Glycerate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Glycerate kinase

Gene product:

glycerate kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AJL2_LEIMU

TriTrypDb:

LmxM.02.0500

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJL2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0031388	organic acid phosphorylation	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008887	glycerate kinase activity	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.385
CLV_C14_Caspase3-7	237	241	PF00656	0.240
CLV_C14_Caspase3-7	341	345	PF00656	0.421
CLV_C14_Caspase3-7	441	445	PF00656	0.600
CLV_C14_Caspase3-7	590	594	PF00656	0.519
CLV_NRD_NRD_1	259	261	PF00675	0.308
CLV_NRD_NRD_1	607	609	PF00675	0.469
CLV_NRD_NRD_1	695	697	PF00675	0.430
CLV_NRD_NRD_1	759	761	PF00675	0.502
CLV_NRD_NRD_1	905	907	PF00675	0.510
CLV_PCSK_KEX2_1	259	261	PF00082	0.308
CLV_PCSK_KEX2_1	607	609	PF00082	0.469
CLV_PCSK_KEX2_1	669	671	PF00082	0.640
CLV_PCSK_KEX2_1	680	682	PF00082	0.516
CLV_PCSK_KEX2_1	695	697	PF00082	0.409
CLV_PCSK_KEX2_1	759	761	PF00082	0.502
CLV_PCSK_KEX2_1	905	907	PF00082	0.510
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.735
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.516
CLV_PCSK_SKI1_1	242	246	PF00082	0.387
CLV_PCSK_SKI1_1	259	263	PF00082	0.315
CLV_PCSK_SKI1_1	296	300	PF00082	0.443
CLV_PCSK_SKI1_1	332	336	PF00082	0.329
CLV_PCSK_SKI1_1	481	485	PF00082	0.324
CLV_PCSK_SKI1_1	621	625	PF00082	0.383
CLV_PCSK_SKI1_1	763	767	PF00082	0.504
CLV_PCSK_SKI1_1	858	862	PF00082	0.480
CLV_PCSK_SKI1_1	905	909	PF00082	0.615
DEG_APCC_DBOX_1	295	303	PF00400	0.421
DEG_APCC_DBOX_1	853	861	PF00400	0.314
DEG_COP1_1	133	141	PF00400	0.606
DEG_COP1_1	197	206	PF00400	0.211
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DOC_ANK_TNKS_1	439	446	PF00023	0.533
DOC_CKS1_1	174	179	PF01111	0.365
DOC_CKS1_1	873	878	PF01111	0.518
DOC_MAPK_gen_1	759	770	PF00069	0.457
DOC_MAPK_MEF2A_6	259	266	PF00069	0.324
DOC_MAPK_MEF2A_6	48	56	PF00069	0.689
DOC_PP1_RVXF_1	247	254	PF00149	0.306
DOC_PP2B_LxvP_1	148	151	PF13499	0.700
DOC_PP2B_LxvP_1	206	209	PF13499	0.211
DOC_PP2B_LxvP_1	450	453	PF13499	0.522
DOC_PP2B_LxvP_1	66	69	PF13499	0.506
DOC_USP7_MATH_1	381	385	PF00917	0.317
DOC_USP7_MATH_1	451	455	PF00917	0.712
DOC_USP7_MATH_1	586	590	PF00917	0.640
DOC_WW_Pin1_4	137	142	PF00397	0.646
DOC_WW_Pin1_4	173	178	PF00397	0.365
DOC_WW_Pin1_4	18	23	PF00397	0.646
