Soluble_NSF_attachment_protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania mexicana

UniProt:

E9AJJ4_LEIMU

TriTrypDb:

LmxM.02.0310

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9AJJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJJ4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0046907	intracellular transport	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0035494	SNARE complex disassembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.536
CLV_C14_Caspase3-7	310	314	PF00656	0.368
CLV_C14_Caspase3-7	468	472	PF00656	0.599
CLV_C14_Caspase3-7	497	501	PF00656	0.502
CLV_NRD_NRD_1	270	272	PF00675	0.368
CLV_NRD_NRD_1	417	419	PF00675	0.558
CLV_NRD_NRD_1	426	428	PF00675	0.500
CLV_NRD_NRD_1	658	660	PF00675	0.579
CLV_PCSK_KEX2_1	270	272	PF00082	0.368
CLV_PCSK_KEX2_1	417	419	PF00082	0.551
CLV_PCSK_KEX2_1	426	428	PF00082	0.488
CLV_PCSK_KEX2_1	65	67	PF00082	0.589
CLV_PCSK_KEX2_1	658	660	PF00082	0.579
CLV_PCSK_KEX2_1	90	92	PF00082	0.707
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.559
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.662
CLV_PCSK_SKI1_1	295	299	PF00082	0.420
CLV_PCSK_SKI1_1	316	320	PF00082	0.420
CLV_PCSK_SKI1_1	399	403	PF00082	0.420
CLV_PCSK_SKI1_1	427	431	PF00082	0.394
CLV_PCSK_SKI1_1	538	542	PF00082	0.454
CLV_PCSK_SKI1_1	595	599	PF00082	0.491
CLV_PCSK_SKI1_1	617	621	PF00082	0.475
CLV_PCSK_SKI1_1	659	663	PF00082	0.576
DEG_APCC_DBOX_1	502	510	PF00400	0.458
DEG_APCC_KENBOX_2	610	614	PF00400	0.491
DEG_SPOP_SBC_1	465	469	PF00917	0.518
DOC_CYCLIN_RxL_1	313	322	PF00134	0.420
DOC_CYCLIN_RxL_1	532	544	PF00134	0.472
DOC_CYCLIN_RxL_1	656	666	PF00134	0.579
DOC_MAPK_gen_1	503	510	PF00069	0.459
DOC_MAPK_gen_1	90	98	PF00069	0.518
DOC_MAPK_MEF2A_6	346	354	PF00069	0.420
DOC_MAPK_MEF2A_6	503	511	PF00069	0.458
DOC_MAPK_MEF2A_6	91	100	PF00069	0.514
DOC_PP1_RVXF_1	293	300	PF00149	0.420
DOC_PP2B_LxvP_1	238	241	PF13499	0.489
DOC_PP2B_PxIxI_1	349	355	PF00149	0.420
DOC_USP7_MATH_1	120	124	PF00917	0.667
DOC_USP7_MATH_1	138	142	PF00917	0.509
DOC_USP7_MATH_1	200	204	PF00917	0.716
DOC_USP7_MATH_1	300	304	PF00917	0.368
DOC_USP7_MATH_1	353	357	PF00917	0.425
DOC_USP7_MATH_1	445	449	PF00917	0.753
DOC_USP7_MATH_1	465	469	PF00917	0.557
DOC_USP7_MATH_1	559	563	PF00917	0.504
DOC_USP7_MATH_1	77	81	PF00917	0.743
DOC_WW_Pin1_4	226	231	PF00397	0.762
DOC_WW_Pin1_4	244	249	PF00397	0.506
DOC_WW_Pin1_4	253	258	PF00397	0.628
DOC_WW_Pin1_4	436	441	PF00397	0.648
DOC_WW_Pin1_4	572	577	PF00397	0.574
