Putative RNA-editing complex protein MP81

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid RNA editing protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AJK4_LEIMU

TriTrypDb:

LmxM.02.0410

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AJK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJK4

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070705	RNA nucleotide insertion	6	1
GO:0070706	RNA nucleotide deletion	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1900864	mitochondrial RNA modification	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045294	alpha-catenin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.588
CLV_C14_Caspase3-7	227	231	PF00656	0.612
CLV_C14_Caspase3-7	608	612	PF00656	0.528
CLV_C14_Caspase3-7	68	72	PF00656	0.692
CLV_C14_Caspase3-7	833	837	PF00656	0.539
CLV_C14_Caspase3-7	864	868	PF00656	0.587
CLV_C14_Caspase3-7	883	887	PF00656	0.765
CLV_NRD_NRD_1	1007	1009	PF00675	0.474
CLV_NRD_NRD_1	2	4	PF00675	0.625
CLV_NRD_NRD_1	217	219	PF00675	0.699
CLV_NRD_NRD_1	292	294	PF00675	0.494
CLV_NRD_NRD_1	496	498	PF00675	0.751
CLV_NRD_NRD_1	638	640	PF00675	0.567
CLV_PCSK_KEX2_1	1007	1009	PF00082	0.474
CLV_PCSK_KEX2_1	169	171	PF00082	0.620
CLV_PCSK_KEX2_1	2	4	PF00082	0.625
CLV_PCSK_KEX2_1	217	219	PF00082	0.699
CLV_PCSK_KEX2_1	291	293	PF00082	0.490
CLV_PCSK_KEX2_1	446	448	PF00082	0.651
CLV_PCSK_KEX2_1	495	497	PF00082	0.614
CLV_PCSK_KEX2_1	638	640	PF00082	0.567
CLV_PCSK_KEX2_1	821	823	PF00082	0.611
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.620
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.651
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.614
CLV_PCSK_PC1ET2_1	821	823	PF00082	0.573
CLV_PCSK_PC7_1	288	294	PF00082	0.470
CLV_PCSK_PC7_1	442	448	PF00082	0.487
CLV_PCSK_SKI1_1	111	115	PF00082	0.392
CLV_PCSK_SKI1_1	26	30	PF00082	0.613
CLV_PCSK_SKI1_1	638	642	PF00082	0.562
CLV_PCSK_SKI1_1	660	664	PF00082	0.521
DEG_APCC_DBOX_1	152	160	PF00400	0.550
DEG_APCC_DBOX_1	5	13	PF00400	0.649
DEG_APCC_DBOX_1	637	645	PF00400	0.557
DEG_APCC_DBOX_1	804	812	PF00400	0.594
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DEG_SPOP_SBC_1	202	206	PF00917	0.758
DEG_SPOP_SBC_1	85	89	PF00917	0.491
DOC_ANK_TNKS_1	483	490	PF00023	0.631
DOC_CDC14_PxL_1	508	516	PF14671	0.497
DOC_CYCLIN_RxL_1	108	116	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	651	654	PF00134	0.613
DOC_MAPK_DCC_7	455	463	PF00069	0.688
DOC_MAPK_DCC_7	969	979	PF00069	0.531
