Pecanex-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UAA transporter family, putative

Species:

Leishmania mexicana

UniProt:

E9AJJ7_LEIMU

TriTrypDb:

LmxM.02.0340

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AJJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0009987	cellular process	1	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.757
CLV_C14_Caspase3-7	317	321	PF00656	0.802
CLV_NRD_NRD_1	240	242	PF00675	0.451
CLV_NRD_NRD_1	351	353	PF00675	0.593
CLV_NRD_NRD_1	391	393	PF00675	0.596
CLV_NRD_NRD_1	403	405	PF00675	0.546
CLV_NRD_NRD_1	651	653	PF00675	0.638
CLV_NRD_NRD_1	806	808	PF00675	0.734
CLV_NRD_NRD_1	823	825	PF00675	0.572
CLV_NRD_NRD_1	895	897	PF00675	0.530
CLV_NRD_NRD_1	910	912	PF00675	0.458
CLV_NRD_NRD_1	936	938	PF00675	0.524
CLV_PCSK_FUR_1	934	938	PF00082	0.517
CLV_PCSK_KEX2_1	240	242	PF00082	0.451
CLV_PCSK_KEX2_1	351	353	PF00082	0.593
CLV_PCSK_KEX2_1	391	393	PF00082	0.596
CLV_PCSK_KEX2_1	403	405	PF00082	0.542
CLV_PCSK_KEX2_1	439	441	PF00082	0.531
CLV_PCSK_KEX2_1	651	653	PF00082	0.638
CLV_PCSK_KEX2_1	806	808	PF00082	0.734
CLV_PCSK_KEX2_1	823	825	PF00082	0.572
CLV_PCSK_KEX2_1	910	912	PF00082	0.636
CLV_PCSK_KEX2_1	934	936	PF00082	0.512
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.502
CLV_PCSK_PC7_1	236	242	PF00082	0.449
CLV_PCSK_PC7_1	399	405	PF00082	0.402
CLV_PCSK_SKI1_1	240	244	PF00082	0.455
CLV_PCSK_SKI1_1	378	382	PF00082	0.457
CLV_PCSK_SKI1_1	427	431	PF00082	0.539
CLV_PCSK_SKI1_1	481	485	PF00082	0.436
CLV_PCSK_SKI1_1	538	542	PF00082	0.698
CLV_PCSK_SKI1_1	759	763	PF00082	0.686
CLV_PCSK_SKI1_1	829	833	PF00082	0.597
CLV_PCSK_SKI1_1	896	900	PF00082	0.530
CLV_PCSK_SKI1_1	910	914	PF00082	0.470
CLV_Separin_Metazoa	467	471	PF03568	0.684
CLV_Separin_Metazoa	606	610	PF03568	0.369
DEG_APCC_DBOX_1	519	527	PF00400	0.382
DEG_APCC_DBOX_1	895	903	PF00400	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.782
DEG_SPOP_SBC_1	29	33	PF00917	0.806
DEG_SPOP_SBC_1	587	591	PF00917	0.419
DOC_ANK_TNKS_1	183	190	PF00023	0.814
DOC_CKS1_1	134	139	PF01111	0.642
DOC_CYCLIN_RxL_1	478	488	PF00134	0.626
DOC_CYCLIN_RxL_1	756	766	PF00134	0.604
DOC_MAPK_gen_1	283	293	PF00069	0.530
DOC_MAPK_gen_1	896	903	PF00069	0.530
DOC_MAPK_MEF2A_6	896	905	PF00069	0.530
DOC_PP2B_LxvP_1	38	41	PF13499	0.670
DOC_PP4_FxxP_1	73	76	PF00568	0.518
DOC_USP7_MATH_1	228	232	PF00917	0.762
DOC_USP7_MATH_1	29	33	PF00917	0.694
DOC_USP7_MATH_1	354	358	PF00917	0.643
DOC_USP7_MATH_1	386	390	PF00917	0.694
