Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJG1_LEIMU

TriTrypDb:

LmxM.01.0740

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.551
CLV_C14_Caspase3-7	217	221	PF00656	0.750
CLV_C14_Caspase3-7	377	381	PF00656	0.641
CLV_C14_Caspase3-7	715	719	PF00656	0.432
CLV_NRD_NRD_1	14	16	PF00675	0.572
CLV_NRD_NRD_1	173	175	PF00675	0.593
CLV_NRD_NRD_1	270	272	PF00675	0.523
CLV_NRD_NRD_1	391	393	PF00675	0.652
CLV_NRD_NRD_1	508	510	PF00675	0.640
CLV_NRD_NRD_1	513	515	PF00675	0.536
CLV_NRD_NRD_1	699	701	PF00675	0.408
CLV_NRD_NRD_1	724	726	PF00675	0.488
CLV_PCSK_KEX2_1	14	16	PF00082	0.572
CLV_PCSK_KEX2_1	173	175	PF00082	0.593
CLV_PCSK_KEX2_1	270	272	PF00082	0.523
CLV_PCSK_KEX2_1	293	295	PF00082	0.474
CLV_PCSK_KEX2_1	391	393	PF00082	0.652
CLV_PCSK_KEX2_1	508	510	PF00082	0.635
CLV_PCSK_KEX2_1	513	515	PF00082	0.546
CLV_PCSK_KEX2_1	539	541	PF00082	0.687
CLV_PCSK_KEX2_1	662	664	PF00082	0.512
CLV_PCSK_KEX2_1	667	669	PF00082	0.449
CLV_PCSK_KEX2_1	698	700	PF00082	0.406
CLV_PCSK_KEX2_1	724	726	PF00082	0.488
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.490
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.557
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.512
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.449
CLV_PCSK_PC7_1	169	175	PF00082	0.584
CLV_PCSK_PC7_1	509	515	PF00082	0.617
CLV_PCSK_PC7_1	663	669	PF00082	0.449
CLV_PCSK_SKI1_1	169	173	PF00082	0.581
CLV_PCSK_SKI1_1	261	265	PF00082	0.484
CLV_PCSK_SKI1_1	270	274	PF00082	0.512
CLV_PCSK_SKI1_1	4	8	PF00082	0.543
CLV_PCSK_SKI1_1	509	513	PF00082	0.618
CLV_PCSK_SKI1_1	540	544	PF00082	0.548
CLV_PCSK_SKI1_1	659	663	PF00082	0.496
CLV_PCSK_SKI1_1	703	707	PF00082	0.458
CLV_Separin_Metazoa	610	614	PF03568	0.441
DEG_APCC_DBOX_1	269	277	PF00400	0.407
DEG_SCF_FBW7_2	603	610	PF00400	0.394
DEG_SPOP_SBC_1	628	632	PF00917	0.287
DOC_ANK_TNKS_1	470	477	PF00023	0.649
DOC_CKS1_1	23	28	PF01111	0.349
DOC_CKS1_1	246	251	PF01111	0.649
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.422
DOC_MAPK_DCC_7	156	166	PF00069	0.521
DOC_MAPK_gen_1	14	20	PF00069	0.511
DOC_MAPK_gen_1	513	521	PF00069	0.507
DOC_MAPK_HePTP_8	307	319	PF00069	0.439
DOC_MAPK_MEF2A_6	310	319	PF00069	0.430
DOC_PP1_RVXF_1	559	566	PF00149	0.522
DOC_PP1_RVXF_1	653	659	PF00149	0.462
DOC_PP2B_LxvP_1	403	406	PF13499	0.585
DOC_PP2B_LxvP_1	612	615	PF13499	0.367
DOC_PP4_FxxP_1	246	249	PF00568	0.657
DOC_USP7_MATH_1	207	211	PF00917	0.646
DOC_USP7_MATH_1	218	222	PF00917	0.651
DOC_USP7_MATH_1	225	229	PF00917	0.573