DOC_WW_Pin1_4	242	247	PF00397	0.211
DOC_WW_Pin1_4	28	33	PF00397	0.647
DOC_WW_Pin1_4	315	320	PF00397	0.460
DOC_WW_Pin1_4	377	382	PF00397	0.211
DOC_WW_Pin1_4	431	436	PF00397	0.605
DOC_WW_Pin1_4	452	457	PF00397	0.640
DOC_WW_Pin1_4	499	504	PF00397	0.639
DOC_WW_Pin1_4	506	511	PF00397	0.638
DOC_WW_Pin1_4	77	82	PF00397	0.515
DOC_WW_Pin1_4	872	877	PF00397	0.514
LIG_14-3-3_CanoR_1	249	254	PF00244	0.306
LIG_14-3-3_CanoR_1	285	290	PF00244	0.407
LIG_14-3-3_CanoR_1	481	486	PF00244	0.329
LIG_14-3-3_CanoR_1	55	63	PF00244	0.618
LIG_14-3-3_CanoR_1	550	557	PF00244	0.472
LIG_14-3-3_CanoR_1	763	771	PF00244	0.460
LIG_14-3-3_CanoR_1	854	858	PF00244	0.482
LIG_14-3-3_CanoR_1	868	872	PF00244	0.398
LIG_14-3-3_CanoR_1	905	915	PF00244	0.634
LIG_APCC_ABBA_1	355	360	PF00400	0.421
LIG_BIR_III_2	673	677	PF00653	0.686
LIG_BIR_III_4	816	820	PF00653	0.442
LIG_BRCT_BRCA1_1	616	620	PF00533	0.352
LIG_BRCT_BRCA1_1	655	659	PF00533	0.473
LIG_BRCT_BRCA1_1	836	840	PF00533	0.422
LIG_EH1_1	288	296	PF00400	0.324
LIG_eIF4E_1	289	295	PF01652	0.324
LIG_FHA_1	19	25	PF00498	0.696
LIG_FHA_1	225	231	PF00498	0.303
LIG_FHA_1	642	648	PF00498	0.465
LIG_FHA_1	702	708	PF00498	0.494
LIG_FHA_1	764	770	PF00498	0.543
LIG_FHA_1	809	815	PF00498	0.493
LIG_FHA_1	873	879	PF00498	0.545
LIG_FHA_1	895	901	PF00498	0.348
LIG_FHA_2	200	206	PF00498	0.266
LIG_FHA_2	389	395	PF00498	0.657
LIG_FHA_2	439	445	PF00498	0.686
LIG_FHA_2	663	669	PF00498	0.585
LIG_Integrin_RGD_1	670	672	PF01839	0.601
LIG_IRF3_LxIS_1	50	57	PF10401	0.677
LIG_LIR_Apic_2	862	867	PF02991	0.496
LIG_LIR_Gen_1	197	208	PF02991	0.211
LIG_LIR_Gen_1	778	788	PF02991	0.569
LIG_LIR_Nem_3	197	203	PF02991	0.211
LIG_LIR_Nem_3	245	251	PF02991	0.211
LIG_LIR_Nem_3	559	564	PF02991	0.469
LIG_LIR_Nem_3	617	623	PF02991	0.389
LIG_LIR_Nem_3	778	783	PF02991	0.634
LIG_MAD2	555	563	PF02301	0.460
LIG_MLH1_MIPbox_1	616	620	PF16413	0.352
LIG_MYND_1	64	68	PF01753	0.511
LIG_MYND_1	876	880	PF01753	0.648
LIG_NRBOX	600	606	PF00104	0.416
LIG_PDZ_Class_2	912	917	PF00595	0.474
LIG_PTB_Apo_2	600	607	PF02174	0.306
LIG_PTB_Phospho_1	600	606	PF10480	0.303
LIG_REV1ctd_RIR_1	617	625	PF16727	0.369
LIG_SH2_CRK	72	76	PF00017	0.485
LIG_SH2_CRK	864	868	PF00017	0.488
LIG_SH2_CRK	889	893	PF00017	0.503
LIG_SH2_SRC	219	222	PF00017	0.324
LIG_SH2_SRC	628	631	PF00017	0.393
LIG_SH2_STAP1	889	893	PF00017	0.465
LIG_SH2_STAT3	622	625	PF00017	0.393
LIG_SH2_STAT5	219	222	PF00017	0.324
LIG_SH2_STAT5	428	431	PF00017	0.578
