Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJL5_LEIMU

TriTrypDb:

LmxM.02.0530

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.723
CLV_C14_Caspase3-7	696	700	PF00656	0.769
CLV_NRD_NRD_1	207	209	PF00675	0.722
CLV_NRD_NRD_1	305	307	PF00675	0.871
CLV_NRD_NRD_1	508	510	PF00675	0.803
CLV_NRD_NRD_1	604	606	PF00675	0.823
CLV_NRD_NRD_1	627	629	PF00675	0.797
CLV_NRD_NRD_1	67	69	PF00675	0.520
CLV_NRD_NRD_1	742	744	PF00675	0.793
CLV_NRD_NRD_1	853	855	PF00675	0.778
CLV_PCSK_KEX2_1	141	143	PF00082	0.561
CLV_PCSK_KEX2_1	207	209	PF00082	0.722
CLV_PCSK_KEX2_1	304	306	PF00082	0.881
CLV_PCSK_KEX2_1	504	506	PF00082	0.816
CLV_PCSK_KEX2_1	508	510	PF00082	0.759
CLV_PCSK_KEX2_1	604	606	PF00082	0.820
CLV_PCSK_KEX2_1	627	629	PF00082	0.797
CLV_PCSK_KEX2_1	853	855	PF00082	0.773
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.561
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.816
CLV_PCSK_SKI1_1	130	134	PF00082	0.744
CLV_PCSK_SKI1_1	270	274	PF00082	0.702
CLV_PCSK_SKI1_1	558	562	PF00082	0.783
DEG_APCC_DBOX_1	207	215	PF00400	0.727
DEG_SPOP_SBC_1	147	151	PF00917	0.694
DOC_CKS1_1	19	24	PF01111	0.670
DOC_MAPK_DCC_7	207	216	PF00069	0.724
DOC_MAPK_gen_1	207	214	PF00069	0.727
DOC_MAPK_HePTP_8	204	216	PF00069	0.585
DOC_MAPK_MEF2A_6	183	192	PF00069	0.547
DOC_MAPK_MEF2A_6	207	216	PF00069	0.724
DOC_MAPK_MEF2A_6	818	825	PF00069	0.460
DOC_PP2B_LxvP_1	362	365	PF13499	0.759
DOC_PP4_MxPP_1	542	545	PF00568	0.725
DOC_SPAK_OSR1_1	726	730	PF12202	0.759
DOC_USP7_MATH_1	164	168	PF00917	0.800
DOC_USP7_MATH_1	184	188	PF00917	0.685
DOC_USP7_MATH_1	193	197	PF00917	0.599
DOC_USP7_MATH_1	20	24	PF00917	0.728
DOC_USP7_MATH_1	221	225	PF00917	0.720
DOC_USP7_MATH_1	262	266	PF00917	0.527
DOC_USP7_MATH_1	27	31	PF00917	0.634
DOC_USP7_MATH_1	307	311	PF00917	0.656
DOC_USP7_MATH_1	323	327	PF00917	0.656
DOC_USP7_MATH_1	330	334	PF00917	0.695
DOC_USP7_MATH_1	378	382	PF00917	0.785
DOC_USP7_MATH_1	409	413	PF00917	0.729
DOC_USP7_MATH_1	435	439	PF00917	0.658
DOC_USP7_MATH_1	456	460	PF00917	0.694
DOC_USP7_MATH_1	519	523	PF00917	0.620
DOC_USP7_MATH_1	575	579	PF00917	0.708
DOC_USP7_MATH_1	590	594	PF00917	0.662
DOC_USP7_MATH_1	6	10	PF00917	0.583
DOC_USP7_MATH_1	671	675	PF00917	0.825
DOC_USP7_MATH_1	761	765	PF00917	0.718
DOC_USP7_MATH_1	842	846	PF00917	0.820
DOC_WW_Pin1_4	11	16	PF00397	0.707
DOC_WW_Pin1_4	111	116	PF00397	0.808
DOC_WW_Pin1_4	149	154	PF00397	0.772
DOC_WW_Pin1_4	18	23	PF00397	0.595
DOC_WW_Pin1_4	2	7	PF00397	0.824
DOC_WW_Pin1_4	293	298	PF00397	0.725
DOC_WW_Pin1_4	299	304	PF00397	0.696
DOC_WW_Pin1_4	365	370	PF00397	0.711
DOC_WW_Pin1_4	383	388	PF00397	0.656
DOC_WW_Pin1_4	431	436	PF00397	0.832
DOC_WW_Pin1_4	441	446	PF00397	0.551
DOC_WW_Pin1_4	503	508	PF00397	0.847
DOC_WW_Pin1_4	577	582	PF00397	0.767
