Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AJL8_LEIMU

TriTrypDb:

LmxM.02.0560

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.760
CLV_C14_Caspase3-7	188	192	PF00656	0.614
CLV_C14_Caspase3-7	3	7	PF00656	0.506
CLV_C14_Caspase3-7	722	726	PF00656	0.776
CLV_NRD_NRD_1	240	242	PF00675	0.703
CLV_NRD_NRD_1	361	363	PF00675	0.791
CLV_NRD_NRD_1	383	385	PF00675	0.797
CLV_NRD_NRD_1	432	434	PF00675	0.768
CLV_NRD_NRD_1	563	565	PF00675	0.880
CLV_NRD_NRD_1	595	597	PF00675	0.835
CLV_NRD_NRD_1	627	629	PF00675	0.755
CLV_NRD_NRD_1	835	837	PF00675	0.813
CLV_PCSK_FUR_1	359	363	PF00082	0.798
CLV_PCSK_KEX2_1	240	242	PF00082	0.703
CLV_PCSK_KEX2_1	359	361	PF00082	0.805
CLV_PCSK_KEX2_1	383	385	PF00082	0.797
CLV_PCSK_KEX2_1	432	434	PF00082	0.768
CLV_PCSK_KEX2_1	562	564	PF00082	0.885
CLV_PCSK_KEX2_1	595	597	PF00082	0.835
CLV_PCSK_KEX2_1	627	629	PF00082	0.755
CLV_PCSK_KEX2_1	835	837	PF00082	0.848
CLV_PCSK_PC7_1	558	564	PF00082	0.586
CLV_PCSK_SKI1_1	332	336	PF00082	0.760
CLV_PCSK_SKI1_1	82	86	PF00082	0.754
DEG_Nend_Nbox_1	1	3	PF02207	0.720
DEG_SCF_FBW7_1	680	687	PF00400	0.842
DEG_SPOP_SBC_1	479	483	PF00917	0.647
DEG_SPOP_SBC_1	817	821	PF00917	0.721
DOC_CKS1_1	229	234	PF01111	0.698
DOC_CKS1_1	681	686	PF01111	0.840
DOC_MAPK_gen_1	832	840	PF00069	0.849
DOC_PP1_RVXF_1	423	430	PF00149	0.693
DOC_PP1_RVXF_1	834	841	PF00149	0.845
DOC_PP4_FxxP_1	491	494	PF00568	0.753
DOC_PP4_FxxP_1	840	843	PF00568	0.836
DOC_PP4_MxPP_1	40	43	PF00568	0.525
DOC_USP7_MATH_1	260	264	PF00917	0.610
DOC_USP7_MATH_1	312	316	PF00917	0.773
DOC_USP7_MATH_1	338	342	PF00917	0.560
DOC_USP7_MATH_1	36	40	PF00917	0.656
DOC_USP7_MATH_1	363	367	PF00917	0.715
DOC_USP7_MATH_1	434	438	PF00917	0.756
DOC_USP7_MATH_1	463	467	PF00917	0.835
DOC_USP7_MATH_1	469	473	PF00917	0.730
DOC_USP7_MATH_1	527	531	PF00917	0.771
DOC_USP7_MATH_1	649	653	PF00917	0.827
DOC_USP7_MATH_1	684	688	PF00917	0.765
DOC_USP7_MATH_1	691	695	PF00917	0.713
DOC_USP7_MATH_1	704	708	PF00917	0.516
DOC_USP7_MATH_1	775	779	PF00917	0.810
DOC_USP7_MATH_1	781	785	PF00917	0.809
DOC_USP7_MATH_1	793	797	PF00917	0.593
DOC_WW_Pin1_4	143	148	PF00397	0.631
DOC_WW_Pin1_4	200	205	PF00397	0.686
DOC_WW_Pin1_4	228	233	PF00397	0.720
DOC_WW_Pin1_4	284	289	PF00397	0.710
DOC_WW_Pin1_4	332	337	PF00397	0.818
DOC_WW_Pin1_4	345	350	PF00397	0.640
DOC_WW_Pin1_4	386	391	PF00397	0.812
DOC_WW_Pin1_4	680	685	PF00397	0.839
DOC_WW_Pin1_4	760	765	PF00397	0.633
LIG_14-3-3_CanoR_1	15	24	PF00244	0.780
LIG_14-3-3_CanoR_1	152	161	PF00244	0.754
LIG_14-3-3_CanoR_1	360	366	PF00244	0.716