DOC_USP7_MATH_1	419	423	PF00917	0.737
DOC_USP7_MATH_1	514	518	PF00917	0.517
DOC_USP7_MATH_1	549	553	PF00917	0.558
DOC_USP7_MATH_1	582	586	PF00917	0.522
DOC_USP7_MATH_1	587	591	PF00917	0.521
DOC_USP7_MATH_1	647	651	PF00917	0.826
DOC_USP7_MATH_1	703	707	PF00917	0.785
DOC_USP7_MATH_1	717	721	PF00917	0.702
DOC_USP7_MATH_1	848	852	PF00917	0.429
DOC_USP7_MATH_1	864	868	PF00917	0.402
DOC_USP7_MATH_1	9	13	PF00917	0.762
DOC_USP7_MATH_2	838	844	PF00917	0.427
DOC_WD40_RPTOR_TOS_1	506	511	PF00400	0.312
DOC_WW_Pin1_4	133	138	PF00397	0.850
DOC_WW_Pin1_4	163	168	PF00397	0.764
DOC_WW_Pin1_4	217	222	PF00397	0.804
DOC_WW_Pin1_4	224	229	PF00397	0.812
DOC_WW_Pin1_4	356	361	PF00397	0.816
DOC_WW_Pin1_4	370	375	PF00397	0.663
DOC_WW_Pin1_4	432	437	PF00397	0.689
DOC_WW_Pin1_4	461	466	PF00397	0.569
DOC_WW_Pin1_4	5	10	PF00397	0.756
DOC_WW_Pin1_4	592	597	PF00397	0.585
DOC_WW_Pin1_4	682	687	PF00397	0.721
DOC_WW_Pin1_4	690	695	PF00397	0.773
DOC_WW_Pin1_4	728	733	PF00397	0.656
DOC_WW_Pin1_4	831	836	PF00397	0.438
DOC_WW_Pin1_4	846	851	PF00397	0.420
LIG_14-3-3_CanoR_1	111	119	PF00244	0.808
LIG_14-3-3_CanoR_1	269	273	PF00244	0.462
LIG_14-3-3_CanoR_1	378	386	PF00244	0.814
LIG_14-3-3_CanoR_1	391	395	PF00244	0.734
LIG_14-3-3_CanoR_1	411	418	PF00244	0.719
LIG_14-3-3_CanoR_1	44	54	PF00244	0.616
LIG_14-3-3_CanoR_1	554	560	PF00244	0.441
LIG_14-3-3_CanoR_1	688	693	PF00244	0.726
LIG_14-3-3_CanoR_1	702	708	PF00244	0.758
LIG_14-3-3_CanoR_1	910	915	PF00244	0.397
LIG_Actin_WH2_2	283	301	PF00022	0.238
LIG_Actin_WH2_2	864	881	PF00022	0.413
LIG_BIR_III_2	198	202	PF00653	0.697
LIG_BRCT_BRCA1_1	328	332	PF00533	0.641
LIG_BRCT_BRCA1_1	361	365	PF00533	0.708
LIG_BRCT_BRCA1_1	588	592	PF00533	0.607
LIG_CSL_BTD_1	395	398	PF09270	0.759
LIG_EVH1_1	35	39	PF00568	0.636
LIG_FHA_1	192	198	PF00498	0.761
LIG_FHA_1	365	371	PF00498	0.798
LIG_FHA_1	46	52	PF00498	0.757
LIG_FHA_1	602	608	PF00498	0.481
LIG_FHA_1	63	69	PF00498	0.249
LIG_FHA_1	77	83	PF00498	0.359
LIG_FHA_1	810	816	PF00498	0.389
LIG_FHA_1	872	878	PF00498	0.394
LIG_FHA_1	898	904	PF00498	0.530
LIG_FHA_1	90	96	PF00498	0.315
LIG_FHA_2	134	140	PF00498	0.694
LIG_FHA_2	773	779	PF00498	0.547
LIG_FHA_2	786	792	PF00498	0.406
LIG_GBD_Chelix_1	256	264	PF00786	0.452
LIG_GBD_Chelix_1	476	484	PF00786	0.533
LIG_GSK3_LRP6_1	846	852	PF00069	0.401
LIG_Integrin_RGD_1	186	188	PF01839	0.521
LIG_LIR_Apic_2	31	37	PF02991	0.651
LIG_LIR_Apic_2	393	398	PF02991	0.628
LIG_LIR_Apic_2	70	76	PF02991	0.508
