Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJN1_LEIMU

TriTrypDb:

LmxM.02.0690

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.662
CLV_NRD_NRD_1	211	213	PF00675	0.770
CLV_NRD_NRD_1	34	36	PF00675	0.613
CLV_NRD_NRD_1	346	348	PF00675	0.318
CLV_NRD_NRD_1	37	39	PF00675	0.669
CLV_NRD_NRD_1	391	393	PF00675	0.578
CLV_NRD_NRD_1	91	93	PF00675	0.752
CLV_PCSK_FUR_1	35	39	PF00082	0.479
CLV_PCSK_KEX2_1	211	213	PF00082	0.770
CLV_PCSK_KEX2_1	36	38	PF00082	0.622
CLV_PCSK_KEX2_1	391	393	PF00082	0.578
CLV_PCSK_KEX2_1	436	438	PF00082	0.374
CLV_PCSK_KEX2_1	91	93	PF00082	0.715
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.672
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.374
CLV_PCSK_SKI1_1	305	309	PF00082	0.454
CLV_PCSK_SKI1_1	348	352	PF00082	0.312
CLV_PCSK_SKI1_1	392	396	PF00082	0.613
CLV_PCSK_SKI1_1	440	444	PF00082	0.299
CLV_Separin_Metazoa	251	255	PF03568	0.454
DEG_APCC_DBOX_1	439	447	PF00400	0.292
DEG_Nend_UBRbox_3	1	3	PF02207	0.646
DEG_SCF_FBW7_1	198	203	PF00400	0.646
DEG_SPOP_SBC_1	108	112	PF00917	0.532
DEG_SPOP_SBC_1	94	98	PF00917	0.761
DOC_CYCLIN_RxL_1	345	352	PF00134	0.560
DOC_MAPK_gen_1	327	334	PF00069	0.514
DOC_MAPK_gen_1	436	443	PF00069	0.598
DOC_MAPK_MEF2A_6	414	423	PF00069	0.563
DOC_MAPK_NFAT4_5	418	426	PF00069	0.548
DOC_MAPK_RevD_3	22	38	PF00069	0.500
DOC_MAPK_RevD_3	332	348	PF00069	0.311
DOC_PP2B_LxvP_1	293	296	PF13499	0.371
DOC_PP4_FxxP_1	408	411	PF00568	0.321
DOC_USP7_MATH_1	143	147	PF00917	0.422
DOC_USP7_MATH_1	200	204	PF00917	0.519
DOC_USP7_MATH_1	288	292	PF00917	0.593
DOC_USP7_MATH_1	41	45	PF00917	0.636
DOC_WW_Pin1_4	196	201	PF00397	0.728
DOC_WW_Pin1_4	28	33	PF00397	0.566
LIG_14-3-3_CanoR_1	190	198	PF00244	0.752
LIG_14-3-3_CanoR_1	254	262	PF00244	0.653
LIG_14-3-3_CanoR_1	92	101	PF00244	0.750
LIG_FHA_1	111	117	PF00498	0.776
LIG_FHA_1	128	134	PF00498	0.462
LIG_FHA_2	148	154	PF00498	0.518
LIG_FHA_2	15	21	PF00498	0.633
LIG_LIR_Apic_2	405	411	PF02991	0.332
LIG_LIR_Gen_1	48	59	PF02991	0.505
LIG_LIR_Nem_3	48	54	PF02991	0.501
LIG_NRBOX	420	426	PF00104	0.483
LIG_PCNA_yPIPBox_3	327	338	PF02747	0.603
LIG_Rb_pABgroove_1	45	53	PF01858	0.612
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.476
LIG_TRAF2_1	394	397	PF00917	0.598
MOD_CDK_SPxxK_3	28	35	PF00069	0.440
MOD_CK1_1	109	115	PF00069	0.751
MOD_CK1_1	127	133	PF00069	0.479
MOD_CK1_1	192	198	PF00069	0.789
