DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJN0_LEIMU

TriTrypDb:

LmxM.02.0680

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	4
GO:0005666	RNA polymerase III complex	4	4
GO:0030880	RNA polymerase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	4
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0140513	nuclear protein-containing complex	2	4
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1990234	transferase complex	3	4

Expansion

Sequence features

E9AJN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJN0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003697	single-stranded DNA binding	5	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	120	124	PF00082	0.480
CLV_PCSK_SKI1_1	146	150	PF00082	0.523
CLV_PCSK_SKI1_1	49	53	PF00082	0.469
CLV_PCSK_SKI1_1	95	99	PF00082	0.562
CLV_Separin_Metazoa	136	140	PF03568	0.467
DEG_APCC_DBOX_1	119	127	PF00400	0.389
DEG_SPOP_SBC_1	6	10	PF00917	0.579
DOC_MAPK_gen_1	146	154	PF00069	0.456
DOC_MAPK_MEF2A_6	85	93	PF00069	0.379
DOC_USP7_MATH_1	109	113	PF00917	0.382
DOC_USP7_MATH_1	138	142	PF00917	0.600
DOC_USP7_MATH_1	148	152	PF00917	0.552
DOC_USP7_MATH_1	31	35	PF00917	0.564
DOC_WW_Pin1_4	36	41	PF00397	0.584
LIG_14-3-3_CanoR_1	139	147	PF00244	0.539
LIG_AP2alpha_1	127	131	PF02296	0.423
LIG_BRCT_BRCA1_1	38	42	PF00533	0.584
LIG_FHA_1	1	7	PF00498	0.589
LIG_FHA_1	138	144	PF00498	0.528
LIG_FHA_1	46	52	PF00498	0.517
LIG_FHA_2	105	111	PF00498	0.402
LIG_LIR_Gen_1	115	123	PF02991	0.387
LIG_LIR_Gen_1	39	50	PF02991	0.556
LIG_LIR_Nem_3	115	119	PF02991	0.399
LIG_LIR_Nem_3	59	64	PF02991	0.620
LIG_LIR_Nem_3	84	89	PF02991	0.401
LIG_Pex14_2	127	131	PF04695	0.423
LIG_SH2_CRK	86	90	PF00017	0.378
LIG_SH2_PTP2	116	119	PF00017	0.393
LIG_SH2_STAP1	24	28	PF00017	0.477
LIG_SH2_STAT5	116	119	PF00017	0.411
LIG_SH2_STAT5	153	156	PF00017	0.384
LIG_SH3_3	141	147	PF00018	0.447
LIG_SH3_4	54	61	PF00018	0.483
MOD_CK1_1	112	118	PF00069	0.506
MOD_CK1_1	41	47	PF00069	0.542
MOD_CK1_1	7	13	PF00069	0.488
MOD_CK2_1	104	110	PF00069	0.400
MOD_CK2_1	6	12	PF00069	0.744
MOD_GlcNHglycan	140	143	PF01048	0.622
MOD_GlcNHglycan	33	36	PF01048	0.674
MOD_GSK3_1	36	43	PF00069	0.585
MOD_N-GLC_1	4	9	PF02516	0.497
MOD_NEK2_1	17	22	PF00069	0.483
MOD_NEK2_2	148	153	PF00069	0.450
MOD_PIKK_1	54	60	PF00454	0.484
MOD_PKA_2	138	144	PF00069	0.514
MOD_Plk_1	104	110	PF00069	0.400
MOD_Plk_2-3	104	110	PF00069	0.400
MOD_Plk_4	112	118	PF00069	0.427
MOD_Plk_4	148	154	PF00069	0.441
MOD_Plk_4	17	23	PF00069	0.382
MOD_ProDKin_1	36	42	PF00069	0.581
TRG_ENDOCYTIC_2	116	119	PF00928	0.568
TRG_ENDOCYTIC_2	86	89	PF00928	0.386
TRG_NES_CRM1_1	121	136	PF08389	0.407
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H514	Leishmania donovani	92%	82%
A4HRR3	Leishmania infantum	93%	82%