PLAC8 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PLAC8 family, putative

Species:

Leishmania mexicana

UniProt:

E9AJF6_LEIMU

TriTrypDb:

LmxM.01.0690

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.591
DOC_PP2B_LxvP_1	220	223	PF13499	0.492
DOC_PP4_FxxP_1	190	193	PF00568	0.333
DOC_USP7_MATH_1	131	135	PF00917	0.403
DOC_USP7_MATH_1	163	167	PF00917	0.313
DOC_USP7_MATH_1	31	35	PF00917	0.521
DOC_WW_Pin1_4	67	72	PF00397	0.666
LIG_14-3-3_CanoR_1	15	19	PF00244	0.628
LIG_14-3-3_CanoR_1	217	221	PF00244	0.574
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_Clathr_ClatBox_1	122	126	PF01394	0.363
LIG_deltaCOP1_diTrp_1	208	214	PF00928	0.531
LIG_FHA_1	177	183	PF00498	0.388
LIG_FHA_1	74	80	PF00498	0.333
LIG_LIR_Nem_3	112	118	PF02991	0.446
LIG_Rb_LxCxE_1	76	96	PF01857	0.333
LIG_SH2_SRC	115	118	PF00017	0.333
LIG_SH2_SRC	135	138	PF00017	0.333
LIG_SH2_STAT3	218	221	PF00017	0.532
LIG_SH2_STAT5	115	118	PF00017	0.383
LIG_SH2_STAT5	135	138	PF00017	0.368
LIG_SH2_STAT5	145	148	PF00017	0.292
LIG_SH2_STAT5	97	100	PF00017	0.303
LIG_TRFH_1	218	222	PF08558	0.402
MOD_CDK_SPK_2	67	72	PF00069	0.553
MOD_CK1_1	130	136	PF00069	0.468
MOD_CK1_1	178	184	PF00069	0.392
MOD_CK1_1	34	40	PF00069	0.476
MOD_CK1_1	56	62	PF00069	0.494
MOD_CK2_1	26	32	PF00069	0.662
MOD_CK2_1	56	62	PF00069	0.606
MOD_GlcNHglycan	100	103	PF01048	0.378
MOD_GlcNHglycan	129	132	PF01048	0.396
MOD_GlcNHglycan	148	151	PF01048	0.363
MOD_GlcNHglycan	158	161	PF01048	0.380
MOD_GlcNHglycan	165	169	PF01048	0.445
MOD_GlcNHglycan	56	59	PF01048	0.614
MOD_GlcNHglycan	76	79	PF01048	0.388
MOD_GSK3_1	127	134	PF00069	0.392
MOD_GSK3_1	164	171	PF00069	0.363
MOD_GSK3_1	176	183	PF00069	0.291
MOD_GSK3_1	212	219	PF00069	0.563
MOD_GSK3_1	56	63	PF00069	0.789
MOD_NEK2_1	14	19	PF00069	0.627
MOD_NEK2_1	146	151	PF00069	0.405
MOD_PKA_2	14	20	PF00069	0.658
MOD_PKA_2	216	222	PF00069	0.590
MOD_PKA_2	53	59	PF00069	0.592
MOD_PKA_2	60	66	PF00069	0.590
MOD_Plk_1	26	32	PF00069	0.608
MOD_Plk_2-3	26	32	PF00069	0.612
MOD_Plk_4	131	137	PF00069	0.465
MOD_Plk_4	14	20	PF00069	0.630
MOD_Plk_4	141	147	PF00069	0.345
MOD_ProDKin_1	67	73	PF00069	0.655
TRG_DiLeu_BaEn_4	111	117	PF01217	0.196
TRG_ENDOCYTIC_2	115	118	PF00928	0.446
TRG_ER_diArg_1	151	154	PF00400	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I201	Leptomonas seymouri	42%	100%
A0A0S4JMM9	Bodo saltans	31%	95%
A0A451EJC3	Leishmania donovani	83%	99%
A4H387	Leishmania braziliensis	67%	100%
A4HRJ2	Leishmania infantum	82%	98%
E9AC60	Leishmania major	80%	100%