LIG_SH2_STAT5	463	466	PF00017	0.493
LIG_SH2_STAT5	485	488	PF00017	0.209
LIG_SH2_STAT5	622	625	PF00017	0.436
LIG_SH2_STAT5	628	631	PF00017	0.385
LIG_SH2_STAT5	745	748	PF00017	0.450
LIG_SH2_STAT5	780	783	PF00017	0.492
LIG_SH2_STAT5	830	833	PF00017	0.399
LIG_SH2_STAT5	864	867	PF00017	0.390
LIG_SH3_3	133	139	PF00018	0.644
LIG_SH3_3	146	152	PF00018	0.478
LIG_SH3_3	215	221	PF00018	0.324
LIG_SH3_3	26	32	PF00018	0.718
LIG_SH3_3	424	430	PF00018	0.527
LIG_SH3_3	43	49	PF00018	0.595
LIG_SH3_3	450	456	PF00018	0.556
LIG_SH3_3	497	503	PF00018	0.665
LIG_SH3_3	557	563	PF00018	0.466
LIG_SH3_3	870	876	PF00018	0.471
LIG_SUMO_SIM_anti_2	766	772	PF11976	0.387
LIG_SUMO_SIM_par_1	260	265	PF11976	0.324
LIG_TRAF2_1	909	912	PF00917	0.580
MOD_CDK_SPxxK_3	242	249	PF00069	0.211
MOD_CDK_SPxxK_3	28	35	PF00069	0.612
MOD_CK1_1	140	146	PF00069	0.657
MOD_CK1_1	156	162	PF00069	0.484
MOD_CK1_1	23	29	PF00069	0.647
MOD_CK1_1	320	326	PF00069	0.480
MOD_CK1_1	454	460	PF00069	0.546
MOD_CK1_1	502	508	PF00069	0.632
MOD_CK1_1	57	63	PF00069	0.581
MOD_CK1_1	722	728	PF00069	0.432
MOD_CK1_1	894	900	PF00069	0.346
MOD_CK2_1	662	668	PF00069	0.580
MOD_CK2_1	711	717	PF00069	0.467
MOD_CK2_1	906	912	PF00069	0.625
MOD_CMANNOS	109	112	PF00535	0.572
MOD_Cter_Amidation	678	681	PF01082	0.534
MOD_DYRK1A_RPxSP_1	242	246	PF00069	0.211
MOD_GlcNHglycan	117	120	PF01048	0.596
MOD_GlcNHglycan	158	161	PF01048	0.570
MOD_GlcNHglycan	163	166	PF01048	0.534
MOD_GlcNHglycan	242	245	PF01048	0.324
MOD_GlcNHglycan	322	325	PF01048	0.365
MOD_GlcNHglycan	4	7	PF01048	0.561
MOD_GlcNHglycan	459	462	PF01048	0.366
MOD_GlcNHglycan	517	520	PF01048	0.748
MOD_GlcNHglycan	552	555	PF01048	0.432
MOD_GlcNHglycan	56	59	PF01048	0.649
MOD_GlcNHglycan	570	573	PF01048	0.573
MOD_GlcNHglycan	616	619	PF01048	0.352
MOD_GlcNHglycan	655	658	PF01048	0.538
MOD_GlcNHglycan	681	684	PF01048	0.714
MOD_GlcNHglycan	685	688	PF01048	0.637
MOD_GlcNHglycan	709	712	PF01048	0.385
MOD_GlcNHglycan	784	787	PF01048	0.448
MOD_GlcNHglycan	811	814	PF01048	0.534
MOD_GlcNHglycan	836	840	PF01048	0.407
MOD_GlcNHglycan	861	864	PF01048	0.394
MOD_GlcNHglycan	881	884	PF01048	0.432
MOD_GlcNHglycan	893	896	PF01048	0.457
MOD_GlcNHglycan	908	911	PF01048	0.523
MOD_GSK3_1	137	144	PF00069	0.654
MOD_GSK3_1	187	194	PF00069	0.331
MOD_GSK3_1	220	227	PF00069	0.322
MOD_GSK3_1	313	320	PF00069	0.316
MOD_GSK3_1	377	384	PF00069	0.411
MOD_GSK3_1	434	441	PF00069	0.656
MOD_GSK3_1	502	509	PF00069	0.645
