UDENN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA processing factor 3 (PRP3)/Protein of unknown function (DUF1115), putative

Species:

Leishmania mexicana

UniProt:

E9AJE3_LEIMU

TriTrypDb:

LmxM.01.0560

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	10
GO:0097525	spliceosomal snRNP complex	4	10
GO:0097526	spliceosomal tri-snRNP complex	5	10
GO:0120114	Sm-like protein family complex	2	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

E9AJE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJE3

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.583
CLV_NRD_NRD_1	108	110	PF00675	0.672
CLV_NRD_NRD_1	124	126	PF00675	0.667
CLV_NRD_NRD_1	206	208	PF00675	0.311
CLV_NRD_NRD_1	26	28	PF00675	0.710
CLV_NRD_NRD_1	329	331	PF00675	0.296
CLV_NRD_NRD_1	333	335	PF00675	0.292
CLV_NRD_NRD_1	420	422	PF00675	0.290
CLV_NRD_NRD_1	442	444	PF00675	0.542
CLV_NRD_NRD_1	588	590	PF00675	0.336
CLV_NRD_NRD_1	84	86	PF00675	0.799
CLV_PCSK_FUR_1	204	208	PF00082	0.183
CLV_PCSK_KEX2_1	108	110	PF00082	0.649
CLV_PCSK_KEX2_1	123	125	PF00082	0.638
CLV_PCSK_KEX2_1	206	208	PF00082	0.311
CLV_PCSK_KEX2_1	329	331	PF00082	0.310
CLV_PCSK_KEX2_1	333	335	PF00082	0.306
CLV_PCSK_KEX2_1	420	422	PF00082	0.290
CLV_PCSK_KEX2_1	436	438	PF00082	0.489
CLV_PCSK_KEX2_1	442	444	PF00082	0.506
CLV_PCSK_KEX2_1	547	549	PF00082	0.321
CLV_PCSK_KEX2_1	555	557	PF00082	0.379
CLV_PCSK_KEX2_1	588	590	PF00082	0.336
CLV_PCSK_KEX2_1	84	86	PF00082	0.784
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.503
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.321
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.379
CLV_PCSK_PC7_1	329	335	PF00082	0.327
CLV_PCSK_PC7_1	80	86	PF00082	0.744
CLV_PCSK_SKI1_1	126	130	PF00082	0.775
CLV_PCSK_SKI1_1	238	242	PF00082	0.361
CLV_PCSK_SKI1_1	340	344	PF00082	0.311
CLV_PCSK_SKI1_1	443	447	PF00082	0.464
CLV_PCSK_SKI1_1	605	609	PF00082	0.484
DEG_APCC_DBOX_1	609	617	PF00400	0.415
DEG_SPOP_SBC_1	18	22	PF00917	0.662
DEG_SPOP_SBC_1	360	364	PF00917	0.433
DOC_CKS1_1	146	151	PF01111	0.742
DOC_CYCLIN_RxL_1	235	243	PF00134	0.508
DOC_CYCLIN_yClb5_NLxxxL_5	383	392	PF00134	0.492
DOC_MAPK_gen_1	24	32	PF00069	0.613
DOC_MAPK_gen_1	519	528	PF00069	0.561
DOC_PP2B_LxvP_1	590	593	PF13499	0.561
DOC_PP4_MxPP_1	1	4	PF00568	0.755
DOC_USP7_MATH_1	113	117	PF00917	0.810
DOC_USP7_MATH_1	12	16	PF00917	0.705
DOC_USP7_MATH_1	151	155	PF00917	0.734
DOC_USP7_MATH_1	18	22	PF00917	0.620
DOC_USP7_MATH_1	360	364	PF00917	0.503
DOC_USP7_MATH_1	369	373	PF00917	0.416
DOC_USP7_MATH_1	43	47	PF00917	0.732
DOC_USP7_MATH_1	56	60	PF00917	0.517
DOC_USP7_MATH_1	591	595	PF00917	0.561
DOC_USP7_MATH_1	7	11	PF00917	0.761
DOC_USP7_UBL2_3	24	28	PF12436	0.659
DOC_USP7_UBL2_3	343	347	PF12436	0.542
DOC_WW_Pin1_4	145	150	PF00397	0.763
DOC_WW_Pin1_4	275	280	PF00397	0.536
