Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJH4_LEIMU

TriTrypDb:

LmxM.02.0080

Length:

997

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.687
CLV_C14_Caspase3-7	943	947	PF00656	0.657
CLV_NRD_NRD_1	145	147	PF00675	0.569
CLV_NRD_NRD_1	454	456	PF00675	0.503
CLV_NRD_NRD_1	744	746	PF00675	0.598
CLV_NRD_NRD_1	895	897	PF00675	0.549
CLV_PCSK_FUR_1	143	147	PF00082	0.553
CLV_PCSK_FUR_1	893	897	PF00082	0.573
CLV_PCSK_KEX2_1	143	145	PF00082	0.549
CLV_PCSK_KEX2_1	454	456	PF00082	0.503
CLV_PCSK_KEX2_1	744	746	PF00082	0.721
CLV_PCSK_KEX2_1	895	897	PF00082	0.575
CLV_PCSK_KEX2_1	978	980	PF00082	0.653
CLV_PCSK_PC1ET2_1	978	980	PF00082	0.653
CLV_PCSK_PC7_1	140	146	PF00082	0.576
CLV_PCSK_SKI1_1	130	134	PF00082	0.520
CLV_PCSK_SKI1_1	228	232	PF00082	0.411
CLV_PCSK_SKI1_1	332	336	PF00082	0.341
CLV_PCSK_SKI1_1	425	429	PF00082	0.462
CLV_PCSK_SKI1_1	486	490	PF00082	0.593
CLV_PCSK_SKI1_1	591	595	PF00082	0.446
CLV_PCSK_SKI1_1	596	600	PF00082	0.460
CLV_PCSK_SKI1_1	615	619	PF00082	0.364
CLV_PCSK_SKI1_1	744	748	PF00082	0.625
CLV_PCSK_SKI1_1	898	902	PF00082	0.579
DEG_APCC_DBOX_1	424	432	PF00400	0.457
DEG_APCC_DBOX_1	827	835	PF00400	0.717
DEG_Kelch_actinfilin_1	649	653	PF01344	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DEG_SCF_FBW7_2	833	839	PF00400	0.748
DEG_SPOP_SBC_1	580	584	PF00917	0.374
DEG_SPOP_SBC_1	814	818	PF00917	0.693
DOC_CKS1_1	514	519	PF01111	0.627
DOC_CKS1_1	618	623	PF01111	0.551
DOC_CKS1_1	833	838	PF01111	0.747
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.594
DOC_MAPK_gen_1	150	158	PF00069	0.569
DOC_MAPK_MEF2A_6	248	255	PF00069	0.490
DOC_PP2B_LxvP_1	114	117	PF13499	0.682
DOC_PP2B_LxvP_1	754	757	PF13499	0.712
DOC_PP2B_LxvP_1	954	957	PF13499	0.535
DOC_USP7_MATH_1	11	15	PF00917	0.643
DOC_USP7_MATH_1	208	212	PF00917	0.625
DOC_USP7_MATH_1	214	218	PF00917	0.545
DOC_USP7_MATH_1	317	321	PF00917	0.525
DOC_USP7_MATH_1	340	344	PF00917	0.600
DOC_USP7_MATH_1	361	365	PF00917	0.669
DOC_USP7_MATH_1	682	686	PF00917	0.600
DOC_USP7_MATH_1	707	711	PF00917	0.789
DOC_USP7_MATH_1	713	717	PF00917	0.656
DOC_USP7_MATH_1	76	80	PF00917	0.348
DOC_USP7_MATH_1	763	767	PF00917	0.581
DOC_USP7_MATH_1	807	811	PF00917	0.771
DOC_USP7_MATH_1	814	818	PF00917	0.704
DOC_USP7_MATH_1	918	922	PF00917	0.574
DOC_USP7_MATH_1	957	961	PF00917	0.829
DOC_USP7_MATH_1	977	981	PF00917	0.439
DOC_WW_Pin1_4	167	172	PF00397	0.695
DOC_WW_Pin1_4	221	226	PF00397	0.558
DOC_WW_Pin1_4	356	361	PF00397	0.685
DOC_WW_Pin1_4	39	44	PF00397	0.748
DOC_WW_Pin1_4	513	518	PF00397	0.622
DOC_WW_Pin1_4	617	622	PF00397	0.586
DOC_WW_Pin1_4	817	822	PF00397	0.807
DOC_WW_Pin1_4	832	837	PF00397	0.571
DOC_WW_Pin1_4	966	971	PF00397	0.682
LIG_14-3-3_CanoR_1	332	337	PF00244	0.416
LIG_14-3-3_CanoR_1	367	377	PF00244	0.537
