069	0.392
MOD_Plk_1	868	874	PF00069	0.434
MOD_Plk_1	880	886	PF00069	0.477
MOD_Plk_1	911	917	PF00069	0.442
MOD_Plk_1	960	966	PF00069	0.443
MOD_Plk_2-3	143	149	PF00069	0.374
MOD_Plk_2-3	64	70	PF00069	0.416
MOD_Plk_4	235	241	PF00069	0.352
MOD_Plk_4	260	266	PF00069	0.487
MOD_Plk_4	361	367	PF00069	0.472
MOD_Plk_4	46	52	PF00069	0.586
MOD_Plk_4	639	645	PF00069	0.448
MOD_Plk_4	776	782	PF00069	0.289
MOD_Plk_4	832	838	PF00069	0.466
MOD_ProDKin_1	230	236	PF00069	0.354
MOD_ProDKin_1	271	277	PF00069	0.314
MOD_ProDKin_1	385	391	PF00069	0.277
MOD_ProDKin_1	455	461	PF00069	0.396
MOD_ProDKin_1	500	506	PF00069	0.283
MOD_ProDKin_1	6	12	PF00069	0.522
MOD_ProDKin_1	684	690	PF00069	0.315
MOD_SUMO_rev_2	921	931	PF00179	0.219
TRG_DiLeu_BaEn_1	639	644	PF01217	0.315
TRG_DiLeu_BaEn_1	673	678	PF01217	0.214
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.310
TRG_ENDOCYTIC_2	43	46	PF00928	0.440
TRG_ER_diArg_1	188	190	PF00400	0.541
TRG_ER_diArg_1	785	788	PF00400	0.454
TRG_NES_CRM1_1	874	885	PF08389	0.215
TRG_NLS_MonoExtC_3	838	844	PF00514	0.305
TRG_Pf-PMV_PEXEL_1	839	844	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P921	Leptomonas seymouri	29%	100%
A0A0S4J2Y5	Bodo saltans	21%	100%
A0A1X0P1M5	Trypanosomatidae	24%	100%
A0A3Q8IGD6	Leishmania donovani	24%	100%
A0A3S5ISR4	Trypanosoma rangeli	25%	100%
A0A451EJK8	Leishmania donovani	88%	91%
A4H3H4	Leishmania braziliensis	71%	100%
A4H3R1	Leishmania braziliensis	26%	100%
C9ZK22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A5U4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	70%
E9ACE9	Leishmania major	86%	100%
E9AG21	Leishmania infantum	87%	97%
F4JNB7	Arabidopsis thaliana	22%	67%
Q4QD45	Leishmania major	28%	100%