Rhomboid-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan S-, family S54, putative

Species:

Leishmania mexicana

UniProt:

E9AJK6_LEIMU

TriTrypDb:

LmxM.02.0430

Length:

370

Annotations

LeishMANIAdb annotations

Despite the signature matches, it is both structurally and sequence-wise very dissimilar from rhomboids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AJK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJK6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0006066	alcohol metabolic process	3	3
GO:0006071	glycerol metabolic process	5	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0019400	alditol metabolic process	4	3
GO:0019751	polyol metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044262	obsolete cellular carbohydrate metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901615	organic hydroxy compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004371	glycerone kinase activity	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0004175	endopeptidase activity	4	4
GO:0004252	serine-type endopeptidase activity	5	4
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	4
GO:0016787	hydrolase activity	2	4
GO:0017171	serine hydrolase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.494
CLV_C14_Caspase3-7	228	232	PF00656	0.443
CLV_NRD_NRD_1	173	175	PF00675	0.375
CLV_NRD_NRD_1	298	300	PF00675	0.480
CLV_NRD_NRD_1	336	338	PF00675	0.623
CLV_NRD_NRD_1	340	342	PF00675	0.630
CLV_NRD_NRD_1	349	351	PF00675	0.624
CLV_NRD_NRD_1	97	99	PF00675	0.743
CLV_PCSK_KEX2_1	173	175	PF00082	0.333
CLV_PCSK_KEX2_1	298	300	PF00082	0.480
CLV_PCSK_KEX2_1	340	342	PF00082	0.631
CLV_PCSK_KEX2_1	348	350	PF00082	0.623
CLV_PCSK_KEX2_1	51	53	PF00082	0.482
CLV_PCSK_KEX2_1	97	99	PF00082	0.745
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.482
CLV_PCSK_SKI1_1	128	132	PF00082	0.692
CLV_PCSK_SKI1_1	256	260	PF00082	0.366
CLV_PCSK_SKI1_1	298	302	PF00082	0.484
CLV_PCSK_SKI1_1	55	59	PF00082	0.537
DOC_CDC14_PxL_1	11	19	PF14671	0.394
DOC_CYCLIN_RxL_1	337	347	PF00134	0.383
DOC_MAPK_gen_1	337	344	PF00069	0.376
DOC_MAPK_gen_1	38	48	PF00069	0.382
DOC_MAPK_gen_1	51	62	PF00069	0.282
DOC_MAPK_MEF2A_6	357	366	PF00069	0.363
DOC_MAPK_MEF2A_6	55	64	PF00069	0.316
DOC_PP2B_LxvP_1	263	266	PF13499	0.596
DOC_PP2B_LxvP_1	282	285	PF13499	0.466
DOC_USP7_MATH_1	108	112	PF00917	0.536
DOC_USP7_MATH_1	115	119	PF00917	0.494
DOC_USP7_MATH_1	217	221	PF00917	0.579
DOC_USP7_MATH_1	300	304	PF00917	0.682
LIG_14-3-3_CanoR_1	122	131	PF00244	0.529
LIG_14-3-3_CanoR_1	256	265	PF00244	0.574
LIG_14-3-3_CanoR_1	299	309	PF00244	0.678
LIG_14-3-3_CanoR_1	341	351	PF00244	0.281
LIG_14-3-3_CanoR_1	41	47	PF00244	0.459
LIG_14-3-3_CanoR_1	55	64	PF00244	0.352
LIG_FHA_1	167	173	PF00498	0.571
LIG_FHA_1	302	308	PF00498	0.686
LIG_FHA_1	309	315	PF00498	0.642
LIG_FHA_1	69	75	PF00498	0.438
