Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AJF5_LEIMU

TriTrypDb:

LmxM.01.0680

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.652
CLV_C14_Caspase3-7	328	332	PF00656	0.675
CLV_C14_Caspase3-7	82	86	PF00656	0.611
CLV_NRD_NRD_1	100	102	PF00675	0.683
CLV_NRD_NRD_1	107	109	PF00675	0.586
CLV_NRD_NRD_1	163	165	PF00675	0.572
CLV_NRD_NRD_1	221	223	PF00675	0.693
CLV_NRD_NRD_1	256	258	PF00675	0.685
CLV_NRD_NRD_1	268	270	PF00675	0.607
CLV_NRD_NRD_1	339	341	PF00675	0.556
CLV_NRD_NRD_1	42	44	PF00675	0.637
CLV_NRD_NRD_1	621	623	PF00675	0.757
CLV_NRD_NRD_1	703	705	PF00675	0.620
CLV_NRD_NRD_1	94	96	PF00675	0.748
CLV_PCSK_FUR_1	105	109	PF00082	0.695
CLV_PCSK_FUR_1	219	223	PF00082	0.695
CLV_PCSK_KEX2_1	107	109	PF00082	0.586
CLV_PCSK_KEX2_1	163	165	PF00082	0.572
CLV_PCSK_KEX2_1	221	223	PF00082	0.693
CLV_PCSK_KEX2_1	255	257	PF00082	0.680
CLV_PCSK_KEX2_1	268	270	PF00082	0.599
CLV_PCSK_KEX2_1	339	341	PF00082	0.556
CLV_PCSK_KEX2_1	41	43	PF00082	0.640
CLV_PCSK_KEX2_1	621	623	PF00082	0.757
CLV_PCSK_KEX2_1	94	96	PF00082	0.748
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.630
CLV_PCSK_SKI1_1	339	343	PF00082	0.559
CLV_PCSK_SKI1_1	35	39	PF00082	0.581
CLV_PCSK_SKI1_1	774	778	PF00082	0.577
DEG_SCF_FBW7_1	306	313	PF00400	0.762
DEG_SCF_FBW7_1	552	559	PF00400	0.681
DEG_SPOP_SBC_1	375	379	PF00917	0.668
DEG_SPOP_SBC_1	551	555	PF00917	0.686
DEG_SPOP_SBC_1	643	647	PF00917	0.606
DEG_SPOP_SBC_1	755	759	PF00917	0.666
DEG_SPOP_SBC_1	766	770	PF00917	0.520
DOC_ANK_TNKS_1	93	100	PF00023	0.666
DOC_CKS1_1	307	312	PF01111	0.835
DOC_CYCLIN_RxL_1	771	780	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.671
DOC_MAPK_gen_1	709	718	PF00069	0.665
DOC_MAPK_RevD_3	324	340	PF00069	0.527
DOC_PP2B_LxvP_1	195	198	PF13499	0.670
DOC_USP7_MATH_1	187	191	PF00917	0.666
DOC_USP7_MATH_1	242	246	PF00917	0.589
DOC_USP7_MATH_1	281	285	PF00917	0.680
DOC_USP7_MATH_1	310	314	PF00917	0.624
DOC_USP7_MATH_1	352	356	PF00917	0.554
DOC_USP7_MATH_1	361	365	PF00917	0.590
DOC_USP7_MATH_1	375	379	PF00917	0.701
DOC_USP7_MATH_1	380	384	PF00917	0.630
DOC_USP7_MATH_1	454	458	PF00917	0.597
DOC_USP7_MATH_1	57	61	PF00917	0.714
DOC_USP7_MATH_1	641	645	PF00917	0.608
DOC_USP7_MATH_1	754	758	PF00917	0.667
DOC_WW_Pin1_4	106	111	PF00397	0.672
DOC_WW_Pin1_4	130	135	PF00397	0.681
