RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AJI1_LEIMU

TriTrypDb:

LmxM.02.0140

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.701
CLV_C14_Caspase3-7	368	372	PF00656	0.771
CLV_C14_Caspase3-7	801	805	PF00656	0.553
CLV_NRD_NRD_1	179	181	PF00675	0.794
CLV_NRD_NRD_1	303	305	PF00675	0.681
CLV_NRD_NRD_1	445	447	PF00675	0.505
CLV_PCSK_KEX2_1	179	181	PF00082	0.780
CLV_PCSK_KEX2_1	445	447	PF00082	0.551
CLV_PCSK_KEX2_1	532	534	PF00082	0.620
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.620
CLV_PCSK_SKI1_1	182	186	PF00082	0.606
CLV_PCSK_SKI1_1	343	347	PF00082	0.518
CLV_PCSK_SKI1_1	527	531	PF00082	0.622
CLV_PCSK_SKI1_1	756	760	PF00082	0.613
CLV_PCSK_SKI1_1	848	852	PF00082	0.430
DEG_APCC_DBOX_1	45	53	PF00400	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.525
DEG_ODPH_VHL_1	75	88	PF01847	0.472
DEG_SPOP_SBC_1	677	681	PF00917	0.377
DOC_ANK_TNKS_1	3	10	PF00023	0.513
DOC_ANK_TNKS_1	98	105	PF00023	0.308
DOC_CDC14_PxL_1	481	489	PF14671	0.451
DOC_CKS1_1	105	110	PF01111	0.563
DOC_CKS1_1	243	248	PF01111	0.567
DOC_CKS1_1	297	302	PF01111	0.733
DOC_CKS1_1	355	360	PF01111	0.452
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.710
DOC_MAPK_DCC_7	479	489	PF00069	0.508
DOC_MAPK_gen_1	179	186	PF00069	0.518
DOC_MAPK_gen_1	428	435	PF00069	0.539
DOC_MAPK_gen_1	561	570	PF00069	0.584
DOC_PP1_SILK_1	95	100	PF00149	0.449
DOC_PP2B_LxvP_1	224	227	PF13499	0.543
DOC_PP2B_LxvP_1	487	490	PF13499	0.551
DOC_PP2B_LxvP_1	579	582	PF13499	0.682
DOC_PP4_FxxP_1	401	404	PF00568	0.720
DOC_PP4_FxxP_1	807	810	PF00568	0.738
DOC_PP4_FxxP_1	876	879	PF00568	0.430
DOC_PP4_MxPP_1	402	405	PF00568	0.500
DOC_USP7_MATH_1	152	156	PF00917	0.711
DOC_USP7_MATH_1	209	213	PF00917	0.597
DOC_USP7_MATH_1	262	266	PF00917	0.604
DOC_USP7_MATH_1	269	273	PF00917	0.541
DOC_USP7_MATH_1	369	373	PF00917	0.700
DOC_USP7_MATH_1	382	386	PF00917	0.788
DOC_USP7_MATH_1	390	394	PF00917	0.719
DOC_USP7_MATH_1	531	535	PF00917	0.686
DOC_USP7_MATH_1	677	681	PF00917	0.540
DOC_USP7_MATH_1	701	705	PF00917	0.781
DOC_USP7_MATH_1	740	744	PF00917	0.549
DOC_USP7_MATH_1	829	833	PF00917	0.730
DOC_WW_Pin1_4	104	109	PF00397	0.485
DOC_WW_Pin1_4	153	158	PF00397	0.710
DOC_WW_Pin1_4	242	247	PF00397	0.615
DOC_WW_Pin1_4	258	263	PF00397	0.527
DOC_WW_Pin1_4	296	301	PF00397	0.734
DOC_WW_Pin1_4	354	359	PF00397	0.457
DOC_WW_Pin1_4	407	412	PF00397	0.763
DOC_WW_Pin1_4	641	646	PF00397	0.594
DOC_WW_Pin1_4	770	775	PF00397	0.770
DOC_WW_Pin1_4	806	811	PF00397	0.704
LIG_14-3-3_CanoR_1	125	135	PF00244	0.532
LIG_14-3-3_CanoR_1	182	187	PF00244	0.520
LIG_14-3-3_CanoR_1	620	629	PF00244	0.478
LIG_14-3-3_CanoR_1	732	738	PF00244	0.600
LIG_14-3-3_CanoR_1	768	774	PF00244	0.458
LIG_14-3-3_CanoR_1	831	839	PF00244	0.468
LIG_14-3-3_CanoR_1	866	875	PF00244	0.387
LIG_Actin_WH2_2	740	758	PF00022	0.530
LIG_APCC_ABBA_1	568	573	PF00400	0.557
LIG_BRCT_BRCA1_1	240	244	PF00533	0.530
LIG_BRCT_BRCA1_1	290	294	PF00533	0.716
LIG_BRCT_BRCA1_1	727	731	PF00533	0.565
LIG_CtBP_PxDLS_1	706	710	PF00389	0.411
LIG_EH1_1	339	347	PF00400	0.510
LIG_FHA_1	127	133	PF00498	0.361
LIG_FHA_1	202	208	PF00498	0.547
LIG_FHA_1	238	244	PF00498	0.530
LIG_FHA_1	250	256	PF00498	0.489
LIG_FHA_1	274	280	PF00498	0.503
LIG_FHA_1	355	361	PF00498	0.450
LIG_FHA_1	468	474	PF00498	0.582
LIG_FHA_1	622	628	PF00498	0.697
LIG_FHA_1	677	683	PF00498	0.487
LIG_FHA_1	721	727	PF00498	0.512
LIG_FHA_1	9	15	PF00498	0.514
LIG_FHA_1	93	99	PF00498	0.492
LIG_FHA_2	105	111	PF00498	0.483
LIG_FHA_2	183	189	PF00498	0.702
LIG_FHA_2	243	249	PF00498	0.564
LIG_Integrin_RGD_1	233	235	PF01839	0.597
LIG_Integrin_RGD_1	822	824	PF01839	0.501
LIG_LIR_Apic_2	353	358	PF02991	0.524
LIG_LIR_Apic_2	448	452	PF02991	0.491
LIG_LIR_Apic_2	491	497	PF02991	0.581
LIG_LIR_Apic_2	804	810	PF02991	0.726
LIG_LIR_Apic_2	873	879	PF02991	0.430
LIG_LIR_Gen_1	251	258	PF02991	0.562
LIG_LIR_Gen_1	291	301	PF02991	0.731
LIG_LIR_Gen_1	35	45	PF02991	0.443
LIG_LIR_Gen_1	463	473	PF02991	0.521
LIG_LIR_Gen_1	743	751	PF02991	0.509
LIG_LIR_Nem_3	241	247	PF02991	0.671
LIG_LIR_Nem_3	251	256	PF02991	0.570
LIG_LIR_Nem_3	291	297	PF02991	0.753
LIG_LIR_Nem_3	329	334	PF02991	0.464
LIG_LIR_Nem_3	35	41	PF02991	0.428
LIG_LIR_Nem_3	353	359	PF02991	0.587
LIG_LIR_Nem_3	423	429	PF02991	0.549
LIG_LIR_Nem_3	463	469	PF02991	0.500
LIG_LIR_Nem_3	725	730	PF02991	0.557
LIG_LIR_Nem_3	743	748	PF02991	0.470
LIG_LIR_Nem_3	833	839	PF02991	0.472
LIG_MLH1_MIPbox_1	727	731	PF16413	0.362
LIG_NRBOX	681	687	PF00104	0.392
LIG_PDZ_Class_2	888	893	PF00595	0.585
LIG_Pex14_2	727	731	PF04695	0.362
LIG_RPA_C_Fungi	817	829	PF08784	0.488
LIG_SH2_CRK	356	360	PF00017	0.450
LIG_SH2_CRK	38	42	PF00017	0.436
LIG_SH2_CRK	466	470	PF00017	0.485
LIG_SH2_CRK	494	498	PF00017	0.579
LIG_SH2_CRK	666	670	PF00017	0.540
LIG_SH2_CRK	745	749	PF00017	0.513
LIG_SH2_NCK_1	38	42	PF00017	0.483
LIG_SH2_NCK_1	666	670	PF00017	0.612
LIG_SH2_PTP2	449	452	PF00017	0.484
LIG_SH2_PTP2	567	570	PF00017	0.515
LIG_SH2_SRC	307	310	PF00017	0.643
LIG_SH2_SRC	449	452	PF00017	0.484
LIG_SH2_SRC	557	560	PF00017	0.589
LIG_SH2_SRC	567	570	PF00017	0.479
LIG_SH2_STAP1	587	591	PF00017	0.735
LIG_SH2_STAP1	745	749	PF00017	0.497
LIG_SH2_STAT3	839	842	PF00017	0.430
LIG_SH2_STAT5	100	103	PF00017	0.504
LIG_SH2_STAT5	333	336	PF00017	0.505
LIG_SH2_STAT5	348	351	PF00017	0.367
LIG_SH2_STAT5	356	359	PF00017	0.482
LIG_SH2_STAT5	38	41	PF00017	0.433
LIG_SH2_STAT5	426	429	PF00017	0.596
LIG_SH2_STAT5	449	452	PF00017	0.484
LIG_SH2_STAT5	472	475	PF00017	0.509
LIG_SH2_STAT5	557	560	PF00017	0.595
LIG_SH2_STAT5	567	570	PF00017	0.461
LIG_SH2_STAT5	59	62	PF00017	0.442
LIG_SH2_STAT5	673	676	PF00017	0.460
LIG_SH2_STAT5	730	733	PF00017	0.409
LIG_SH2_STAT5	766	769	PF00017	0.499
LIG_SH2_STAT5	836	839	PF00017	0.438
LIG_SH3_1	494	500	PF00018	0.597
LIG_SH3_1	794	800	PF00018	0.657
LIG_SH3_2	300	305	PF14604	0.679
LIG_SH3_3	22	28	PF00018	0.496
LIG_SH3_3	297	303	PF00018	0.763
LIG_SH3_3	360	366	PF00018	0.615
LIG_SH3_3	389	395	PF00018	0.653
LIG_SH3_3	494	500	PF00018	0.597
LIG_SH3_3	787	793	PF00018	0.603
LIG_SH3_3	794	800	PF00018	0.755
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.317
LIG_SUMO_SIM_par_1	222	228	PF11976	0.593
LIG_SUMO_SIM_par_1	357	362	PF11976	0.442
LIG_SUMO_SIM_par_1	485	492	PF11976	0.554
LIG_TYR_ITIM	354	359	PF00017	0.457
LIG_TYR_ITIM	36	41	PF00017	0.479
LIG_TYR_ITIM	565	570	PF00017	0.509
LIG_UBA3_1	243	250	PF00899	0.507
LIG_WRC_WIRS_1	759	764	PF05994	0.567
LIG_WW_3	668	672	PF00397	0.472
MOD_CDC14_SPxK_1	644	647	PF00782	0.649
MOD_CDK_SPxK_1	296	302	PF00069	0.734
MOD_CDK_SPxK_1	641	647	PF00069	0.610
MOD_CDK_SPxxK_3	770	777	PF00069	0.704
MOD_CK1_1	133	139	PF00069	0.387
MOD_CK1_1	144	150	PF00069	0.619
MOD_CK1_1	196	202	PF00069	0.711
MOD_CK1_1	225	231	PF00069	0.697
MOD_CK1_1	251	257	PF00069	0.600
MOD_CK1_1	29	35	PF00069	0.482
MOD_CK1_1	370	376	PF00069	0.562
MOD_CK1_1	414	420	PF00069	0.782
MOD_CK1_1	44	50	PF00069	0.466
MOD_CK1_1	507	513	PF00069	0.770
MOD_CK1_1	734	740	PF00069	0.546
MOD_CK1_1	809	815	PF00069	0.714
MOD_GlcNHglycan	143	146	PF01048	0.618
MOD_GlcNHglycan	175	178	PF01048	0.719
MOD_GlcNHglycan	211	214	PF01048	0.670
MOD_GlcNHglycan	240	243	PF01048	0.684
MOD_GlcNHglycan	270	274	PF01048	0.719
MOD_GlcNHglycan	290	293	PF01048	0.817
MOD_GlcNHglycan	367	370	PF01048	0.754
MOD_GlcNHglycan	377	380	PF01048	0.705
MOD_GlcNHglycan	384	387	PF01048	0.567
MOD_GlcNHglycan	453	456	PF01048	0.521
MOD_GlcNHglycan	507	510	PF01048	0.782
MOD_GlcNHglycan	533	536	PF01048	0.600
MOD_GlcNHglycan	608	611	PF01048	0.773
MOD_GlcNHglycan	690	693	PF01048	0.609
MOD_GlcNHglycan	703	706	PF01048	0.562
MOD_GlcNHglycan	738	741	PF01048	0.651
MOD_GlcNHglycan	782	785	PF01048	0.824
MOD_GlcNHglycan	800	803	PF01048	0.438
MOD_GlcNHglycan	818	821	PF01048	0.718
MOD_GlcNHglycan	824	828	PF01048	0.705
MOD_GlcNHglycan	832	835	PF01048	0.669
MOD_GSK3_1	126	133	PF00069	0.579
MOD_GSK3_1	182	189	PF00069	0.678
MOD_GSK3_1	238	245	PF00069	0.714
MOD_GSK3_1	258	265	PF00069	0.647
MOD_GSK3_1	269	276	PF00069	0.639
MOD_GSK3_1	288	295	PF00069	0.754
MOD_GSK3_1	32	39	PF00069	0.451
MOD_GSK3_1	346	353	PF00069	0.536
MOD_GSK3_1	365	372	PF00069	0.434
MOD_GSK3_1	407	414	PF00069	0.737
MOD_GSK3_1	416	423	PF00069	0.660
MOD_GSK3_1	44	51	PF00069	0.530
MOD_GSK3_1	500	507	PF00069	0.732
MOD_GSK3_1	54	61	PF00069	0.539
MOD_GSK3_1	701	708	PF00069	0.744
MOD_GSK3_1	736	743	PF00069	0.550
MOD_GSK3_1	88	95	PF00069	0.403
MOD_N-GLC_1	32	37	PF02516	0.515
MOD_N-GLC_1	500	505	PF02516	0.638
MOD_N-GLC_1	769	774	PF02516	0.563
MOD_NEK2_1	36	41	PF00069	0.422
MOD_NEK2_1	441	446	PF00069	0.472
MOD_NEK2_1	505	510	PF00069	0.783
MOD_NEK2_1	816	821	PF00069	0.709
MOD_NEK2_1	844	849	PF00069	0.262
MOD_NEK2_1	88	93	PF00069	0.483
MOD_NEK2_2	350	355	PF00069	0.610
MOD_NEK2_2	54	59	PF00069	0.536
MOD_NEK2_2	740	745	PF00069	0.562
MOD_PIKK_1	225	231	PF00454	0.753
MOD_PIKK_1	500	506	PF00454	0.746
MOD_PIKK_1	592	598	PF00454	0.506
MOD_PIKK_1	621	627	PF00454	0.682
MOD_PIKK_1	731	737	PF00454	0.577
MOD_PIKK_1	809	815	PF00454	0.674
MOD_PKA_1	182	188	PF00069	0.550
MOD_PKA_2	196	202	PF00069	0.665
MOD_PKA_2	215	221	PF00069	0.727
MOD_PKA_2	350	356	PF00069	0.570
MOD_PKA_2	720	726	PF00069	0.603
MOD_PKA_2	731	737	PF00069	0.401
MOD_PKA_2	830	836	PF00069	0.657
MOD_PKB_1	180	188	PF00069	0.519
MOD_Plk_1	32	38	PF00069	0.511
MOD_Plk_1	500	506	PF00069	0.674
MOD_Plk_1	545	551	PF00069	0.556
MOD_Plk_2-3	8	14	PF00069	0.540
MOD_Plk_4	130	136	PF00069	0.446
MOD_Plk_4	32	38	PF00069	0.461
MOD_Plk_4	350	356	PF00069	0.612
MOD_Plk_4	521	527	PF00069	0.513
MOD_Plk_4	740	746	PF00069	0.476
MOD_Plk_4	81	87	PF00069	0.537
MOD_ProDKin_1	104	110	PF00069	0.488
MOD_ProDKin_1	153	159	PF00069	0.711
MOD_ProDKin_1	242	248	PF00069	0.615
MOD_ProDKin_1	258	264	PF00069	0.528
MOD_ProDKin_1	296	302	PF00069	0.734
MOD_ProDKin_1	354	360	PF00069	0.457
MOD_ProDKin_1	407	413	PF00069	0.766
MOD_ProDKin_1	641	647	PF00069	0.610
MOD_ProDKin_1	770	776	PF00069	0.777
MOD_ProDKin_1	806	812	PF00069	0.705
MOD_SUMO_rev_2	2	11	PF00179	0.460
MOD_SUMO_rev_2	572	577	PF00179	0.647
MOD_SUMO_rev_2	68	72	PF00179	0.468
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.527
TRG_ENDOCYTIC_2	356	359	PF00928	0.449
TRG_ENDOCYTIC_2	38	41	PF00928	0.433
TRG_ENDOCYTIC_2	466	469	PF00928	0.489
TRG_ENDOCYTIC_2	567	570	PF00928	0.515
TRG_ENDOCYTIC_2	730	733	PF00928	0.551
TRG_ENDOCYTIC_2	745	748	PF00928	0.453
TRG_ER_diArg_1	179	181	PF00400	0.780
TRG_ER_diArg_1	301	304	PF00400	0.709
TRG_NES_CRM1_1	467	482	PF08389	0.513
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	848	852	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB49	Leptomonas seymouri	53%	100%
A0A3R7M1K8	Trypanosoma rangeli	27%	100%
A0A3S7WNL7	Leishmania donovani	85%	100%
A4H3A8	Leishmania braziliensis	64%	99%
A4HRL7	Leishmania infantum	87%	100%
E9AC88	Leishmania major	82%	100%