LIG_FHA_2	77	83	PF00498	0.310
LIG_FHA_2	87	93	PF00498	0.417
LIG_FHA_2	99	105	PF00498	0.538
LIG_LIR_Gen_1	259	269	PF02991	0.565
LIG_LIR_Gen_1	360	370	PF02991	0.337
LIG_LIR_Gen_1	58	69	PF02991	0.383
LIG_LIR_Nem_3	259	264	PF02991	0.562
LIG_LIR_Nem_3	303	308	PF02991	0.684
LIG_LIR_Nem_3	360	366	PF02991	0.522
LIG_LIR_Nem_3	58	64	PF02991	0.384
LIG_LIR_Nem_3	82	86	PF02991	0.374
LIG_PDZ_Class_1	365	370	PF00595	0.514
LIG_Pex14_1	327	331	PF04695	0.181
LIG_Pex14_2	323	327	PF04695	0.181
LIG_RPA_C_Fungi	169	181	PF08784	0.499
LIG_SH2_PTP2	279	282	PF00017	0.512
LIG_SH2_PTP2	363	366	PF00017	0.420
LIG_SH2_STAP1	292	296	PF00017	0.555
LIG_SH2_STAT5	279	282	PF00017	0.534
LIG_SH2_STAT5	331	334	PF00017	0.420
LIG_SH2_STAT5	363	366	PF00017	0.516
LIG_Sin3_3	261	268	PF02671	0.432
LIG_SUMO_SIM_par_1	15	21	PF11976	0.415
LIG_TRAF2_1	225	228	PF00917	0.510
LIG_UBA3_1	200	206	PF00899	0.491
LIG_WRC_WIRS_1	73	78	PF05994	0.487
MOD_CK1_1	193	199	PF00069	0.421
MOD_CK1_1	247	253	PF00069	0.474
MOD_CK2_1	222	228	PF00069	0.515
MOD_CK2_1	76	82	PF00069	0.366
MOD_CK2_1	86	92	PF00069	0.500
MOD_GlcNHglycan	105	111	PF01048	0.595
MOD_GlcNHglycan	117	120	PF01048	0.505
MOD_GlcNHglycan	142	145	PF01048	0.450
MOD_GlcNHglycan	193	196	PF01048	0.452
MOD_GlcNHglycan	224	227	PF01048	0.503
MOD_GlcNHglycan	239	242	PF01048	0.268
MOD_GlcNHglycan	246	249	PF01048	0.338
MOD_GlcNHglycan	25	28	PF01048	0.548
MOD_GSK3_1	18	25	PF00069	0.431
MOD_GSK3_1	283	290	PF00069	0.486
MOD_GSK3_1	68	75	PF00069	0.477
MOD_LATS_1	254	260	PF00433	0.266
MOD_N-GLC_1	166	171	PF02516	0.449
MOD_NEK2_1	222	227	PF00069	0.536
MOD_NEK2_1	301	306	PF00069	0.662
MOD_NEK2_1	342	347	PF00069	0.541
MOD_NEK2_1	76	81	PF00069	0.362
MOD_PIKK_1	158	164	PF00454	0.181
MOD_PIKK_1	308	314	PF00454	0.536
MOD_PIKK_1	342	348	PF00454	0.324
MOD_PIKK_1	357	363	PF00454	0.370
MOD_PKA_1	97	103	PF00069	0.621
MOD_PKA_2	336	342	PF00069	0.278
MOD_PKA_2	97	103	PF00069	0.721
MOD_Plk_1	166	172	PF00069	0.446
TRG_ENDOCYTIC_2	165	168	PF00928	0.504
TRG_ENDOCYTIC_2	279	282	PF00928	0.529
TRG_ENDOCYTIC_2	331	334	PF00928	0.483
TRG_ENDOCYTIC_2	363	366	PF00928	0.420
TRG_ER_diArg_1	134	137	PF00400	0.512
TRG_ER_diArg_1	172	174	PF00400	0.453
TRG_ER_diArg_1	211	214	PF00400	0.461
TRG_ER_diArg_1	340	343	PF00400	0.505
TRG_ER_diArg_1	348	350	PF00400	0.552
TRG_ER_diArg_1	364	367	PF00400	0.536
TRG_ER_diArg_1	97	99	PF00400	0.627
TRG_NLS_MonoExtC_3	336	341	PF00514	0.538
TRG_PTS1	367	370	PF00515	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG61	Leptomonas seymouri	54%	100%
A0A1X0NK02	Trypanosomatidae	33%	100%
A0A3R7KGS4	Trypanosoma rangeli	30%	100%
A0A3S5H501	Leishmania donovani	85%	100%
A4H3C4	Leishmania braziliensis	65%	100%
A4HRP0	Leishmania infantum	85%	100%
C9ZJ23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACB8	Leishmania major	84%	100%
V5BCY2	Trypanosoma cruzi	30%	71%