DOC_USP7_MATH_1	235	239	PF00917	0.537
DOC_USP7_MATH_1	256	260	PF00917	0.580
DOC_USP7_MATH_1	410	414	PF00917	0.610
DOC_USP7_MATH_1	475	479	PF00917	0.718
DOC_USP7_MATH_1	628	632	PF00917	0.334
DOC_USP7_MATH_1	648	652	PF00917	0.477
DOC_WW_Pin1_4	157	162	PF00397	0.653
DOC_WW_Pin1_4	195	200	PF00397	0.662
DOC_WW_Pin1_4	203	208	PF00397	0.645
DOC_WW_Pin1_4	22	27	PF00397	0.601
DOC_WW_Pin1_4	237	242	PF00397	0.640
DOC_WW_Pin1_4	245	250	PF00397	0.763
DOC_WW_Pin1_4	541	546	PF00397	0.652
DOC_WW_Pin1_4	585	590	PF00397	0.637
DOC_WW_Pin1_4	595	600	PF00397	0.403
DOC_WW_Pin1_4	603	608	PF00397	0.410
DOC_WW_Pin1_4	70	75	PF00397	0.605
DOC_WW_Pin1_4	708	713	PF00397	0.456
LIG_14-3-3_CanoR_1	125	134	PF00244	0.498
LIG_14-3-3_CanoR_1	277	287	PF00244	0.566
LIG_14-3-3_CanoR_1	540	545	PF00244	0.586
LIG_14-3-3_CanoR_1	590	595	PF00244	0.548
LIG_14-3-3_CanoR_1	684	689	PF00244	0.440
LIG_14-3-3_CanoR_1	703	713	PF00244	0.332
LIG_14-3-3_CanoR_1	724	730	PF00244	0.342
LIG_deltaCOP1_diTrp_1	557	566	PF00928	0.553
LIG_eIF4E_1	666	672	PF01652	0.515
LIG_FHA_1	103	109	PF00498	0.600
LIG_FHA_1	111	117	PF00498	0.511
LIG_FHA_1	26	32	PF00498	0.625
LIG_FHA_1	280	286	PF00498	0.546
LIG_FHA_1	457	463	PF00498	0.438
LIG_FHA_1	604	610	PF00498	0.426
LIG_FHA_1	667	673	PF00498	0.465
LIG_FHA_1	709	715	PF00498	0.498
LIG_FHA_2	215	221	PF00498	0.705
LIG_FHA_2	246	252	PF00498	0.602
LIG_FHA_2	309	315	PF00498	0.446
LIG_FHA_2	352	358	PF00498	0.518
LIG_FHA_2	500	506	PF00498	0.578
LIG_Integrin_RGD_1	663	665	PF01839	0.579
LIG_LIR_Apic_2	244	249	PF02991	0.667
LIG_LIR_Apic_2	55	60	PF02991	0.529
LIG_LIR_Gen_1	240	249	PF02991	0.500
LIG_LIR_Gen_1	309	319	PF02991	0.435
LIG_LIR_Gen_1	621	628	PF02991	0.458
LIG_LIR_Gen_1	642	649	PF02991	0.479
LIG_LIR_Nem_3	240	246	PF02991	0.640
LIG_LIR_Nem_3	254	260	PF02991	0.506
LIG_LIR_Nem_3	299	305	PF02991	0.443
LIG_LIR_Nem_3	309	315	PF02991	0.586
LIG_LIR_Nem_3	557	563	PF02991	0.554
LIG_LIR_Nem_3	621	626	PF02991	0.379
LIG_LIR_Nem_3	642	646	PF02991	0.479
LIG_MAD2	324	332	PF02301	0.386
LIG_MYND_1	730	734	PF01753	0.455
LIG_PCNA_yPIPBox_3	552	561	PF02747	0.460
LIG_Pex14_1	343	347	PF04695	0.398
LIG_PTAP_UEV_1	544	549	PF05743	0.566
LIG_REV1ctd_RIR_1	27	35	PF16727	0.533
LIG_REV1ctd_RIR_1	563	573	PF16727	0.536
LIG_RPA_C_Fungi	452	464	PF08784	0.539
LIG_RPA_C_Fungi	526	538	PF08784	0.432
LIG_SH2_CRK	260	264	PF00017	0.484
LIG_SH2_CRK	298	302	PF00017	0.374
LIG_SH2_NCK_1	302	306	PF00017	0.426
LIG_SH2_NCK_1	57	61	PF00017	0.549
LIG_SH2_PTP2	17	20	PF00017	0.495
LIG_SH2_PTP2	623	626	PF00017	0.394
