Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJM3_LEIMU

TriTrypDb:

LmxM.02.0610

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.527
CLV_NRD_NRD_1	136	138	PF00675	0.481
CLV_NRD_NRD_1	150	152	PF00675	0.362
CLV_NRD_NRD_1	187	189	PF00675	0.682
CLV_NRD_NRD_1	308	310	PF00675	0.576
CLV_NRD_NRD_1	33	35	PF00675	0.412
CLV_NRD_NRD_1	41	43	PF00675	0.411
CLV_PCSK_KEX2_1	11	13	PF00082	0.510
CLV_PCSK_KEX2_1	136	138	PF00082	0.521
CLV_PCSK_KEX2_1	150	152	PF00082	0.403
CLV_PCSK_KEX2_1	187	189	PF00082	0.659
CLV_PCSK_KEX2_1	310	312	PF00082	0.556
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.510
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.551
CLV_PCSK_SKI1_1	102	106	PF00082	0.563
CLV_PCSK_SKI1_1	202	206	PF00082	0.648
CLV_PCSK_SKI1_1	311	315	PF00082	0.597
CLV_PCSK_SKI1_1	34	38	PF00082	0.412
DEG_APCC_DBOX_1	135	143	PF00400	0.436
DOC_ANK_TNKS_1	277	284	PF00023	0.608
DOC_CKS1_1	195	200	PF01111	0.676
DOC_CKS1_1	232	237	PF01111	0.679
DOC_CYCLIN_RxL_1	31	40	PF00134	0.417
DOC_MAPK_gen_1	172	182	PF00069	0.488
DOC_MAPK_MEF2A_6	114	121	PF00069	0.295
DOC_USP7_MATH_1	203	207	PF00917	0.628
DOC_USP7_MATH_1	211	215	PF00917	0.530
DOC_USP7_MATH_1	222	226	PF00917	0.511
DOC_USP7_MATH_1	227	231	PF00917	0.553
DOC_USP7_MATH_1	263	267	PF00917	0.636
DOC_USP7_MATH_1	271	275	PF00917	0.620
DOC_USP7_MATH_1	317	321	PF00917	0.457
DOC_USP7_UBL2_3	229	233	PF12436	0.588
DOC_USP7_UBL2_3	31	35	PF12436	0.515
DOC_WW_Pin1_4	194	199	PF00397	0.612
DOC_WW_Pin1_4	231	236	PF00397	0.676
LIG_14-3-3_CanoR_1	12	20	PF00244	0.490
LIG_14-3-3_CanoR_1	188	198	PF00244	0.765
LIG_14-3-3_CanoR_1	250	259	PF00244	0.649
LIG_14-3-3_CanoR_1	261	268	PF00244	0.507
LIG_14-3-3_CanoR_1	296	301	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.420
LIG_FHA_2	125	131	PF00498	0.560
LIG_FHA_2	203	209	PF00498	0.644
LIG_FHA_2	55	61	PF00498	0.564
LIG_FHA_2	74	80	PF00498	0.309
LIG_LIR_Apic_2	299	303	PF02991	0.659
LIG_LIR_Gen_1	92	101	PF02991	0.401
LIG_LIR_Nem_3	92	97	PF02991	0.513
LIG_MAD2	188	196	PF02301	0.610
LIG_PTB_Apo_2	93	100	PF02174	0.460
LIG_SH2_CRK	300	304	PF00017	0.669
LIG_SH2_GRB2like	94	97	PF00017	0.461
LIG_SH2_SRC	44	47	PF00017	0.515
LIG_SH2_STAP1	44	48	PF00017	0.398
LIG_SH3_3	195	201	PF00018	0.669
LIG_TRAF2_1	129	132	PF00917	0.410
LIG_TRAF2_1	16	19	PF00917	0.534
LIG_TRAF2_1	206	209	PF00917	0.698
MOD_CDK_SPK_2	197	202	PF00069	0.728
MOD_CK1_1	237	243	PF00069	0.696
MOD_CK1_1	266	272	PF00069	0.614
MOD_CK2_1	11	17	PF00069	0.527
MOD_CK2_1	124	130	PF00069	0.559
MOD_CK2_1	162	168	PF00069	0.570
MOD_CK2_1	202	208	PF00069	0.642
MOD_CK2_1	54	60	PF00069	0.543
MOD_CK2_1	73	79	PF00069	0.301
MOD_GlcNHglycan	205	208	PF01048	0.649
MOD_GlcNHglycan	213	216	PF01048	0.589
MOD_GlcNHglycan	224	227	PF01048	0.634
MOD_GlcNHglycan	236	239	PF01048	0.700
MOD_GlcNHglycan	240	243	PF01048	0.667
MOD_GlcNHglycan	255	258	PF01048	0.622
MOD_GlcNHglycan	273	276	PF01048	0.678
MOD_GSK3_1	190	197	PF00069	0.585
MOD_GSK3_1	227	234	PF00069	0.677
MOD_GSK3_1	236	243	PF00069	0.626
MOD_GSK3_1	249	256	PF00069	0.647
MOD_GSK3_1	257	264	PF00069	0.560
MOD_PIKK_1	261	267	PF00454	0.573
MOD_PKA_1	11	17	PF00069	0.527
MOD_PKA_2	11	17	PF00069	0.527
MOD_PKA_2	122	128	PF00069	0.474
MOD_PKA_2	249	255	PF00069	0.742
MOD_Plk_1	73	79	PF00069	0.516
MOD_Plk_2-3	124	130	PF00069	0.504
MOD_Plk_4	263	269	PF00069	0.570
MOD_ProDKin_1	194	200	PF00069	0.612
MOD_ProDKin_1	231	237	PF00069	0.678
MOD_SUMO_for_1	37	40	PF00179	0.273
TRG_DiLeu_BaEn_1	51	56	PF01217	0.467
TRG_DiLeu_BaEn_2	207	213	PF01217	0.689
TRG_DiLeu_BaEn_2	94	100	PF01217	0.462
TRG_DiLeu_BaEn_4	130	136	PF01217	0.442
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.563
TRG_ENDOCYTIC_2	44	47	PF00928	0.402
TRG_ENDOCYTIC_2	94	97	PF00928	0.385
TRG_ER_diArg_1	135	137	PF00400	0.548
TRG_ER_diArg_1	187	189	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT89	Leptomonas seymouri	64%	98%
A0A1X0NQ36	Trypanosomatidae	36%	93%
A0A3R7LN24	Trypanosoma rangeli	39%	95%
A0A3S5H510	Leishmania donovani	96%	100%
A4H3F2	Leishmania braziliensis	85%	100%
A4HRQ6	Leishmania infantum	96%	100%
C9ZUN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	94%
E9ACD5	Leishmania major	95%	100%
V5DPV7	Trypanosoma cruzi	38%	94%