RNA ligase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA ligase (ATP)

Gene product:

mitochondrial RNA editing ligase 1

Species:

Leishmania mexicana

UniProt:

E9AJE6_LEIMU

TriTrypDb:

LmxM.01.0590

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AJE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJE6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	24
GO:0003824	catalytic activity	1	24
GO:0003972	RNA ligase (ATP) activity	5	24
GO:0005488	binding	1	24
GO:0005524	ATP binding	5	24
GO:0008452	RNA ligase activity	4	24
GO:0016874	ligase activity	2	24
GO:0016886	ligase activity, forming phosphoric ester bonds	3	24
GO:0017076	purine nucleotide binding	4	24
GO:0030554	adenyl nucleotide binding	5	24
GO:0032553	ribonucleotide binding	3	24
GO:0032555	purine ribonucleotide binding	4	24
GO:0032559	adenyl ribonucleotide binding	5	24
GO:0035639	purine ribonucleoside triphosphate binding	4	24
GO:0036094	small molecule binding	2	24
GO:0043167	ion binding	2	24
GO:0043168	anion binding	3	24
GO:0097159	organic cyclic compound binding	2	24
GO:0097367	carbohydrate derivative binding	2	24
GO:0140098	catalytic activity, acting on RNA	3	24
GO:0140640	catalytic activity, acting on a nucleic acid	2	24
GO:1901265	nucleoside phosphate binding	3	24
GO:1901363	heterocyclic compound binding	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.412
CLV_NRD_NRD_1	229	231	PF00675	0.564
CLV_NRD_NRD_1	29	31	PF00675	0.418
CLV_NRD_NRD_1	311	313	PF00675	0.428
CLV_PCSK_FUR_1	227	231	PF00082	0.402
CLV_PCSK_KEX2_1	178	180	PF00082	0.340
CLV_PCSK_KEX2_1	229	231	PF00082	0.542
CLV_PCSK_KEX2_1	29	31	PF00082	0.471
CLV_PCSK_KEX2_1	70	72	PF00082	0.382
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.313
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.382
CLV_PCSK_SKI1_1	232	236	PF00082	0.506
CLV_PCSK_SKI1_1	294	298	PF00082	0.420
CLV_PCSK_SKI1_1	40	44	PF00082	0.327
DEG_Nend_UBRbox_2	1	3	PF02207	0.259
DOC_CDC14_PxL_1	150	158	PF14671	0.414
DOC_CKS1_1	149	154	PF01111	0.329
DOC_MAPK_gen_1	194	203	PF00069	0.408
DOC_MAPK_gen_1	227	236	PF00069	0.581
DOC_PP1_RVXF_1	315	322	PF00149	0.450
DOC_PP4_FxxP_1	149	152	PF00568	0.329
DOC_USP7_MATH_1	183	187	PF00917	0.486
DOC_USP7_UBL2_3	204	208	PF12436	0.497
DOC_USP7_UBL2_3	294	298	PF12436	0.422
DOC_WW_Pin1_4	148	153	PF00397	0.329
DOC_WW_Pin1_4	85	90	PF00397	0.270
LIG_14-3-3_CanoR_1	196	201	PF00244	0.399
LIG_14-3-3_CanoR_1	312	316	PF00244	0.485
LIG_14-3-3_CanoR_1	337	345	PF00244	0.518
LIG_APCC_ABBA_1	111	116	PF00400	0.313
LIG_APCC_ABBA_1	41	46	PF00400	0.448
LIG_APCC_ABBAyCdc20_2	40	46	PF00400	0.448
LIG_BRCT_BRCA1_1	3	7	PF00533	0.349
LIG_BRCT_BRCA1_1	307	311	PF00533	0.481
LIG_BRCT_BRCA1_1	317	321	PF00533	0.464
LIG_BRCT_BRCA1_1	80	84	PF00533	0.416
LIG_BRCT_BRCA1_2	307	313	PF00533	0.489
LIG_Clathr_ClatBox_1	111	115	PF01394	0.448
LIG_DLG_GKlike_1	196	203	PF00625	0.410
LIG_FHA_1	16	22	PF00498	0.368
LIG_FHA_1	274	280	PF00498	0.573
LIG_FHA_1	298	304	PF00498	0.549
LIG_FHA_2	135	141	PF00498	0.371
LIG_FHA_2	213	219	PF00498	0.512
LIG_FHA_2	278	284	PF00498	0.434
LIG_Integrin_RGD_1	179	181	PF01839	0.345
LIG_LIR_Apic_2	147	152	PF02991	0.329
LIG_LIR_Gen_1	115	125	PF02991	0.337
LIG_LIR_Gen_1	198	206	PF02991	0.445
LIG_LIR_Gen_1	330	338	PF02991	0.428
LIG_LIR_Gen_1	60	67	PF02991	0.323
LIG_LIR_Nem_3	115	120	PF02991	0.303
LIG_LIR_Nem_3	198	203	PF02991	0.421
LIG_LIR_Nem_3	4	10	PF02991	0.382
LIG_LIR_Nem_3	60	66	PF02991	0.386
LIG_LIR_Nem_3	81	87	PF02991	0.297
LIG_LIR_Nem_3	90	96	PF02991	0.335
LIG_MLH1_MIPbox_1	317	321	PF16413	0.391