MOD_CK1_1	203	209	PF00069	0.814
MOD_CK1_1	325	331	PF00069	0.592
MOD_CK1_1	343	349	PF00069	0.438
MOD_CK1_1	448	454	PF00069	0.665
MOD_CK2_1	147	153	PF00069	0.461
MOD_CK2_1	190	196	PF00069	0.835
MOD_CK2_1	448	454	PF00069	0.609
MOD_GlcNHglycan	119	122	PF01048	0.703
MOD_GlcNHglycan	184	187	PF01048	0.767
MOD_GlcNHglycan	277	280	PF01048	0.577
MOD_GlcNHglycan	290	293	PF01048	0.404
MOD_GlcNHglycan	299	302	PF01048	0.499
MOD_GlcNHglycan	309	312	PF01048	0.504
MOD_GlcNHglycan	43	46	PF01048	0.653
MOD_GlcNHglycan	54	57	PF01048	0.610
MOD_GlcNHglycan	84	87	PF01048	0.761
MOD_GlcNHglycan	97	100	PF01048	0.641
MOD_GSK3_1	106	113	PF00069	0.675
MOD_GSK3_1	143	150	PF00069	0.605
MOD_GSK3_1	190	197	PF00069	0.748
MOD_GSK3_1	235	242	PF00069	0.623
MOD_GSK3_1	41	48	PF00069	0.652
MOD_GSK3_1	445	452	PF00069	0.645
MOD_N-GLC_1	322	327	PF02516	0.534
MOD_N-GLC_1	340	345	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.773
MOD_NEK2_1	154	159	PF00069	0.599
MOD_NEK2_1	275	280	PF00069	0.556
MOD_NEK2_1	307	312	PF00069	0.494
MOD_NEK2_1	322	327	PF00069	0.280
MOD_NEK2_1	50	55	PF00069	0.559
MOD_NEK2_1	84	89	PF00069	0.785
MOD_NEK2_1	95	100	PF00069	0.616
MOD_NEK2_2	431	436	PF00069	0.435
MOD_PIKK_1	369	375	PF00454	0.496
MOD_PKA_2	189	195	PF00069	0.764
MOD_PKA_2	2	8	PF00069	0.709
MOD_PKA_2	253	259	PF00069	0.449
MOD_PKB_1	188	196	PF00069	0.778
MOD_Plk_1	147	153	PF00069	0.444
MOD_Plk_1	239	245	PF00069	0.591
MOD_Plk_1	340	346	PF00069	0.620
MOD_Plk_2-3	235	241	PF00069	0.589
MOD_Plk_4	84	90	PF00069	0.728
MOD_ProDKin_1	196	202	PF00069	0.728
MOD_ProDKin_1	28	34	PF00069	0.561
MOD_SUMO_for_1	417	420	PF00179	0.540
MOD_SUMO_rev_2	300	310	PF00179	0.479
TRG_DiLeu_BaEn_1	420	425	PF01217	0.450
TRG_ER_diArg_1	187	190	PF00400	0.697
TRG_ER_diArg_1	211	213	PF00400	0.709
TRG_ER_diArg_1	34	37	PF00400	0.484
TRG_ER_diArg_1	399	402	PF00400	0.309
TRG_ER_diArg_1	91	93	PF00400	0.707
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB8	Leptomonas seymouri	49%	77%
A0A1X0NJU7	Trypanosomatidae	30%	100%
A0A3S5H515	Leishmania donovani	87%	100%
A0A3S7X120	Leishmania donovani	88%	100%
A0A422NAX6	Trypanosoma rangeli	29%	100%
A4HG32	Leishmania braziliensis	70%	97%
C9ZJ54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACE3	Leishmania major	86%	100%
E9ACX2	Leishmania major	88%	100%
E9AG19	Leishmania infantum	88%	100%
E9AG20	Leishmania infantum	88%	100%