Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJM4_LEIMU

TriTrypDb:

LmxM.02.0620

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJM4

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006448	regulation of translational elongation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0017182	peptidyl-diphthamide metabolic process	7	1
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018202	peptidyl-histidine modification	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1900247	regulation of cytoplasmic translational elongation	8	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0061685	diphthine methylesterase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.570
CLV_C14_Caspase3-7	270	274	PF00656	0.760
CLV_C14_Caspase3-7	330	334	PF00656	0.572
CLV_C14_Caspase3-7	498	502	PF00656	0.535
CLV_C14_Caspase3-7	555	559	PF00656	0.483
CLV_C14_Caspase3-7	94	98	PF00656	0.764
CLV_NRD_NRD_1	133	135	PF00675	0.574
CLV_NRD_NRD_1	362	364	PF00675	0.571
CLV_NRD_NRD_1	541	543	PF00675	0.461
CLV_NRD_NRD_1	563	565	PF00675	0.507
CLV_PCSK_KEX2_1	133	135	PF00082	0.574
CLV_PCSK_KEX2_1	362	364	PF00082	0.469
CLV_PCSK_KEX2_1	425	427	PF00082	0.701
CLV_PCSK_KEX2_1	541	543	PF00082	0.437
CLV_PCSK_KEX2_1	563	565	PF00082	0.507
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.750
CLV_PCSK_SKI1_1	197	201	PF00082	0.243
CLV_PCSK_SKI1_1	229	233	PF00082	0.488
CLV_PCSK_SKI1_1	380	384	PF00082	0.558
CLV_PCSK_SKI1_1	68	72	PF00082	0.542
DEG_APCC_DBOX_1	67	75	PF00400	0.601
DEG_SPOP_SBC_1	82	86	PF00917	0.588
DOC_CKS1_1	30	35	PF01111	0.475
DOC_CYCLIN_RxL_1	377	387	PF00134	0.545
DOC_MAPK_gen_1	15	22	PF00069	0.396
DOC_MAPK_gen_1	377	385	PF00069	0.590
DOC_PP1_RVXF_1	510	517	PF00149	0.395
DOC_PP2B_LxvP_1	40	43	PF13499	0.598
DOC_PP2B_LxvP_1	444	447	PF13499	0.371
DOC_USP7_MATH_1	285	289	PF00917	0.647
DOC_USP7_MATH_1	390	394	PF00917	0.697
DOC_USP7_MATH_1	526	530	PF00917	0.603
DOC_USP7_MATH_1	534	538	PF00917	0.478
DOC_USP7_MATH_1	55	59	PF00917	0.748
DOC_USP7_MATH_1	83	87	PF00917	0.659
DOC_WW_Pin1_4	182	187	PF00397	0.588
DOC_WW_Pin1_4	206	211	PF00397	0.490
DOC_WW_Pin1_4	257	262	PF00397	0.658
DOC_WW_Pin1_4	29	34	PF00397	0.515
DOC_WW_Pin1_4	305	310	PF00397	0.578
DOC_WW_Pin1_4	323	328	PF00397	0.463
DOC_WW_Pin1_4	338	343	PF00397	0.517
DOC_WW_Pin1_4	41	46	PF00397	0.490
LIG_14-3-3_CanoR_1	133	141	PF00244	0.603
LIG_14-3-3_CanoR_1	15	24	PF00244	0.593
LIG_14-3-3_CanoR_1	26	31	PF00244	0.526
LIG_14-3-3_CanoR_1	284	291	PF00244	0.605
LIG_14-3-3_CanoR_1	362	366	PF00244	0.330
LIG_14-3-3_CanoR_1	426	431	PF00244	0.732
LIG_14-3-3_CanoR_1	461	468	PF00244	0.555
LIG_14-3-3_CanoR_1	563	572	PF00244	0.492
LIG_14-3-3_CanoR_1	81	90	PF00244	0.513
LIG_Actin_WH2_2	67	83	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	148	152	PF00533	0.547