LIG_14-3-3_CanoR_1	194	198	PF00244	0.615
LIG_14-3-3_CanoR_1	250	258	PF00244	0.592
LIG_14-3-3_CanoR_1	270	274	PF00244	0.417
LIG_14-3-3_CanoR_1	489	495	PF00244	0.541
LIG_14-3-3_CanoR_1	624	629	PF00244	0.552
LIG_Actin_WH2_2	331	348	PF00022	0.420
LIG_APCC_ABBA_1	402	407	PF00400	0.420
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_2	47	51	PF00653	0.615
LIG_BIR_III_4	232	236	PF00653	0.642
LIG_BRCT_BRCA1_1	197	201	PF00533	0.656
LIG_BRCT_BRCA1_1	476	480	PF00533	0.701
LIG_deltaCOP1_diTrp_1	289	298	PF00928	0.420
LIG_FHA_1	150	156	PF00498	0.635
LIG_FHA_1	205	211	PF00498	0.690
LIG_FHA_1	292	298	PF00498	0.420
LIG_FHA_1	426	432	PF00498	0.530
LIG_FHA_1	436	442	PF00498	0.544
LIG_FHA_1	465	471	PF00498	0.623
LIG_FHA_1	542	548	PF00498	0.405
LIG_FHA_2	204	210	PF00498	0.660
LIG_FHA_2	627	633	PF00498	0.419
LIG_FHA_2	635	641	PF00498	0.377
LIG_FHA_2	68	74	PF00498	0.544
LIG_LIR_Gen_1	303	312	PF02991	0.368
LIG_LIR_Gen_1	584	591	PF02991	0.477
LIG_LIR_Gen_1	97	105	PF02991	0.513
LIG_LIR_Nem_3	198	204	PF02991	0.709
LIG_LIR_Nem_3	303	308	PF02991	0.368
LIG_LIR_Nem_3	584	590	PF02991	0.475
LIG_LIR_Nem_3	594	600	PF02991	0.413
LIG_LIR_Nem_3	637	641	PF02991	0.444
LIG_LIR_Nem_3	97	103	PF02991	0.511
LIG_NRBOX	505	511	PF00104	0.454
LIG_PCNA_yPIPBox_3	23	34	PF02747	0.593
LIG_PCNA_yPIPBox_3	609	620	PF02747	0.433
LIG_PTAP_UEV_1	456	461	PF05743	0.656
LIG_PTB_Apo_2	322	329	PF02174	0.420
LIG_SH2_CRK	542	546	PF00017	0.437
LIG_SH2_SRC	516	519	PF00017	0.483
LIG_SH2_STAT3	364	367	PF00017	0.368
LIG_SH2_STAT5	539	542	PF00017	0.487
LIG_SH2_STAT5	586	589	PF00017	0.493
LIG_SH2_STAT5	596	599	PF00017	0.376
LIG_SH2_STAT5	641	644	PF00017	0.332
LIG_SH3_3	13	19	PF00018	0.685
LIG_SH3_3	454	460	PF00018	0.524
LIG_SH3_3	475	481	PF00018	0.635
LIG_SH3_3	93	99	PF00018	0.507
LIG_SUMO_SIM_par_1	236	242	PF11976	0.568
LIG_TRAF2_1	275	278	PF00917	0.368
LIG_TRAF2_1	390	393	PF00917	0.368
LIG_TYR_ITIM	540	545	PF00017	0.438
LIG_UBA3_1	383	391	PF00899	0.368
LIG_WW_1	485	488	PF00397	0.641
MOD_CDK_SPxK_1	244	250	PF00069	0.478
MOD_CK1_1	171	177	PF00069	0.600
MOD_CK1_1	195	201	PF00069	0.636
MOD_CK1_1	203	209	PF00069	0.711
MOD_CK1_1	256	262	PF00069	0.381
MOD_CK1_1	558	564	PF00069	0.579
MOD_CK1_1	76	82	PF00069	0.737
MOD_CK2_1	203	209	PF00069	0.690
MOD_CK2_1	634	640	PF00069	0.401
MOD_CK2_1	67	73	PF00069	0.545
MOD_GlcNHglycan	108	112	PF01048	0.572
MOD_GlcNHglycan	122	125	PF01048	0.676
MOD_GlcNHglycan	140	143	PF01048	0.554
MOD_GlcNHglycan	175	178	PF01048	0.707