DOC_WW_Pin1_4	139	144	PF00397	0.612
DOC_WW_Pin1_4	156	161	PF00397	0.546
DOC_WW_Pin1_4	292	297	PF00397	0.655
DOC_WW_Pin1_4	306	311	PF00397	0.771
DOC_WW_Pin1_4	364	369	PF00397	0.677
DOC_WW_Pin1_4	389	394	PF00397	0.695
DOC_WW_Pin1_4	423	428	PF00397	0.694
DOC_WW_Pin1_4	429	434	PF00397	0.634
DOC_WW_Pin1_4	552	557	PF00397	0.683
DOC_WW_Pin1_4	59	64	PF00397	0.667
DOC_WW_Pin1_4	598	603	PF00397	0.581
DOC_WW_Pin1_4	612	617	PF00397	0.676
DOC_WW_Pin1_4	662	667	PF00397	0.728
LIG_14-3-3_CanoR_1	137	145	PF00244	0.728
LIG_14-3-3_CanoR_1	163	168	PF00244	0.691
LIG_14-3-3_CanoR_1	286	292	PF00244	0.538
LIG_14-3-3_CanoR_1	339	346	PF00244	0.620
LIG_14-3-3_CanoR_1	564	570	PF00244	0.590
LIG_14-3-3_CanoR_1	671	679	PF00244	0.705
LIG_14-3-3_CanoR_1	70	79	PF00244	0.638
LIG_14-3-3_CanoR_1	704	713	PF00244	0.664
LIG_AP2alpha_2	114	116	PF02296	0.517
LIG_APCC_ABBA_1	781	786	PF00400	0.573
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_2	193	197	PF00653	0.663
LIG_BIR_III_2	483	487	PF00653	0.615
LIG_BRCT_BRCA1_1	2	6	PF00533	0.508
LIG_BRCT_BRCA1_1	334	338	PF00533	0.596
LIG_BRCT_BRCA1_1	45	49	PF00533	0.558
LIG_CaM_NSCaTE_8	448	455	PF13499	0.652
LIG_EVH1_1	131	135	PF00568	0.508
LIG_FHA_1	171	177	PF00498	0.548
LIG_FHA_1	190	196	PF00498	0.610
LIG_FHA_1	306	312	PF00498	0.691
LIG_FHA_1	321	327	PF00498	0.590
LIG_FHA_1	588	594	PF00498	0.677
LIG_FHA_1	768	774	PF00498	0.653
LIG_FHA_2	202	208	PF00498	0.706
LIG_FHA_2	236	242	PF00498	0.558
LIG_FHA_2	602	608	PF00498	0.596
LIG_FHA_2	706	712	PF00498	0.588
LIG_FHA_2	71	77	PF00498	0.674
LIG_GSK3_LRP6_1	306	312	PF00069	0.537
LIG_Integrin_RGD_1	83	85	PF01839	0.625
LIG_LIR_Gen_1	489	498	PF02991	0.577
LIG_LIR_Gen_1	508	516	PF02991	0.393
LIG_LIR_Gen_1	711	721	PF02991	0.531
LIG_LIR_Nem_3	166	171	PF02991	0.705
LIG_LIR_Nem_3	489	493	PF02991	0.615
LIG_LIR_Nem_3	495	501	PF02991	0.583
LIG_LIR_Nem_3	508	514	PF02991	0.415
LIG_LIR_Nem_3	711	716	PF02991	0.533
LIG_MYND_1	292	296	PF01753	0.533
LIG_PTAP_UEV_1	109	114	PF05743	0.716
LIG_SH2_CRK	490	494	PF00017	0.576
LIG_SH2_SRC	784	787	PF00017	0.585
LIG_SH2_STAT5	511	514	PF00017	0.593
LIG_SH3_1	107	113	PF00018	0.690
LIG_SH3_1	424	430	PF00018	0.547
LIG_SH3_2	132	137	PF14604	0.520
LIG_SH3_2	263	268	PF14604	0.737
LIG_SH3_2	666	671	PF14604	0.721
