C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJG6_LEIMU

TriTrypDb:

LmxM.01.0800

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.693
CLV_NRD_NRD_1	270	272	PF00675	0.543
CLV_NRD_NRD_1	433	435	PF00675	0.667
CLV_NRD_NRD_1	436	438	PF00675	0.727
CLV_NRD_NRD_1	443	445	PF00675	0.749
CLV_NRD_NRD_1	454	456	PF00675	0.552
CLV_NRD_NRD_1	64	66	PF00675	0.662
CLV_NRD_NRD_1	78	80	PF00675	0.532
CLV_PCSK_FUR_1	268	272	PF00082	0.538
CLV_PCSK_KEX2_1	107	109	PF00082	0.716
CLV_PCSK_KEX2_1	118	120	PF00082	0.482
CLV_PCSK_KEX2_1	270	272	PF00082	0.543
CLV_PCSK_KEX2_1	445	447	PF00082	0.660
CLV_PCSK_KEX2_1	454	456	PF00082	0.573
CLV_PCSK_KEX2_1	64	66	PF00082	0.662
CLV_PCSK_KEX2_1	78	80	PF00082	0.532
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.470
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.590
CLV_PCSK_PC7_1	441	447	PF00082	0.536
CLV_PCSK_SKI1_1	118	122	PF00082	0.518
CLV_PCSK_SKI1_1	240	244	PF00082	0.647
CLV_PCSK_SKI1_1	379	383	PF00082	0.558
CLV_PCSK_SKI1_1	390	394	PF00082	0.668
CLV_PCSK_SKI1_1	94	98	PF00082	0.548
DEG_ODPH_VHL_1	49	60	PF01847	0.634
DEG_SPOP_SBC_1	244	248	PF00917	0.477
DOC_CDC14_PxL_1	16	24	PF14671	0.527
DOC_CYCLIN_RxL_1	373	385	PF00134	0.524
DOC_MAPK_gen_1	130	138	PF00069	0.545
DOC_MAPK_gen_1	276	284	PF00069	0.487
DOC_MAPK_JIP1_4	271	277	PF00069	0.533
DOC_PP1_RVXF_1	254	261	PF00149	0.503
DOC_PP1_RVXF_1	283	290	PF00149	0.494
DOC_USP7_MATH_1	189	193	PF00917	0.761
DOC_USP7_MATH_1	245	249	PF00917	0.755
DOC_USP7_MATH_1	332	336	PF00917	0.488
DOC_USP7_MATH_1	38	42	PF00917	0.560
DOC_USP7_MATH_1	417	421	PF00917	0.546
DOC_USP7_MATH_1	425	429	PF00917	0.750
DOC_WW_Pin1_4	240	245	PF00397	0.664
DOC_WW_Pin1_4	247	252	PF00397	0.569
DOC_WW_Pin1_4	305	310	PF00397	0.620
DOC_WW_Pin1_4	373	378	PF00397	0.742
DOC_WW_Pin1_4	382	387	PF00397	0.724
DOC_WW_Pin1_4	391	396	PF00397	0.642
DOC_WW_Pin1_4	43	48	PF00397	0.525
DOC_WW_Pin1_4	99	104	PF00397	0.613
LIG_14-3-3_CanoR_1	128	136	PF00244	0.423
LIG_14-3-3_CanoR_1	13	17	PF00244	0.478
LIG_14-3-3_CanoR_1	379	388	PF00244	0.549
LIG_14-3-3_CanoR_1	390	395	PF00244	0.662
LIG_14-3-3_CanoR_1	94	103	PF00244	0.503
LIG_Actin_WH2_2	156	173	PF00022	0.508
LIG_Actin_WH2_2	19	35	PF00022	0.472
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BIR_III_4	353	357	PF00653	0.524
LIG_Clathr_ClatBox_1	199	203	PF01394	0.655
LIG_eIF4E_1	278	284	PF01652	0.481
LIG_FHA_1	194	200	PF00498	0.668
LIG_FHA_1	310	316	PF00498	0.635
LIG_FHA_1	340	346	PF00498	0.359
LIG_FHA_1	376	382	PF00498	0.525
LIG_FHA_2	35	41	PF00498	0.631
LIG_FHA_2	392	398	PF00498	0.679
LIG_LIR_Apic_2	75	80	PF02991	0.492
LIG_LIR_Gen_1	335	345	PF02991	0.506
LIG_LIR_Nem_3	335	340	PF02991	0.516
LIG_MYND_1	47	51	PF01753	0.680
LIG_SH2_CRK	337	341	PF00017	0.510
LIG_SH2_CRK	77	81	PF00017	0.637
LIG_SH2_NCK_1	337	341	PF00017	0.510
LIG_SH2_STAT5	286	289	PF00017	0.495
LIG_SH3_3	227	233	PF00018	0.490
LIG_SH3_3	304	310	PF00018	0.615
LIG_SH3_3	357	363	PF00018	0.436
LIG_SH3_CIN85_PxpxPR_1	251	256	PF14604	0.543
LIG_SUMO_SIM_par_1	232	238	PF11976	0.535
LIG_SUMO_SIM_par_1	50	57	PF11976	0.636
LIG_SxIP_EBH_1	3	13	PF03271	0.478
MOD_CDC14_SPxK_1	376	379	PF00782	0.596
