Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJM7_LEIMU

TriTrypDb:

LmxM.02.0650

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.562
CLV_NRD_NRD_1	170	172	PF00675	0.644
CLV_PCSK_KEX2_1	122	124	PF00082	0.781
CLV_PCSK_KEX2_1	170	172	PF00082	0.669
CLV_PCSK_KEX2_1	47	49	PF00082	0.663
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.691
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.669
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.663
CLV_PCSK_SKI1_1	122	126	PF00082	0.760
CLV_PCSK_SKI1_1	181	185	PF00082	0.586
CLV_PCSK_SKI1_1	228	232	PF00082	0.448
CLV_PCSK_SKI1_1	47	51	PF00082	0.549
DEG_SPOP_SBC_1	25	29	PF00917	0.773
DOC_CKS1_1	11	16	PF01111	0.763
DOC_MAPK_DCC_7	170	180	PF00069	0.582
DOC_MAPK_gen_1	80	90	PF00069	0.700
DOC_MAPK_MEF2A_6	171	180	PF00069	0.577
DOC_USP7_MATH_1	140	144	PF00917	0.577
DOC_USP7_MATH_1	161	165	PF00917	0.525
DOC_USP7_MATH_1	166	170	PF00917	0.493
DOC_USP7_MATH_1	266	270	PF00917	0.724
DOC_USP7_MATH_1	39	43	PF00917	0.608
DOC_WW_Pin1_4	115	120	PF00397	0.584
DOC_WW_Pin1_4	189	194	PF00397	0.600
DOC_WW_Pin1_4	5	10	PF00397	0.689
LIG_14-3-3_CanoR_1	135	139	PF00244	0.766
LIG_14-3-3_CanoR_1	181	188	PF00244	0.543
LIG_14-3-3_CanoR_1	48	56	PF00244	0.628
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_CtBP_PxDLS_1	177	181	PF00389	0.497
LIG_FHA_1	11	17	PF00498	0.759
LIG_FHA_1	190	196	PF00498	0.569
LIG_FHA_2	144	150	PF00498	0.808
LIG_FHA_2	182	188	PF00498	0.562
LIG_LIR_Nem_3	218	224	PF02991	0.579
LIG_NRBOX	51	57	PF00104	0.500
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.615
LIG_PDZ_Class_3	309	314	PF00595	0.582
LIG_SH2_CRK	221	225	PF00017	0.591
LIG_SH2_NCK_1	34	38	PF00017	0.465
LIG_SH2_SRC	34	37	PF00017	0.473
LIG_SH2_STAT5	223	226	PF00017	0.537
LIG_SH3_3	149	155	PF00018	0.746
LIG_SH3_3	8	14	PF00018	0.722
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.595
LIG_TRAF2_1	184	187	PF00917	0.638
LIG_TRAF2_1	42	45	PF00917	0.555
LIG_TRAF2_1	62	65	PF00917	0.576
LIG_UBA3_1	67	71	PF00899	0.363
LIG_WRPW_2	105	108	PF00400	0.626
LIG_WW_2	14	17	PF00397	0.606
MOD_CDK_SPxxK_3	115	122	PF00069	0.560
MOD_CDK_SPxxK_3	189	196	PF00069	0.631
MOD_CK1_1	143	149	PF00069	0.723
MOD_CK1_1	26	32	PF00069	0.753
MOD_CK2_1	143	149	PF00069	0.809
MOD_CK2_1	18	24	PF00069	0.812
MOD_CK2_1	181	187	PF00069	0.542
MOD_CK2_1	35	41	PF00069	0.672
MOD_CMANNOS	108	111	PF00535	0.636
MOD_GlcNHglycan	112	115	PF01048	0.548
MOD_GlcNHglycan	127	132	PF01048	0.648
MOD_GlcNHglycan	142	145	PF01048	0.556
MOD_GlcNHglycan	262	265	PF01048	0.634
MOD_GlcNHglycan	273	276	PF01048	0.733
MOD_GlcNHglycan	37	40	PF01048	0.525
MOD_GlcNHglycan	72	75	PF01048	0.633
MOD_GSK3_1	1	8	PF00069	0.715
MOD_GSK3_1	106	113	PF00069	0.519
MOD_GSK3_1	123	130	PF00069	0.672
MOD_GSK3_1	139	146	PF00069	0.673
MOD_GSK3_1	23	30	PF00069	0.722
MOD_GSK3_1	35	42	PF00069	0.728
MOD_N-GLC_1	18	23	PF02516	0.746
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	216	221	PF00069	0.644
MOD_NEK2_1	70	75	PF00069	0.616
MOD_PIKK_1	143	149	PF00454	0.736
MOD_PKA_1	47	53	PF00069	0.640
MOD_PKA_2	134	140	PF00069	0.714
MOD_PKA_2	47	53	PF00069	0.640
MOD_Plk_1	216	222	PF00069	0.594
MOD_Plk_4	299	305	PF00069	0.595
MOD_ProDKin_1	115	121	PF00069	0.587
MOD_ProDKin_1	189	195	PF00069	0.600
MOD_ProDKin_1	5	11	PF00069	0.690
MOD_SUMO_for_1	230	233	PF00179	0.606
MOD_SUMO_rev_2	160	167	PF00179	0.595
MOD_SUMO_rev_2	245	252	PF00179	0.338
MOD_SUMO_rev_2	41	49	PF00179	0.651
MOD_SUMO_rev_2	63	68	PF00179	0.637
TRG_DiLeu_BaEn_1	198	203	PF01217	0.524
TRG_DiLeu_BaEn_4	186	192	PF01217	0.634
TRG_DiLeu_BaEn_4	44	50	PF01217	0.582
TRG_ENDOCYTIC_2	221	224	PF00928	0.592
TRG_NLS_MonoCore_2	169	174	PF00514	0.682
TRG_NLS_MonoExtN_4	168	175	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W5	Leptomonas seymouri	50%	100%
A0A0S4JF25	Bodo saltans	26%	100%
A0A1X0NJL7	Trypanosomatidae	38%	95%
A0A3S5H512	Leishmania donovani	90%	100%
A0A422NAY0	Trypanosoma rangeli	34%	95%
A4H3F6	Leishmania braziliensis	77%	96%
A4HRR0	Leishmania infantum	90%	100%
C9ZJ49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ACD9	Leishmania major	90%	100%
V5D620	Trypanosoma cruzi	39%	98%