LIG_LIR_Gen_1	250	261	PF02991	0.591
LIG_LIR_Gen_1	362	372	PF02991	0.788
LIG_LIR_Gen_1	464	474	PF02991	0.685
LIG_LIR_Gen_1	858	868	PF02991	0.373
LIG_LIR_Nem_3	234	238	PF02991	0.658
LIG_LIR_Nem_3	250	256	PF02991	0.569
LIG_LIR_Nem_3	270	276	PF02991	0.296
LIG_LIR_Nem_3	362	368	PF02991	0.786
LIG_LIR_Nem_3	464	469	PF02991	0.694
LIG_LIR_Nem_3	691	695	PF02991	0.648
LIG_LIR_Nem_3	858	863	PF02991	0.373
LIG_LIR_Nem_3	883	887	PF02991	0.606
LIG_LIR_Nem_3	904	908	PF02991	0.530
LIG_MYND_1	36	40	PF01753	0.630
LIG_NRBOX	479	485	PF00104	0.734
LIG_NRBOX	898	904	PF00104	0.530
LIG_NRBOX	94	100	PF00104	0.530
LIG_PAM2_1	243	255	PF00658	0.697
LIG_Pex14_1	396	400	PF04695	0.760
LIG_Pex14_2	502	506	PF04695	0.452
LIG_PTAP_UEV_1	841	846	PF05743	0.553
LIG_Rb_LxCxE_1	79	93	PF01857	0.435
LIG_SH2_CRK	105	109	PF00017	0.768
LIG_SH2_PTP2	253	256	PF00017	0.530
LIG_SH2_STAP1	276	280	PF00017	0.311
LIG_SH2_STAP1	504	508	PF00017	0.531
LIG_SH2_STAP1	557	561	PF00017	0.510
LIG_SH2_STAT3	276	279	PF00017	0.435
LIG_SH2_STAT3	504	507	PF00017	0.547
LIG_SH2_STAT3	930	933	PF00017	0.690
LIG_SH2_STAT5	253	256	PF00017	0.530
LIG_SH2_STAT5	265	268	PF00017	0.453
LIG_SH2_STAT5	635	638	PF00017	0.712
LIG_SH3_2	39	44	PF14604	0.624
LIG_SH3_3	131	137	PF00018	0.819
LIG_SH3_3	18	24	PF00018	0.790
LIG_SH3_3	239	245	PF00018	0.782
LIG_SH3_3	33	39	PF00018	0.721
LIG_SH3_3	369	375	PF00018	0.766
LIG_SH3_3	40	46	PF00018	0.746
LIG_SH3_3	446	452	PF00018	0.648
LIG_SH3_3	581	587	PF00018	0.510
LIG_SH3_3	676	682	PF00018	0.819
LIG_SH3_3	691	697	PF00018	0.696
LIG_SH3_3	726	732	PF00018	0.649
LIG_SH3_3	832	838	PF00018	0.528
LIG_SH3_3	839	845	PF00018	0.614
LIG_SH3_CIN85_PxpxPR_1	39	44	PF14604	0.624
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.435
LIG_SUMO_SIM_par_1	366	371	PF11976	0.798
LIG_SUMO_SIM_par_1	760	766	PF11976	0.418
LIG_SUMO_SIM_par_1	79	85	PF11976	0.435
LIG_SUMO_SIM_par_1	861	867	PF11976	0.530
LIG_SUMO_SIM_par_1	899	904	PF11976	0.530
LIG_TRAF2_1	385	388	PF00917	0.633
LIG_TRAF2_1	67	70	PF00917	0.610
LIG_TRAF2_1	731	734	PF00917	0.764
LIG_TRAF2_2	20	25	PF00917	0.647
LIG_WRC_WIRS_1	742	747	PF05994	0.452
LIG_WRC_WIRS_1	902	907	PF05994	0.530
LIG_WW_2	36	39	PF00397	0.632
LIG_WW_3	41	45	PF00397	0.831
MOD_CDK_SPxK_1	682	688	PF00069	0.647
MOD_CDK_SPxxK_3	432	439	PF00069	0.690
MOD_CK1_1	12	18	PF00069	0.783
MOD_CK1_1	123	129	PF00069	0.859
MOD_CK1_1	217	223	PF00069	0.857
MOD_CK1_1	231	237	PF00069	0.634
MOD_CK1_1	30	36	PF00069	0.700
