CULT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJH5_LEIMU

TriTrypDb:

LmxM.02.0085

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.539
CLV_NRD_NRD_1	19	21	PF00675	0.547
CLV_NRD_NRD_1	211	213	PF00675	0.531
CLV_NRD_NRD_1	258	260	PF00675	0.675
CLV_NRD_NRD_1	328	330	PF00675	0.614
CLV_NRD_NRD_1	47	49	PF00675	0.734
CLV_PCSK_KEX2_1	161	163	PF00082	0.539
CLV_PCSK_KEX2_1	19	21	PF00082	0.547
CLV_PCSK_KEX2_1	211	213	PF00082	0.531
CLV_PCSK_KEX2_1	257	259	PF00082	0.693
CLV_PCSK_KEX2_1	328	330	PF00082	0.614
CLV_PCSK_KEX2_1	47	49	PF00082	0.735
CLV_PCSK_PC7_1	43	49	PF00082	0.626
DEG_SPOP_SBC_1	174	178	PF00917	0.335
DOC_CKS1_1	192	197	PF01111	0.550
DOC_CYCLIN_RxL_1	161	172	PF00134	0.401
DOC_MAPK_gen_1	16	26	PF00069	0.561
DOC_MAPK_gen_1	161	168	PF00069	0.458
DOC_MAPK_gen_1	217	226	PF00069	0.529
DOC_MAPK_gen_1	257	265	PF00069	0.621
DOC_MAPK_MEF2A_6	19	28	PF00069	0.552
DOC_MAPK_MEF2A_6	219	228	PF00069	0.543
DOC_MAPK_MEF2A_6	282	291	PF00069	0.574
DOC_MAPK_RevD_3	198	212	PF00069	0.450
DOC_PP1_RVXF_1	162	169	PF00149	0.419
DOC_PP2B_LxvP_1	138	141	PF13499	0.480
DOC_PP2B_LxvP_1	228	231	PF13499	0.471
DOC_PP4_FxxP_1	189	192	PF00568	0.412
DOC_USP7_MATH_1	118	122	PF00917	0.683
DOC_USP7_MATH_1	174	178	PF00917	0.485
DOC_USP7_MATH_1	210	214	PF00917	0.488
DOC_USP7_MATH_1	240	244	PF00917	0.532
DOC_USP7_MATH_1	290	294	PF00917	0.449
DOC_USP7_MATH_1	33	37	PF00917	0.662
DOC_USP7_MATH_1	87	91	PF00917	0.634
DOC_WW_Pin1_4	1	6	PF00397	0.437
DOC_WW_Pin1_4	114	119	PF00397	0.816
DOC_WW_Pin1_4	123	128	PF00397	0.521
DOC_WW_Pin1_4	14	19	PF00397	0.443
DOC_WW_Pin1_4	149	154	PF00397	0.547
DOC_WW_Pin1_4	191	196	PF00397	0.556
DOC_WW_Pin1_4	212	217	PF00397	0.643
DOC_WW_Pin1_4	294	299	PF00397	0.507
LIG_14-3-3_CanoR_1	120	125	PF00244	0.686
LIG_14-3-3_CanoR_1	199	204	PF00244	0.597
LIG_14-3-3_CanoR_1	311	320	PF00244	0.453
LIG_14-3-3_CanoR_1	59	65	PF00244	0.741
LIG_14-3-3_CanoR_1	66	70	PF00244	0.681
LIG_14-3-3_CanoR_1	73	83	PF00244	0.583
LIG_14-3-3_CanoR_1	88	92	PF00244	0.612
LIG_14-3-3_CanoR_1	93	97	PF00244	0.698
LIG_BRCT_BRCA1_1	169	173	PF00533	0.403
LIG_BRCT_BRCA1_1	3	7	PF00533	0.441
LIG_eIF4E_1	21	27	PF01652	0.496
LIG_EVH1_2	132	136	PF00568	0.595
LIG_FHA_1	174	180	PF00498	0.566
LIG_FHA_1	23	29	PF00498	0.685
LIG_FHA_1	232	238	PF00498	0.611
LIG_FHA_1	260	266	PF00498	0.605
LIG_FHA_1	308	314	PF00498	0.525
LIG_FHA_2	268	274	PF00498	0.549
LIG_LIR_Apic_2	188	192	PF02991	0.467
LIG_LIR_Gen_1	139	149	PF02991	0.636
LIG_LIR_Gen_1	4	15	PF02991	0.458
LIG_LIR_Nem_3	139	145	PF02991	0.491
LIG_LIR_Nem_3	184	189	PF02991	0.404
LIG_LIR_Nem_3	4	10	PF02991	0.451
LIG_LIR_Nem_3	57	61	PF02991	0.457
LIG_MLH1_MIPbox_1	3	7	PF16413	0.441
LIG_MYND_1	50	54	PF01753	0.507
LIG_SH2_STAT5	158	161	PF00017	0.383
LIG_SH2_STAT5	312	315	PF00017	0.382
LIG_SH3_1	48	54	PF00018	0.578
LIG_SH3_3	121	127	PF00018	0.547
LIG_SH3_3	189	195	PF00018	0.545
LIG_SH3_3	48	54	PF00018	0.713
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.506
LIG_SUMO_SIM_par_1	261	268	PF11976	0.603
LIG_SUMO_SIM_par_1	287	293	PF11976	0.449
