Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJL6_LEIMU

TriTrypDb:

LmxM.02.0540

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AJL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.626
CLV_NRD_NRD_1	139	141	PF00675	0.464
CLV_NRD_NRD_1	225	227	PF00675	0.504
CLV_NRD_NRD_1	229	231	PF00675	0.560
CLV_PCSK_FUR_1	137	141	PF00082	0.467
CLV_PCSK_FUR_1	223	227	PF00082	0.460
CLV_PCSK_KEX2_1	139	141	PF00082	0.464
CLV_PCSK_KEX2_1	204	206	PF00082	0.393
CLV_PCSK_KEX2_1	225	227	PF00082	0.504
CLV_PCSK_KEX2_1	228	230	PF00082	0.542
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.411
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.461
CLV_PCSK_PC7_1	221	227	PF00082	0.458
CLV_PCSK_SKI1_1	201	205	PF00082	0.376
CLV_PCSK_SKI1_1	272	276	PF00082	0.299
CLV_PCSK_SKI1_1	301	305	PF00082	0.566
DEG_SPOP_SBC_1	26	30	PF00917	0.473
DOC_MAPK_gen_1	201	210	PF00069	0.613
DOC_MAPK_JIP1_4	49	55	PF00069	0.299
DOC_MAPK_MEF2A_6	155	162	PF00069	0.292
DOC_MAPK_MEF2A_6	49	57	PF00069	0.299
DOC_PP2B_LxvP_1	22	25	PF13499	0.512
DOC_PP2B_LxvP_1	295	298	PF13499	0.400
DOC_USP7_MATH_1	123	127	PF00917	0.591
DOC_USP7_MATH_1	238	242	PF00917	0.608
DOC_USP7_MATH_1	25	29	PF00917	0.460
DOC_USP7_MATH_1	308	312	PF00917	0.346
DOC_USP7_UBL2_3	301	305	PF12436	0.404
DOC_WW_Pin1_4	124	129	PF00397	0.689
LIG_14-3-3_CanoR_1	140	150	PF00244	0.658
LIG_14-3-3_CanoR_1	213	217	PF00244	0.647
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BIR_III_3	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	198	202	PF00533	0.498
LIG_BRCT_BRCA1_1	270	274	PF00533	0.600
LIG_BRCT_BRCA1_2	198	204	PF00533	0.503
LIG_eIF4E_1	17	23	PF01652	0.569
LIG_FHA_1	18	24	PF00498	0.424
LIG_FHA_1	183	189	PF00498	0.292
LIG_FHA_2	248	254	PF00498	0.554
LIG_GBD_Chelix_1	284	292	PF00786	0.384
LIG_GBD_Chelix_1	55	63	PF00786	0.346
LIG_LIR_Gen_1	154	162	PF02991	0.460
LIG_LIR_Gen_1	51	60	PF02991	0.406
LIG_LIR_Gen_1	90	99	PF02991	0.643
LIG_LIR_Nem_3	154	160	PF02991	0.460
LIG_LIR_Nem_3	164	170	PF02991	0.292
LIG_LIR_Nem_3	199	203	PF02991	0.506
LIG_LIR_Nem_3	275	281	PF02991	0.346
LIG_LIR_Nem_3	51	57	PF02991	0.406
LIG_LIR_Nem_3	61	67	PF02991	0.180
LIG_LIR_Nem_3	83	89	PF02991	0.642
LIG_LIR_Nem_3	9	13	PF02991	0.359
LIG_LIR_Nem_3	90	95	PF02991	0.600
LIG_PCNA_PIPBox_1	267	276	PF02747	0.600
LIG_Pex14_2	274	278	PF04695	0.315
LIG_SH2_CRK	138	142	PF00017	0.666
LIG_SH2_CRK	157	161	PF00017	0.188
LIG_SH2_CRK	195	199	PF00017	0.292
LIG_SH2_CRK	200	204	PF00017	0.577