DOC_MAPK_gen_1	495	504	PF00069	0.552
DOC_MAPK_HePTP_8	1005	1017	PF00069	0.558
DOC_MAPK_MEF2A_6	1008	1017	PF00069	0.427
DOC_MAPK_MEF2A_6	120	127	PF00069	0.580
DOC_MAPK_MEF2A_6	397	404	PF00069	0.530
DOC_MAPK_MEF2A_6	455	463	PF00069	0.688
DOC_MAPK_MEF2A_6	579	588	PF00069	0.592
DOC_PIKK_1	406	413	PF02985	0.453
DOC_PP1_RVXF_1	399	405	PF00149	0.466
DOC_PP2B_LxvP_1	125	128	PF13499	0.604
DOC_PP2B_LxvP_1	211	214	PF13499	0.697
DOC_PP2B_LxvP_1	651	654	PF13499	0.613
DOC_PP4_FxxP_1	456	459	PF00568	0.589
DOC_SPAK_OSR1_1	455	459	PF12202	0.592
DOC_USP7_MATH_1	224	228	PF00917	0.646
DOC_USP7_MATH_1	231	235	PF00917	0.656
DOC_USP7_MATH_1	238	242	PF00917	0.645
DOC_USP7_MATH_1	24	28	PF00917	0.627
DOC_USP7_MATH_1	243	247	PF00917	0.675
DOC_USP7_MATH_1	248	252	PF00917	0.530
DOC_USP7_MATH_1	356	360	PF00917	0.508
DOC_USP7_MATH_1	379	383	PF00917	0.771
DOC_USP7_MATH_1	445	449	PF00917	0.562
DOC_USP7_MATH_1	598	602	PF00917	0.591
DOC_USP7_MATH_1	604	608	PF00917	0.679
DOC_USP7_MATH_1	662	666	PF00917	0.652
DOC_USP7_MATH_1	703	707	PF00917	0.785
DOC_USP7_MATH_1	716	720	PF00917	0.657
DOC_USP7_MATH_1	85	89	PF00917	0.500
DOC_USP7_MATH_1	866	870	PF00917	0.559
DOC_USP7_MATH_1	875	879	PF00917	0.570
DOC_USP7_MATH_1	932	936	PF00917	0.505
DOC_USP7_MATH_1	942	946	PF00917	0.613
DOC_WW_Pin1_4	37	42	PF00397	0.768
DOC_WW_Pin1_4	396	401	PF00397	0.608
DOC_WW_Pin1_4	483	488	PF00397	0.632
DOC_WW_Pin1_4	503	508	PF00397	0.432
DOC_WW_Pin1_4	566	571	PF00397	0.584
DOC_WW_Pin1_4	612	617	PF00397	0.674
DOC_WW_Pin1_4	870	875	PF00397	0.753
DOC_WW_Pin1_4	90	95	PF00397	0.551
LIG_14-3-3_CanoR_1	1007	1015	PF00244	0.443
LIG_14-3-3_CanoR_1	2	9	PF00244	0.655
LIG_14-3-3_CanoR_1	291	300	PF00244	0.397
LIG_14-3-3_CanoR_1	310	318	PF00244	0.396
LIG_14-3-3_CanoR_1	350	356	PF00244	0.677
LIG_14-3-3_CanoR_1	36	41	PF00244	0.740
LIG_14-3-3_CanoR_1	480	484	PF00244	0.655
LIG_14-3-3_CanoR_1	496	505	PF00244	0.586
LIG_14-3-3_CanoR_1	822	830	PF00244	0.657
LIG_APCC_ABBA_1	582	587	PF00400	0.592
LIG_BIR_III_4	941	945	PF00653	0.649
LIG_BRCT_BRCA1_1	92	96	PF00533	0.477
LIG_BRCT_BRCA1_1	987	991	PF00533	0.487
LIG_CSL_BTD_1	211	214	PF09270	0.531
LIG_CtBP_PxDLS_1	653	657	PF00389	0.625
LIG_deltaCOP1_diTrp_1	619	626	PF00928	0.693
LIG_deltaCOP1_diTrp_1	730	734	PF00928	0.503
LIG_EH_1	563	567	PF12763	0.560
LIG_EH_1	582	586	PF12763	0.591
LIG_FHA_1	206	212	PF00498	0.649
LIG_FHA_1	266	272	PF00498	0.614
LIG_FHA_1	30	36	PF00498	0.741
LIG_FHA_1	350	356	PF00498	0.677