LIG_EH_1	179	183	PF12763	0.274
LIG_FHA_1	133	139	PF00498	0.597
LIG_FHA_1	152	158	PF00498	0.609
LIG_FHA_1	207	213	PF00498	0.538
LIG_FHA_1	216	222	PF00498	0.316
LIG_FHA_1	230	236	PF00498	0.344
LIG_FHA_1	243	249	PF00498	0.447
LIG_FHA_1	285	291	PF00498	0.589
LIG_FHA_1	324	330	PF00498	0.499
LIG_FHA_1	339	345	PF00498	0.394
LIG_FHA_1	438	444	PF00498	0.542
LIG_FHA_1	520	526	PF00498	0.454
LIG_FHA_2	413	419	PF00498	0.580
LIG_FHA_2	496	502	PF00498	0.613
LIG_FHA_2	522	528	PF00498	0.675
LIG_FHA_2	563	569	PF00498	0.496
LIG_LIR_Gen_1	296	303	PF02991	0.537
LIG_LIR_Gen_1	341	349	PF02991	0.413
LIG_LIR_Nem_3	296	302	PF02991	0.537
LIG_LIR_Nem_3	341	346	PF02991	0.420
LIG_MLH1_MIPbox_1	148	152	PF16413	0.547
LIG_NRBOX	407	413	PF00104	0.659
LIG_SH2_CRK	113	117	PF00017	0.512
LIG_SH2_CRK	299	303	PF00017	0.538
LIG_SH2_NCK_1	224	228	PF00017	0.482
LIG_SH2_SRC	222	225	PF00017	0.484
LIG_SH2_SRC	349	352	PF00017	0.418
LIG_SH2_STAP1	349	353	PF00017	0.368
LIG_SH2_STAP1	458	462	PF00017	0.540
LIG_SH2_STAP1	506	510	PF00017	0.388
LIG_SH2_STAP1	539	543	PF00017	0.516
LIG_SH2_STAP1	78	82	PF00017	0.496
LIG_SH2_STAT5	222	225	PF00017	0.436
LIG_SH2_STAT5	299	302	PF00017	0.538
LIG_SH2_STAT5	343	346	PF00017	0.434
LIG_SH2_STAT5	477	480	PF00017	0.481
LIG_SH3_3	175	181	PF00018	0.523
LIG_SH3_3	184	190	PF00018	0.530
LIG_SH3_3	252	258	PF00018	0.633
LIG_SH3_3	27	33	PF00018	0.535
LIG_SH3_3	40	46	PF00018	0.565
LIG_SH3_3	451	457	PF00018	0.368
LIG_SH3_3	488	494	PF00018	0.664
LIG_SH3_3	507	513	PF00018	0.475
LIG_SH3_3	63	69	PF00018	0.705
LIG_SUMO_SIM_anti_2	350	357	PF11976	0.473
LIG_SUMO_SIM_anti_2	440	447	PF11976	0.520
LIG_SUMO_SIM_par_1	321	326	PF11976	0.458
LIG_SUMO_SIM_par_1	354	360	PF11976	0.521
LIG_SUMO_SIM_par_1	568	573	PF11976	0.483
LIG_TRAF2_1	463	466	PF00917	0.525
LIG_TRFH_1	182	186	PF08558	0.512
LIG_TYR_ITSM	339	346	PF00017	0.492
LIG_WW_3	560	564	PF00397	0.508
MOD_CDC14_SPxK_1	308	311	PF00782	0.315
MOD_CDK_SPK_2	29	34	PF00069	0.403
MOD_CDK_SPxK_1	305	311	PF00069	0.319
MOD_CK1_1	146	152	PF00069	0.500
MOD_CK1_1	2	8	PF00069	0.704
MOD_CK1_1	215	221	PF00069	0.479
MOD_CK1_1	260	266	PF00069	0.749
MOD_CK1_1	29	35	PF00069	0.432
MOD_CK1_1	414	420	PF00069	0.666
MOD_CK1_1	519	525	PF00069	0.486
MOD_CK1_1	54	60	PF00069	0.737
MOD_CK1_1	85	91	PF00069	0.578
MOD_CK2_1	222	228	PF00069	0.519
MOD_CK2_1	345	351	PF00069	0.386
MOD_CK2_1	460	466	PF00069	0.526
MOD_CK2_1	534	540	PF00069	0.498
MOD_CK2_1	562	568	PF00069	0.501
MOD_GlcNHglycan	117	120	PF01048	0.565
MOD_GlcNHglycan	154	157	PF01048	0.652
MOD_GlcNHglycan	17	20	PF01048	0.665
MOD_GlcNHglycan	214	217	PF01048	0.452
MOD_GlcNHglycan	262	265	PF01048	0.742
MOD_GlcNHglycan	287	290	PF01048	0.472
MOD_GlcNHglycan	292	295	PF01048	0.337
MOD_GlcNHglycan	462	465	PF01048	0.587