LIG_14-3-3_CanoR_1	454	458	PF00244	0.508
LIG_14-3-3_CanoR_1	476	484	PF00244	0.521
LIG_14-3-3_CanoR_1	486	491	PF00244	0.430
LIG_14-3-3_CanoR_1	525	530	PF00244	0.589
LIG_14-3-3_CanoR_1	596	601	PF00244	0.562
LIG_14-3-3_CanoR_1	640	645	PF00244	0.690
LIG_14-3-3_CanoR_1	706	712	PF00244	0.499
LIG_14-3-3_CanoR_1	782	787	PF00244	0.568
LIG_14-3-3_CanoR_1	828	832	PF00244	0.602
LIG_14-3-3_CanoR_1	89	97	PF00244	0.636
LIG_14-3-3_CanoR_1	924	928	PF00244	0.537
LIG_14-3-3_CanoR_1	965	970	PF00244	0.712
LIG_14-3-3_CanoR_1	988	994	PF00244	0.578
LIG_Actin_WH2_2	394	409	PF00022	0.577
LIG_BIR_III_2	676	680	PF00653	0.457
LIG_BRCT_BRCA1_1	318	322	PF00533	0.567
LIG_BRCT_BRCA1_1	560	564	PF00533	0.633
LIG_BRCT_BRCA1_1	674	678	PF00533	0.696
LIG_BRCT_BRCA1_1	935	939	PF00533	0.679
LIG_FHA_1	158	164	PF00498	0.721
LIG_FHA_1	459	465	PF00498	0.546
LIG_FHA_1	551	557	PF00498	0.679
LIG_FHA_1	590	596	PF00498	0.448
LIG_FHA_1	763	769	PF00498	0.757
LIG_FHA_1	828	834	PF00498	0.596
LIG_FHA_1	863	869	PF00498	0.690
LIG_FHA_1	895	901	PF00498	0.544
LIG_FHA_1	982	988	PF00498	0.620
LIG_FHA_2	180	186	PF00498	0.626
LIG_FHA_2	442	448	PF00498	0.460
LIG_FHA_2	785	791	PF00498	0.759
LIG_GBD_Chelix_1	400	408	PF00786	0.462
LIG_Integrin_RGD_1	153	155	PF01839	0.575
LIG_LIR_Apic_2	721	726	PF02991	0.717
LIG_LIR_Gen_1	396	406	PF02991	0.427
LIG_LIR_Gen_1	442	452	PF02991	0.595
LIG_LIR_Gen_1	489	497	PF02991	0.509
LIG_LIR_Gen_1	561	572	PF02991	0.516
LIG_LIR_Gen_1	592	602	PF02991	0.557
LIG_LIR_Gen_1	772	781	PF02991	0.605
LIG_LIR_Gen_1	79	87	PF02991	0.438
LIG_LIR_Nem_3	220	226	PF02991	0.352
LIG_LIR_Nem_3	396	401	PF02991	0.441
LIG_LIR_Nem_3	442	448	PF02991	0.605
LIG_LIR_Nem_3	489	494	PF02991	0.495
LIG_LIR_Nem_3	561	567	PF02991	0.505
LIG_LIR_Nem_3	592	597	PF02991	0.402
LIG_LIR_Nem_3	675	681	PF02991	0.676
LIG_LIR_Nem_3	728	734	PF02991	0.594
LIG_LIR_Nem_3	772	776	PF02991	0.586
LIG_LIR_Nem_3	79	84	PF02991	0.602
LIG_NRBOX	596	602	PF00104	0.562
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.343
LIG_PDZ_Class_2	992	997	PF00595	0.524
LIG_Pex14_1	369	373	PF04695	0.552
LIG_PTB_Apo_2	587	594	PF02174	0.375
LIG_REV1ctd_RIR_1	591	600	PF16727	0.413
LIG_SH2_CRK	326	330	PF00017	0.401
LIG_SH2_GRB2like	147	150	PF00017	0.638
LIG_SH2_GRB2like	588	591	PF00017	0.506
LIG_SH2_SRC	328	331	PF00017	0.501
LIG_SH2_STAP1	285	289	PF00017	0.598
LIG_SH2_STAP1	293	297	PF00017	0.437
LIG_SH2_STAP1	326	330	PF00017	0.477
LIG_SH2_STAT3	902	905	PF00017	0.635
LIG_SH2_STAT5	147	150	PF00017	0.638
LIG_SH2_STAT5	315	318	PF00017	0.633
LIG_SH2_STAT5	328	331	PF00017	0.563
LIG_SH2_STAT5	405	408	PF00017	0.458
LIG_SH2_STAT5	445	448	PF00017	0.592
LIG_SH2_STAT5	723	726	PF00017	0.709
LIG_SH3_3	676	682	PF00018	0.666
LIG_SH3_3	801	807	PF00018	0.637
LIG_SH3_3	830	836	PF00018	0.665
LIG_SH3_3	865	871	PF00018	0.698