DOC_WW_Pin1_4	676	681	PF00397	0.857
DOC_WW_Pin1_4	719	724	PF00397	0.500
LIG_14-3-3_CanoR_1	183	189	PF00244	0.597
LIG_14-3-3_CanoR_1	529	533	PF00244	0.771
LIG_14-3-3_CanoR_1	604	608	PF00244	0.835
LIG_14-3-3_CanoR_1	81	86	PF00244	0.690
LIG_14-3-3_CanoR_1	93	101	PF00244	0.568
LIG_Actin_WH2_2	337	355	PF00022	0.692
LIG_Actin_WH2_2	514	531	PF00022	0.726
LIG_BIR_II_1	1	5	PF00653	0.803
LIG_BIR_III_2	432	436	PF00653	0.738
LIG_BRCT_BRCA1_1	52	56	PF00533	0.566
LIG_BRCT_BRCA1_1	723	727	PF00533	0.732
LIG_eIF4E_1	206	212	PF01652	0.723
LIG_eIF4E_1	554	560	PF01652	0.782
LIG_EVH1_1	543	547	PF00568	0.715
LIG_FHA_1	14	20	PF00498	0.817
LIG_FHA_1	330	336	PF00498	0.672
LIG_FHA_1	394	400	PF00498	0.620
LIG_FHA_1	50	56	PF00498	0.761
LIG_FHA_1	534	540	PF00498	0.765
LIG_FHA_1	559	565	PF00498	0.789
LIG_FHA_1	621	627	PF00498	0.620
LIG_FHA_1	733	739	PF00498	0.688
LIG_FHA_1	827	833	PF00498	0.741
LIG_FHA_2	177	183	PF00498	0.552
LIG_FHA_2	366	372	PF00498	0.768
LIG_FHA_2	442	448	PF00498	0.526
LIG_FHA_2	578	584	PF00498	0.566
LIG_FHA_2	617	623	PF00498	0.555
LIG_FHA_2	694	700	PF00498	0.769
LIG_FHA_2	778	784	PF00498	0.636
LIG_GBD_Chelix_1	340	348	PF00786	0.688
LIG_LIR_Apic_2	793	799	PF02991	0.664
LIG_LIR_Gen_1	32	38	PF02991	0.743
LIG_LIR_Gen_1	346	357	PF02991	0.689
LIG_LIR_Gen_1	412	422	PF02991	0.755
LIG_LIR_Gen_1	811	821	PF02991	0.686
LIG_LIR_Nem_3	32	37	PF02991	0.743
LIG_LIR_Nem_3	346	352	PF02991	0.735
LIG_LIR_Nem_3	355	361	PF02991	0.615
LIG_LIR_Nem_3	412	418	PF02991	0.748
LIG_LIR_Nem_3	53	59	PF02991	0.560
LIG_LIR_Nem_3	786	792	PF02991	0.649
LIG_LIR_Nem_3	811	816	PF02991	0.674
LIG_MYND_1	541	545	PF01753	0.723
LIG_PCNA_yPIPBox_3	218	230	PF02747	0.655
LIG_PDZ_Class_2	858	863	PF00595	0.723
LIG_PTAP_UEV_1	142	147	PF05743	0.604
LIG_Rb_LxCxE_1	414	432	PF01857	0.774
LIG_RPA_C_Fungi	220	232	PF08784	0.653
LIG_SH2_CRK	813	817	PF00017	0.681
LIG_SH2_PTP2	415	418	PF00017	0.763
LIG_SH2_STAP1	781	785	PF00017	0.679
LIG_SH2_STAP1	813	817	PF00017	0.681
LIG_SH2_STAT5	38	41	PF00017	0.735
LIG_SH2_STAT5	415	418	PF00017	0.763
LIG_SH2_STAT5	779	782	PF00017	0.476
LIG_SH3_1	140	146	PF00018	0.556
LIG_SH3_1	538	544	PF00018	0.772
LIG_SH3_3	140	146	PF00018	0.661
LIG_SH3_3	150	156	PF00018	0.588
LIG_SH3_3	160	166	PF00018	0.799
LIG_SH3_3	366	372	PF00018	0.686
LIG_SH3_3	538	544	PF00018	0.822
LIG_SH3_3	615	621	PF00018	0.557
LIG_SH3_3	674	680	PF00018	0.777
LIG_SH3_3	9	15	PF00018	0.656
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.512
LIG_SUMO_SIM_anti_2	783	790	PF11976	0.705
LIG_SUMO_SIM_par_1	732	740	PF11976	0.635
LIG_TRAF2_1	424	427	PF00917	0.724
LIG_TRAF2_1	663	666	PF00917	0.573
LIG_TRAF2_1	800	803	PF00917	0.448
LIG_WW_2	544	547	PF00397	0.710
MOD_CDC14_SPxK_1	506	509	PF00782	0.864
MOD_CDK_SPK_2	299	304	PF00069	0.621