LIG_SH3_3	107	113	PF00018	0.690
LIG_SH3_3	129	135	PF00018	0.526
LIG_SH3_3	154	160	PF00018	0.678
LIG_SH3_3	260	266	PF00018	0.721
LIG_SH3_3	304	310	PF00018	0.805
LIG_SH3_3	424	430	PF00018	0.728
LIG_SH3_3	663	669	PF00018	0.724
LIG_SH3_3	745	751	PF00018	0.554
LIG_SH3_CIN85_PxpxPR_1	158	163	PF14604	0.642
LIG_SUMO_SIM_anti_2	473	478	PF11976	0.510
LIG_SUMO_SIM_par_1	124	130	PF11976	0.657
LIG_SUMO_SIM_par_1	325	331	PF11976	0.519
LIG_SUMO_SIM_par_1	589	594	PF11976	0.540
LIG_TYR_ITIM	488	493	PF00017	0.579
LIG_WRC_WIRS_1	168	173	PF05994	0.492
MOD_CDC14_SPxK_1	161	164	PF00782	0.569
MOD_CDC14_SPxK_1	668	671	PF00782	0.726
MOD_CDK_SPK_2	158	163	PF00069	0.642
MOD_CDK_SPK_2	389	394	PF00069	0.527
MOD_CDK_SPxK_1	158	164	PF00069	0.569
MOD_CDK_SPxK_1	665	671	PF00069	0.723
MOD_CDK_SPxxK_3	130	137	PF00069	0.658
MOD_CDK_SPxxK_3	156	163	PF00069	0.646
MOD_CDK_SPxxK_3	292	299	PF00069	0.561
MOD_CK1_1	127	133	PF00069	0.639
MOD_CK1_1	146	152	PF00069	0.578
MOD_CK1_1	170	176	PF00069	0.540
MOD_CK1_1	189	195	PF00069	0.742
MOD_CK1_1	2	8	PF00069	0.666
MOD_CK1_1	228	234	PF00069	0.685
MOD_CK1_1	271	277	PF00069	0.823
MOD_CK1_1	284	290	PF00069	0.594
MOD_CK1_1	301	307	PF00069	0.647
MOD_CK1_1	364	370	PF00069	0.633
MOD_CK1_1	378	384	PF00069	0.695
MOD_CK1_1	423	429	PF00069	0.739
MOD_CK1_1	457	463	PF00069	0.703
MOD_CK1_1	532	538	PF00069	0.760
MOD_CK1_1	546	552	PF00069	0.689
MOD_CK1_1	565	571	PF00069	0.582
MOD_CK1_1	575	581	PF00069	0.670
MOD_CK1_1	586	592	PF00069	0.628
MOD_CK1_1	610	616	PF00069	0.739
MOD_CK1_1	644	650	PF00069	0.721
MOD_CK1_1	656	662	PF00069	0.549
MOD_CK1_1	664	670	PF00069	0.626
MOD_CK1_1	678	684	PF00069	0.560
MOD_CK1_1	729	735	PF00069	0.698
MOD_CK1_1	758	764	PF00069	0.646
MOD_CK2_1	115	121	PF00069	0.657
MOD_CK2_1	201	207	PF00069	0.704
MOD_CK2_1	217	223	PF00069	0.591
MOD_CK2_1	235	241	PF00069	0.600
MOD_CK2_1	242	248	PF00069	0.538
MOD_CK2_1	601	607	PF00069	0.600
MOD_CK2_1	70	76	PF00069	0.679
MOD_CK2_1	705	711	PF00069	0.589
MOD_GlcNHglycan	110	113	PF01048	0.716
MOD_GlcNHglycan	139	142	PF01048	0.697
MOD_GlcNHglycan	148	151	PF01048	0.623
MOD_GlcNHglycan	153	156	PF01048	0.572
MOD_GlcNHglycan	199	202	PF01048	0.688
MOD_GlcNHglycan	214	218	PF01048	0.681
MOD_GlcNHglycan	227	230	PF01048	0.565
MOD_GlcNHglycan	258	261	PF01048	0.700
MOD_GlcNHglycan	279	282	PF01048	0.639