MOD_CDK_SPK_2	43	48	PF00069	0.514
MOD_CDK_SPxK_1	373	379	PF00069	0.597
MOD_CDK_SPxxK_3	391	398	PF00069	0.564
MOD_CK1_1	2	8	PF00069	0.597
MOD_CK1_1	21	27	PF00069	0.513
MOD_CK1_1	222	228	PF00069	0.577
MOD_CK1_1	31	37	PF00069	0.612
MOD_CK1_1	341	347	PF00069	0.534
MOD_CK1_1	413	419	PF00069	0.667
MOD_CK1_1	439	445	PF00069	0.622
MOD_CK1_1	72	78	PF00069	0.614
MOD_CK1_1	95	101	PF00069	0.554
MOD_CK2_1	137	143	PF00069	0.518
MOD_CK2_1	243	249	PF00069	0.479
MOD_CK2_1	34	40	PF00069	0.628
MOD_Cter_Amidation	116	119	PF01082	0.478
MOD_GlcNHglycan	139	142	PF01048	0.556
MOD_GlcNHglycan	187	190	PF01048	0.619
MOD_GlcNHglycan	191	194	PF01048	0.596
MOD_GlcNHglycan	212	215	PF01048	0.630
MOD_GlcNHglycan	302	305	PF01048	0.725
MOD_GlcNHglycan	33	36	PF01048	0.658
MOD_GlcNHglycan	412	415	PF01048	0.700
MOD_GlcNHglycan	419	422	PF01048	0.602
MOD_GlcNHglycan	427	430	PF01048	0.750
MOD_GlcNHglycan	466	469	PF01048	0.518
MOD_GlcNHglycan	8	11	PF01048	0.630
MOD_GlcNHglycan	80	83	PF01048	0.618
MOD_GlcNHglycan	88	91	PF01048	0.675
MOD_GlcNHglycan	97	100	PF01048	0.544
MOD_GSK3_1	185	192	PF00069	0.648
MOD_GSK3_1	2	9	PF00069	0.612
MOD_GSK3_1	222	229	PF00069	0.534
MOD_GSK3_1	24	31	PF00069	0.537
MOD_GSK3_1	240	247	PF00069	0.565
MOD_GSK3_1	305	312	PF00069	0.622
MOD_GSK3_1	34	41	PF00069	0.583
MOD_GSK3_1	382	389	PF00069	0.612
MOD_GSK3_1	393	400	PF00069	0.605
MOD_GSK3_1	413	420	PF00069	0.499
MOD_GSK3_1	436	443	PF00069	0.638
MOD_GSK3_1	464	471	PF00069	0.562
MOD_GSK3_1	95	102	PF00069	0.536
MOD_N-GLC_1	401	406	PF02516	0.542
MOD_N-GLC_2	91	93	PF02516	0.616
MOD_NEK2_1	26	31	PF00069	0.499
MOD_NEK2_1	277	282	PF00069	0.457
MOD_NEK2_1	339	344	PF00069	0.369
MOD_NEK2_1	381	386	PF00069	0.593
MOD_NEK2_1	60	65	PF00069	0.687
MOD_NEK2_2	226	231	PF00069	0.438
MOD_PIKK_1	339	345	PF00454	0.365
MOD_PK_1	3	9	PF00069	0.617
MOD_PKA_1	445	451	PF00069	0.675
MOD_PKA_1	78	84	PF00069	0.573
MOD_PKA_2	12	18	PF00069	0.465
MOD_PKA_2	129	135	PF00069	0.573
MOD_PKA_2	2	8	PF00069	0.481
MOD_PKA_2	210	216	PF00069	0.668
MOD_PKA_2	397	403	PF00069	0.547
MOD_PKA_2	436	442	PF00069	0.613
MOD_PKA_2	445	451	PF00069	0.618
MOD_PKA_2	78	84	PF00069	0.617
MOD_PKB_1	84	92	PF00069	0.554
MOD_Plk_4	72	78	PF00069	0.489
MOD_ProDKin_1	240	246	PF00069	0.663
MOD_ProDKin_1	247	253	PF00069	0.564
MOD_ProDKin_1	305	311	PF00069	0.621
MOD_ProDKin_1	373	379	PF00069	0.744
MOD_ProDKin_1	382	388	PF00069	0.724
MOD_ProDKin_1	391	397	PF00069	0.644
MOD_ProDKin_1	43	49	PF00069	0.526
MOD_ProDKin_1	99	105	PF00069	0.610
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.596
TRG_ENDOCYTIC_2	337	340	PF00928	0.518
TRG_ER_diArg_1	107	110	PF00400	0.470
TRG_ER_diArg_1	127	130	PF00400	0.372
TRG_ER_diArg_1	270	272	PF00400	0.543
TRG_ER_diArg_1	64	66	PF00400	0.499
TRG_ER_diArg_1	77	79	PF00400	0.550
TRG_ER_diArg_1	83	86	PF00400	0.477
TRG_NLS_Bipartite_1	434	448	PF00514	0.530
TRG_NLS_MonoExtC_3	433	438	PF00514	0.522
TRG_NLS_MonoExtN_4	441	448	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNL4	Leishmania donovani	82%	96%
A4H395	Leishmania braziliensis	66%	100%
A4HRK3	Leishmania infantum	82%	96%
E9AC71	Leishmania major	77%	100%