LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
Mitogen-activated kinase kinase kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AJJ2_LEIMU
TriTrypDb:
LmxM.02.0290
Length:
539

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 35
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 38
NetGPI no yes: 0, no: 38
Cellular components
Term Name Level Count
GO:0005815 microtubule organizing center 2 1
GO:0005929 cilium 4 1
GO:0036064 ciliary basal body 3 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 1
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9AJJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJJ2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 39
GO:0006793 phosphorus metabolic process 3 39
GO:0006796 phosphate-containing compound metabolic process 4 39
GO:0006807 nitrogen compound metabolic process 2 39
GO:0008152 metabolic process 1 39
GO:0009987 cellular process 1 39
GO:0016310 phosphorylation 5 39
GO:0019538 protein metabolic process 3 39
GO:0036211 protein modification process 4 39
GO:0043170 macromolecule metabolic process 3 39
GO:0043412 macromolecule modification 4 39
GO:0044237 cellular metabolic process 2 39
GO:0044238 primary metabolic process 2 39
GO:0071704 organic substance metabolic process 2 39
GO:1901564 organonitrogen compound metabolic process 3 39
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 39
GO:0003824 catalytic activity 1 39
GO:0004672 protein kinase activity 3 39
GO:0005488 binding 1 39
GO:0005524 ATP binding 5 39
GO:0016301 kinase activity 4 39
GO:0016740 transferase activity 2 39
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 39
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 39
GO:0017076 purine nucleotide binding 4 39
GO:0030554 adenyl nucleotide binding 5 39
GO:0032553 ribonucleotide binding 3 39
GO:0032555 purine ribonucleotide binding 4 39
GO:0032559 adenyl ribonucleotide binding 5 39
GO:0035639 purine ribonucleoside triphosphate binding 4 39
GO:0036094 small molecule binding 2 39
GO:0043167 ion binding 2 39
GO:0043168 anion binding 3 39
GO:0097159 organic cyclic compound binding 2 39
GO:0097367 carbohydrate derivative binding 2 39
GO:0140096 catalytic activity, acting on a protein 2 39
GO:1901265 nucleoside phosphate binding 3 39
GO:1901363 heterocyclic compound binding 2 39
GO:0004674 protein serine/threonine kinase activity 4 21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.307
CLV_NRD_NRD_1 256 258 PF00675 0.344
CLV_NRD_NRD_1 450 452 PF00675 0.247
CLV_PCSK_KEX2_1 256 258 PF00082 0.285
CLV_PCSK_KEX2_1 450 452 PF00082 0.258
CLV_PCSK_KEX2_1 535 537 PF00082 0.542
CLV_PCSK_PC1ET2_1 535 537 PF00082 0.592
CLV_PCSK_PC7_1 446 452 PF00082 0.239
CLV_PCSK_SKI1_1 211 215 PF00082 0.238
CLV_PCSK_SKI1_1 319 323 PF00082 0.315