MOD_GlcNHglycan	286	289	PF01048	0.652
MOD_GlcNHglycan	303	306	PF01048	0.556
MOD_GlcNHglycan	378	381	PF01048	0.616
MOD_GlcNHglycan	389	392	PF01048	0.583
MOD_GlcNHglycan	394	397	PF01048	0.542
MOD_GlcNHglycan	452	455	PF01048	0.654
MOD_GlcNHglycan	456	459	PF01048	0.692
MOD_GlcNHglycan	468	471	PF01048	0.548
MOD_GlcNHglycan	531	534	PF01048	0.783
MOD_GlcNHglycan	548	551	PF01048	0.556
MOD_GlcNHglycan	564	567	PF01048	0.583
MOD_GlcNHglycan	574	577	PF01048	0.672
MOD_GlcNHglycan	59	62	PF01048	0.627
MOD_GlcNHglycan	6	9	PF01048	0.642
MOD_GlcNHglycan	653	656	PF01048	0.623
MOD_GlcNHglycan	658	661	PF01048	0.658
MOD_GlcNHglycan	728	731	PF01048	0.694
MOD_GlcNHglycan	752	755	PF01048	0.715
MOD_GlcNHglycan	758	761	PF01048	0.632
MOD_GSK3_1	126	133	PF00069	0.791
MOD_GSK3_1	139	146	PF00069	0.618
MOD_GSK3_1	163	170	PF00069	0.551
MOD_GSK3_1	197	204	PF00069	0.719
MOD_GSK3_1	206	213	PF00069	0.682
MOD_GSK3_1	270	277	PF00069	0.755
MOD_GSK3_1	301	308	PF00069	0.780
MOD_GSK3_1	364	371	PF00069	0.718
MOD_GSK3_1	374	381	PF00069	0.729
MOD_GSK3_1	450	457	PF00069	0.715
MOD_GSK3_1	459	466	PF00069	0.620
MOD_GSK3_1	534	541	PF00069	0.719
MOD_GSK3_1	546	553	PF00069	0.614
MOD_GSK3_1	582	589	PF00069	0.720
MOD_GSK3_1	643	650	PF00069	0.677
MOD_GSK3_1	661	668	PF00069	0.674
MOD_GSK3_1	71	78	PF00069	0.712
MOD_GSK3_1	726	733	PF00069	0.600
MOD_GSK3_1	746	753	PF00069	0.592
MOD_GSK3_1	754	761	PF00069	0.638
MOD_N-GLC_1	205	210	PF02516	0.681
MOD_N-GLC_1	274	279	PF02516	0.736
MOD_N-GLC_1	332	337	PF02516	0.662
MOD_N-GLC_1	352	357	PF02516	0.553
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	126	131	PF00069	0.590
MOD_NEK2_1	145	150	PF00069	0.561
MOD_NEK2_1	235	240	PF00069	0.570
MOD_NEK2_1	282	287	PF00069	0.686
MOD_NEK2_1	298	303	PF00069	0.671
MOD_NEK2_1	387	392	PF00069	0.779
MOD_NEK2_1	400	405	PF00069	0.622
MOD_NEK2_1	452	457	PF00069	0.714
MOD_NEK2_1	465	470	PF00069	0.566
MOD_NEK2_1	497	502	PF00069	0.632
MOD_NEK2_1	670	675	PF00069	0.722
MOD_NEK2_1	777	782	PF00069	0.615
MOD_PIKK_1	344	350	PF00454	0.566
MOD_PIKK_1	380	386	PF00454	0.714
MOD_PIKK_1	577	583	PF00454	0.696
MOD_PIKK_1	596	602	PF00454	0.549
MOD_PK_1	124	130	PF00069	0.644
MOD_PKA_1	163	169	PF00069	0.568
MOD_PKA_1	256	262	PF00069	0.669
MOD_PKA_1	268	274	PF00069	0.629
