RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJF0_LEIMU

TriTrypDb:

LmxM.01.0630

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.657
CLV_C14_Caspase3-7	281	285	PF00656	0.587
CLV_C14_Caspase3-7	421	425	PF00656	0.670
CLV_C14_Caspase3-7	503	507	PF00656	0.529
CLV_NRD_NRD_1	117	119	PF00675	0.514
CLV_NRD_NRD_1	156	158	PF00675	0.658
CLV_NRD_NRD_1	164	166	PF00675	0.670
CLV_NRD_NRD_1	300	302	PF00675	0.694
CLV_NRD_NRD_1	36	38	PF00675	0.537
CLV_NRD_NRD_1	368	370	PF00675	0.659
CLV_NRD_NRD_1	458	460	PF00675	0.670
CLV_NRD_NRD_1	58	60	PF00675	0.567
CLV_PCSK_FUR_1	154	158	PF00082	0.613
CLV_PCSK_FUR_1	162	166	PF00082	0.649
CLV_PCSK_FUR_1	300	304	PF00082	0.651
CLV_PCSK_KEX2_1	117	119	PF00082	0.514
CLV_PCSK_KEX2_1	156	158	PF00082	0.658
CLV_PCSK_KEX2_1	164	166	PF00082	0.670
CLV_PCSK_KEX2_1	300	302	PF00082	0.789
CLV_PCSK_KEX2_1	36	38	PF00082	0.537
CLV_PCSK_KEX2_1	368	370	PF00082	0.659
CLV_PCSK_KEX2_1	457	459	PF00082	0.653
CLV_PCSK_KEX2_1	58	60	PF00082	0.567
CLV_PCSK_KEX2_1	595	597	PF00082	0.489
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.746
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.489
CLV_PCSK_SKI1_1	448	452	PF00082	0.497
CLV_PCSK_SKI1_1	58	62	PF00082	0.601
CLV_Separin_Metazoa	147	151	PF03568	0.661
DEG_Nend_UBRbox_3	1	3	PF02207	0.437
DEG_ODPH_VHL_1	197	208	PF01847	0.517
DEG_SCF_TRCP1_1	588	594	PF00400	0.497
DEG_SPOP_SBC_1	278	282	PF00917	0.526
DEG_SPOP_SBC_1	370	374	PF00917	0.531
DEG_SPOP_SBC_1	542	546	PF00917	0.565
DEG_SPOP_SBC_1	627	631	PF00917	0.563
DOC_MAPK_DCC_7	492	502	PF00069	0.633
DOC_USP7_MATH_1	100	104	PF00917	0.634
DOC_USP7_MATH_1	190	194	PF00917	0.653
DOC_USP7_MATH_1	200	204	PF00917	0.515
DOC_USP7_MATH_1	228	232	PF00917	0.644
DOC_USP7_MATH_1	269	273	PF00917	0.565
DOC_USP7_MATH_1	278	282	PF00917	0.637
DOC_USP7_MATH_1	370	374	PF00917	0.599
DOC_USP7_MATH_1	382	386	PF00917	0.671
DOC_USP7_MATH_1	52	56	PF00917	0.671
DOC_USP7_MATH_1	535	539	PF00917	0.635
DOC_USP7_MATH_1	542	546	PF00917	0.600
DOC_USP7_MATH_1	575	579	PF00917	0.533
DOC_USP7_MATH_1	586	590	PF00917	0.503
DOC_USP7_MATH_1	627	631	PF00917	0.647
DOC_USP7_MATH_1	94	98	PF00917	0.620
DOC_WW_Pin1_4	286	291	PF00397	0.549
DOC_WW_Pin1_4	310	315	PF00397	0.687
DOC_WW_Pin1_4	404	409	PF00397	0.597