CLV_PCSK_SKI1_1 429 433 PF00082 0.424
CLV_PCSK_SKI1_1 450 454 PF00082 0.246
DEG_APCC_DBOX_1 445 453 PF00400 0.240
DEG_APCC_DBOX_1 458 466 PF00400 0.379
DEG_Nend_UBRbox_2 1 3 PF02207 0.468
DEG_SIAH_1 73 81 PF03145 0.463
DEG_SPOP_SBC_1 23 27 PF00917 0.470
DEG_SPOP_SBC_1 258 262 PF00917 0.240
DEG_SPOP_SBC_1 276 280 PF00917 0.391
DOC_ANK_TNKS_1 493 500 PF00023 0.435
DOC_CDC14_PxL_1 361 369 PF14671 0.299
DOC_CKS1_1 488 493 PF01111 0.452
DOC_CYCLIN_RxL_1 389 400 PF00134 0.202
DOC_CYCLIN_yCln2_LP_2 291 297 PF00134 0.166
DOC_MAPK_gen_1 319 328 PF00069 0.330
DOC_USP7_MATH_1 121 125 PF00917 0.559
DOC_USP7_MATH_1 129 133 PF00917 0.726
DOC_USP7_MATH_1 202 206 PF00917 0.195
DOC_USP7_MATH_1 268 272 PF00917 0.345
DOC_USP7_MATH_1 306 310 PF00917 0.321
DOC_USP7_MATH_1 46 50 PF00917 0.661
DOC_USP7_MATH_1 486 490 PF00917 0.686
DOC_USP7_MATH_1 54 58 PF00917 0.740
DOC_WW_Pin1_4 266 271 PF00397 0.226
DOC_WW_Pin1_4 356 361 PF00397 0.319
DOC_WW_Pin1_4 411 416 PF00397 0.352
DOC_WW_Pin1_4 487 492 PF00397 0.485
DOC_WW_Pin1_4 63 68 PF00397 0.530
LIG_14-3-3_CanoR_1 103 113 PF00244 0.499
LIG_14-3-3_CanoR_1 494 501 PF00244 0.456
LIG_14-3-3_CanoR_1 81 85 PF00244 0.452
LIG_Actin_WH2_2 434 452 PF00022 0.243
LIG_BRCT_BRCA1_1 427 431 PF00533 0.266
LIG_BRCT_BRCA1_1 491 495 PF00533 0.659
LIG_Clathr_ClatBox_1 438 442 PF01394 0.286
LIG_deltaCOP1_diTrp_1 378 386 PF00928 0.389
LIG_deltaCOP1_diTrp_1 6 10 PF00928 0.573
LIG_eIF4E_1 362 368 PF01652 0.231
LIG_FHA_1 105 111 PF00498 0.526
LIG_FHA_1 178 184 PF00498 0.250
LIG_FHA_1 332 338 PF00498 0.323
LIG_FHA_2 25 31 PF00498 0.686
LIG_FHA_2 342 348 PF00498 0.339
LIG_FHA_2 350 356 PF00498 0.191
LIG_HOMEOBOX 5 8 PF00046 0.470
LIG_LIR_Apic_2 359 365 PF02991 0.328
LIG_LIR_Gen_1 2 10 PF02991 0.594
LIG_LIR_Gen_1 237 245 PF02991 0.246
LIG_LIR_Gen_1 298 307 PF02991 0.412
LIG_LIR_Gen_1 498 509 PF02991 0.572
LIG_LIR_Gen_1 66 76 PF02991 0.455
LIG_LIR_Nem_3 146 150 PF02991 0.497
LIG_LIR_Nem_3 298 303 PF02991 0.394
LIG_LIR_Nem_3 312 317 PF02991 0.265
LIG_LIR_Nem_3 428 434 PF02991 0.429
LIG_LIR_Nem_3 498 504 PF02991 0.622
LIG_LIR_Nem_3 6 10 PF02991 0.573
LIG_LIR_Nem_3 66 72 PF02991 0.461
LIG_Rb_pABgroove_1 221 229 PF01858 0.302
LIG_SH2_CRK 314 318 PF00017 0.314
LIG_SH2_CRK 501 505 PF00017 0.420
LIG_SH2_SRC 222 225 PF00017 0.323
LIG_SH2_SRC 464 467 PF00017 0.286
LIG_SH2_STAP1 427 431 PF00017 0.378
LIG_SH2_STAP1 501 505 PF00017 0.399
LIG_SH2_STAT3 128 131 PF00017 0.555
LIG_SH2_STAT3 427 430 PF00017 0.302
LIG_SH2_STAT5 222 225 PF00017 0.353
LIG_SH2_STAT5 243 246 PF00017 0.299
LIG_SH2_STAT5 295 298 PF00017 0.255
LIG_SH2_STAT5 457 460 PF00017 0.342
LIG_SH2_STAT5 464 467 PF00017 0.358
LIG_SH3_2 475 480 PF14604 0.428
LIG_SH3_3 229 235 PF00018 0.256
LIG_SH3_3 264 270 PF00018 0.199
LIG_SH3_3 472 478 PF00018 0.555