MOD_GlcNHglycan	518	521	PF01048	0.633
MOD_GlcNHglycan	527	531	PF01048	0.609
MOD_GlcNHglycan	53	56	PF01048	0.760
MOD_GlcNHglycan	57	60	PF01048	0.746
MOD_GlcNHglycan	85	88	PF01048	0.728
MOD_GSK3_1	143	150	PF00069	0.570
MOD_GSK3_1	152	159	PF00069	0.578
MOD_GSK3_1	2	9	PF00069	0.496
MOD_GSK3_1	260	267	PF00069	0.560
MOD_GSK3_1	280	287	PF00069	0.457
MOD_GSK3_1	307	314	PF00069	0.605
MOD_GSK3_1	334	341	PF00069	0.481
MOD_GSK3_1	345	352	PF00069	0.398
MOD_GSK3_1	357	364	PF00069	0.499
MOD_GSK3_1	41	48	PF00069	0.529
MOD_GSK3_1	51	58	PF00069	0.725
MOD_GSK3_1	81	88	PF00069	0.578
MOD_LATS_1	195	201	PF00433	0.255
MOD_N-GLC_1	406	411	PF02516	0.664
MOD_N-GLC_1	438	443	PF02516	0.579
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	151	156	PF00069	0.610
MOD_NEK2_1	198	203	PF00069	0.409
MOD_NEK2_1	212	217	PF00069	0.179
MOD_NEK2_1	290	295	PF00069	0.495
MOD_NEK2_1	302	307	PF00069	0.546
MOD_NEK2_1	361	366	PF00069	0.457
MOD_NEK2_1	411	416	PF00069	0.638
MOD_NEK2_1	532	537	PF00069	0.496
MOD_NEK2_2	534	539	PF00069	0.496
MOD_PIKK_1	229	235	PF00454	0.517
MOD_PK_1	26	32	PF00069	0.579
MOD_PKA_1	563	569	PF00069	0.496
MOD_PKA_2	132	138	PF00069	0.602
MOD_PKA_2	283	289	PF00069	0.661
MOD_PKA_2	361	367	PF00069	0.470
MOD_PKA_2	376	382	PF00069	0.429
MOD_PKA_2	460	466	PF00069	0.593
MOD_PKA_2	562	568	PF00069	0.501
MOD_Plk_1	124	130	PF00069	0.671
MOD_Plk_1	349	355	PF00069	0.484
MOD_Plk_1	406	412	PF00069	0.662
MOD_Plk_1	500	506	PF00069	0.497
MOD_Plk_2-3	351	357	PF00069	0.527
MOD_Plk_4	147	153	PF00069	0.584
MOD_Plk_4	406	412	PF00069	0.662
MOD_Plk_4	473	479	PF00069	0.543
MOD_Plk_4	500	506	PF00069	0.497
MOD_Plk_4	534	540	PF00069	0.407
MOD_ProDKin_1	182	188	PF00069	0.585
MOD_ProDKin_1	206	212	PF00069	0.479
MOD_ProDKin_1	257	263	PF00069	0.657
MOD_ProDKin_1	29	35	PF00069	0.512
MOD_ProDKin_1	305	311	PF00069	0.578
MOD_ProDKin_1	323	329	PF00069	0.467
MOD_ProDKin_1	338	344	PF00069	0.509
MOD_ProDKin_1	41	47	PF00069	0.502
MOD_SUMO_rev_2	418	427	PF00179	0.598
TRG_DiLeu_BaEn_1	351	356	PF01217	0.398
TRG_ENDOCYTIC_2	113	116	PF00928	0.500
TRG_ENDOCYTIC_2	299	302	PF00928	0.538
TRG_ENDOCYTIC_2	343	346	PF00928	0.407
TRG_ER_diArg_1	14	17	PF00400	0.455
TRG_ER_diArg_1	315	318	PF00400	0.542
TRG_ER_diArg_1	361	363	PF00400	0.566
TRG_ER_diArg_1	368	371	PF00400	0.528
TRG_ER_diArg_1	541	543	PF00400	0.461
TRG_ER_diArg_1	562	564	PF00400	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU3	Leptomonas seymouri	49%	100%
A0A1X0NJL9	Trypanosomatidae	29%	100%
A0A3R7NH89	Trypanosoma rangeli	29%	100%
A0A3S7WNM2	Leishmania donovani	88%	100%
A4H3F3	Leishmania braziliensis	73%	100%
A4HRQ7	Leishmania infantum	87%	100%
C9ZJ47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACD6	Leishmania major	85%	100%
V5BER3	Trypanosoma cruzi	30%	100%