Peptidase_M3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJG9_LEIMU

TriTrypDb:

LmxM.01.0830

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJG9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0004222	metalloendopeptidase activity	5	2
GO:0005488	binding	1	2
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.865
CLV_NRD_NRD_1	238	240	PF00675	0.549
CLV_NRD_NRD_1	40	42	PF00675	0.549
CLV_NRD_NRD_1	51	53	PF00675	0.357
CLV_NRD_NRD_1	80	82	PF00675	0.549
CLV_PCSK_KEX2_1	16	18	PF00082	0.865
CLV_PCSK_KEX2_1	238	240	PF00082	0.549
CLV_PCSK_KEX2_1	51	53	PF00082	0.549
CLV_PCSK_KEX2_1	79	81	PF00082	0.549
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.549
DOC_MAPK_gen_1	116	125	PF00069	0.549
DOC_PP2B_LxvP_1	104	107	PF13499	0.549
DOC_PP4_FxxP_1	97	100	PF00568	0.549
DOC_USP7_MATH_1	179	183	PF00917	0.549
DOC_USP7_MATH_1	32	36	PF00917	0.840
DOC_USP7_MATH_1	61	65	PF00917	0.549
DOC_WW_Pin1_4	127	132	PF00397	0.549
DOC_WW_Pin1_4	149	154	PF00397	0.549
LIG_14-3-3_CanoR_1	122	126	PF00244	0.549
LIG_14-3-3_CanoR_1	79	84	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.836
LIG_BIR_III_1	1	5	PF00653	0.836
LIG_BIR_III_3	1	5	PF00653	0.836
LIG_FHA_1	122	128	PF00498	0.549
LIG_FHA_1	242	248	PF00498	0.549
LIG_FHA_2	67	73	PF00498	0.549
LIG_LIR_Gen_1	162	172	PF02991	0.549
LIG_LIR_Nem_3	162	168	PF02991	0.549
LIG_LIR_Nem_3	93	97	PF02991	0.549
LIG_MYND_1	107	111	PF01753	0.549
LIG_MYND_1	54	58	PF01753	0.549
LIG_PDZ_Class_2	250	255	PF00595	0.549
LIG_SH2_CRK	7	11	PF00017	0.855
LIG_SH3_1	191	197	PF00018	0.549
LIG_SH3_3	105	111	PF00018	0.410
LIG_SH3_3	173	179	PF00018	0.549
LIG_SH3_3	191	197	PF00018	0.234
LIG_SH3_3	222	228	PF00018	0.549
LIG_SH3_3	97	103	PF00018	0.549
MOD_CK2_1	15	21	PF00069	0.868
MOD_CK2_1	66	72	PF00069	0.549
MOD_Cter_Amidation	14	17	PF01082	0.863
MOD_GlcNHglycan	17	20	PF01048	0.868
MOD_GlcNHglycan	63	66	PF01048	0.549
MOD_GSK3_1	180	187	PF00069	0.549
MOD_N-GLC_1	32	37	PF02516	0.835
MOD_NEK2_2	74	79	PF00069	0.549
MOD_PIKK_1	195	201	PF00454	0.549
MOD_PKA_1	79	85	PF00069	0.549
MOD_PKA_2	121	127	PF00069	0.549
MOD_PKA_2	15	21	PF00069	0.868
MOD_PKA_2	79	85	PF00069	0.549
MOD_PKB_1	239	247	PF00069	0.549
MOD_Plk_4	160	166	PF00069	0.549
MOD_ProDKin_1	127	133	PF00069	0.549
MOD_ProDKin_1	149	155	PF00069	0.549
TRG_ENDOCYTIC_2	7	10	PF00928	0.855
TRG_ER_diArg_1	113	116	PF00400	0.549
TRG_ER_diArg_1	238	241	PF00400	0.549
TRG_ER_diArg_1	78	81	PF00400	0.549
TRG_NLS_Bipartite_1	41	55	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A1CTP5	ASPCL	33%	32%
A2VDQ5	BOVIN	25%	36%
A6SHZ5	BOTFB	35%	33%
A7E7L8	SCLS1	38%	32%
F4KDA5	ARATH	28%	36%
P0CQ18	CRYNJ	35%	34%
P0CQ19	CRYNB	35%	34%
P0CQ20	CRYNJ	28%	31%
P0CQ21	CRYNB	28%	31%
P24155	RAT	25%	37%
P24171	ECOLI	36%	37%
P27236	SALTY	35%	38%
P27237	SALTY	30%	38%
P27298	ECOLI	30%	38%
P42675	RABIT	25%	36%
P42676	RAT	31%	36%
P44573	HAEIN	27%	37%
P47788	PIG	25%	37%
P52888	HUMAN	31%	37%
Q02038	PIG	25%	36%
Q0TXL7	PHANO	31%	32%
Q1E8M9	COCIM	31%	32%
Q1JPJ8	BOVIN	25%	37%
Q2HFL8	CHAGB	38%	33%
Q54DD2	DICDI	29%	38%
Q5R9V6	PONAB	26%	36%
Q7SDD5	NEUCR	32%	32%
Q8C1A5	MOUSE	27%	37%
Q91YP2	MOUSE	31%	36%
Q949P2	ARATH	29%	36%
Q94AM1	ARATH	27%	32%
Q9BYT8	HUMAN	26%	36%