LIG_MYND_3	242	246	PF01753	0.545
LIG_NRBOX	23	29	PF00104	0.345
LIG_PCNA_PIPBox_1	290	299	PF02747	0.476
LIG_PCNA_yPIPBox_3	290	298	PF02747	0.469
LIG_PTB_Apo_2	123	130	PF02174	0.342
LIG_PTB_Phospho_1	123	129	PF10480	0.342
LIG_SH2_CRK	10	14	PF00017	0.365
LIG_SH2_CRK	129	133	PF00017	0.386
LIG_SH2_STAT5	320	323	PF00017	0.406
LIG_SH2_STAT5	93	96	PF00017	0.462
LIG_SH3_1	52	58	PF00018	0.326
LIG_SH3_3	107	113	PF00018	0.313
LIG_SH3_3	52	58	PF00018	0.320
LIG_SUMO_SIM_anti_2	105	113	PF11976	0.270
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.408
LIG_SUMO_SIM_par_1	299	308	PF11976	0.578
LIG_TRAF2_1	322	325	PF00917	0.507
LIG_TRAF2_1	350	353	PF00917	0.579
LIG_UBA3_1	334	339	PF00899	0.273
MOD_CK1_1	187	193	PF00069	0.448
MOD_CK2_1	100	106	PF00069	0.358
MOD_CK2_1	134	140	PF00069	0.392
MOD_CK2_1	196	202	PF00069	0.404
MOD_CK2_1	338	344	PF00069	0.426
MOD_Cter_Amidation	230	233	PF01082	0.666
MOD_GlcNHglycan	102	105	PF01048	0.329
MOD_GlcNHglycan	185	189	PF01048	0.448
MOD_GSK3_1	183	190	PF00069	0.440
MOD_GSK3_1	212	219	PF00069	0.502
MOD_GSK3_1	260	267	PF00069	0.398
MOD_GSK3_1	273	280	PF00069	0.416
MOD_GSK3_1	307	314	PF00069	0.408
MOD_GSK3_1	58	65	PF00069	0.325
MOD_N-GLC_1	255	260	PF02516	0.413
MOD_N-GLC_1	305	310	PF02516	0.478
MOD_NEK2_1	195	200	PF00069	0.398
MOD_NEK2_1	212	217	PF00069	0.514
MOD_NEK2_1	237	242	PF00069	0.578
MOD_NEK2_1	305	310	PF00069	0.446
MOD_NEK2_1	311	316	PF00069	0.366
MOD_NEK2_1	338	343	PF00069	0.530
MOD_PIKK_1	277	283	PF00454	0.494
MOD_PIKK_1	338	344	PF00454	0.586
MOD_PKA_1	232	238	PF00069	0.615
MOD_PKA_2	134	140	PF00069	0.329
MOD_PKA_2	195	201	PF00069	0.396
MOD_PKA_2	260	266	PF00069	0.395
MOD_PKA_2	311	317	PF00069	0.494
MOD_Plk_1	305	311	PF00069	0.456
MOD_Plk_4	188	194	PF00069	0.324
MOD_Plk_4	196	202	PF00069	0.391
MOD_Plk_4	212	218	PF00069	0.487
MOD_Plk_4	232	238	PF00069	0.520
MOD_Plk_4	311	317	PF00069	0.468
MOD_ProDKin_1	148	154	PF00069	0.329
MOD_ProDKin_1	85	91	PF00069	0.270
MOD_SUMO_for_1	243	246	PF00179	0.594
MOD_SUMO_rev_2	198	206	PF00179	0.439
TRG_DiLeu_BaEn_1	107	112	PF01217	0.346
TRG_DiLeu_BaEn_1	282	287	PF01217	0.538
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.432
TRG_ENDOCYTIC_2	10	13	PF00928	0.347
TRG_ENDOCYTIC_2	93	96	PF00928	0.454
TRG_ER_diArg_1	177	179	PF00400	0.379
TRG_ER_diArg_1	227	230	PF00400	0.509
TRG_NLS_MonoExtC_3	68	73	PF00514	0.313
TRG_NLS_MonoExtN_4	67	73	PF00514	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTX0	Leptomonas seymouri	38%	86%
A0A0N1IKD9	Leptomonas seymouri	83%	70%
A0A0S4IH84	Bodo saltans	71%	73%
A0A0S4JB92	Bodo saltans	43%	100%
A0A0S4JRM1	Bodo saltans	39%	70%
A0A1X0NW43	Trypanosomatidae	41%	86%
A0A1X0P2V9	Trypanosomatidae	76%	77%
A0A3R7NWI2	Trypanosoma rangeli	40%	86%
A0A3S5H791	Leishmania donovani	38%	86%
A0A422NFE4	Trypanosoma rangeli	78%	78%
A0A451EJB4	Leishmania donovani	97%	84%
A4H382	Leishmania braziliensis	90%	100%
A4HRI2	Leishmania infantum	97%	84%
A4HZ02	Leishmania infantum	38%	86%
C9ZIM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	86%
C9ZXL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	76%
E9AC50	Leishmania major	97%	100%
E9AIM1	Leishmania braziliensis	38%	100%
E9AUV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	86%
P86924	Trypanosoma brucei brucei	40%	86%
P86925	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	40%	86%
P86926	Trypanosoma brucei brucei	76%	76%
P86927	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	76%	76%
Q6T452	Leishmania major	39%	100%
V5ASZ3	Trypanosoma cruzi	39%	86%
V5DD75	Trypanosoma cruzi	76%	72%