TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AJM1_LEIMU

TriTrypDb:

LmxM.02.0590

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJM1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	285	287	PF00675	0.620
CLV_NRD_NRD_1	338	340	PF00675	0.593
CLV_NRD_NRD_1	391	393	PF00675	0.762
CLV_NRD_NRD_1	443	445	PF00675	0.660
CLV_NRD_NRD_1	467	469	PF00675	0.683
CLV_NRD_NRD_1	515	517	PF00675	0.515
CLV_PCSK_KEX2_1	241	243	PF00082	0.372
CLV_PCSK_KEX2_1	285	287	PF00082	0.625
CLV_PCSK_KEX2_1	337	339	PF00082	0.610
CLV_PCSK_KEX2_1	443	445	PF00082	0.660
CLV_PCSK_KEX2_1	466	468	PF00082	0.692
CLV_PCSK_KEX2_1	517	519	PF00082	0.519
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.372
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.657
CLV_PCSK_SKI1_1	100	104	PF00082	0.718
CLV_PCSK_SKI1_1	380	384	PF00082	0.702
CLV_PCSK_SKI1_1	397	401	PF00082	0.698
CLV_PCSK_SKI1_1	48	52	PF00082	0.761
CLV_PCSK_SKI1_1	518	522	PF00082	0.568
CLV_PCSK_SKI1_1	7	11	PF00082	0.568
CLV_Separin_Metazoa	410	414	PF03568	0.574
DEG_SPOP_SBC_1	171	175	PF00917	0.524
DEG_SPOP_SBC_1	306	310	PF00917	0.777
DEG_SPOP_SBC_1	55	59	PF00917	0.485
DOC_PP1_RVXF_1	105	112	PF00149	0.708
DOC_PP4_FxxP_1	103	106	PF00568	0.746
DOC_PP4_FxxP_1	485	488	PF00568	0.666
DOC_USP7_MATH_1	117	121	PF00917	0.766
DOC_USP7_MATH_1	129	133	PF00917	0.635
DOC_USP7_MATH_1	274	278	PF00917	0.368
DOC_USP7_MATH_1	306	310	PF00917	0.782
DOC_USP7_MATH_1	320	324	PF00917	0.681
DOC_USP7_MATH_1	376	380	PF00917	0.608
DOC_USP7_MATH_1	399	403	PF00917	0.689
DOC_USP7_MATH_1	415	419	PF00917	0.677
DOC_USP7_MATH_1	502	506	PF00917	0.664
DOC_USP7_MATH_1	55	59	PF00917	0.768
DOC_USP7_MATH_2	496	502	PF00917	0.557
DOC_USP7_UBL2_3	393	397	PF12436	0.651
DOC_WW_Pin1_4	380	385	PF00397	0.738
DOC_WW_Pin1_4	447	452	PF00397	0.755
DOC_WW_Pin1_4	51	56	PF00397	0.730
DOC_WW_Pin1_4	86	91	PF00397	0.684
LIG_14-3-3_CanoR_1	100	106	PF00244	0.745
LIG_14-3-3_CanoR_1	218	223	PF00244	0.441
LIG_14-3-3_CanoR_1	273	282	PF00244	0.586
LIG_14-3-3_CanoR_1	289	298	PF00244	0.579
LIG_14-3-3_CanoR_1	339	347	PF00244	0.430
LIG_14-3-3_CanoR_1	392	396	PF00244	0.758
LIG_14-3-3_CanoR_1	421	428	PF00244	0.657
LIG_14-3-3_CanoR_1	468	474	PF00244	0.729
LIG_Actin_WH2_2	71	88	PF00022	0.644
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_FHA_1	133	139	PF00498	0.440
LIG_FHA_1	162	168	PF00498	0.400
LIG_FHA_1	217	223	PF00498	0.514
LIG_FHA_1	293	299	PF00498	0.664
LIG_FHA_1	41	47	PF00498	0.684
LIG_FHA_1	55	61	PF00498	0.531
LIG_FHA_1	80	86	PF00498	0.713
LIG_FHA_2	1	7	PF00498	0.583
LIG_FHA_2	15	21	PF00498	0.566