LIG_SH2_NCK_1	195	199	PF00017	0.213
LIG_SH2_STAP1	92	96	PF00017	0.615
LIG_SH2_STAT5	195	198	PF00017	0.292
LIG_SH3_3	122	128	PF00018	0.703
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.370
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.619
LIG_SUMO_SIM_par_1	184	189	PF11976	0.292
LIG_SUMO_SIM_par_1	262	268	PF11976	0.611
LIG_SUMO_SIM_par_1	55	61	PF11976	0.346
LIG_TYR_ITIM	136	141	PF00017	0.667
LIG_TYR_ITIM	193	198	PF00017	0.292
LIG_UBA3_1	63	72	PF00899	0.292
LIG_WRC_WIRS_1	7	12	PF05994	0.346
MOD_CK1_1	126	132	PF00069	0.574
MOD_CK1_1	28	34	PF00069	0.462
MOD_CK1_1	36	42	PF00069	0.510
MOD_CK1_1	58	64	PF00069	0.346
MOD_GlcNHglycan	10	13	PF01048	0.381
MOD_GlcNHglycan	120	123	PF01048	0.427
MOD_GlcNHglycan	132	135	PF01048	0.466
MOD_GlcNHglycan	210	213	PF01048	0.432
MOD_GlcNHglycan	216	219	PF01048	0.413
MOD_GlcNHglycan	310	313	PF01048	0.481
MOD_GlcNHglycan	35	38	PF01048	0.720
MOD_GlcNHglycan	45	48	PF01048	0.591
MOD_GlcNHglycan	64	67	PF01048	0.346
MOD_GSK3_1	123	130	PF00069	0.653
MOD_GSK3_1	182	189	PF00069	0.260
MOD_GSK3_1	208	215	PF00069	0.633
MOD_GSK3_1	25	32	PF00069	0.452
MOD_GSK3_1	268	275	PF00069	0.694
MOD_GSK3_1	58	65	PF00069	0.458
MOD_N-GLC_1	182	187	PF02516	0.460
MOD_NEK2_1	143	148	PF00069	0.697
MOD_NEK2_1	16	21	PF00069	0.644
MOD_NEK2_1	188	193	PF00069	0.346
MOD_NEK2_1	208	213	PF00069	0.630
MOD_NEK2_1	216	221	PF00069	0.603
MOD_NEK2_1	273	278	PF00069	0.416
MOD_NEK2_1	290	295	PF00069	0.411
MOD_NEK2_1	33	38	PF00069	0.420
MOD_NEK2_1	55	60	PF00069	0.346
MOD_PKA_2	148	154	PF00069	0.543
MOD_PKA_2	208	214	PF00069	0.680
MOD_PKA_2	48	54	PF00069	0.431
MOD_Plk_4	182	188	PF00069	0.372
MOD_Plk_4	193	199	PF00069	0.416
MOD_Plk_4	48	54	PF00069	0.526
MOD_Plk_4	55	61	PF00069	0.221
MOD_ProDKin_1	124	130	PF00069	0.687
MOD_SUMO_rev_2	73	80	PF00179	0.632
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.643
TRG_ENDOCYTIC_2	13	16	PF00928	0.394
TRG_ENDOCYTIC_2	138	141	PF00928	0.773
TRG_ENDOCYTIC_2	157	160	PF00928	0.188
TRG_ENDOCYTIC_2	195	198	PF00928	0.292
TRG_ENDOCYTIC_2	200	203	PF00928	0.577
TRG_ENDOCYTIC_2	92	95	PF00928	0.640
TRG_ER_diArg_1	138	140	PF00400	0.670
TRG_ER_diArg_1	223	226	PF00400	0.697
TRG_ER_diArg_1	229	231	PF00400	0.622
TRG_NES_CRM1_1	253	265	PF08389	0.532
TRG_NLS_MonoExtN_4	225	232	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IR47	Trypanosoma rangeli	36%	100%
A0A451EJI9	Leishmania donovani	90%	99%
A4HRP9	Leishmania infantum	91%	100%
E9ACC8	Leishmania major	90%	100%