LIG_FHA_1	397	403	PF00498	0.577
LIG_FHA_1	8	14	PF00498	0.522
LIG_FHA_1	916	922	PF00498	0.465
LIG_FHA_1	987	993	PF00498	0.381
LIG_FHA_1	99	105	PF00498	0.593
LIG_FHA_2	110	116	PF00498	0.468
LIG_FHA_2	179	185	PF00498	0.733
LIG_FHA_2	293	299	PF00498	0.368
LIG_FHA_2	47	53	PF00498	0.615
LIG_FHA_2	547	553	PF00498	0.540
LIG_FHA_2	606	612	PF00498	0.765
LIG_FHA_2	616	622	PF00498	0.575
LIG_FHA_2	823	829	PF00498	0.666
LIG_FHA_2	831	837	PF00498	0.607
LIG_FHA_2	881	887	PF00498	0.747
LIG_FHA_2	904	910	PF00498	0.529
LIG_LIR_Apic_2	559	565	PF02991	0.537
LIG_LIR_Gen_1	415	424	PF02991	0.477
LIG_LIR_Nem_3	1009	1015	PF02991	0.433
LIG_LIR_Nem_3	415	421	PF02991	0.477
LIG_LIR_Nem_3	503	508	PF02991	0.543
LIG_LIR_Nem_3	730	735	PF02991	0.498
LIG_LIR_Nem_3	787	793	PF02991	0.512
LIG_LYPXL_yS_3	1012	1015	PF13949	0.418
LIG_MYND_1	129	133	PF01753	0.629
LIG_MYND_1	512	516	PF01753	0.671
LIG_MYND_1	650	654	PF01753	0.559
LIG_NRBOX	8	14	PF00104	0.507
LIG_PDZ_Class_2	1024	1029	PF00595	0.567
LIG_Pex14_1	790	794	PF04695	0.530
LIG_Pex14_2	98	102	PF04695	0.586
LIG_PTAP_UEV_1	386	391	PF05743	0.501
LIG_SH2_CRK	631	635	PF00017	0.573
LIG_SH2_PTP2	1014	1017	PF00017	0.384
LIG_SH2_STAP1	31	35	PF00017	0.503
LIG_SH2_STAP1	330	334	PF00017	0.555
LIG_SH2_STAP1	735	739	PF00017	0.528
LIG_SH2_STAT5	1014	1017	PF00017	0.384
LIG_SH2_STAT5	31	34	PF00017	0.500
LIG_SH2_STAT5	923	926	PF00017	0.377
LIG_SH3_3	1014	1020	PF00018	0.403
LIG_SH3_3	130	136	PF00018	0.630
LIG_SH3_3	138	144	PF00018	0.614
LIG_SH3_3	210	216	PF00018	0.526
LIG_SH3_3	232	238	PF00018	0.736
LIG_SH3_3	271	277	PF00018	0.514
LIG_SH3_3	381	387	PF00018	0.728
LIG_SH3_3	399	405	PF00018	0.572
LIG_SH3_3	501	507	PF00018	0.615
LIG_SH3_3	578	584	PF00018	0.595
LIG_SH3_3	61	67	PF00018	0.611
LIG_SH3_3	610	616	PF00018	0.760
LIG_SH3_3	647	653	PF00018	0.581
LIG_SH3_3	814	820	PF00018	0.555
LIG_SUMO_SIM_anti_2	411	420	PF11976	0.436
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.627
LIG_SUMO_SIM_anti_2	962	969	PF11976	0.438
LIG_SUMO_SIM_par_1	460	465	PF11976	0.627
LIG_SUMO_SIM_par_1	900	906	PF11976	0.546
LIG_TRAF2_1	295	298	PF00917	0.533
LIG_TRAF2_1	549	552	PF00917	0.546
MOD_CDK_SPK_2	396	401	PF00069	0.646
MOD_CDK_SPxxK_3	37	44	PF00069	0.699
MOD_CK1_1	1006	1012	PF00069	0.458
MOD_CK1_1	241	247	PF00069	0.628
MOD_CK1_1	309	315	PF00069	0.621
MOD_CK1_1	336	342	PF00069	0.552
MOD_CK1_1	39	45	PF00069	0.765
MOD_CK1_1	448	454	PF00069	0.542
MOD_CK1_1	46	52	PF00069	0.625
MOD_CK1_1	5	11	PF00069	0.783