LIG_FHA_2	202	208	PF00498	0.296
LIG_FHA_2	308	314	PF00498	0.776
LIG_FHA_2	326	332	PF00498	0.739
LIG_FHA_2	355	361	PF00498	0.643
LIG_FHA_2	424	430	PF00498	0.654
LIG_FHA_2	82	88	PF00498	0.800
LIG_LIR_Apic_2	101	106	PF02991	0.675
LIG_LIR_Nem_3	224	230	PF02991	0.419
LIG_LIR_Nem_3	235	240	PF02991	0.330
LIG_MYND_1	461	465	PF01753	0.732
LIG_Pex14_1	226	230	PF04695	0.312
LIG_PTB_Apo_2	145	152	PF02174	0.460
LIG_SH2_CRK	52	56	PF00017	0.742
LIG_SH2_GRB2like	188	191	PF00017	0.425
LIG_SH2_NCK_1	52	56	PF00017	0.742
LIG_SH2_STAP1	163	167	PF00017	0.365
LIG_SH2_STAP1	209	213	PF00017	0.525
LIG_SH2_STAP1	250	254	PF00017	0.328
LIG_SH2_STAT3	230	233	PF00017	0.312
LIG_SH2_STAT3	366	369	PF00017	0.612
LIG_SH2_STAT5	163	166	PF00017	0.398
LIG_SH2_STAT5	195	198	PF00017	0.380
LIG_SH2_STAT5	237	240	PF00017	0.454
LIG_SH2_STAT5	395	398	PF00017	0.556
LIG_SH3_2	461	466	PF14604	0.735
LIG_SH3_3	18	24	PF00018	0.604
LIG_SH3_3	458	464	PF00018	0.729
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.410
LIG_SUMO_SIM_par_1	180	185	PF11976	0.438
LIG_SUMO_SIM_par_1	217	225	PF11976	0.476
LIG_TRAF2_1	278	281	PF00917	0.555
LIG_WW_3	463	467	PF00397	0.743
MOD_CDK_SPxxK_3	380	387	PF00069	0.532
MOD_CK1_1	115	121	PF00069	0.664
MOD_CK1_1	132	138	PF00069	0.459
MOD_CK1_1	189	195	PF00069	0.346
MOD_CK1_1	221	227	PF00069	0.462
MOD_CK1_1	290	296	PF00069	0.625
MOD_CK1_1	297	303	PF00069	0.658
MOD_CK1_1	34	40	PF00069	0.731
MOD_CK1_1	340	346	PF00069	0.473
MOD_CK1_1	420	426	PF00069	0.747
MOD_CK1_1	450	456	PF00069	0.793
MOD_CK1_1	54	60	PF00069	0.541
MOD_CK1_1	98	104	PF00069	0.678
MOD_CK2_1	174	180	PF00069	0.567
MOD_CK2_1	274	280	PF00069	0.382
MOD_CK2_1	307	313	PF00069	0.801
MOD_CK2_1	354	360	PF00069	0.685
MOD_Cter_Amidation	335	338	PF01082	0.652
MOD_GlcNHglycan	103	106	PF01048	0.609
MOD_GlcNHglycan	131	134	PF01048	0.680
MOD_GlcNHglycan	176	179	PF01048	0.549
MOD_GlcNHglycan	184	187	PF01048	0.393
MOD_GlcNHglycan	191	194	PF01048	0.260
MOD_GlcNHglycan	276	279	PF01048	0.423
MOD_GlcNHglycan	317	320	PF01048	0.589
MOD_GlcNHglycan	339	342	PF01048	0.655
MOD_GlcNHglycan	401	404	PF01048	0.637
MOD_GlcNHglycan	417	420	PF01048	0.630
MOD_GlcNHglycan	422	425	PF01048	0.649
MOD_GlcNHglycan	469	472	PF01048	0.793
MOD_GlcNHglycan	500	503	PF01048	0.694
MOD_GlcNHglycan	504	507	PF01048	0.613
MOD_GlcNHglycan	65	68	PF01048	0.731
MOD_GlcNHglycan	93	96	PF01048	0.747
MOD_GSK3_1	101	108	PF00069	0.644
MOD_GSK3_1	112	119	PF00069	0.692
MOD_GSK3_1	170	177	PF00069	0.571
MOD_GSK3_1	182	189	PF00069	0.499
MOD_GSK3_1	218	225	PF00069	0.474
MOD_GSK3_1	27	34	PF00069	0.777
MOD_GSK3_1	284	291	PF00069	0.523
