Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJH2_LEIMU

TriTrypDb:

LmxM.02.0060

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	118	122	PF00917	0.304
DOC_USP7_MATH_1	2	6	PF00917	0.520
DOC_WW_Pin1_4	59	64	PF00397	0.535
LIG_14-3-3_CanoR_1	30	34	PF00244	0.667
LIG_14-3-3_CanoR_1	64	69	PF00244	0.443
LIG_14-3-3_CanoR_1	88	97	PF00244	0.526
LIG_Clathr_ClatBox_1	96	100	PF01394	0.556
LIG_FHA_1	138	144	PF00498	0.392
LIG_FHA_1	202	208	PF00498	0.435
LIG_FHA_1	4	10	PF00498	0.438
LIG_FHA_2	20	26	PF00498	0.396
LIG_GBD_Chelix_1	127	135	PF00786	0.380
LIG_LIR_Gen_1	41	50	PF02991	0.438
LIG_LIR_Nem_3	167	173	PF02991	0.469
LIG_LIR_Nem_3	176	182	PF02991	0.446
LIG_LIR_Nem_3	41	47	PF02991	0.442
LIG_LIR_Nem_3	52	57	PF02991	0.426
LIG_Pex14_2	164	168	PF04695	0.459
LIG_Pex14_2	50	54	PF04695	0.494
LIG_SH2_CRK	179	183	PF00017	0.342
LIG_SH2_GRB2like	142	145	PF00017	0.439
LIG_SH2_STAP1	175	179	PF00017	0.343
LIG_SH2_STAT5	142	145	PF00017	0.308
LIG_SH3_3	6	12	PF00018	0.475
LIG_Sin3_3	170	177	PF02671	0.228
LIG_TRAF2_1	33	36	PF00917	0.353
MOD_CDK_SPK_2	59	64	PF00069	0.276
MOD_CK1_1	114	120	PF00069	0.443
MOD_CK1_1	90	96	PF00069	0.533
MOD_CK2_1	19	25	PF00069	0.397
MOD_CK2_1	29	35	PF00069	0.511
MOD_GlcNHglycan	116	119	PF01048	0.322
MOD_GlcNHglycan	31	34	PF01048	0.603
MOD_GlcNHglycan	82	85	PF01048	0.545
MOD_GSK3_1	110	117	PF00069	0.561
MOD_GSK3_1	87	94	PF00069	0.526
MOD_N-GLC_1	111	116	PF02516	0.575
MOD_N-GLC_1	64	69	PF02516	0.507
MOD_NEK2_1	119	124	PF00069	0.376
MOD_NEK2_1	164	169	PF00069	0.393
MOD_NEK2_1	89	94	PF00069	0.564
MOD_PIKK_1	121	127	PF00454	0.439
MOD_PIKK_1	91	97	PF00454	0.496
MOD_PK_1	64	70	PF00069	0.369
MOD_PKA_2	29	35	PF00069	0.662
MOD_PKA_2	87	93	PF00069	0.524
MOD_Plk_1	111	117	PF00069	0.530
MOD_Plk_1	175	181	PF00069	0.349
MOD_Plk_1	64	70	PF00069	0.502
MOD_Plk_2-3	19	25	PF00069	0.397
MOD_Plk_4	137	143	PF00069	0.409
MOD_ProDKin_1	59	65	PF00069	0.550
TRG_DiLeu_BaEn_1	35	40	PF01217	0.307
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.394
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.282
TRG_ENDOCYTIC_2	15	18	PF00928	0.309
TRG_ENDOCYTIC_2	179	182	PF00928	0.340
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ46	Leptomonas seymouri	48%	100%
A0A1X0NKM1	Trypanosomatidae	35%	100%
A0A422N6X4	Trypanosoma rangeli	30%	100%
A0A451EJE3	Leishmania donovani	86%	100%
A4H3A2	Leishmania braziliensis	77%	100%
A4HRK8	Leishmania infantum	86%	100%
C9ZIZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AC80	Leishmania major	86%	100%
V5BFA7	Trypanosoma cruzi	32%	100%