MOD_CK1_1	500	506	PF00069	0.597
MOD_CK1_1	615	621	PF00069	0.641
MOD_CK1_1	699	705	PF00069	0.613
MOD_CK1_1	707	713	PF00069	0.574
MOD_CK1_1	826	832	PF00069	0.618
MOD_CK1_1	873	879	PF00069	0.656
MOD_CK1_1	931	937	PF00069	0.563
MOD_CK2_1	109	115	PF00069	0.469
MOD_CK2_1	178	184	PF00069	0.739
MOD_CK2_1	243	249	PF00069	0.758
MOD_CK2_1	292	298	PF00069	0.371
MOD_CK2_1	546	552	PF00069	0.556
MOD_CK2_1	574	580	PF00069	0.597
MOD_CK2_1	615	621	PF00069	0.518
MOD_CK2_1	682	688	PF00069	0.542
MOD_CK2_1	781	787	PF00069	0.606
MOD_CK2_1	822	828	PF00069	0.741
MOD_GlcNHglycan	149	152	PF01048	0.691
MOD_GlcNHglycan	174	177	PF01048	0.632
MOD_GlcNHglycan	226	229	PF01048	0.652
MOD_GlcNHglycan	245	248	PF01048	0.640
MOD_GlcNHglycan	26	29	PF01048	0.620
MOD_GlcNHglycan	283	286	PF01048	0.488
MOD_GlcNHglycan	306	309	PF01048	0.669
MOD_GlcNHglycan	311	314	PF01048	0.691
MOD_GlcNHglycan	358	361	PF01048	0.699
MOD_GlcNHglycan	387	390	PF01048	0.628
MOD_GlcNHglycan	45	48	PF01048	0.558
MOD_GlcNHglycan	499	502	PF01048	0.545
MOD_GlcNHglycan	55	58	PF01048	0.726
MOD_GlcNHglycan	60	64	PF01048	0.678
MOD_GlcNHglycan	600	603	PF01048	0.727
MOD_GlcNHglycan	664	667	PF01048	0.732
MOD_GlcNHglycan	67	70	PF01048	0.564
MOD_GlcNHglycan	698	701	PF01048	0.573
MOD_GlcNHglycan	709	712	PF01048	0.591
MOD_GlcNHglycan	71	74	PF01048	0.553
MOD_GlcNHglycan	716	719	PF01048	0.581
MOD_GlcNHglycan	825	828	PF01048	0.766
MOD_GlcNHglycan	854	857	PF01048	0.643
MOD_GlcNHglycan	875	878	PF01048	0.662
MOD_GlcNHglycan	896	899	PF01048	0.533
MOD_GlcNHglycan	930	933	PF01048	0.604
MOD_GlcNHglycan	934	937	PF01048	0.640
MOD_GlcNHglycan	938	941	PF01048	0.637
MOD_GSK3_1	1	8	PF00069	0.636
MOD_GSK3_1	172	179	PF00069	0.685
MOD_GSK3_1	201	208	PF00069	0.643
MOD_GSK3_1	226	233	PF00069	0.700
MOD_GSK3_1	254	261	PF00069	0.594
MOD_GSK3_1	304	311	PF00069	0.462
MOD_GSK3_1	333	340	PF00069	0.574
MOD_GSK3_1	36	43	PF00069	0.660
MOD_GSK3_1	479	486	PF00069	0.622
MOD_GSK3_1	496	503	PF00069	0.595
MOD_GSK3_1	611	618	PF00069	0.672
MOD_GSK3_1	65	72	PF00069	0.737
MOD_GSK3_1	662	669	PF00069	0.794
MOD_GSK3_1	695	702	PF00069	0.674
MOD_GSK3_1	703	710	PF00069	0.760
MOD_GSK3_1	822	829	PF00069	0.629
MOD_GSK3_1	86	93	PF00069	0.741
MOD_GSK3_1	862	869	PF00069	0.677
MOD_GSK3_1	881	888	PF00069	0.647
MOD_GSK3_1	927	934	PF00069	0.612
MOD_GSK3_1	98	105	PF00069	0.730
MOD_N-GLC_1	928	933	PF02516	0.540
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	109	114	PF00069	0.483
MOD_NEK2_1	203	208	PF00069	0.642
