WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJE5_LEIMU

TriTrypDb:

LmxM.01.0580

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.540
CLV_C14_Caspase3-7	758	762	PF00656	0.463
CLV_C14_Caspase3-7	879	883	PF00656	0.688
CLV_C14_Caspase3-7	888	892	PF00656	0.724
CLV_NRD_NRD_1	398	400	PF00675	0.456
CLV_NRD_NRD_1	463	465	PF00675	0.632
CLV_NRD_NRD_1	557	559	PF00675	0.587
CLV_NRD_NRD_1	792	794	PF00675	0.347
CLV_PCSK_FUR_1	554	558	PF00082	0.546
CLV_PCSK_KEX2_1	465	467	PF00082	0.502
CLV_PCSK_KEX2_1	540	542	PF00082	0.373
CLV_PCSK_KEX2_1	553	555	PF00082	0.511
CLV_PCSK_KEX2_1	556	558	PF00082	0.555
CLV_PCSK_KEX2_1	791	793	PF00082	0.407
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.324
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.373
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.511
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.408
CLV_PCSK_PC7_1	787	793	PF00082	0.317
CLV_PCSK_SKI1_1	278	282	PF00082	0.560
CLV_PCSK_SKI1_1	399	403	PF00082	0.417
CLV_PCSK_SKI1_1	434	438	PF00082	0.491
CLV_PCSK_SKI1_1	540	544	PF00082	0.436
CLV_PCSK_SKI1_1	59	63	PF00082	0.655
CLV_PCSK_SKI1_1	67	71	PF00082	0.593
CLV_PCSK_SKI1_1	729	733	PF00082	0.533
CLV_PCSK_SKI1_1	912	916	PF00082	0.650
DEG_APCC_DBOX_1	800	808	PF00400	0.582
DEG_COP1_1	559	569	PF00400	0.508
DEG_MDM2_SWIB_1	794	802	PF02201	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.505
DEG_SCF_FBW7_1	347	354	PF00400	0.614
DEG_SCF_FBW7_1	421	427	PF00400	0.754
DEG_SPOP_SBC_1	144	148	PF00917	0.625
DEG_SPOP_SBC_1	312	316	PF00917	0.635
DOC_CKS1_1	248	253	PF01111	0.570
DOC_CKS1_1	348	353	PF01111	0.612
DOC_CKS1_1	421	426	PF01111	0.756
DOC_CKS1_1	646	651	PF01111	0.694
DOC_CKS1_1	731	736	PF01111	0.532
DOC_CYCLIN_RxL_1	272	285	PF00134	0.529
DOC_MAPK_DCC_7	801	809	PF00069	0.582
DOC_MAPK_gen_1	62	70	PF00069	0.569
DOC_MAPK_gen_1	952	960	PF00069	0.550
DOC_MAPK_MEF2A_6	123	131	PF00069	0.621
DOC_MAPK_MEF2A_6	474	483	PF00069	0.475
DOC_MAPK_MEF2A_6	623	632	PF00069	0.541
DOC_MAPK_MEF2A_6	729	738	PF00069	0.504
DOC_MAPK_MEF2A_6	801	809	PF00069	0.582
DOC_MAPK_MEF2A_6	954	962	PF00069	0.574
DOC_PP1_RVXF_1	950	956	PF00149	0.467
DOC_PP2B_LxvP_1	17	20	PF13499	0.491
DOC_PP2B_LxvP_1	178	181	PF13499	0.488
DOC_PP2B_PxIxI_1	126	132	PF00149	0.636
DOC_PP2B_PxIxI_1	733	739	PF00149	0.452
DOC_SPAK_OSR1_1	474	478	PF12202	0.519
DOC_SPAK_OSR1_1	65	69	PF12202	0.622
DOC_USP7_MATH_1	100	104	PF00917	0.694
DOC_USP7_MATH_1	140	144	PF00917	0.562
DOC_USP7_MATH_1	18	22	PF00917	0.761
DOC_USP7_MATH_1	270	274	PF00917	0.631
DOC_USP7_MATH_1	306	310	PF00917	0.784
DOC_USP7_MATH_1	312	316	PF00917	0.718