LIG_SH3_3 485 491 PF00018 0.568
LIG_SH3_3 81 87 PF00018 0.448
LIG_SUMO_SIM_par_1 436 442 PF11976 0.351
LIG_TRAF2_1 196 199 PF00917 0.201
LIG_WW_1 231 234 PF00397 0.191
MOD_CDK_SPxxK_3 487 494 PF00069 0.456
MOD_CK1_1 143 149 PF00069 0.488
MOD_CK1_1 269 275 PF00069 0.319
MOD_CK1_1 309 315 PF00069 0.302
MOD_CK1_1 425 431 PF00069 0.344
MOD_CK1_1 437 443 PF00069 0.235
MOD_CK1_1 468 474 PF00069 0.490
MOD_CK1_1 489 495 PF00069 0.733
MOD_CK1_1 49 55 PF00069 0.702
MOD_CK1_1 88 94 PF00069 0.494
MOD_CK2_1 349 355 PF00069 0.323
MOD_CK2_1 397 403 PF00069 0.404
MOD_Cter_Amidation 254 257 PF01082 0.191
MOD_GlcNHglycan 123 126 PF01048 0.670
MOD_GlcNHglycan 132 135 PF01048 0.541
MOD_GlcNHglycan 142 145 PF01048 0.572
MOD_GlcNHglycan 173 176 PF01048 0.369
MOD_GlcNHglycan 399 402 PF01048 0.368
MOD_GlcNHglycan 482 485 PF01048 0.598
MOD_GlcNHglycan 495 498 PF01048 0.439
MOD_GlcNHglycan 530 533 PF01048 0.566
MOD_GlcNHglycan 54 57 PF01048 0.810
MOD_GSK3_1 18 25 PF00069 0.485
MOD_GSK3_1 226 233 PF00069 0.218
MOD_GSK3_1 274 281 PF00069 0.377
MOD_GSK3_1 421 428 PF00069 0.363
MOD_GSK3_1 433 440 PF00069 0.284
MOD_GSK3_1 45 52 PF00069 0.533
MOD_GSK3_1 489 496 PF00069 0.558
MOD_GSK3_1 500 507 PF00069 0.406
MOD_NEK2_1 226 231 PF00069 0.333
MOD_NEK2_1 275 280 PF00069 0.333
MOD_NEK2_1 340 345 PF00069 0.243
MOD_NEK2_1 434 439 PF00069 0.219
MOD_NEK2_1 500 505 PF00069 0.446
MOD_NEK2_2 162 167 PF00069 0.239
MOD_NEK2_2 295 300 PF00069 0.410
MOD_NEK2_2 306 311 PF00069 0.306
MOD_PIKK_1 341 347 PF00454 0.201
MOD_PIKK_1 489 495 PF00454 0.460
MOD_PIKK_1 512 518 PF00454 0.411
MOD_PKA_2 102 108 PF00069 0.521
MOD_PKA_2 425 431 PF00069 0.487
MOD_PKA_2 445 451 PF00069 0.303
MOD_PKA_2 458 464 PF00069 0.417
MOD_PKA_2 493 499 PF00069 0.445
MOD_PKA_2 80 86 PF00069 0.660
MOD_Plk_4 162 168 PF00069 0.278
MOD_Plk_4 189 195 PF00069 0.316
MOD_Plk_4 234 240 PF00069 0.251
MOD_Plk_4 295 301 PF00069 0.338
MOD_Plk_4 434 440 PF00069 0.215
MOD_Plk_4 465 471 PF00069 0.423
MOD_Plk_4 500 506 PF00069 0.556
MOD_Plk_4 88 94 PF00069 0.506
MOD_ProDKin_1 266 272 PF00069 0.226
MOD_ProDKin_1 356 362 PF00069 0.319
MOD_ProDKin_1 411 417 PF00069 0.352
MOD_ProDKin_1 487 493 PF00069 0.466
MOD_ProDKin_1 63 69 PF00069 0.529
MOD_SUMO_rev_2 205 210 PF00179 0.285
TRG_DiLeu_BaEn_1 403 408 PF01217 0.201
TRG_ENDOCYTIC_2 314 317 PF00928 0.271
TRG_ENDOCYTIC_2 387 390 PF00928 0.299
TRG_ENDOCYTIC_2 501 504 PF00928 0.427
TRG_ER_diArg_1 152 155 PF00400 0.262
TRG_ER_diArg_1 256 258 PF00400 0.177
TRG_ER_diArg_1 449 451 PF00400 0.245
TRG_NES_CRM1_1 331 345 PF08389 0.201

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2D3 Leptomonas seymouri 51% 100%
A0A0N1HTF0 Leptomonas seymouri 23% 85%
A0A0N1HZW6 Leptomonas seymouri 26% 100%
A0A0S4IZ14 Bodo saltans 23% 91%
A0A0S4J757 Bodo saltans 26% 100%