LIG_TRAF2_1	264	267	PF00917	0.595
LIG_TRFH_1	136	140	PF08558	0.601
LIG_WRPW_2	58	61	PF00400	0.459
MOD_CDC14_SPxK_1	117	120	PF00782	0.714
MOD_CDK_SPK_2	14	19	PF00069	0.469
MOD_CDK_SPK_2	212	217	PF00069	0.674
MOD_CDK_SPxK_1	114	120	PF00069	0.713
MOD_CDK_SPxK_1	14	20	PF00069	0.471
MOD_CDK_SPxxK_3	212	219	PF00069	0.601
MOD_CK1_1	193	199	PF00069	0.470
MOD_CK1_1	222	228	PF00069	0.756
MOD_CK1_1	261	267	PF00069	0.489
MOD_CK1_1	65	71	PF00069	0.687
MOD_CK1_1	99	105	PF00069	0.688
MOD_CK2_1	261	267	PF00069	0.629
MOD_CK2_1	324	330	PF00069	0.615
MOD_DYRK1A_RPxSP_1	212	216	PF00069	0.483
MOD_GlcNHglycan	102	105	PF01048	0.698
MOD_GlcNHglycan	183	186	PF01048	0.466
MOD_GlcNHglycan	195	198	PF01048	0.415
MOD_GlcNHglycan	292	295	PF01048	0.496
MOD_GlcNHglycan	30	33	PF01048	0.643
MOD_GlcNHglycan	304	307	PF01048	0.631
MOD_GlcNHglycan	35	38	PF01048	0.628
MOD_GlcNHglycan	77	80	PF01048	0.749
MOD_GSK3_1	114	121	PF00069	0.699
MOD_GSK3_1	169	176	PF00069	0.431
MOD_GSK3_1	181	188	PF00069	0.454
MOD_GSK3_1	222	229	PF00069	0.723
MOD_GSK3_1	261	268	PF00069	0.611
MOD_GSK3_1	290	297	PF00069	0.514
MOD_GSK3_1	307	314	PF00069	0.586
MOD_GSK3_1	65	72	PF00069	0.656
MOD_GSK3_1	87	94	PF00069	0.765
MOD_GSK3_1	96	103	PF00069	0.625
MOD_N-GLC_1	222	227	PF02516	0.602
MOD_N-GLC_1	69	74	PF02516	0.551
MOD_NEK2_1	173	178	PF00069	0.523
MOD_NEK2_1	198	203	PF00069	0.473
MOD_NEK2_1	204	209	PF00069	0.528
MOD_NEK2_1	265	270	PF00069	0.643
MOD_NEK2_1	28	33	PF00069	0.656
MOD_NEK2_1	38	43	PF00069	0.660
MOD_NEK2_1	69	74	PF00069	0.721
MOD_NEK2_1	82	87	PF00069	0.578
MOD_NEK2_1	91	96	PF00069	0.532
MOD_PIKK_1	300	306	PF00454	0.560
MOD_PKA_1	258	264	PF00069	0.502
MOD_PKA_2	198	204	PF00069	0.519
MOD_PKA_2	210	216	PF00069	0.531
MOD_PKA_2	258	264	PF00069	0.508
MOD_PKA_2	271	277	PF00069	0.621
MOD_PKA_2	65	71	PF00069	0.700
MOD_PKA_2	87	93	PF00069	0.636
MOD_PKB_1	217	225	PF00069	0.604
MOD_PKB_1	257	265	PF00069	0.648
MOD_Plk_1	174	180	PF00069	0.490
MOD_Plk_1	222	228	PF00069	0.485
MOD_Plk_2-3	267	273	PF00069	0.668
MOD_Plk_4	120	126	PF00069	0.567
MOD_Plk_4	185	191	PF00069	0.503
MOD_Plk_4	199	205	PF00069	0.462
MOD_Plk_4	22	28	PF00069	0.496
MOD_Plk_4	87	93	PF00069	0.527
MOD_ProDKin_1	1	7	PF00069	0.441
MOD_ProDKin_1	114	120	PF00069	0.818
MOD_ProDKin_1	123	129	PF00069	0.517
MOD_ProDKin_1	14	20	PF00069	0.446
MOD_ProDKin_1	149	155	PF00069	0.563
MOD_ProDKin_1	191	197	PF00069	0.550
MOD_ProDKin_1	212	218	PF00069	0.641
MOD_ProDKin_1	294	300	PF00069	0.504
MOD_SUMO_for_1	145	148	PF00179	0.307
TRG_ENDOCYTIC_2	21	24	PF00928	0.653
TRG_ER_diArg_1	161	164	PF00400	0.481
TRG_ER_diArg_1	18	20	PF00400	0.538
TRG_ER_diArg_1	216	219	PF00400	0.528
TRG_ER_diArg_1	256	259	PF00400	0.685
TRG_ER_diArg_1	46	48	PF00400	0.734
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7LQ19	Trypanosoma rangeli	32%	100%
A0A3S5H4Y0	Leishmania donovani	87%	100%
A4H3B3	Leishmania braziliensis	65%	100%
A4HRL1	Leishmania infantum	87%	100%
C9ZIZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AC83	Leishmania major	86%	100%