DOC_USP7_MATH_1	325	329	PF00917	0.700
DOC_USP7_MATH_1	388	392	PF00917	0.476
DOC_USP7_MATH_1	4	8	PF00917	0.741
DOC_USP7_MATH_1	441	445	PF00917	0.331
DOC_USP7_MATH_1	511	515	PF00917	0.754
DOC_USP7_MATH_1	576	580	PF00917	0.660
DOC_USP7_MATH_1	624	628	PF00917	0.535
DOC_USP7_MATH_1	684	688	PF00917	0.281
DOC_USP7_MATH_1	819	823	PF00917	0.679
DOC_USP7_MATH_1	865	869	PF00917	0.710
DOC_USP7_MATH_1	873	877	PF00917	0.754
DOC_USP7_MATH_1	938	942	PF00917	0.539
DOC_WW_Pin1_4	233	238	PF00397	0.659
DOC_WW_Pin1_4	244	249	PF00397	0.665
DOC_WW_Pin1_4	271	276	PF00397	0.536
DOC_WW_Pin1_4	290	295	PF00397	0.533
DOC_WW_Pin1_4	30	35	PF00397	0.782
DOC_WW_Pin1_4	347	352	PF00397	0.649
DOC_WW_Pin1_4	420	425	PF00397	0.698
DOC_WW_Pin1_4	523	528	PF00397	0.508
DOC_WW_Pin1_4	645	650	PF00397	0.500
DOC_WW_Pin1_4	724	729	PF00397	0.552
DOC_WW_Pin1_4	730	735	PF00397	0.546
DOC_WW_Pin1_4	777	782	PF00397	0.590
LIG_14-3-3_CanoR_1	220	230	PF00244	0.582
LIG_14-3-3_CanoR_1	399	408	PF00244	0.409
LIG_14-3-3_CanoR_1	432	441	PF00244	0.395
LIG_14-3-3_CanoR_1	464	469	PF00244	0.561
LIG_14-3-3_CanoR_1	474	478	PF00244	0.452
LIG_14-3-3_CanoR_1	54	59	PF00244	0.512
LIG_14-3-3_CanoR_1	556	561	PF00244	0.523
LIG_14-3-3_CanoR_1	638	644	PF00244	0.560
LIG_14-3-3_CanoR_1	773	781	PF00244	0.715
LIG_14-3-3_CanoR_1	793	799	PF00244	0.608
LIG_14-3-3_CanoR_1	821	828	PF00244	0.499
LIG_14-3-3_CanoR_1	843	847	PF00244	0.449
LIG_Actin_WH2_2	608	625	PF00022	0.271
LIG_AP2alpha_2	420	422	PF02296	0.752
LIG_APCC_ABBA_1	674	679	PF00400	0.616
LIG_BRCT_BRCA1_1	371	375	PF00533	0.463
LIG_eIF4E_1	830	836	PF01652	0.536
LIG_EVH1_1	348	352	PF00568	0.642
LIG_FHA_1	222	228	PF00498	0.665
LIG_FHA_1	248	254	PF00498	0.642
LIG_FHA_1	384	390	PF00498	0.483
LIG_FHA_1	396	402	PF00498	0.459
LIG_FHA_1	541	547	PF00498	0.527
LIG_FHA_1	639	645	PF00498	0.585
LIG_FHA_1	663	669	PF00498	0.508
LIG_FHA_1	731	737	PF00498	0.520
LIG_FHA_1	751	757	PF00498	0.315
LIG_FHA_1	904	910	PF00498	0.696
LIG_FHA_2	203	209	PF00498	0.574
LIG_FHA_2	31	37	PF00498	0.783
LIG_FHA_2	6	12	PF00498	0.500
LIG_FHA_2	646	652	PF00498	0.675
LIG_FHA_2	673	679	PF00498	0.467
LIG_FHA_2	756	762	PF00498	0.620
LIG_FHA_2	89	95	PF00498	0.600
LIG_GBD_Chelix_1	253	261	PF00786	0.562
LIG_Integrin_RGD_1	217	219	PF01839	0.562
LIG_LIR_Apic_2	641	646	PF02991	0.592
LIG_LIR_Gen_1	166	175	PF02991	0.662
LIG_LIR_Gen_1	366	376	PF02991	0.419
LIG_LIR_Gen_1	423	430	PF02991	0.451
LIG_LIR_Gen_1	435	443	PF02991	0.289
LIG_LIR_Gen_1	634	644	PF02991	0.581
LIG_LIR_Gen_1	710	720	PF02991	0.465
LIG_LIR_Gen_1	747	757	PF02991	0.575
LIG_LIR_Gen_1	911	919	PF02991	0.593