LIG_SH2_SRC	57	60	PF00017	0.546
LIG_SH2_STAP1	112	116	PF00017	0.346
LIG_SH2_STAP1	298	302	PF00017	0.374
LIG_SH2_STAT5	112	115	PF00017	0.355
LIG_SH2_STAT5	17	20	PF00017	0.495
LIG_SH2_STAT5	262	265	PF00017	0.608
LIG_SH2_STAT5	298	301	PF00017	0.384
LIG_SH2_STAT5	61	64	PF00017	0.573
LIG_SH2_STAT5	623	626	PF00017	0.366
LIG_SH3_3	118	124	PF00018	0.457
LIG_SH3_3	196	202	PF00018	0.591
LIG_SH3_3	20	26	PF00018	0.475
LIG_SH3_3	329	335	PF00018	0.426
LIG_SH3_3	356	362	PF00018	0.726
LIG_SH3_3	542	548	PF00018	0.623
LIG_SH3_3	583	589	PF00018	0.502
LIG_SH3_3	66	72	PF00018	0.588
LIG_SH3_3	728	734	PF00018	0.448
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.504
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.469
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.590
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.564
LIG_SUMO_SIM_anti_2	597	604	PF11976	0.441
LIG_SUMO_SIM_anti_2	685	691	PF11976	0.480
LIG_SUMO_SIM_par_1	105	111	PF11976	0.592
LIG_SUMO_SIM_par_1	112	117	PF11976	0.559
LIG_SUMO_SIM_par_1	303	309	PF11976	0.451
LIG_TRAF2_1	619	622	PF00917	0.430
LIG_TYR_ITIM	300	305	PF00017	0.533
MOD_CDK_SPK_2	585	590	PF00069	0.508
MOD_CDK_SPxxK_3	198	205	PF00069	0.519
MOD_CK1_1	198	204	PF00069	0.686
MOD_CK1_1	221	227	PF00069	0.755
MOD_CK1_1	378	384	PF00069	0.678
MOD_CK1_1	546	552	PF00069	0.783
MOD_CK1_1	564	570	PF00069	0.557
MOD_CK1_1	67	73	PF00069	0.629
MOD_CK2_1	207	213	PF00069	0.743
MOD_CK2_1	308	314	PF00069	0.457
MOD_CK2_1	351	357	PF00069	0.503
MOD_CK2_1	410	416	PF00069	0.631
MOD_CK2_1	475	481	PF00069	0.704
MOD_CK2_1	499	505	PF00069	0.650
MOD_Cter_Amidation	268	271	PF01082	0.508
MOD_Cter_Amidation	373	376	PF01082	0.509
MOD_DYRK1A_RPxSP_1	585	589	PF00069	0.440
MOD_GlcNHglycan	144	148	PF01048	0.667
MOD_GlcNHglycan	209	212	PF01048	0.640
MOD_GlcNHglycan	223	226	PF01048	0.560
MOD_GlcNHglycan	227	230	PF01048	0.792
MOD_GlcNHglycan	354	357	PF01048	0.457
MOD_GlcNHglycan	369	372	PF01048	0.615
MOD_GlcNHglycan	377	380	PF01048	0.608
MOD_GlcNHglycan	412	415	PF01048	0.601
MOD_GlcNHglycan	471	474	PF01048	0.586
MOD_GlcNHglycan	477	480	PF01048	0.667
MOD_GlcNHglycan	545	548	PF01048	0.645
MOD_GlcNHglycan	690	693	PF01048	0.484
MOD_GlcNHglycan	706	709	PF01048	0.445
MOD_GlcNHglycan	714	717	PF01048	0.541
MOD_GlcNHglycan	89	92	PF01048	0.539
MOD_GSK3_1	18	25	PF00069	0.567
MOD_GSK3_1	203	210	PF00069	0.654
MOD_GSK3_1	214	221	PF00069	0.778
MOD_GSK3_1	231	238	PF00069	0.739
MOD_GSK3_1	241	248	PF00069	0.615
MOD_GSK3_1	363	370	PF00069	0.635