LIG_SH3_3	984	990	PF00018	0.579
LIG_SUMO_SIM_anti_2	55	64	PF11976	0.529
LIG_SUMO_SIM_par_1	460	466	PF11976	0.546
LIG_TRAF2_1	159	162	PF00917	0.689
LIG_TRAF2_1	182	185	PF00917	0.615
LIG_TRAF2_1	503	506	PF00917	0.522
LIG_TRAF2_1	689	692	PF00917	0.600
LIG_TRAF2_1	787	790	PF00917	0.758
LIG_TYR_ITIM	324	329	PF00017	0.574
LIG_UBA3_1	569	573	PF00899	0.640
LIG_WRC_WIRS_1	370	375	PF05994	0.546
LIG_WRC_WIRS_1	78	83	PF05994	0.438
LIG_WRPW_2	88	91	PF00400	0.594
MOD_CDC14_SPxK_1	46	49	PF00782	0.518
MOD_CDK_SPxK_1	43	49	PF00069	0.518
MOD_CDK_SPxxK_3	221	228	PF00069	0.554
MOD_CK1_1	263	269	PF00069	0.652
MOD_CK1_1	359	365	PF00069	0.638
MOD_CK1_1	368	374	PF00069	0.391
MOD_CK1_1	515	521	PF00069	0.596
MOD_CK1_1	558	564	PF00069	0.529
MOD_CK1_1	643	649	PF00069	0.570
MOD_CK1_1	671	677	PF00069	0.552
MOD_CK1_1	785	791	PF00069	0.635
MOD_CK1_1	810	816	PF00069	0.817
MOD_CK1_1	817	823	PF00069	0.712
MOD_CK1_1	958	964	PF00069	0.729
MOD_CK1_1	966	972	PF00069	0.727
MOD_CK2_1	125	131	PF00069	0.451
MOD_CK2_1	156	162	PF00069	0.677
MOD_CK2_1	179	185	PF00069	0.540
MOD_CK2_1	221	227	PF00069	0.505
MOD_CK2_1	630	636	PF00069	0.541
MOD_CK2_1	784	790	PF00069	0.758
MOD_CK2_1	858	864	PF00069	0.681
MOD_CK2_1	89	95	PF00069	0.441
MOD_CK2_1	957	963	PF00069	0.717
MOD_CK2_1	977	983	PF00069	0.728
MOD_GlcNHglycan	108	111	PF01048	0.499
MOD_GlcNHglycan	262	265	PF01048	0.664
MOD_GlcNHglycan	294	297	PF01048	0.575
MOD_GlcNHglycan	319	322	PF01048	0.529
MOD_GlcNHglycan	342	345	PF01048	0.710
MOD_GlcNHglycan	350	355	PF01048	0.674
MOD_GlcNHglycan	361	364	PF01048	0.535
MOD_GlcNHglycan	478	481	PF01048	0.386
MOD_GlcNHglycan	632	635	PF01048	0.518
MOD_GlcNHglycan	809	812	PF01048	0.791
MOD_GlcNHglycan	9	12	PF01048	0.710
MOD_GlcNHglycan	91	94	PF01048	0.579
MOD_GlcNHglycan	935	938	PF01048	0.635
MOD_GlcNHglycan	957	960	PF01048	0.827
MOD_GlcNHglycan	965	968	PF01048	0.700
MOD_GlcNHglycan	973	976	PF01048	0.551
MOD_GlcNHglycan	979	982	PF01048	0.615
MOD_GSK3_1	121	128	PF00069	0.528
MOD_GSK3_1	157	164	PF00069	0.700
MOD_GSK3_1	179	186	PF00069	0.563
MOD_GSK3_1	209	216	PF00069	0.632
MOD_GSK3_1	259	266	PF00069	0.590
MOD_GSK3_1	311	318	PF00069	0.701
MOD_GSK3_1	359	366	PF00069	0.635
MOD_GSK3_1	39	46	PF00069	0.686
MOD_GSK3_1	417	424	PF00069	0.556
MOD_GSK3_1	453	460	PF00069	0.561
MOD_GSK3_1	525	532	PF00069	0.695
MOD_GSK3_1	55	62	PF00069	0.497
MOD_GSK3_1	555	562	PF00069	0.564
MOD_GSK3_1	639	646	PF00069	0.597
MOD_GSK3_1	668	675	PF00069	0.700
MOD_GSK3_1	7	14	PF00069	0.665
MOD_GSK3_1	759	766	PF00069	0.621
MOD_GSK3_1	798	805	PF00069	0.696
MOD_GSK3_1	809	816	PF00069	0.745
MOD_GSK3_1	845	852	PF00069	0.688
MOD_GSK3_1	858	865	PF00069	0.631
MOD_GSK3_1	89	96	PF00069	0.491
MOD_GSK3_1	955	962	PF00069	0.746
MOD_GSK3_1	97	104	PF00069	0.753
MOD_GSK3_1	977	984	PF00069	0.745