MOD_GSK3_1	293	300	PF00069	0.631
MOD_GSK3_1	36	43	PF00069	0.721
MOD_GSK3_1	376	383	PF00069	0.684
MOD_GSK3_1	397	404	PF00069	0.644
MOD_GSK3_1	413	420	PF00069	0.781
MOD_GSK3_1	452	459	PF00069	0.791
MOD_GSK3_1	498	505	PF00069	0.643
MOD_GSK3_1	51	58	PF00069	0.733
MOD_GSK3_1	61	68	PF00069	0.719
MOD_GSK3_1	74	81	PF00069	0.705
MOD_GSK3_1	91	98	PF00069	0.727
MOD_N-GLC_1	147	152	PF02516	0.470
MOD_N-GLC_1	189	194	PF02516	0.344
MOD_N-GLC_1	40	45	PF02516	0.754
MOD_N-GLC_1	79	84	PF02516	0.732
MOD_NEK2_1	170	175	PF00069	0.541
MOD_NEK2_1	182	187	PF00069	0.444
MOD_NEK2_1	222	227	PF00069	0.526
MOD_NEK2_1	267	272	PF00069	0.462
MOD_NEK2_1	284	289	PF00069	0.578
MOD_NEK2_1	298	303	PF00069	0.686
MOD_NEK2_1	31	36	PF00069	0.707
MOD_NEK2_1	452	457	PF00069	0.681
MOD_NEK2_1	63	68	PF00069	0.690
MOD_NEK2_1	78	83	PF00069	0.575
MOD_NEK2_1	85	90	PF00069	0.720
MOD_PIKK_1	120	126	PF00454	0.733
MOD_PIKK_1	31	37	PF00454	0.761
MOD_PIKK_1	320	326	PF00454	0.753
MOD_PIKK_1	340	346	PF00454	0.391
MOD_PK_1	413	419	PF00069	0.678
MOD_PKA_1	337	343	PF00069	0.616
MOD_PKA_1	467	473	PF00069	0.796
MOD_PKA_2	222	228	PF00069	0.426
MOD_PKA_2	274	280	PF00069	0.460
MOD_PKA_2	284	290	PF00069	0.480
MOD_PKA_2	337	343	PF00069	0.639
MOD_PKA_2	376	382	PF00069	0.666
MOD_PKA_2	391	397	PF00069	0.768
MOD_PKA_2	420	426	PF00069	0.666
MOD_PKA_2	467	473	PF00069	0.742
MOD_PKA_2	85	91	PF00069	0.807
MOD_Plk_1	112	118	PF00069	0.666
MOD_Plk_1	147	153	PF00069	0.465
MOD_Plk_1	216	222	PF00069	0.503
MOD_Plk_1	354	360	PF00069	0.547
MOD_Plk_1	413	419	PF00069	0.758
MOD_Plk_4	222	228	PF00069	0.426
MOD_Plk_4	27	33	PF00069	0.591
MOD_Plk_4	391	397	PF00069	0.547
MOD_ProDKin_1	380	386	PF00069	0.735
MOD_ProDKin_1	447	453	PF00069	0.757
MOD_ProDKin_1	51	57	PF00069	0.729
MOD_ProDKin_1	86	92	PF00069	0.683
MOD_SUMO_for_1	350	353	PF00179	0.550
MOD_SUMO_rev_2	141	146	PF00179	0.457
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.531
TRG_ENDOCYTIC_2	237	240	PF00928	0.438
TRG_ER_diArg_1	284	286	PF00400	0.621
TRG_ER_diArg_1	337	339	PF00400	0.623
TRG_ER_diArg_1	374	377	PF00400	0.578
TRG_ER_diArg_1	465	468	PF00400	0.686
TRG_ER_diArg_1	515	518	PF00400	0.512
TRG_NLS_MonoCore_2	515	520	PF00514	0.574
TRG_NLS_MonoExtN_4	516	521	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B2	Leptomonas seymouri	44%	93%
A0A1X0NJW2	Trypanosomatidae	34%	100%
A0A3S5H509	Leishmania donovani	91%	100%
A0A422NAY7	Trypanosoma rangeli	32%	100%
A4H3F0	Leishmania braziliensis	73%	100%
A4HRQ4	Leishmania infantum	91%	100%
E9ACD3	Leishmania major	91%	98%
V5B5N7	Trypanosoma cruzi	33%	100%