MOD_CDK_SPK_2	503	508	PF00069	0.815
MOD_CDK_SPxK_1	299	305	PF00069	0.623
MOD_CDK_SPxK_1	503	509	PF00069	0.868
MOD_CDK_SPxxK_3	293	300	PF00069	0.727
MOD_CDK_SPxxK_3	383	390	PF00069	0.540
MOD_CDK_SPxxK_3	719	726	PF00069	0.495
MOD_CK1_1	104	110	PF00069	0.796
MOD_CK1_1	149	155	PF00069	0.646
MOD_CK1_1	167	173	PF00069	0.566
MOD_CK1_1	2	8	PF00069	0.815
MOD_CK1_1	224	230	PF00069	0.742
MOD_CK1_1	281	287	PF00069	0.769
MOD_CK1_1	299	305	PF00069	0.568
MOD_CK1_1	30	36	PF00069	0.673
MOD_CK1_1	321	327	PF00069	0.747
MOD_CK1_1	329	335	PF00069	0.672
MOD_CK1_1	379	385	PF00069	0.741
MOD_CK1_1	405	411	PF00069	0.734
MOD_CK1_1	500	506	PF00069	0.595
MOD_CK1_1	522	528	PF00069	0.730
MOD_CK1_1	569	575	PF00069	0.595
MOD_CK1_1	616	622	PF00069	0.672
MOD_CK1_1	660	666	PF00069	0.602
MOD_CK1_1	679	685	PF00069	0.858
MOD_CK1_1	732	738	PF00069	0.688
MOD_CK1_1	755	761	PF00069	0.782
MOD_CK1_1	835	841	PF00069	0.623
MOD_CK2_1	365	371	PF00069	0.764
MOD_CK2_1	458	464	PF00069	0.728
MOD_CK2_1	577	583	PF00069	0.566
MOD_CK2_1	603	609	PF00069	0.819
MOD_CK2_1	616	622	PF00069	0.556
MOD_CK2_1	660	666	PF00069	0.586
MOD_CK2_1	797	803	PF00069	0.458
MOD_GlcNHglycan	1	4	PF01048	0.827
MOD_GlcNHglycan	103	106	PF01048	0.731
MOD_GlcNHglycan	143	146	PF01048	0.730
MOD_GlcNHglycan	195	198	PF01048	0.689
MOD_GlcNHglycan	22	25	PF01048	0.544
MOD_GlcNHglycan	27	30	PF01048	0.651
MOD_GlcNHglycan	318	321	PF01048	0.748
MOD_GlcNHglycan	328	331	PF01048	0.735
MOD_GlcNHglycan	332	335	PF01048	0.703
MOD_GlcNHglycan	378	381	PF01048	0.785
MOD_GlcNHglycan	404	407	PF01048	0.781
MOD_GlcNHglycan	411	414	PF01048	0.636
MOD_GlcNHglycan	460	463	PF01048	0.688
MOD_GlcNHglycan	481	484	PF01048	0.564
MOD_GlcNHglycan	495	498	PF01048	0.668
MOD_GlcNHglycan	570	574	PF01048	0.788
MOD_GlcNHglycan	576	580	PF01048	0.684
MOD_GlcNHglycan	615	618	PF01048	0.850
MOD_GlcNHglycan	662	665	PF01048	0.574
MOD_GlcNHglycan	687	690	PF01048	0.804
MOD_GlcNHglycan	708	711	PF01048	0.730
MOD_GlcNHglycan	713	716	PF01048	0.736
MOD_GlcNHglycan	754	757	PF01048	0.768
MOD_GlcNHglycan	765	768	PF01048	0.680
MOD_GlcNHglycan	799	802	PF01048	0.454
MOD_GlcNHglycan	8	11	PF01048	0.727
MOD_GlcNHglycan	95	98	PF01048	0.635
MOD_GSK3_1	111	118	PF00069	0.689
MOD_GSK3_1	165	172	PF00069	0.599
MOD_GSK3_1	173	180	PF00069	0.767
MOD_GSK3_1	2	9	PF00069	0.693
MOD_GSK3_1	25	32	PF00069	0.553
MOD_GSK3_1	278	285	PF00069	0.727
MOD_GSK3_1	314	321	PF00069	0.663
MOD_GSK3_1	322	329	PF00069	0.599
MOD_GSK3_1	343	350	PF00069	0.651
MOD_GSK3_1	372	379	PF00069	0.757
MOD_GSK3_1	405	412	PF00069	0.732
MOD_GSK3_1	431	438	PF00069	0.740
MOD_GSK3_1	45	52	PF00069	0.767
MOD_GSK3_1	493	500	PF00069	0.762
MOD_GSK3_1	528	535	PF00069	0.719
MOD_GSK3_1	560	567	PF00069	0.766
MOD_GSK3_1	575	582	PF00069	0.827
MOD_GSK3_1	616	623	PF00069	0.638