DOC_WW_Pin1_4	424	429	PF00397	0.793
DOC_WW_Pin1_4	495	500	PF00397	0.807
DOC_WW_Pin1_4	543	548	PF00397	0.571
DOC_WW_Pin1_4	635	640	PF00397	0.698
DOC_WW_Pin1_4	96	101	PF00397	0.585
LIG_14-3-3_CanoR_1	164	173	PF00244	0.641
LIG_14-3-3_CanoR_1	202	206	PF00244	0.694
LIG_14-3-3_CanoR_1	214	221	PF00244	0.666
LIG_14-3-3_CanoR_1	244	250	PF00244	0.607
LIG_14-3-3_CanoR_1	479	484	PF00244	0.616
LIG_14-3-3_CanoR_1	492	497	PF00244	0.628
LIG_14-3-3_CanoR_1	596	604	PF00244	0.479
LIG_BRCT_BRCA1_1	247	251	PF00533	0.663
LIG_BRCT_BRCA1_1	264	268	PF00533	0.526
LIG_BRCT_BRCA1_1	597	601	PF00533	0.471
LIG_EH1_1	387	395	PF00400	0.530
LIG_FHA_1	17	23	PF00498	0.588
LIG_FHA_1	214	220	PF00498	0.731
LIG_FHA_1	272	278	PF00498	0.603
LIG_FHA_1	334	340	PF00498	0.525
LIG_FHA_1	394	400	PF00498	0.543
LIG_FHA_1	424	430	PF00498	0.579
LIG_FHA_1	598	604	PF00498	0.477
LIG_FHA_1	627	633	PF00498	0.561
LIG_FHA_1	75	81	PF00498	0.562
LIG_FHA_1	87	93	PF00498	0.610
LIG_FHA_2	419	425	PF00498	0.673
LIG_FHA_2	518	524	PF00498	0.627
LIG_FHA_2	558	564	PF00498	0.529
LIG_KLC1_Yacidic_2	177	181	PF13176	0.513
LIG_LIR_Gen_1	181	190	PF02991	0.633
LIG_LIR_Gen_1	237	247	PF02991	0.621
LIG_LIR_Gen_1	248	257	PF02991	0.610
LIG_LIR_Gen_1	509	517	PF02991	0.518
LIG_LIR_Gen_1	598	609	PF02991	0.478
LIG_LIR_Nem_3	181	187	PF02991	0.630
LIG_LIR_Nem_3	237	243	PF02991	0.640
LIG_LIR_Nem_3	248	254	PF02991	0.593
LIG_LIR_Nem_3	409	415	PF02991	0.716
LIG_LIR_Nem_3	509	515	PF02991	0.516
LIG_LIR_Nem_3	598	604	PF02991	0.477
LIG_PCNA_yPIPBox_3	2	15	PF02747	0.373
LIG_PCNA_yPIPBox_3	457	470	PF02747	0.440
LIG_SH2_NCK_1	184	188	PF00017	0.636
LIG_SH2_SRC	130	133	PF00017	0.633
LIG_SH2_SRC	179	182	PF00017	0.599
LIG_SH2_STAT5	130	133	PF00017	0.690
LIG_SH2_STAT5	179	182	PF00017	0.599
LIG_SH3_1	78	84	PF00018	0.511
LIG_SH3_3	184	190	PF00018	0.647
LIG_SH3_3	193	199	PF00018	0.623
LIG_SH3_3	272	278	PF00018	0.632
LIG_SH3_3	78	84	PF00018	0.515
LIG_SUMO_SIM_par_1	430	436	PF11976	0.494
LIG_SUMO_SIM_par_1	498	503	PF11976	0.616
LIG_SUMO_SIM_par_1	610	616	PF11976	0.554
LIG_SxIP_EBH_1	202	212	PF03271	0.513
LIG_TRAF2_1	453	456	PF00917	0.549
MOD_CDK_SPK_2	310	315	PF00069	0.631
MOD_CDK_SPK_2	635	640	PF00069	0.558
MOD_CDK_SPxxK_3	315	322	PF00069	0.567
MOD_CDK_SPxxK_3	545	552	PF00069	0.543
