DNA-damage inducible protein DDI1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-damage inducible protein DDI1-like protein

Species:

Leishmania mexicana

UniProt:

E9AJE8_LEIMU

TriTrypDb:

LmxM.01.0610

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJE8

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004175	endopeptidase activity	4	5
GO:0004190	aspartic-type endopeptidase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0016787	hydrolase activity	2	5
GO:0070001	aspartic-type peptidase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.489
CLV_NRD_NRD_1	134	136	PF00675	0.367
CLV_PCSK_KEX2_1	10	12	PF00082	0.489
CLV_PCSK_KEX2_1	134	136	PF00082	0.390
CLV_PCSK_KEX2_1	68	70	PF00082	0.276
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.276
DEG_APCC_DBOX_1	72	80	PF00400	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DEG_SCF_TRCP1_1	58	64	PF00400	0.476
DOC_CDC14_PxL_1	36	44	PF14671	0.385

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNK4	Leishmania donovani	92%	100%
A4HRI4	Leishmania infantum	92%	100%
E9AC52	Leishmania major	92%	100%
Q10256	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	73%

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