Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJH6_LEIMU

TriTrypDb:

LmxM.02.0090

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.560
CLV_C14_Caspase3-7	317	321	PF00656	0.490
CLV_NRD_NRD_1	118	120	PF00675	0.447
CLV_NRD_NRD_1	301	303	PF00675	0.473
CLV_NRD_NRD_1	69	71	PF00675	0.631
CLV_NRD_NRD_1	74	76	PF00675	0.573
CLV_NRD_NRD_1	8	10	PF00675	0.613
CLV_PCSK_KEX2_1	117	119	PF00082	0.452
CLV_PCSK_KEX2_1	351	353	PF00082	0.640
CLV_PCSK_KEX2_1	69	71	PF00082	0.627
CLV_PCSK_KEX2_1	74	76	PF00082	0.567
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.578
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.643
CLV_PCSK_PC7_1	70	76	PF00082	0.679
CLV_PCSK_SKI1_1	111	115	PF00082	0.579
CLV_PCSK_SKI1_1	15	19	PF00082	0.504
CLV_PCSK_SKI1_1	285	289	PF00082	0.614
DOC_CKS1_1	333	338	PF01111	0.676
DOC_PP2B_LxvP_1	168	171	PF13499	0.540
DOC_USP7_MATH_1	162	166	PF00917	0.490
DOC_USP7_MATH_1	321	325	PF00917	0.680
DOC_USP7_MATH_1	342	346	PF00917	0.687
DOC_USP7_MATH_1	46	50	PF00917	0.635
DOC_USP7_UBL2_3	29	33	PF12436	0.596
DOC_USP7_UBL2_3	59	63	PF12436	0.643
DOC_WW_Pin1_4	226	231	PF00397	0.574
DOC_WW_Pin1_4	332	337	PF00397	0.743
DOC_WW_Pin1_4	88	93	PF00397	0.652
LIG_14-3-3_CanoR_1	223	230	PF00244	0.532
LIG_14-3-3_CanoR_1	285	291	PF00244	0.340
LIG_14-3-3_CanoR_1	74	82	PF00244	0.545
LIG_FHA_1	279	285	PF00498	0.435
LIG_FHA_1	99	105	PF00498	0.617
LIG_FHA_2	204	210	PF00498	0.507
LIG_FHA_2	231	237	PF00498	0.558
LIG_FHA_2	62	68	PF00498	0.657
LIG_Integrin_isoDGR_2	37	39	PF01839	0.638
LIG_LIR_Gen_1	208	218	PF02991	0.425
LIG_LIR_Gen_1	266	274	PF02991	0.341
LIG_LIR_Gen_1	81	90	PF02991	0.529
LIG_LIR_Nem_3	208	213	PF02991	0.441
LIG_LIR_Nem_3	246	251	PF02991	0.454
LIG_LIR_Nem_3	266	272	PF02991	0.342
LIG_LIR_Nem_3	295	300	PF02991	0.491
LIG_LIR_Nem_3	5	11	PF02991	0.552
LIG_LIR_Nem_3	81	86	PF02991	0.543
LIG_NRP_CendR_1	351	354	PF00754	0.752
LIG_Pex14_2	293	297	PF04695	0.489
LIG_SH2_NCK_1	161	165	PF00017	0.389
LIG_SH2_SRC	129	132	PF00017	0.463
LIG_SH2_STAT5	129	132	PF00017	0.439
LIG_SH2_STAT5	156	159	PF00017	0.394
LIG_SH2_STAT5	203	206	PF00017	0.597
LIG_SH2_STAT5	237	240	PF00017	0.530
LIG_SH2_STAT5	292	295	PF00017	0.475
LIG_UBA3_1	17	23	PF00899	0.486
LIG_UBA3_1	24	33	PF00899	0.536
MOD_CDK_SPK_2	88	93	PF00069	0.497
MOD_CK1_1	183	189	PF00069	0.425
MOD_CK1_1	19	25	PF00069	0.587
MOD_CK1_1	61	67	PF00069	0.524
MOD_CK1_1	91	97	PF00069	0.668
MOD_CK2_1	203	209	PF00069	0.481
MOD_Cter_Amidation	347	350	PF01082	0.735
MOD_GlcNHglycan	108	111	PF01048	0.575
MOD_GlcNHglycan	131	134	PF01048	0.464
MOD_GlcNHglycan	186	189	PF01048	0.580
MOD_GlcNHglycan	226	229	PF01048	0.506
MOD_GlcNHglycan	304	308	PF01048	0.591
MOD_GlcNHglycan	323	326	PF01048	0.655
MOD_GlcNHglycan	337	340	PF01048	0.660
MOD_GlcNHglycan	346	349	PF01048	0.705
MOD_GSK3_1	180	187	PF00069	0.580
MOD_GSK3_1	201	208	PF00069	0.543
MOD_GSK3_1	226	233	PF00069	0.517
MOD_GSK3_1	54	61	PF00069	0.594
MOD_GSK3_1	65	72	PF00069	0.612
MOD_GSK3_1	94	101	PF00069	0.576
MOD_NEK2_1	180	185	PF00069	0.578
MOD_NEK2_1	305	310	PF00069	0.568
MOD_NEK2_1	58	63	PF00069	0.489
MOD_PIKK_1	272	278	PF00454	0.586
MOD_PIKK_1	69	75	PF00454	0.738
MOD_PKA_1	69	75	PF00069	0.621
MOD_PKA_2	106	112	PF00069	0.516
MOD_PKA_2	224	230	PF00069	0.461
MOD_PKA_2	272	278	PF00069	0.488
MOD_PKA_2	69	75	PF00069	0.629
MOD_Plk_1	201	207	PF00069	0.578
MOD_Plk_4	78	84	PF00069	0.530
MOD_ProDKin_1	226	232	PF00069	0.574
MOD_ProDKin_1	332	338	PF00069	0.743
MOD_ProDKin_1	88	94	PF00069	0.651
TRG_DiLeu_BaEn_1	13	18	PF01217	0.548
TRG_DiLeu_BaEn_4	13	19	PF01217	0.568
TRG_ER_diArg_1	270	273	PF00400	0.481
TRG_ER_diArg_1	352	354	PF00400	0.687
TRG_ER_diLys_1	349	354	PF00400	0.706
TRG_NLS_MonoCore_2	348	353	PF00514	0.752
TRG_NLS_MonoExtC_3	348	353	PF00514	0.678
TRG_NLS_MonoExtC_3	61	66	PF00514	0.673
TRG_NLS_MonoExtN_4	349	354	PF00514	0.699
TRG_NLS_MonoExtN_4	59	66	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM5	Leptomonas seymouri	61%	100%
A0A0S4JHT8	Bodo saltans	28%	99%
A0A1X0NKG5	Trypanosomatidae	36%	90%
A0A3S5H4Y1	Leishmania donovani	90%	100%
A0A422N6Z1	Trypanosoma rangeli	38%	91%
A4H3B2	Leishmania braziliensis	76%	100%
A4HRL2	Leishmania infantum	91%	100%
C9ZJ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
E9AC84	Leishmania major	86%	99%
V5B685	Trypanosoma cruzi	37%	91%