MOD_GlcNHglycan	183	186	PF01048	0.609
MOD_GlcNHglycan	197	200	PF01048	0.648
MOD_GlcNHglycan	221	224	PF01048	0.708
MOD_GlcNHglycan	232	236	PF01048	0.613
MOD_GlcNHglycan	241	244	PF01048	0.519
MOD_GlcNHglycan	258	261	PF01048	0.378
MOD_GlcNHglycan	42	45	PF01048	0.744
MOD_GlcNHglycan	443	446	PF01048	0.681
MOD_GlcNHglycan	52	56	PF01048	0.673
MOD_GlcNHglycan	557	560	PF01048	0.521
MOD_GlcNHglycan	561	564	PF01048	0.528
MOD_GlcNHglycan	61	64	PF01048	0.617
MOD_GlcNHglycan	75	78	PF01048	0.761
MOD_GlcNHglycan	86	89	PF01048	0.643
MOD_GSK3_1	103	110	PF00069	0.697
MOD_GSK3_1	116	123	PF00069	0.691
MOD_GSK3_1	169	176	PF00069	0.637
MOD_GSK3_1	200	207	PF00069	0.726
MOD_GSK3_1	249	256	PF00069	0.607
MOD_GSK3_1	334	341	PF00069	0.420
MOD_GSK3_1	441	448	PF00069	0.658
MOD_GSK3_1	490	497	PF00069	0.565
MOD_GSK3_1	555	562	PF00069	0.602
MOD_GSK3_1	572	579	PF00069	0.534
MOD_GSK3_1	586	593	PF00069	0.320
MOD_GSK3_1	73	80	PF00069	0.734
MOD_LATS_1	487	493	PF00433	0.420
MOD_N-GLC_1	329	334	PF02516	0.368
MOD_NEK2_1	129	134	PF00069	0.620
MOD_NEK2_1	149	154	PF00069	0.626
MOD_NEK2_1	319	324	PF00069	0.420
MOD_NEK2_1	345	350	PF00069	0.420
MOD_NEK2_1	425	430	PF00069	0.456
MOD_NEK2_1	498	503	PF00069	0.428
MOD_NEK2_1	541	546	PF00069	0.446
MOD_NEK2_2	300	305	PF00069	0.368
MOD_NEK2_2	581	586	PF00069	0.522
MOD_PIKK_1	6	12	PF00454	0.701
MOD_PIKK_1	77	83	PF00454	0.554
MOD_PK_1	474	480	PF00069	0.585
MOD_PKA_1	555	561	PF00069	0.542
MOD_PKA_2	129	135	PF00069	0.615
MOD_PKA_2	149	155	PF00069	0.523
MOD_PKA_2	193	199	PF00069	0.737
MOD_PKA_2	249	255	PF00069	0.614
MOD_PKA_2	269	275	PF00069	0.225
MOD_PKA_2	425	431	PF00069	0.394
MOD_PKA_2	488	494	PF00069	0.600
MOD_Plk_1	169	175	PF00069	0.504
MOD_Plk_1	192	198	PF00069	0.519
MOD_Plk_1	603	609	PF00069	0.541
MOD_Plk_4	300	306	PF00069	0.407
MOD_Plk_4	319	325	PF00069	0.260
MOD_Plk_4	353	359	PF00069	0.372
MOD_Plk_4	581	587	PF00069	0.520
MOD_ProDKin_1	226	232	PF00069	0.762
MOD_ProDKin_1	244	250	PF00069	0.508
MOD_ProDKin_1	253	259	PF00069	0.616
MOD_ProDKin_1	436	442	PF00069	0.647
MOD_ProDKin_1	572	578	PF00069	0.569
MOD_SUMO_for_1	390	393	PF00179	0.368
TRG_DiLeu_BaEn_1	261	266	PF01217	0.420
TRG_ENDOCYTIC_2	542	545	PF00928	0.474
TRG_ER_diArg_1	292	295	PF00400	0.225
TRG_ER_diArg_1	417	419	PF00400	0.548
TRG_ER_diArg_1	425	427	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4Z6	Leishmania donovani	76%	97%
A4H3C9	Leishmania braziliensis	56%	100%
A4HRM8	Leishmania infantum	76%	97%
E9ACA6	Leishmania major	75%	99%