MOD_GSK3_1	671	678	PF00069	0.672
MOD_GSK3_1	730	737	PF00069	0.635
MOD_GSK3_1	751	758	PF00069	0.780
MOD_GSK3_1	761	768	PF00069	0.668
MOD_GSK3_1	832	839	PF00069	0.500
MOD_GSK3_1	93	100	PF00069	0.705
MOD_N-GLC_1	173	178	PF02516	0.646
MOD_NEK2_1	148	153	PF00069	0.702
MOD_NEK2_1	352	357	PF00069	0.692
MOD_NEK2_1	528	533	PF00069	0.753
MOD_NEK2_1	564	569	PF00069	0.730
MOD_PIKK_1	279	285	PF00454	0.602
MOD_PIKK_1	343	349	PF00454	0.690
MOD_PIKK_1	435	441	PF00454	0.726
MOD_PIKK_1	519	525	PF00454	0.728
MOD_PIKK_1	69	75	PF00454	0.517
MOD_PIKK_1	737	743	PF00454	0.695
MOD_PKA_1	141	147	PF00069	0.747
MOD_PKA_2	141	147	PF00069	0.554
MOD_PKA_2	224	230	PF00069	0.653
MOD_PKA_2	352	358	PF00069	0.696
MOD_PKA_2	528	534	PF00069	0.770
MOD_PKA_2	584	590	PF00069	0.670
MOD_PKA_2	603	609	PF00069	0.819
MOD_PKB_1	423	431	PF00069	0.649
MOD_Plk_1	173	179	PF00069	0.560
MOD_Plk_1	425	431	PF00069	0.647
MOD_Plk_1	446	452	PF00069	0.513
MOD_Plk_1	471	477	PF00069	0.728
MOD_Plk_1	657	663	PF00069	0.802
MOD_Plk_1	783	789	PF00069	0.654
MOD_Plk_1	811	817	PF00069	0.677
MOD_Plk_2-3	777	783	PF00069	0.641
MOD_Plk_4	212	218	PF00069	0.724
MOD_Plk_4	30	36	PF00069	0.785
MOD_Plk_4	411	417	PF00069	0.742
MOD_Plk_4	425	431	PF00069	0.591
MOD_Plk_4	446	452	PF00069	0.758
MOD_Plk_4	657	663	PF00069	0.780
MOD_Plk_4	679	685	PF00069	0.656
MOD_Plk_4	783	789	PF00069	0.654
MOD_Plk_4	811	817	PF00069	0.677
MOD_Plk_4	827	833	PF00069	0.728
MOD_ProDKin_1	11	17	PF00069	0.707
MOD_ProDKin_1	111	117	PF00069	0.810
MOD_ProDKin_1	149	155	PF00069	0.771
MOD_ProDKin_1	18	24	PF00069	0.592
MOD_ProDKin_1	2	8	PF00069	0.823
MOD_ProDKin_1	293	299	PF00069	0.726
MOD_ProDKin_1	365	371	PF00069	0.712
MOD_ProDKin_1	383	389	PF00069	0.658
MOD_ProDKin_1	431	437	PF00069	0.830
MOD_ProDKin_1	441	447	PF00069	0.552
MOD_ProDKin_1	503	509	PF00069	0.847
MOD_ProDKin_1	577	583	PF00069	0.766
MOD_ProDKin_1	676	682	PF00069	0.859
MOD_ProDKin_1	719	725	PF00069	0.495
TRG_DiLeu_BaEn_1	657	662	PF01217	0.770
TRG_DiLeu_BaEn_1	812	817	PF01217	0.675
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.708
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.782
TRG_ENDOCYTIC_2	415	418	PF00928	0.763
TRG_ENDOCYTIC_2	813	816	PF00928	0.678
TRG_ER_diArg_1	128	131	PF00400	0.744
TRG_ER_diArg_1	206	208	PF00400	0.729
TRG_ER_diArg_1	242	245	PF00400	0.531
TRG_ER_diArg_1	303	306	PF00400	0.870
TRG_ER_diArg_1	507	509	PF00400	0.570
TRG_ER_diArg_1	626	628	PF00400	0.778
TRG_ER_diArg_1	852	854	PF00400	0.772
TRG_Pf-PMV_PEXEL_1	515	520	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.814
TRG_Pf-PMV_PEXEL_1	854	859	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJI8	Leishmania donovani	80%	100%
A4H3E3	Leishmania braziliensis	55%	97%
A4HRP8	Leishmania infantum	80%	100%
E9ACC7	Leishmania major	80%	99%