Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AJM2_LEIMU

TriTrypDb:

LmxM.02.0600

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005885	Arp2/3 protein complex	2	9
GO:0032991	protein-containing complex	1	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AJM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJM2

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	9
GO:0008064	regulation of actin polymerization or depolymerization	6	9
GO:0008154	actin polymerization or depolymerization	6	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0030041	actin filament polymerization	7	9
GO:0030832	regulation of actin filament length	5	9
GO:0030833	regulation of actin filament polymerization	7	9
GO:0032271	regulation of protein polymerization	6	9
GO:0032535	regulation of cellular component size	4	9
GO:0032956	regulation of actin cytoskeleton organization	5	9
GO:0032970	regulation of actin filament-based process	4	9
GO:0033043	regulation of organelle organization	5	9
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	9
GO:0043254	regulation of protein-containing complex assembly	5	9
GO:0043933	protein-containing complex organization	4	9
GO:0044087	regulation of cellular component biogenesis	4	9
GO:0045010	actin nucleation	6	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0051128	regulation of cellular component organization	4	9
GO:0051258	protein polymerization	6	9
GO:0051493	regulation of cytoskeleton organization	6	9
GO:0065003	protein-containing complex assembly	5	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0090066	regulation of anatomical structure size	3	9
GO:0097435	supramolecular fiber organization	4	9
GO:0110053	regulation of actin filament organization	6	9
GO:1902903	regulation of supramolecular fiber organization	5	9