MOD_CK1_1	171	177	PF00069	0.668
MOD_CK1_1	201	207	PF00069	0.723
MOD_CK1_1	213	219	PF00069	0.601
MOD_CK1_1	223	229	PF00069	0.604
MOD_CK1_1	239	245	PF00069	0.520
MOD_CK1_1	310	316	PF00069	0.781
MOD_CK1_1	373	379	PF00069	0.559
MOD_CK1_1	389	395	PF00069	0.643
MOD_CK1_1	418	424	PF00069	0.579
MOD_CK1_1	490	496	PF00069	0.669
MOD_CK1_1	545	551	PF00069	0.634
MOD_CK1_1	557	563	PF00069	0.557
MOD_CK1_1	580	586	PF00069	0.631
MOD_CK1_1	589	595	PF00069	0.571
MOD_CK1_1	597	603	PF00069	0.513
MOD_CK1_1	74	80	PF00069	0.597
MOD_CK1_1	98	104	PF00069	0.534
MOD_CK2_1	349	355	PF00069	0.724
MOD_CK2_1	380	386	PF00069	0.697
MOD_CK2_1	517	523	PF00069	0.627
MOD_CK2_1	557	563	PF00069	0.532
MOD_Cter_Amidation	115	118	PF01082	0.513
MOD_Cter_Amidation	162	165	PF01082	0.667
MOD_Cter_Amidation	34	37	PF01082	0.470
MOD_GlcNHglycan	100	103	PF01048	0.716
MOD_GlcNHglycan	181	184	PF01048	0.544
MOD_GlcNHglycan	192	195	PF01048	0.629
MOD_GlcNHglycan	222	225	PF01048	0.705
MOD_GlcNHglycan	264	267	PF01048	0.526
MOD_GlcNHglycan	284	287	PF01048	0.542
MOD_GlcNHglycan	290	293	PF01048	0.571
MOD_GlcNHglycan	309	312	PF01048	0.644
MOD_GlcNHglycan	355	359	PF01048	0.571
MOD_GlcNHglycan	375	378	PF01048	0.750
MOD_GlcNHglycan	408	411	PF01048	0.733
MOD_GlcNHglycan	466	469	PF01048	0.510
MOD_GlcNHglycan	528	531	PF01048	0.656
MOD_GlcNHglycan	536	540	PF01048	0.590
MOD_GlcNHglycan	54	57	PF01048	0.719
MOD_GlcNHglycan	556	559	PF01048	0.675
MOD_GlcNHglycan	582	585	PF01048	0.608
MOD_GlcNHglycan	588	591	PF01048	0.551
MOD_GSK3_1	164	171	PF00069	0.701
MOD_GSK3_1	210	217	PF00069	0.803
MOD_GSK3_1	226	233	PF00069	0.562
MOD_GSK3_1	239	246	PF00069	0.555
MOD_GSK3_1	264	271	PF00069	0.765
MOD_GSK3_1	273	280	PF00069	0.656
MOD_GSK3_1	282	289	PF00069	0.521
MOD_GSK3_1	335	342	PF00069	0.640
MOD_GSK3_1	345	352	PF00069	0.589
MOD_GSK3_1	369	376	PF00069	0.701
MOD_GSK3_1	382	389	PF00069	0.731
MOD_GSK3_1	402	409	PF00069	0.519
MOD_GSK3_1	418	425	PF00069	0.585
MOD_GSK3_1	487	494	PF00069	0.689
MOD_GSK3_1	522	529	PF00069	0.665
MOD_GSK3_1	541	548	PF00069	0.567
MOD_GSK3_1	591	598	PF00069	0.573
MOD_GSK3_1	61	68	PF00069	0.630
MOD_GSK3_1	616	623	PF00069	0.658
MOD_GSK3_1	627	634	PF00069	0.592
MOD_GSK3_1	94	101	PF00069	0.629
MOD_N-GLC_1	169	174	PF02516	0.543