LIG_14-3-3_CanoR_1	425	430	PF00244	0.691
LIG_14-3-3_CanoR_1	627	635	PF00244	0.652
LIG_14-3-3_CanoR_1	803	812	PF00244	0.819
LIG_14-3-3_CanoR_1	835	839	PF00244	0.848
LIG_ActinCP_TwfCPI_2	491	500	PF01115	0.567
LIG_BRCT_BRCA1_1	134	138	PF00533	0.758
LIG_BRCT_BRCA1_1	202	206	PF00533	0.516
LIG_BRCT_BRCA1_1	651	655	PF00533	0.826
LIG_eIF4E_1	155	161	PF01652	0.749
LIG_FHA_1	154	160	PF00498	0.751
LIG_FHA_1	221	227	PF00498	0.752
LIG_FHA_1	229	235	PF00498	0.560
LIG_FHA_1	480	486	PF00498	0.546
LIG_FHA_1	61	67	PF00498	0.633
LIG_FHA_1	681	687	PF00498	0.842
LIG_FHA_1	818	824	PF00498	0.560
LIG_FHA_2	373	379	PF00498	0.773
LIG_FHA_2	784	790	PF00498	0.855
LIG_FHA_2	806	812	PF00498	0.752
LIG_FHA_2	813	819	PF00498	0.843
LIG_Integrin_RGD_1	305	307	PF01839	0.770
LIG_LIR_Apic_2	490	495	PF02991	0.627
LIG_LIR_Apic_2	837	843	PF02991	0.840
LIG_LIR_Gen_1	603	612	PF02991	0.848
LIG_LIR_Gen_1	736	745	PF02991	0.645
LIG_LIR_Nem_3	135	141	PF02991	0.761
LIG_LIR_Nem_3	148	154	PF02991	0.556
LIG_LIR_Nem_3	202	208	PF02991	0.805
LIG_LIR_Nem_3	295	299	PF02991	0.505
LIG_LIR_Nem_3	379	385	PF02991	0.784
LIG_LIR_Nem_3	603	607	PF02991	0.852
LIG_LIR_Nem_3	736	740	PF02991	0.646
LIG_MLH1_MIPbox_1	202	206	PF16413	0.516
LIG_NRBOX	233	239	PF00104	0.680
LIG_NRBOX	85	91	PF00104	0.756
LIG_Pex14_1	151	155	PF04695	0.768
LIG_Pex14_1	431	435	PF04695	0.690
LIG_Pex14_1	534	538	PF04695	0.770
LIG_PTAP_UEV_1	458	463	PF05743	0.677
LIG_SH2_CRK	282	286	PF00017	0.699
LIG_SH2_CRK	492	496	PF00017	0.565
LIG_SH2_CRK	604	608	PF00017	0.784
LIG_SH2_NCK_1	264	268	PF00017	0.702
LIG_SH2_PTP2	371	374	PF00017	0.716
LIG_SH2_PTP2	540	543	PF00017	0.780
LIG_SH2_SRC	371	374	PF00017	0.716
LIG_SH2_STAP1	155	159	PF00017	0.746
LIG_SH2_STAP1	282	286	PF00017	0.699
LIG_SH2_STAP1	292	296	PF00017	0.541
LIG_SH2_STAT5	139	142	PF00017	0.766
LIG_SH2_STAT5	155	158	PF00017	0.485
LIG_SH2_STAT5	205	208	PF00017	0.808
LIG_SH2_STAT5	228	231	PF00017	0.715
LIG_SH2_STAT5	273	276	PF00017	0.628
LIG_SH2_STAT5	371	374	PF00017	0.794
LIG_SH2_STAT5	540	543	PF00017	0.780
LIG_SH3_2	147	152	PF14604	0.776
LIG_SH3_2	557	562	PF14604	0.863
LIG_SH3_3	141	147	PF00018	0.736
LIG_SH3_3	204	210	PF00018	0.798
LIG_SH3_3	212	218	PF00018	0.652
LIG_SH3_3	285	291	PF00018	0.711
LIG_SH3_3	313	319	PF00018	0.789
LIG_SH3_3	40	46	PF00018	0.675
LIG_SH3_3	450	456	PF00018	0.833
LIG_SH3_3	473	479	PF00018	0.792
LIG_SH3_3	554	560	PF00018	0.857
LIG_SH3_3	69	75	PF00018	0.730
LIG_SUMO_SIM_par_1	372	380	PF11976	0.698
LIG_TRAF2_1	375	378	PF00917	0.771