MOD_PKA_1	339	345	PF00069	0.561
MOD_PKA_1	704	710	PF00069	0.667
MOD_PKA_2	136	142	PF00069	0.622
MOD_PKA_2	163	169	PF00069	0.568
MOD_PKA_2	256	262	PF00069	0.720
MOD_PKA_2	268	274	PF00069	0.736
MOD_PKA_2	298	304	PF00069	0.634
MOD_PKA_2	339	345	PF00069	0.624
MOD_PKA_2	400	406	PF00069	0.703
MOD_PKA_2	546	552	PF00069	0.800
MOD_PKA_2	641	647	PF00069	0.659
MOD_PKA_2	656	662	PF00069	0.589
MOD_PKA_2	670	676	PF00069	0.657
MOD_PKA_2	703	709	PF00069	0.695
MOD_PKA_2	711	717	PF00069	0.681
MOD_PKA_2	726	732	PF00069	0.578
MOD_PKB_1	41	49	PF00069	0.582
MOD_PKB_1	536	544	PF00069	0.551
MOD_Plk_1	205	211	PF00069	0.681
MOD_Plk_1	235	241	PF00069	0.567
MOD_Plk_1	274	280	PF00069	0.662
MOD_Plk_1	332	338	PF00069	0.666
MOD_Plk_1	586	592	PF00069	0.537
MOD_Plk_2-3	325	331	PF00069	0.519
MOD_Plk_4	115	121	PF00069	0.507
MOD_Plk_4	167	173	PF00069	0.493
MOD_Plk_4	431	437	PF00069	0.665
MOD_Plk_4	460	466	PF00069	0.664
MOD_Plk_4	779	785	PF00069	0.603
MOD_ProDKin_1	106	112	PF00069	0.671
MOD_ProDKin_1	130	136	PF00069	0.685
MOD_ProDKin_1	139	145	PF00069	0.614
MOD_ProDKin_1	156	162	PF00069	0.546
MOD_ProDKin_1	292	298	PF00069	0.659
MOD_ProDKin_1	306	312	PF00069	0.773
MOD_ProDKin_1	364	370	PF00069	0.676
MOD_ProDKin_1	389	395	PF00069	0.695
MOD_ProDKin_1	423	429	PF00069	0.690
MOD_ProDKin_1	552	558	PF00069	0.681
MOD_ProDKin_1	59	65	PF00069	0.670
MOD_ProDKin_1	598	604	PF00069	0.584
MOD_ProDKin_1	612	618	PF00069	0.677
MOD_ProDKin_1	662	668	PF00069	0.728
MOD_SUMO_rev_2	118	126	PF00179	0.635
TRG_DiLeu_BaEn_1	121	126	PF01217	0.631
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.724
TRG_ENDOCYTIC_2	168	171	PF00928	0.690
TRG_ENDOCYTIC_2	490	493	PF00928	0.583
TRG_ENDOCYTIC_2	511	514	PF00928	0.598
TRG_ER_diArg_1	162	164	PF00400	0.575
TRG_ER_diArg_1	219	222	PF00400	0.694
TRG_ER_diArg_1	267	269	PF00400	0.678
TRG_ER_diArg_1	338	340	PF00400	0.557
TRG_ER_diArg_1	41	43	PF00400	0.590
TRG_ER_diArg_1	545	548	PF00400	0.687
TRG_ER_diArg_1	620	622	PF00400	0.762
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	249	254	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	774	779	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJC2	Leishmania donovani	77%	100%
A4H386	Leishmania braziliensis	47%	99%
A4HRJ1	Leishmania infantum	77%	100%
E9AC59	Leishmania major	76%	97%