LIG_LIR_Nem_3	147	153	PF02991	0.595
LIG_LIR_Nem_3	166	170	PF02991	0.454
LIG_LIR_Nem_3	366	371	PF02991	0.433
LIG_LIR_Nem_3	419	425	PF02991	0.727
LIG_LIR_Nem_3	435	440	PF02991	0.426
LIG_LIR_Nem_3	57	61	PF02991	0.495
LIG_LIR_Nem_3	579	585	PF02991	0.461
LIG_LIR_Nem_3	634	639	PF02991	0.553
LIG_LIR_Nem_3	710	715	PF02991	0.484
LIG_LIR_Nem_3	747	752	PF02991	0.516
LIG_LIR_Nem_3	844	849	PF02991	0.420
LIG_LIR_Nem_3	911	916	PF02991	0.574
LIG_LYPXL_SIV_4	711	719	PF13949	0.481
LIG_LYPXL_yS_3	150	153	PF13949	0.617
LIG_MLH1_MIPbox_1	371	375	PF16413	0.463
LIG_NRBOX	276	282	PF00104	0.540
LIG_NRBOX	491	497	PF00104	0.434
LIG_NRBOX	751	757	PF00104	0.562
LIG_PAM2_1	631	643	PF00658	0.410
LIG_PDZ_Class_2	957	962	PF00595	0.563
LIG_Pex14_1	847	851	PF04695	0.491
LIG_Pex14_2	794	798	PF04695	0.455
LIG_PTAP_UEV_1	293	298	PF05743	0.787
LIG_PTB_Apo_2	614	621	PF02174	0.558
LIG_REV1ctd_RIR_1	448	458	PF16727	0.598
LIG_SH2_CRK	385	389	PF00017	0.572
LIG_SH2_CRK	583	587	PF00017	0.555
LIG_SH2_CRK	712	716	PF00017	0.541
LIG_SH2_NCK_1	583	587	PF00017	0.555
LIG_SH2_NCK_1	712	716	PF00017	0.541
LIG_SH2_PTP2	913	916	PF00017	0.613
LIG_SH2_SRC	643	646	PF00017	0.614
LIG_SH2_STAP1	636	640	PF00017	0.555
LIG_SH2_STAT5	145	148	PF00017	0.636
LIG_SH2_STAT5	374	377	PF00017	0.510
LIG_SH2_STAT5	385	388	PF00017	0.544
LIG_SH2_STAT5	425	428	PF00017	0.457
LIG_SH2_STAT5	643	646	PF00017	0.612
LIG_SH2_STAT5	730	733	PF00017	0.522
LIG_SH2_STAT5	830	833	PF00017	0.547
LIG_SH2_STAT5	913	916	PF00017	0.613
LIG_SH2_STAT5	942	945	PF00017	0.365
LIG_SH3_1	643	649	PF00018	0.393
LIG_SH3_3	121	127	PF00018	0.630
LIG_SH3_3	245	251	PF00018	0.611
LIG_SH3_3	291	297	PF00018	0.687
LIG_SH3_3	31	37	PF00018	0.652
LIG_SH3_3	343	349	PF00018	0.647
LIG_SH3_3	415	421	PF00018	0.701
LIG_SH3_3	521	527	PF00018	0.482
LIG_SH3_3	627	633	PF00018	0.446
LIG_SH3_3	643	649	PF00018	0.547
LIG_SH3_3	655	661	PF00018	0.423
LIG_SH3_3	693	699	PF00018	0.502
LIG_SH3_3	804	810	PF00018	0.589
LIG_SH3_3	913	919	PF00018	0.538
LIG_SUMO_SIM_par_1	905	911	PF11976	0.634
LIG_TRFH_1	620	624	PF08558	0.272
LIG_TRFH_1	730	734	PF08558	0.514
LIG_TYR_ITSM	146	153	PF00017	0.670
LIG_TYR_ITSM	708	715	PF00017	0.548
LIG_WRC_WIRS_1	164	169	PF05994	0.666
LIG_WRC_WIRS_1	632	637	PF05994	0.585
LIG_WW_2	346	349	PF00397	0.662
MOD_CDK_SPK_2	724	729	PF00069	0.507
MOD_CDK_SPxxK_3	271	278	PF00069	0.615
MOD_CK1_1	103	109	PF00069	0.441
MOD_CK1_1	13	19	PF00069	0.792
MOD_CK1_1	143	149	PF00069	0.642
MOD_CK1_1	171	177	PF00069	0.538
MOD_CK1_1	191	197	PF00069	0.374
MOD_CK1_1	247	253	PF00069	0.633
MOD_CK1_1	292	298	PF00069	0.770