LIG_TRAF2_1	808	811	PF00917	0.564
LIG_TRFH_1	206	210	PF08558	0.681
LIG_TRFH_1	214	218	PF08558	0.765
LIG_WW_1	270	273	PF00397	0.745
LIG_WW_3	493	497	PF00397	0.854
MOD_CDC14_SPxK_1	389	392	PF00782	0.743
MOD_CDK_SPK_2	228	233	PF00069	0.720
MOD_CDK_SPxK_1	386	392	PF00069	0.737
MOD_CK1_1	192	198	PF00069	0.752
MOD_CK1_1	25	31	PF00069	0.688
MOD_CK1_1	287	293	PF00069	0.721
MOD_CK1_1	395	401	PF00069	0.599
MOD_CK1_1	412	418	PF00069	0.774
MOD_CK1_1	447	453	PF00069	0.821
MOD_CK1_1	530	536	PF00069	0.770
MOD_CK1_1	603	609	PF00069	0.852
MOD_CK1_1	629	635	PF00069	0.727
MOD_CK1_1	644	650	PF00069	0.556
MOD_CK1_1	758	764	PF00069	0.772
MOD_CK1_1	773	779	PF00069	0.634
MOD_CK1_1	831	837	PF00069	0.842
MOD_CK2_1	162	168	PF00069	0.669
MOD_CK2_1	256	262	PF00069	0.721
MOD_CK2_1	29	35	PF00069	0.811
MOD_CK2_1	312	318	PF00069	0.778
MOD_CK2_1	372	378	PF00069	0.779
MOD_CK2_1	436	442	PF00069	0.689
MOD_CK2_1	702	708	PF00069	0.851
MOD_CK2_1	805	811	PF00069	0.641
MOD_DYRK1A_RPxSP_1	143	147	PF00069	0.646
MOD_GlcNHglycan	134	137	PF01048	0.758
MOD_GlcNHglycan	156	159	PF01048	0.743
MOD_GlcNHglycan	17	20	PF01048	0.596
MOD_GlcNHglycan	191	194	PF01048	0.679
MOD_GlcNHglycan	25	28	PF01048	0.703
MOD_GlcNHglycan	258	261	PF01048	0.720
MOD_GlcNHglycan	276	279	PF01048	0.406
MOD_GlcNHglycan	3	6	PF01048	0.722
MOD_GlcNHglycan	31	34	PF01048	0.612
MOD_GlcNHglycan	340	343	PF01048	0.556
MOD_GlcNHglycan	365	368	PF01048	0.720
MOD_GlcNHglycan	438	441	PF01048	0.735
MOD_GlcNHglycan	446	449	PF01048	0.703
MOD_GlcNHglycan	459	462	PF01048	0.636
MOD_GlcNHglycan	465	468	PF01048	0.547
MOD_GlcNHglycan	529	532	PF01048	0.658
MOD_GlcNHglycan	630	634	PF01048	0.652
MOD_GlcNHglycan	636	639	PF01048	0.552
MOD_GlcNHglycan	647	650	PF01048	0.534
MOD_GlcNHglycan	730	733	PF01048	0.571
MOD_GlcNHglycan	760	763	PF01048	0.778
MOD_GlcNHglycan	773	776	PF01048	0.722
MOD_GlcNHglycan	777	780	PF01048	0.660
MOD_GlcNHglycan	783	786	PF01048	0.690
MOD_GlcNHglycan	795	798	PF01048	0.590
MOD_GlcNHglycan	81	85	PF01048	0.755
MOD_GSK3_1	1	8	PF00069	0.707
MOD_GSK3_1	191	198	PF00069	0.645
MOD_GSK3_1	220	227	PF00069	0.756
MOD_GSK3_1	25	32	PF00069	0.689
MOD_GSK3_1	256	263	PF00069	0.625
MOD_GSK3_1	386	393	PF00069	0.818
MOD_GSK3_1	395	402	PF00069	0.695
MOD_GSK3_1	444	451	PF00069	0.808
MOD_GSK3_1	463	470	PF00069	0.546
MOD_GSK3_1	479	486	PF00069	0.613
MOD_GSK3_1	641	648	PF00069	0.587
MOD_GSK3_1	676	683	PF00069	0.782
MOD_GSK3_1	698	705	PF00069	0.729
MOD_GSK3_1	771	778	PF00069	0.731
MOD_GSK3_1	812	819	PF00069	0.857
MOD_GSK3_1	827	834	PF00069	0.600