A0A0S4JIJ6 Bodo saltans 26% 95%
A0A0S4JKY4 Bodo saltans 31% 68%
A0A0S4JMY6 Bodo saltans 25% 70%
A0A0S4JPZ1 Bodo saltans 27% 100%
A0A1X0NKA1 Trypanosomatidae 39% 100%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 25% 100%
A0A3Q8IAQ1 Leishmania donovani 32% 100%
A0A3Q8IDY1 Leishmania donovani 27% 100%
A0A3Q8IFK8 Leishmania donovani 29% 100%
A0A3Q8IFW0 Leishmania donovani 31% 100%
A0A3Q8IIG1 Leishmania donovani 28% 100%
A0A3Q8IPJ5 Leishmania donovani 26% 100%
A0A3S5H4Z4 Leishmania donovani 89% 100%
A0A3S7WUE7 Leishmania donovani 26% 97%
A0A3S7X6T8 Leishmania donovani 27% 100%
A0A422N701 Trypanosoma rangeli 40% 100%
A4H3C7 Leishmania braziliensis 75% 100%
A4HC09 Leishmania braziliensis 31% 67%
A4HCE6 Leishmania braziliensis 30% 100%
A4HFA1 Leishmania braziliensis 26% 100%
A4HHP8 Leishmania braziliensis 27% 100%
A4HJT5 Leishmania braziliensis 28% 100%
A4HJW2 Leishmania braziliensis 31% 100%
A4HLR0 Leishmania braziliensis 28% 100%
A4HRM6 Leishmania infantum 89% 100%
A4HW76 Leishmania infantum 23% 67%
A4HX71 Leishmania infantum 26% 97%
A4HZW8 Leishmania infantum 32% 100%
A4I2H8 Leishmania infantum 26% 100%
A4I435 Leishmania infantum 28% 100%
A4I4W3 Leishmania infantum 27% 100%
A4I7A1 Leishmania infantum 29% 100%
A4I7C4 Leishmania infantum 31% 100%
A4I960 Leishmania infantum 27% 100%
C9ZIZ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZQL9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 84%
C9ZX04 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
C9ZX09 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9ACA4 Leishmania major 89% 100%
E9AEB1 Leishmania major 26% 100%
E9ALH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9ARC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 97%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AWZ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 89%
E9AYN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
P24723 Homo sapiens 25% 79%
P49101 Zea mays 27% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 25% 100%
P62344 Plasmodium falciparum (isolate 3D7) 25% 100%
Q0VD22 Bos taurus 24% 100%
Q4Q3Y9 Leishmania major 27% 100%
Q4Q5T9 Leishmania major 31% 100%
Q4Q5W2 Leishmania major 29% 100%
Q4Q7W2 Leishmania major 28% 100%
Q4Q8T4 Leishmania major 26% 100%
Q4QBQ2 Leishmania major 33% 100%
Q4QCK0 Leishmania major 28% 100%
Q4QEJ2 Leishmania major 26% 97%
Q5VQQ5 Oryza sativa subsp. japonica 27% 100%
Q64617 Rattus norvegicus 25% 79%
Q6Z2M9 Oryza sativa subsp. japonica 27% 100%
Q7SY24 Danio rerio 25% 80%
Q924X7 Mus musculus 24% 100%
Q9NJU9 Plasmodium falciparum (isolate 3D7) 23% 96%
Q9Y243 Homo sapiens 26% 100%
Q9Y6E0 Homo sapiens 25% 100%
V5BHW8 Trypanosoma cruzi 25% 85%
V5D179 Trypanosoma cruzi 26% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS