C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJI0_LEIMU

TriTrypDb:

LmxM.02.0130

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	5
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	5
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	5
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

E9AJI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJI0

Function

Biological processes
Term	Name	Level	Count
GO:0000245	spliceosomal complex assembly	7	1
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	5
GO:0008270	zinc ion binding	6	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.417
CLV_NRD_NRD_1	62	64	PF00675	0.626
CLV_NRD_NRD_1	78	80	PF00675	0.525
CLV_NRD_NRD_1	87	89	PF00675	0.636
CLV_PCSK_KEX2_1	25	27	PF00082	0.557
CLV_PCSK_KEX2_1	62	64	PF00082	0.600
CLV_PCSK_KEX2_1	78	80	PF00082	0.503
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.575
CLV_PCSK_SKI1_1	200	204	PF00082	0.459
DOC_CKS1_1	118	123	PF01111	0.417
DOC_MAPK_gen_1	135	144	PF00069	0.417
DOC_MAPK_gen_1	62	73	PF00069	0.681
DOC_MAPK_gen_1	86	96	PF00069	0.670
DOC_MAPK_HePTP_8	132	144	PF00069	0.417
DOC_MAPK_MEF2A_6	135	144	PF00069	0.417
DOC_PP4_FxxP_1	118	121	PF00568	0.342
DOC_USP7_MATH_1	206	210	PF00917	0.402
DOC_USP7_UBL2_3	189	193	PF12436	0.374
DOC_WW_Pin1_4	117	122	PF00397	0.417
LIG_14-3-3_CanoR_1	156	165	PF00244	0.318
LIG_14-3-3_CanoR_1	223	228	PF00244	0.391
LIG_CaM_IQ_9	55	71	PF13499	0.681
LIG_deltaCOP1_diTrp_1	212	218	PF00928	0.459
LIG_eIF4E_1	172	178	PF01652	0.417
LIG_FHA_1	149	155	PF00498	0.374
LIG_FHA_1	183	189	PF00498	0.342
LIG_FHA_1	31	37	PF00498	0.572
LIG_FHA_1	53	59	PF00498	0.642
LIG_FHA_2	125	131	PF00498	0.318
LIG_FHA_2	143	149	PF00498	0.318
LIG_FHA_2	79	85	PF00498	0.741
LIG_IBAR_NPY_1	21	23	PF08397	0.655
LIG_LIR_Gen_1	136	147	PF02991	0.323
LIG_LIR_Gen_1	170	179	PF02991	0.324
LIG_LIR_Gen_1	181	191	PF02991	0.304
LIG_LIR_Nem_3	136	142	PF02991	0.323
LIG_LIR_Nem_3	170	176	PF02991	0.324
LIG_LIR_Nem_3	181	186	PF02991	0.304
LIG_LIR_Nem_3	217	221	PF02991	0.301
LIG_LIR_Nem_3	226	231	PF02991	0.524
LIG_LIR_Nem_3	9	15	PF02991	0.615
LIG_PTB_Apo_2	18	25	PF02174	0.657
LIG_Rb_LxCxE_1	35	57	PF01857	0.628
LIG_SH2_CRK	183	187	PF00017	0.374
LIG_SH2_NCK_1	12	16	PF00017	0.641
LIG_SH2_NCK_1	183	187	PF00017	0.342
LIG_SH2_SRC	12	15	PF00017	0.645
LIG_SH2_STAP1	183	187	PF00017	0.374
LIG_SH2_STAP1	225	229	PF00017	0.519
LIG_SH2_STAT5	172	175	PF00017	0.328
LIG_SH2_STAT5	225	228	PF00017	0.572
LIG_SH2_STAT5	23	26	PF00017	0.656
LIG_SH2_STAT5	40	43	PF00017	0.605
LIG_SH3_3	162	168	PF00018	0.374
LIG_SH3_3	8	14	PF00018	0.408
LIG_SH3_5	168	172	PF00018	0.459
LIG_SUMO_SIM_par_1	90	97	PF11976	0.667
LIG_WRC_WIRS_1	122	127	PF05994	0.394
MOD_CK1_1	124	130	PF00069	0.415
MOD_CK2_1	142	148	PF00069	0.464
MOD_CK2_1	156	162	PF00069	0.128
MOD_CK2_1	206	212	PF00069	0.354
MOD_CK2_1	78	84	PF00069	0.739
MOD_CMANNOS	215	218	PF00535	0.459
MOD_GlcNHglycan	107	110	PF01048	0.657
MOD_GlcNHglycan	158	161	PF01048	0.330
MOD_GlcNHglycan	2	5	PF01048	0.670
MOD_GlcNHglycan	6	9	PF01048	0.593
MOD_GlcNHglycan	96	99	PF01048	0.661
MOD_GSK3_1	117	124	PF00069	0.378
MOD_N-GLC_1	194	199	PF02516	0.459
MOD_NEK2_1	94	99	PF00069	0.600
MOD_NEK2_2	121	126	PF00069	0.374
MOD_PIKK_1	142	148	PF00454	0.451
MOD_PIKK_1	194	200	PF00454	0.430
MOD_PKA_1	78	84	PF00069	0.563
MOD_PKA_2	78	84	PF00069	0.569
MOD_Plk_4	223	229	PF00069	0.562
MOD_ProDKin_1	117	123	PF00069	0.417
TRG_DiLeu_BaEn_2	42	48	PF01217	0.597
TRG_DiLeu_BaEn_4	43	49	PF01217	0.604
TRG_ENDOCYTIC_2	12	15	PF00928	0.645
TRG_ENDOCYTIC_2	175	178	PF00928	0.327
TRG_ENDOCYTIC_2	183	186	PF00928	0.304
TRG_ENDOCYTIC_2	225	228	PF00928	0.509
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I8	Leptomonas seymouri	74%	94%
A0A0S4J697	Bodo saltans	42%	100%
A0A3S5H4Y4	Leishmania donovani	91%	97%
A4H3A7	Leishmania braziliensis	86%	100%
A4HRL6	Leishmania infantum	91%	97%
C9ZJ05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AC87	Leishmania major	86%	100%
Q54B65	Dictyostelium discoideum	31%	100%
Q9P7L8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5AQR9	Trypanosoma cruzi	50%	95%