MOD_CK1_1	328	334	PF00069	0.735
MOD_CK1_1	364	370	PF00069	0.491
MOD_CK1_1	395	401	PF00069	0.530
MOD_CK1_1	453	459	PF00069	0.596
MOD_CK1_1	5	11	PF00069	0.771
MOD_CK1_1	526	532	PF00069	0.434
MOD_CK1_1	559	565	PF00069	0.616
MOD_CK1_1	672	678	PF00069	0.423
MOD_CK1_1	772	778	PF00069	0.698
MOD_CK1_1	797	803	PF00069	0.529
MOD_CK1_1	87	93	PF00069	0.710
MOD_CK1_1	876	882	PF00069	0.699
MOD_CK1_1	892	898	PF00069	0.586
MOD_CK2_1	101	107	PF00069	0.692
MOD_CK2_1	173	179	PF00069	0.567
MOD_CK2_1	30	36	PF00069	0.798
MOD_CK2_1	336	342	PF00069	0.685
MOD_CK2_1	672	678	PF00069	0.388
MOD_CK2_1	772	778	PF00069	0.820
MOD_CK2_1	88	94	PF00069	0.659
MOD_CK2_1	882	888	PF00069	0.685
MOD_GlcNHglycan	142	145	PF01048	0.571
MOD_GlcNHglycan	157	160	PF01048	0.515
MOD_GlcNHglycan	2	5	PF01048	0.751
MOD_GlcNHglycan	20	23	PF01048	0.793
MOD_GlcNHglycan	294	297	PF01048	0.709
MOD_GlcNHglycan	306	309	PF01048	0.662
MOD_GlcNHglycan	315	318	PF01048	0.737
MOD_GlcNHglycan	332	335	PF01048	0.693
MOD_GlcNHglycan	363	366	PF01048	0.524
MOD_GlcNHglycan	392	395	PF01048	0.544
MOD_GlcNHglycan	434	437	PF01048	0.330
MOD_GlcNHglycan	513	516	PF01048	0.633
MOD_GlcNHglycan	547	550	PF01048	0.508
MOD_GlcNHglycan	571	574	PF01048	0.451
MOD_GlcNHglycan	655	658	PF01048	0.740
MOD_GlcNHglycan	671	674	PF01048	0.537
MOD_GlcNHglycan	739	742	PF01048	0.491
MOD_GlcNHglycan	823	826	PF01048	0.689
MOD_GlcNHglycan	851	854	PF01048	0.656
MOD_GlcNHglycan	869	872	PF01048	0.732
MOD_GlcNHglycan	875	878	PF01048	0.759
MOD_GlcNHglycan	894	897	PF01048	0.465
MOD_GSK3_1	109	116	PF00069	0.519
MOD_GSK3_1	140	147	PF00069	0.563
MOD_GSK3_1	18	25	PF00069	0.659
MOD_GSK3_1	202	209	PF00069	0.540
MOD_GSK3_1	233	240	PF00069	0.719
MOD_GSK3_1	282	289	PF00069	0.557
MOD_GSK3_1	325	332	PF00069	0.624
MOD_GSK3_1	347	354	PF00069	0.637
MOD_GSK3_1	388	395	PF00069	0.434
MOD_GSK3_1	420	427	PF00069	0.703
MOD_GSK3_1	662	669	PF00069	0.549
MOD_GSK3_1	703	710	PF00069	0.538
MOD_GSK3_1	74	81	PF00069	0.736
MOD_GSK3_1	769	776	PF00069	0.768
MOD_GSK3_1	84	91	PF00069	0.526
MOD_GSK3_1	938	945	PF00069	0.596
MOD_N-GLC_1	769	774	PF02516	0.749
MOD_N-GLC_2	120	122	PF02516	0.671
MOD_NEK2_1	113	118	PF00069	0.484
MOD_NEK2_1	12	17	PF00069	0.708
MOD_NEK2_1	152	157	PF00069	0.626
MOD_NEK2_1	383	388	PF00069	0.516
MOD_NEK2_1	392	397	PF00069	0.440
MOD_NEK2_1	450	455	PF00069	0.605
MOD_NEK2_1	491	496	PF00069	0.363
MOD_NEK2_1	545	550	PF00069	0.497
MOD_NEK2_1	569	574	PF00069	0.460
MOD_NEK2_1	639	644	PF00069	0.603
MOD_NEK2_1	721	726	PF00069	0.453
MOD_NEK2_1	755	760	PF00069	0.580
MOD_NEK2_1	794	799	PF00069	0.415
MOD_NEK2_1	835	840	PF00069	0.409