MOD_NEK2_1	29	34	PF00069	0.642
MOD_NEK2_1	53	58	PF00069	0.781
MOD_NEK2_1	86	91	PF00069	0.730
MOD_NEK2_1	903	908	PF00069	0.473
MOD_NEK2_1	915	920	PF00069	0.366
MOD_NEK2_1	98	103	PF00069	0.684
MOD_NEK2_1	986	991	PF00069	0.514
MOD_PIKK_1	514	520	PF00454	0.678
MOD_PK_1	333	339	PF00069	0.515
MOD_PKA_1	2	8	PF00069	0.629
MOD_PKA_1	292	298	PF00069	0.371
MOD_PKA_1	496	502	PF00069	0.720
MOD_PKA_1	821	827	PF00069	0.649
MOD_PKA_2	1	7	PF00069	0.639
MOD_PKA_2	1006	1012	PF00069	0.458
MOD_PKA_2	194	200	PF00069	0.674
MOD_PKA_2	292	298	PF00069	0.371
MOD_PKA_2	309	315	PF00069	0.441
MOD_PKA_2	349	355	PF00069	0.681
MOD_PKA_2	43	49	PF00069	0.632
MOD_PKA_2	479	485	PF00069	0.535
MOD_PKA_2	496	502	PF00069	0.689
MOD_PKA_2	821	827	PF00069	0.649
MOD_PKA_2	927	933	PF00069	0.601
MOD_PKB_1	170	178	PF00069	0.664
MOD_PKB_1	680	688	PF00069	0.542
MOD_Plk_1	248	254	PF00069	0.680
MOD_Plk_1	551	557	PF00069	0.518
MOD_Plk_1	781	787	PF00069	0.514
MOD_Plk_2-3	783	789	PF00069	0.531
MOD_Plk_4	275	281	PF00069	0.569
MOD_Plk_4	457	463	PF00069	0.689
MOD_Plk_4	500	506	PF00069	0.589
MOD_Plk_4	652	658	PF00069	0.682
MOD_Plk_4	8	14	PF00069	0.507
MOD_Plk_4	98	104	PF00069	0.702
MOD_Plk_4	986	992	PF00069	0.388
MOD_ProDKin_1	37	43	PF00069	0.770
MOD_ProDKin_1	396	402	PF00069	0.605
MOD_ProDKin_1	483	489	PF00069	0.631
MOD_ProDKin_1	503	509	PF00069	0.433
MOD_ProDKin_1	566	572	PF00069	0.581
MOD_ProDKin_1	612	618	PF00069	0.668
MOD_ProDKin_1	870	876	PF00069	0.754
MOD_ProDKin_1	90	96	PF00069	0.552
MOD_SUMO_rev_2	326	335	PF00179	0.546
MOD_SUMO_rev_2	587	593	PF00179	0.527
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.741
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.684
TRG_DiLeu_BaLyEn_6	740	745	PF01217	0.577
TRG_DiLeu_BaLyEn_6	788	793	PF01217	0.405
TRG_DiLeu_LyEn_5	721	726	PF01217	0.464
TRG_ENDOCYTIC_2	1012	1015	PF00928	0.418
TRG_ENDOCYTIC_2	815	818	PF00928	0.503
TRG_ER_diArg_1	1	3	PF00400	0.660
TRG_ER_diArg_1	14	17	PF00400	0.532
TRG_ER_diArg_1	216	218	PF00400	0.532
TRG_ER_diArg_1	290	293	PF00400	0.473
TRG_ER_diArg_1	496	498	PF00400	0.751
TRG_ER_diArg_1	680	683	PF00400	0.540
TRG_NES_CRM1_1	411	427	PF08389	0.485
TRG_NLS_MonoExtN_4	492	499	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	639	643	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0H5	Leptomonas seymouri	44%	97%
A0A3S5H4Z9	Leishmania donovani	81%	90%
A4H3D6	Leishmania braziliensis	63%	97%
A4HRN8	Leishmania infantum	81%	93%
Q6T446	Leishmania major	80%	99%