MOD_GSK3_1	679	686	PF00069	0.677
MOD_GSK3_1	707	714	PF00069	0.392
MOD_GSK3_1	778	785	PF00069	0.478
MOD_GSK3_1	804	811	PF00069	0.704
MOD_GSK3_1	87	94	PF00069	0.524
MOD_NEK2_1	153	158	PF00069	0.592
MOD_NEK2_1	185	190	PF00069	0.324
MOD_NEK2_1	54	59	PF00069	0.658
MOD_NEK2_1	641	646	PF00069	0.345
MOD_NEK2_1	730	735	PF00069	0.266
MOD_NEK2_1	834	839	PF00069	0.390
MOD_NEK2_1	900	905	PF00069	0.465
MOD_NEK2_1	91	96	PF00069	0.509
MOD_NEK2_2	87	92	PF00069	0.538
MOD_OFUCOSY	700	705	PF10250	0.402
MOD_OFUCOSY	844	849	PF10250	0.364
MOD_PIKK_1	642	648	PF00454	0.341
MOD_PKA_1	905	911	PF00069	0.558
MOD_PKA_2	284	290	PF00069	0.407
MOD_PKA_2	364	370	PF00069	0.403
MOD_PKA_2	54	60	PF00069	0.758
MOD_PKA_2	853	859	PF00069	0.462
MOD_PKA_2	867	873	PF00069	0.424
MOD_PKA_2	905	911	PF00069	0.558
MOD_Plk_1	204	210	PF00069	0.211
MOD_Plk_1	473	479	PF00069	0.436
MOD_Plk_1	642	648	PF00069	0.353
MOD_Plk_1	716	722	PF00069	0.464
MOD_Plk_1	730	736	PF00069	0.442
MOD_Plk_1	778	784	PF00069	0.485
MOD_Plk_1	835	841	PF00069	0.293
MOD_Plk_1	900	906	PF00069	0.569
MOD_Plk_1	911	917	PF00069	0.545
MOD_Plk_4	153	159	PF00069	0.594
MOD_Plk_4	473	479	PF00069	0.345
MOD_Plk_4	556	562	PF00069	0.507
MOD_Plk_4	716	722	PF00069	0.505
MOD_Plk_4	791	797	PF00069	0.407
MOD_Plk_4	867	873	PF00069	0.411
MOD_Plk_4	874	880	PF00069	0.531
MOD_ProDKin_1	137	143	PF00069	0.645
MOD_ProDKin_1	173	179	PF00069	0.365
MOD_ProDKin_1	18	24	PF00069	0.648
MOD_ProDKin_1	242	248	PF00069	0.211
MOD_ProDKin_1	28	34	PF00069	0.648
MOD_ProDKin_1	315	321	PF00069	0.460
MOD_ProDKin_1	377	383	PF00069	0.211
MOD_ProDKin_1	431	437	PF00069	0.611
MOD_ProDKin_1	452	458	PF00069	0.633
MOD_ProDKin_1	499	505	PF00069	0.640
MOD_ProDKin_1	506	512	PF00069	0.640
MOD_ProDKin_1	77	83	PF00069	0.502
MOD_ProDKin_1	872	878	PF00069	0.523
TRG_DiLeu_BaEn_1	258	263	PF01217	0.421
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.391
TRG_ENDOCYTIC_2	780	783	PF00928	0.584
TRG_ENDOCYTIC_2	889	892	PF00928	0.512
TRG_ER_diArg_1	259	261	PF00400	0.308
TRG_ER_diArg_1	606	608	PF00400	0.487
TRG_ER_diArg_1	694	696	PF00400	0.437
TRG_ER_diArg_1	904	906	PF00400	0.502
TRG_NES_CRM1_1	408	421	PF08389	0.402
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	763	767	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L9	Leptomonas seymouri	45%	100%
A0A3S5H505	Leishmania donovani	85%	97%
A4H3E1	Leishmania braziliensis	67%	100%
A4HRP5	Leishmania infantum	85%	97%
E9ACC4	Leishmania major	85%	100%