MOD_CK1_1	321	327	PF00069	0.638
MOD_CK1_1	359	365	PF00069	0.807
MOD_CK1_1	410	416	PF00069	0.600
MOD_CK1_1	456	462	PF00069	0.645
MOD_CK1_1	591	597	PF00069	0.477
MOD_CK1_1	650	656	PF00069	0.708
MOD_CK1_1	708	714	PF00069	0.779
MOD_CK1_1	785	791	PF00069	0.375
MOD_CK1_1	805	811	PF00069	0.502
MOD_CK1_1	849	855	PF00069	0.390
MOD_CK1_1	867	873	PF00069	0.475
MOD_CK2_1	133	139	PF00069	0.698
MOD_CK2_1	306	312	PF00069	0.832
MOD_CK2_1	461	467	PF00069	0.674
MOD_CK2_1	717	723	PF00069	0.859
MOD_CK2_1	728	734	PF00069	0.649
MOD_CK2_1	772	778	PF00069	0.544
MOD_CK2_1	785	791	PF00069	0.411
MOD_CK2_1	82	88	PF00069	0.460
MOD_CMANNOS	394	397	PF00535	0.412
MOD_Cter_Amidation	908	911	PF01082	0.580
MOD_GlcNHglycan	216	219	PF01048	0.654
MOD_GlcNHglycan	230	233	PF01048	0.459
MOD_GlcNHglycan	320	323	PF01048	0.625
MOD_GlcNHglycan	381	384	PF01048	0.481
MOD_GlcNHglycan	412	415	PF01048	0.464
MOD_GlcNHglycan	455	458	PF01048	0.532
MOD_GlcNHglycan	515	519	PF01048	0.651
MOD_GlcNHglycan	530	533	PF01048	0.696
MOD_GlcNHglycan	549	552	PF01048	0.607
MOD_GlcNHglycan	610	613	PF01048	0.679
MOD_GlcNHglycan	65	68	PF01048	0.452
MOD_GlcNHglycan	707	710	PF01048	0.543
MOD_GlcNHglycan	719	722	PF01048	0.522
MOD_GlcNHglycan	751	754	PF01048	0.452
MOD_GlcNHglycan	784	787	PF01048	0.639
MOD_GlcNHglycan	842	845	PF01048	0.816
MOD_GlcNHglycan	9	12	PF01048	0.561
MOD_GSK3_1	129	136	PF00069	0.857
MOD_GSK3_1	224	231	PF00069	0.836
MOD_GSK3_1	243	250	PF00069	0.551
MOD_GSK3_1	260	267	PF00069	0.315
MOD_GSK3_1	268	275	PF00069	0.434
MOD_GSK3_1	355	362	PF00069	0.825
MOD_GSK3_1	386	393	PF00069	0.764
MOD_GSK3_1	5	12	PF00069	0.760
MOD_GSK3_1	582	589	PF00069	0.524
MOD_GSK3_1	591	598	PF00069	0.563
MOD_GSK3_1	643	650	PF00069	0.730
MOD_GSK3_1	703	710	PF00069	0.802
MOD_GSK3_1	767	774	PF00069	0.378
MOD_GSK3_1	805	812	PF00069	0.420
MOD_GSK3_1	82	89	PF00069	0.530
MOD_GSK3_1	849	856	PF00069	0.506
MOD_GSK3_1	863	870	PF00069	0.313
MOD_GSK3_1	897	904	PF00069	0.530
MOD_LATS_1	344	350	PF00433	0.790
MOD_N-GLC_1	267	272	PF02516	0.725
MOD_N-GLC_1	643	648	PF02516	0.394
MOD_N-GLC_1	809	814	PF02516	0.583
MOD_N-GLC_2	758	760	PF02516	0.538
MOD_NEK2_1	260	265	PF00069	0.530
MOD_NEK2_1	272	277	PF00069	0.394
MOD_NEK2_1	282	287	PF00069	0.394
MOD_NEK2_1	298	303	PF00069	0.578
MOD_NEK2_1	453	458	PF00069	0.661
MOD_NEK2_1	588	593	PF00069	0.444
MOD_NEK2_1	599	604	PF00069	0.495
MOD_NEK2_1	643	648	PF00069	0.802
MOD_NEK2_1	751	756	PF00069	0.410
MOD_NEK2_1	767	772	PF00069	0.458