MOD_N-GLC_1	226	231	PF02516	0.701
MOD_N-GLC_1	315	320	PF02516	0.678
MOD_N-GLC_1	394	399	PF02516	0.546
MOD_N-GLC_1	504	509	PF02516	0.499
MOD_NEK2_1	1	6	PF00069	0.412
MOD_NEK2_1	238	243	PF00069	0.617
MOD_NEK2_1	327	332	PF00069	0.587
MOD_NEK2_1	339	344	PF00069	0.626
MOD_NEK2_1	393	398	PF00069	0.545
MOD_NEK2_1	402	407	PF00069	0.537
MOD_NEK2_1	473	478	PF00069	0.398
MOD_NEK2_1	491	496	PF00069	0.646
MOD_NEK2_1	554	559	PF00069	0.693
MOD_NEK2_1	61	66	PF00069	0.676
MOD_OFUCOSY	343	349	PF10250	0.568
MOD_PIKK_1	226	232	PF00454	0.758
MOD_PIKK_1	557	563	PF00454	0.574
MOD_PIKK_1	602	608	PF00454	0.592
MOD_PK_1	214	220	PF00069	0.686
MOD_PK_1	479	485	PF00069	0.451
MOD_PKA_1	164	170	PF00069	0.648
MOD_PKA_1	595	601	PF00069	0.480
MOD_PKA_2	149	155	PF00069	0.665
MOD_PKA_2	164	170	PF00069	0.554
MOD_PKA_2	201	207	PF00069	0.698
MOD_PKA_2	213	219	PF00069	0.727
MOD_PKA_2	243	249	PF00069	0.609
MOD_PKA_2	370	376	PF00069	0.614
MOD_PKA_2	40	46	PF00069	0.634
MOD_PKA_2	415	421	PF00069	0.579
MOD_PKA_2	491	497	PF00069	0.644
MOD_PKA_2	580	586	PF00069	0.609
MOD_PKA_2	595	601	PF00069	0.480
MOD_PKB_1	162	170	PF00069	0.652
MOD_PKB_1	369	377	PF00069	0.564
MOD_Plk_1	169	175	PF00069	0.678
MOD_Plk_1	236	242	PF00069	0.648
MOD_Plk_1	386	392	PF00069	0.634
MOD_Plk_1	394	400	PF00069	0.599
MOD_Plk_1	575	581	PF00069	0.537
MOD_Plk_4	1	7	PF00069	0.406
MOD_Plk_4	201	207	PF00069	0.659
MOD_Plk_4	214	220	PF00069	0.675
MOD_Plk_4	250	256	PF00069	0.565
MOD_Plk_4	389	395	PF00069	0.646
MOD_ProDKin_1	286	292	PF00069	0.542
MOD_ProDKin_1	310	316	PF00069	0.686
MOD_ProDKin_1	404	410	PF00069	0.598
MOD_ProDKin_1	424	430	PF00069	0.792
MOD_ProDKin_1	495	501	PF00069	0.810
MOD_ProDKin_1	543	549	PF00069	0.569
MOD_ProDKin_1	96	102	PF00069	0.585
TRG_DiLeu_BaEn_4	455	461	PF01217	0.555
TRG_ENDOCYTIC_2	184	187	PF00928	0.633
TRG_ER_diArg_1	154	157	PF00400	0.619
TRG_ER_diArg_1	162	165	PF00400	0.632
TRG_ER_diArg_1	300	303	PF00400	0.704
TRG_ER_diArg_1	367	369	PF00400	0.672
TRG_ER_diArg_1	457	459	PF00400	0.621
TRG_ER_diArg_1	478	481	PF00400	0.425
TRG_NLS_MonoExtN_4	300	305	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4W2	Leishmania donovani	67%	91%
A4H332	Leishmania braziliensis	45%	66%
A4HRI6	Leishmania infantum	67%	71%
E9AC54	Leishmania major	69%	100%