MOD_N-GLC_1	589	594	PF02516	0.492
MOD_N-GLC_1	640	645	PF02516	0.499
MOD_N-GLC_1	797	802	PF02516	0.633
MOD_NEK2_1	199	204	PF00069	0.613
MOD_NEK2_1	292	297	PF00069	0.565
MOD_NEK2_1	309	314	PF00069	0.487
MOD_NEK2_1	324	329	PF00069	0.574
MOD_NEK2_1	457	462	PF00069	0.515
MOD_NEK2_1	59	64	PF00069	0.617
MOD_NEK2_1	845	850	PF00069	0.770
MOD_NEK2_1	862	867	PF00069	0.469
MOD_NEK2_1	923	928	PF00069	0.604
MOD_NEK2_1	931	936	PF00069	0.527
MOD_NEK2_2	589	594	PF00069	0.453
MOD_NEK2_2	918	923	PF00069	0.557
MOD_PIKK_1	200	206	PF00454	0.521
MOD_PIKK_1	439	445	PF00454	0.548
MOD_PIKK_1	668	674	PF00454	0.716
MOD_PIKK_1	713	719	PF00454	0.479
MOD_PIKK_1	785	791	PF00454	0.759
MOD_PIKK_1	95	101	PF00454	0.557
MOD_PK_1	782	788	PF00069	0.463
MOD_PKA_2	453	459	PF00069	0.504
MOD_PKA_2	6	12	PF00069	0.525
MOD_PKA_2	639	645	PF00069	0.607
MOD_PKA_2	827	833	PF00069	0.636
MOD_PKA_2	894	900	PF00069	0.650
MOD_PKA_2	923	929	PF00069	0.532
MOD_Plk_1	421	427	PF00069	0.518
MOD_Plk_1	558	564	PF00069	0.359
MOD_Plk_1	589	595	PF00069	0.451
MOD_Plk_1	640	646	PF00069	0.678
MOD_Plk_1	771	777	PF00069	0.410
MOD_Plk_1	846	852	PF00069	0.486
MOD_Plk_4	311	317	PF00069	0.702
MOD_Plk_4	324	330	PF00069	0.425
MOD_Plk_4	369	375	PF00069	0.449
MOD_Plk_4	441	447	PF00069	0.508
MOD_Plk_4	486	492	PF00069	0.597
MOD_Plk_4	525	531	PF00069	0.622
MOD_Plk_4	55	61	PF00069	0.606
MOD_Plk_4	559	565	PF00069	0.568
MOD_Plk_4	596	602	PF00069	0.494
MOD_Plk_4	682	688	PF00069	0.630
MOD_Plk_4	718	724	PF00069	0.729
MOD_Plk_4	749	755	PF00069	0.684
MOD_Plk_4	77	83	PF00069	0.368
MOD_Plk_4	918	924	PF00069	0.553
MOD_Plk_4	981	987	PF00069	0.638
MOD_Plk_4	989	995	PF00069	0.578
MOD_ProDKin_1	167	173	PF00069	0.696
MOD_ProDKin_1	221	227	PF00069	0.551
MOD_ProDKin_1	356	362	PF00069	0.682
MOD_ProDKin_1	39	45	PF00069	0.749
MOD_ProDKin_1	513	519	PF00069	0.623
MOD_ProDKin_1	617	623	PF00069	0.579
MOD_ProDKin_1	817	823	PF00069	0.803
MOD_ProDKin_1	832	838	PF00069	0.567
MOD_ProDKin_1	966	972	PF00069	0.680
MOD_SUMO_rev_2	104	110	PF00179	0.581
MOD_SUMO_rev_2	568	575	PF00179	0.640
MOD_SUMO_rev_2	936	945	PF00179	0.694
TRG_DiLeu_BaEn_3	741	747	PF01217	0.722
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.485
TRG_ENDOCYTIC_2	326	329	PF00928	0.459
TRG_ENDOCYTIC_2	405	408	PF00928	0.416
TRG_ENDOCYTIC_2	445	448	PF00928	0.592
TRG_ER_diArg_1	143	146	PF00400	0.549
TRG_ER_diArg_1	744	746	PF00400	0.598
TRG_ER_diArg_1	892	895	PF00400	0.586
TRG_ER_diArg_1	896	899	PF00400	0.464
TRG_NES_CRM1_1	524	539	PF08389	0.599
TRG_Pf-PMV_PEXEL_1	929	933	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K8	Leptomonas seymouri	37%	83%
A0A3S5H4X9	Leishmania donovani	87%	100%
A4H3A4	Leishmania braziliensis	71%	100%
A4HRL0	Leishmania infantum	87%	100%
E9AC82	Leishmania major	88%	100%