MOD_GSK3_1	387	394	PF00069	0.783
MOD_GSK3_1	406	413	PF00069	0.648
MOD_GSK3_1	629	636	PF00069	0.377
MOD_GSK3_1	684	691	PF00069	0.501
MOD_GSK3_1	704	711	PF00069	0.618
MOD_LATS_1	140	146	PF00433	0.550
MOD_N-GLC_1	628	633	PF02516	0.280
MOD_NEK2_1	102	107	PF00069	0.465
MOD_NEK2_1	172	177	PF00069	0.669
MOD_NEK2_1	193	198	PF00069	0.592
MOD_NEK2_1	236	241	PF00069	0.506
MOD_NEK2_2	719	724	PF00069	0.494
MOD_PIKK_1	67	73	PF00454	0.627
MOD_PIKK_1	79	85	PF00454	0.576
MOD_PK_1	119	125	PF00069	0.559
MOD_PK_1	684	690	PF00069	0.438
MOD_PKA_1	375	381	PF00069	0.509
MOD_PKA_1	391	397	PF00069	0.494
MOD_PKA_2	172	178	PF00069	0.636
MOD_PKA_2	387	393	PF00069	0.623
MOD_PKA_2	456	462	PF00069	0.565
MOD_PKA_2	576	582	PF00069	0.514
MOD_PKB_1	467	475	PF00069	0.553
MOD_Plk_1	102	108	PF00069	0.455
MOD_Plk_1	110	116	PF00069	0.437
MOD_Plk_1	308	314	PF00069	0.457
MOD_Plk_1	561	567	PF00069	0.555
MOD_Plk_1	628	634	PF00069	0.277
MOD_Plk_4	102	108	PF00069	0.458
MOD_Plk_4	25	31	PF00069	0.604
MOD_Plk_4	296	302	PF00069	0.448
MOD_Plk_4	561	567	PF00069	0.555
MOD_Plk_4	648	654	PF00069	0.490
MOD_Plk_4	684	690	PF00069	0.541
MOD_ProDKin_1	157	163	PF00069	0.648
MOD_ProDKin_1	195	201	PF00069	0.662
MOD_ProDKin_1	203	209	PF00069	0.646
MOD_ProDKin_1	22	28	PF00069	0.595
MOD_ProDKin_1	237	243	PF00069	0.642
MOD_ProDKin_1	245	251	PF00069	0.759
MOD_ProDKin_1	541	547	PF00069	0.653
MOD_ProDKin_1	585	591	PF00069	0.645
MOD_ProDKin_1	595	601	PF00069	0.394
MOD_ProDKin_1	603	609	PF00069	0.436
MOD_ProDKin_1	70	76	PF00069	0.609
MOD_ProDKin_1	708	714	PF00069	0.452
TRG_DiLeu_BaEn_1	621	626	PF01217	0.406
TRG_DiLeu_BaEn_3	80	86	PF01217	0.544
TRG_DiLeu_BaEn_4	621	627	PF01217	0.404
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.523
TRG_ENDOCYTIC_2	17	20	PF00928	0.495
TRG_ENDOCYTIC_2	243	246	PF00928	0.614
TRG_ENDOCYTIC_2	260	263	PF00928	0.493
TRG_ENDOCYTIC_2	298	301	PF00928	0.384
TRG_ENDOCYTIC_2	302	305	PF00928	0.435
TRG_ENDOCYTIC_2	623	626	PF00928	0.442
TRG_ENDOCYTIC_2	643	646	PF00928	0.483
TRG_ENDOCYTIC_2	675	678	PF00928	0.437
TRG_ER_diArg_1	13	15	PF00400	0.522
TRG_ER_diArg_1	172	174	PF00400	0.587
TRG_ER_diArg_1	31	34	PF00400	0.473
TRG_ER_diArg_1	512	514	PF00400	0.570
TRG_ER_diArg_1	582	585	PF00400	0.471
TRG_ER_diArg_1	698	700	PF00400	0.406
TRG_ER_diArg_1	723	725	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II66	Leptomonas seymouri	60%	99%
A0A3S5H4W8	Leishmania donovani	85%	98%
A4H391	Leishmania braziliensis	74%	96%
A4HRJ7	Leishmania infantum	86%	99%
E9AC65	Leishmania major	85%	99%