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.314
CLV_NRD_NRD_1	198	200	PF00675	0.215
CLV_PCSK_KEX2_1	136	138	PF00082	0.322
CLV_PCSK_KEX2_1	197	199	PF00082	0.217
CLV_PCSK_SKI1_1	14	18	PF00082	0.329
CLV_PCSK_SKI1_1	174	178	PF00082	0.366
CLV_PCSK_SKI1_1	191	195	PF00082	0.193
DEG_APCC_DBOX_1	13	21	PF00400	0.482
DEG_APCC_DBOX_1	173	181	PF00400	0.405
DEG_COP1_1	27	38	PF00400	0.484
DOC_CKS1_1	58	63	PF01111	0.353
DOC_CYCLIN_yCln2_LP_2	40	43	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.438
DOC_MAPK_gen_1	171	179	PF00069	0.437
DOC_MAPK_MEF2A_6	14	22	PF00069	0.431
DOC_PP1_RVXF_1	69	75	PF00149	0.480
DOC_PP1_RVXF_1	88	94	PF00149	0.562
DOC_PP2B_LxvP_1	40	43	PF13499	0.396
DOC_PP2B_LxvP_1	55	58	PF13499	0.366
DOC_PP4_FxxP_1	206	209	PF00568	0.449
DOC_PP4_FxxP_1	54	57	PF00568	0.353
DOC_WW_Pin1_4	130	135	PF00397	0.353
DOC_WW_Pin1_4	57	62	PF00397	0.353
LIG_14-3-3_CanoR_1	136	143	PF00244	0.448
LIG_14-3-3_CanoR_1	174	180	PF00244	0.495
LIG_14-3-3_CanoR_1	71	81	PF00244	0.451
LIG_14-3-3_CanoR_1	90	94	PF00244	0.428
LIG_Actin_WH2_2	176	193	PF00022	0.431
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_BIR_III_3	1	5	PF00653	0.409
LIG_eIF4E_1	153	159	PF01652	0.428
LIG_EVH1_2	50	54	PF00568	0.448
LIG_FHA_1	105	111	PF00498	0.495
LIG_FHA_1	122	128	PF00498	0.495
LIG_FHA_1	13	19	PF00498	0.483
LIG_FHA_2	176	182	PF00498	0.409
LIG_HCF-1_HBM_1	162	165	PF13415	0.405
LIG_LIR_Apic_2	204	209	PF02991	0.462
LIG_LIR_Apic_2	53	57	PF02991	0.353
LIG_LIR_Gen_1	111	117	PF02991	0.480
LIG_LIR_Gen_1	154	165	PF02991	0.482
LIG_LIR_Nem_3	111	116	PF02991	0.480
LIG_LIR_Nem_3	154	160	PF02991	0.482
LIG_LIR_Nem_3	204	208	PF02991	0.395
LIG_PDZ_Class_2	205	210	PF00595	0.534
LIG_Pex14_1	175	179	PF04695	0.353
LIG_SH2_GRB2like	8	11	PF00017	0.353
LIG_SH2_NCK_1	9	13	PF00017	0.482
LIG_SH2_SRC	165	168	PF00017	0.373
LIG_SH2_STAP1	153	157	PF00017	0.428
LIG_SH2_STAT3	167	170	PF00017	0.448
LIG_SH3_3	55	61	PF00018	0.435
LIG_SH3_3	98	104	PF00018	0.379
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.469
LIG_TRAF2_1	201	204	PF00917	0.353
LIG_WRC_WIRS_1	176	181	PF05994	0.431
LIG_WRC_WIRS_1	22	27	PF05994	0.482
MOD_CDK_SPxK_1	130	136	PF00069	0.353
MOD_CDK_SPxxK_3	130	137	PF00069	0.353
MOD_CK1_1	24	30	PF00069	0.484
MOD_CK1_1	85	91	PF00069	0.453
MOD_CK2_1	175	181	PF00069	0.463
MOD_CK2_1	73	79	PF00069	0.456
MOD_GlcNHglycan	75	78	PF01048	0.282
MOD_GSK3_1	104	111	PF00069	0.398
MOD_GSK3_1	82	89	PF00069	0.453
MOD_NEK2_1	116	121	PF00069	0.517
MOD_NEK2_1	72	77	PF00069	0.523
MOD_OFUCOSY	80	86	PF10250	0.248
MOD_PIKK_1	104	110	PF00454	0.431
MOD_PKA_1	136	142	PF00069	0.448
MOD_PKA_2	135	141	PF00069	0.448
MOD_PKA_2	89	95	PF00069	0.428
MOD_Plk_1	12	18	PF00069	0.495
MOD_Plk_1	153	159	PF00069	0.428
MOD_Plk_1	86	92	PF00069	0.454
MOD_Plk_4	153	159	PF00069	0.482
MOD_Plk_4	175	181	PF00069	0.439
MOD_Plk_4	50	56	PF00069	0.448
MOD_Plk_4	89	95	PF00069	0.466
MOD_ProDKin_1	130	136	PF00069	0.353
MOD_ProDKin_1	57	63	PF00069	0.353
TRG_DiLeu_BaEn_1	13	18	PF01217	0.431
TRG_ENDOCYTIC_2	113	116	PF00928	0.453
TRG_ENDOCYTIC_2	9	12	PF00928	0.453
TRG_ER_diArg_1	135	137	PF00400	0.522
TRG_ER_diArg_1	169	172	PF00400	0.387
TRG_ER_diArg_1	197	199	PF00400	0.413
TRG_NES_CRM1_1	150	162	PF08389	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU0	Leptomonas seymouri	48%	100%
A0A0S4KGM1	Bodo saltans	27%	100%
A0A1X0NJU3	Trypanosomatidae	32%	100%
A0A3R7MB12	Trypanosoma rangeli	30%	100%
A0A451EJJ5	Leishmania donovani	86%	100%
A4H3F1	Leishmania braziliensis	70%	100%
A4HRQ5	Leishmania infantum	85%	100%
C9ZJ46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
F4JUL9	Arabidopsis thaliana	30%	100%
O96625	Dictyostelium discoideum	27%	100%
P33204	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P58798	Caenorhabditis elegans	27%	100%
P59998	Homo sapiens	28%	100%
P59999	Mus musculus	28%	100%
Q148J6	Bos taurus	28%	100%
Q19R45	Leishmania major	82%	100%
Q641G7	Xenopus laevis	28%	100%
Q92352	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%