MOD_N-GLC_1	691	696	PF02516	0.675
MOD_NEK2_1	22	27	PF00069	0.692
MOD_NEK2_1	274	279	PF00069	0.571
MOD_NEK2_1	544	549	PF00069	0.794
MOD_NEK2_1	552	557	PF00069	0.712
MOD_NEK2_1	715	720	PF00069	0.791
MOD_NEK2_1	727	732	PF00069	0.620
MOD_NEK2_1	770	775	PF00069	0.783
MOD_PIKK_1	649	655	PF00454	0.827
MOD_PIKK_1	805	811	PF00454	0.641
MOD_PK_1	361	367	PF00069	0.715
MOD_PK_1	399	405	PF00069	0.832
MOD_PKA_1	361	367	PF00069	0.715
MOD_PKA_1	827	833	PF00069	0.849
MOD_PKA_2	14	20	PF00069	0.717
MOD_PKA_2	189	195	PF00069	0.734
MOD_PKA_2	361	367	PF00069	0.715
MOD_PKA_2	412	418	PF00069	0.807
MOD_PKA_2	503	509	PF00069	0.581
MOD_PKA_2	626	632	PF00069	0.732
MOD_PKA_2	781	787	PF00069	0.818
MOD_PKA_2	812	818	PF00069	0.858
MOD_PKA_2	831	837	PF00069	0.532
MOD_PKB_1	359	367	PF00069	0.719
MOD_PKB_1	397	405	PF00069	0.836
MOD_PKB_1	496	504	PF00069	0.576
MOD_PKB_1	803	811	PF00069	0.567
MOD_Plk_1	312	318	PF00069	0.778
MOD_Plk_1	629	635	PF00069	0.649
MOD_Plk_1	691	697	PF00069	0.688
MOD_Plk_1	80	86	PF00069	0.755
MOD_Plk_1	838	844	PF00069	0.840
MOD_Plk_4	224	230	PF00069	0.740
MOD_Plk_4	312	318	PF00069	0.778
MOD_Plk_4	412	418	PF00069	0.807
MOD_Plk_4	425	431	PF00069	0.554
MOD_Plk_4	530	536	PF00069	0.770
MOD_Plk_4	676	682	PF00069	0.844
MOD_ProDKin_1	143	149	PF00069	0.631
MOD_ProDKin_1	200	206	PF00069	0.687
MOD_ProDKin_1	228	234	PF00069	0.709
MOD_ProDKin_1	284	290	PF00069	0.707
MOD_ProDKin_1	332	338	PF00069	0.820
MOD_ProDKin_1	345	351	PF00069	0.638
MOD_ProDKin_1	386	392	PF00069	0.815
MOD_ProDKin_1	680	686	PF00069	0.841
MOD_ProDKin_1	760	766	PF00069	0.634
MOD_SUMO_rev_2	112	121	PF00179	0.755
MOD_SUMO_rev_2	32	39	PF00179	0.821
MOD_SUMO_rev_2	822	830	PF00179	0.775
TRG_DiLeu_BaEn_4	568	574	PF01217	0.779
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.822
TRG_ENDOCYTIC_2	205	208	PF00928	0.808
TRG_ENDOCYTIC_2	282	285	PF00928	0.544
TRG_ENDOCYTIC_2	371	374	PF00928	0.794
TRG_ENDOCYTIC_2	435	438	PF00928	0.758
TRG_ENDOCYTIC_2	604	607	PF00928	0.786
TRG_ER_diArg_1	239	241	PF00400	0.694
TRG_ER_diArg_1	359	362	PF00400	0.801
TRG_ER_diArg_1	382	384	PF00400	0.792
TRG_ER_diArg_1	431	433	PF00400	0.698
TRG_ER_diArg_1	495	498	PF00400	0.862
TRG_ER_diArg_1	562	564	PF00400	0.885
TRG_ER_diArg_1	594	596	PF00400	0.839
TRG_ER_diArg_1	626	628	PF00400	0.753
TRG_ER_diArg_1	802	805	PF00400	0.788

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H507	Leishmania donovani	88%	100%
A4H3E6	Leishmania braziliensis	71%	99%
A4HRQ1	Leishmania infantum	89%	100%
E9ACD0	Leishmania major	88%	100%