MOD_NEK2_1	802	807	PF00069	0.514
MOD_NEK2_1	82	87	PF00069	0.378
MOD_NEK2_1	855	860	PF00069	0.386
MOD_NEK2_1	871	876	PF00069	0.302
MOD_NEK2_1	90	95	PF00069	0.398
MOD_NEK2_2	549	554	PF00069	0.421
MOD_NEK2_2	664	669	PF00069	0.635
MOD_PIKK_1	346	352	PF00454	0.790
MOD_PIKK_1	386	392	PF00454	0.626
MOD_PIKK_1	45	51	PF00454	0.768
MOD_PIKK_1	577	583	PF00454	0.415
MOD_PIKK_1	709	715	PF00454	0.735
MOD_PKA_1	910	916	PF00069	0.435
MOD_PKA_2	268	274	PF00069	0.458
MOD_PKA_2	298	304	PF00069	0.634
MOD_PKA_2	312	318	PF00069	0.707
MOD_PKA_2	390	396	PF00069	0.755
MOD_PKA_2	410	416	PF00069	0.667
MOD_PKA_2	484	490	PF00069	0.707
MOD_PKA_2	569	575	PF00069	0.571
MOD_PKA_2	608	614	PF00069	0.567
MOD_PKA_2	650	656	PF00069	0.838
MOD_PKA_2	805	811	PF00069	0.530
MOD_PKA_2	910	916	PF00069	0.435
MOD_Plk_1	267	273	PF00069	0.527
MOD_Plk_1	363	369	PF00069	0.793
MOD_Plk_1	407	413	PF00069	0.672
MOD_Plk_1	809	815	PF00069	0.482
MOD_Plk_2-3	312	318	PF00069	0.841
MOD_Plk_4	192	198	PF00069	0.817
MOD_Plk_4	260	266	PF00069	0.499
MOD_Plk_4	268	274	PF00069	0.455
MOD_Plk_4	30	36	PF00069	0.684
MOD_Plk_4	595	601	PF00069	0.489
MOD_Plk_4	614	620	PF00069	0.390
MOD_Plk_4	741	747	PF00069	0.530
MOD_Plk_4	751	757	PF00069	0.365
MOD_Plk_4	772	778	PF00069	0.392
MOD_Plk_4	855	861	PF00069	0.366
MOD_Plk_4	867	873	PF00069	0.316
MOD_Plk_4	897	903	PF00069	0.530
MOD_Plk_4	90	96	PF00069	0.530
MOD_ProDKin_1	133	139	PF00069	0.851
MOD_ProDKin_1	163	169	PF00069	0.766
MOD_ProDKin_1	217	223	PF00069	0.805
MOD_ProDKin_1	224	230	PF00069	0.810
MOD_ProDKin_1	356	362	PF00069	0.816
MOD_ProDKin_1	370	376	PF00069	0.664
MOD_ProDKin_1	432	438	PF00069	0.689
MOD_ProDKin_1	461	467	PF00069	0.563
MOD_ProDKin_1	5	11	PF00069	0.759
MOD_ProDKin_1	592	598	PF00069	0.581
MOD_ProDKin_1	682	688	PF00069	0.722
MOD_ProDKin_1	690	696	PF00069	0.766
MOD_ProDKin_1	728	734	PF00069	0.652
MOD_ProDKin_1	831	837	PF00069	0.439
MOD_ProDKin_1	846	852	PF00069	0.414
MOD_SUMO_rev_2	329	338	PF00179	0.712
TRG_DiLeu_BaLyEn_6	797	802	PF01217	0.420
TRG_ENDOCYTIC_2	253	256	PF00928	0.464
TRG_ER_diArg_1	182	185	PF00400	0.858
TRG_ER_diArg_1	239	241	PF00400	0.660
TRG_ER_diArg_1	351	353	PF00400	0.640
TRG_ER_diArg_1	823	825	PF00400	0.525
TRG_ER_diArg_1	910	912	PF00400	0.435
TRG_ER_diArg_1	934	937	PF00400	0.714
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJH0	Leishmania donovani	78%	97%
A4H3D0	Leishmania braziliensis	56%	99%
A4HRN1	Leishmania infantum	78%	97%
E9ACA9	Leishmania major	75%	99%