MOD_NEK2_1	86	91	PF00069	0.634
MOD_NEK2_1	943	948	PF00069	0.471
MOD_OFUCOSY	525	530	PF10250	0.511
MOD_PIKK_1	750	756	PF00454	0.542
MOD_PK_1	954	960	PF00069	0.579
MOD_PKA_1	399	405	PF00069	0.416
MOD_PKA_1	464	470	PF00069	0.471
MOD_PKA_1	540	546	PF00069	0.466
MOD_PKA_1	556	562	PF00069	0.413
MOD_PKA_2	122	128	PF00069	0.512
MOD_PKA_2	213	219	PF00069	0.466
MOD_PKA_2	473	479	PF00069	0.513
MOD_PKA_2	540	546	PF00069	0.398
MOD_PKA_2	556	562	PF00069	0.563
MOD_PKA_2	772	778	PF00069	0.617
MOD_PKA_2	820	826	PF00069	0.520
MOD_PKA_2	842	848	PF00069	0.450
MOD_PKB_1	554	562	PF00069	0.526
MOD_Plk_1	133	139	PF00069	0.615
MOD_Plk_1	742	748	PF00069	0.440
MOD_Plk_1	769	775	PF00069	0.747
MOD_Plk_2-3	94	100	PF00069	0.480
MOD_Plk_4	133	139	PF00069	0.540
MOD_Plk_4	163	169	PF00069	0.607
MOD_Plk_4	182	188	PF00069	0.400
MOD_Plk_4	202	208	PF00069	0.616
MOD_Plk_4	358	364	PF00069	0.450
MOD_Plk_4	369	375	PF00069	0.412
MOD_Plk_4	585	591	PF00069	0.387
MOD_Plk_4	631	637	PF00069	0.587
MOD_Plk_4	639	645	PF00069	0.589
MOD_Plk_4	663	669	PF00069	0.525
MOD_Plk_4	842	848	PF00069	0.430
MOD_Plk_4	889	895	PF00069	0.668
MOD_Plk_4	938	944	PF00069	0.575
MOD_ProDKin_1	233	239	PF00069	0.660
MOD_ProDKin_1	244	250	PF00069	0.656
MOD_ProDKin_1	271	277	PF00069	0.527
MOD_ProDKin_1	290	296	PF00069	0.537
MOD_ProDKin_1	30	36	PF00069	0.780
MOD_ProDKin_1	347	353	PF00069	0.654
MOD_ProDKin_1	420	426	PF00069	0.699
MOD_ProDKin_1	523	529	PF00069	0.507
MOD_ProDKin_1	645	651	PF00069	0.509
MOD_ProDKin_1	724	730	PF00069	0.555
MOD_ProDKin_1	777	783	PF00069	0.585
TRG_DiLeu_BaEn_1	413	418	PF01217	0.670
TRG_DiLeu_BaEn_1	478	483	PF01217	0.424
TRG_DiLeu_BaEn_1	678	683	PF01217	0.544
TRG_ENDOCYTIC_2	150	153	PF00928	0.573
TRG_ENDOCYTIC_2	164	167	PF00928	0.515
TRG_ENDOCYTIC_2	425	428	PF00928	0.457
TRG_ENDOCYTIC_2	582	585	PF00928	0.580
TRG_ENDOCYTIC_2	636	639	PF00928	0.595
TRG_ENDOCYTIC_2	712	715	PF00928	0.542
TRG_ENDOCYTIC_2	830	833	PF00928	0.547
TRG_ENDOCYTIC_2	913	916	PF00928	0.588
TRG_ER_diArg_1	53	56	PF00400	0.679
TRG_ER_diArg_1	554	557	PF00400	0.591
TRG_ER_diArg_1	785	788	PF00400	0.499
TRG_ER_diArg_1	792	794	PF00400	0.472
TRG_NLS_Bipartite_1	540	557	PF00514	0.407
TRG_NLS_MonoExtC_3	552	557	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V6	Leptomonas seymouri	56%	91%
A0A1X0P2P9	Trypanosomatidae	29%	100%
A0A3S5IR38	Trypanosoma rangeli	30%	100%
A0A451EJB3	Leishmania donovani	85%	100%
A4H381	Leishmania braziliensis	67%	100%
A4HRI1	Leishmania infantum	85%	100%
C9ZXL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC49	Leishmania major	82%	99%
V5AX28	Trypanosoma cruzi	31%	100%