DOC_WW_Pin1_4	592	597	PF00397	0.561
LIG_14-3-3_CanoR_1	19	25	PF00244	0.647
LIG_14-3-3_CanoR_1	253	259	PF00244	0.575
LIG_14-3-3_CanoR_1	382	390	PF00244	0.561
LIG_14-3-3_CanoR_1	442	451	PF00244	0.466
LIG_14-3-3_CanoR_1	522	527	PF00244	0.490
LIG_Actin_WH2_2	423	438	PF00022	0.692
LIG_Actin_WH2_2	596	612	PF00022	0.452
LIG_APCC_Cbox_2	424	430	PF00515	0.591
LIG_BIR_III_4	112	116	PF00653	0.717
LIG_BRCT_BRCA1_1	532	536	PF00533	0.591
LIG_Clathr_ClatBox_2	249	254	PF01394	0.490
LIG_deltaCOP1_diTrp_1	249	254	PF00928	0.490
LIG_deltaCOP1_diTrp_1	504	513	PF00928	0.490
LIG_FHA_1	231	237	PF00498	0.543
LIG_FHA_1	279	285	PF00498	0.536
LIG_FHA_1	383	389	PF00498	0.561
LIG_FHA_1	403	409	PF00498	0.355
LIG_FHA_1	516	522	PF00498	0.493
LIG_FHA_1	567	573	PF00498	0.444
LIG_FHA_2	206	212	PF00498	0.517
LIG_FHA_2	214	220	PF00498	0.477
LIG_FHA_2	323	329	PF00498	0.429
LIG_FHA_2	577	583	PF00498	0.586
LIG_LIR_Gen_1	36	44	PF02991	0.590
LIG_LIR_Gen_1	570	580	PF02991	0.508
LIG_LIR_Gen_1	594	603	PF02991	0.561
LIG_LIR_Nem_3	302	308	PF02991	0.546
LIG_LIR_Nem_3	310	314	PF02991	0.573
LIG_LIR_Nem_3	36	42	PF02991	0.588
LIG_LIR_Nem_3	594	600	PF02991	0.490
LIG_Pex14_1	604	608	PF04695	0.554
LIG_PROFILIN_1	2	8	PF00235	0.718
LIG_SH2_CRK	261	265	PF00017	0.452
LIG_SH2_CRK	86	90	PF00017	0.797
LIG_SH2_STAP1	106	110	PF00017	0.710
LIG_SH2_STAP1	305	309	PF00017	0.490
LIG_SH2_STAT3	194	197	PF00017	0.561
LIG_SH2_STAT5	106	109	PF00017	0.686
LIG_SH2_STAT5	194	197	PF00017	0.540
LIG_SH2_STAT5	305	308	PF00017	0.536
LIG_SH2_STAT5	483	486	PF00017	0.561
LIG_SH3_3	1	7	PF00018	0.732
LIG_SH3_3	154	160	PF00018	0.590
LIG_SH3_3	273	279	PF00018	0.598
LIG_SH3_3	292	298	PF00018	0.420
LIG_SH3_3	394	400	PF00018	0.490
LIG_SH3_3	590	596	PF00018	0.561
LIG_SH3_4	24	31	PF00018	0.727
LIG_SUMO_SIM_anti_2	488	494	PF11976	0.508
LIG_SUMO_SIM_par_1	28	34	PF11976	0.683
LIG_TRAF2_1	140	143	PF00917	0.653
LIG_TRAF2_1	325	328	PF00917	0.440
LIG_TRAF2_1	579	582	PF00917	0.474
LIG_WW_2	6	9	PF00397	0.734
MOD_CK1_1	10	16	PF00069	0.783
MOD_CK1_1	265	271	PF00069	0.436
MOD_CK1_1	278	284	PF00069	0.517
MOD_CK1_1	362	368	PF00069	0.513
MOD_CK1_1	373	379	PF00069	0.505
MOD_CK1_1	595	601	PF00069	0.548
MOD_CK2_1	137	143	PF00069	0.651
MOD_CK2_1	158	164	PF00069	0.691
MOD_CK2_1	205	211	PF00069	0.490
MOD_CK2_1	213	219	PF00069	0.449
MOD_CK2_1	322	328	PF00069	0.429
MOD_CK2_1	576	582	PF00069	0.486
MOD_CMANNOS	251	254	PF00535	0.290
MOD_Cter_Amidation	204	207	PF01082	0.183
MOD_Cter_Amidation	553	556	PF01082	0.336
MOD_Cter_Amidation	82	85	PF01082	0.781
MOD_GlcNHglycan	10	13	PF01048	0.751
MOD_GlcNHglycan	139	142	PF01048	0.708
MOD_GlcNHglycan	14	17	PF01048	0.701
MOD_GlcNHglycan	149	152	PF01048	0.613
MOD_GlcNHglycan	182	185	PF01048	0.392
MOD_GlcNHglycan	211	214	PF01048	0.325
MOD_GlcNHglycan	267	270	PF01048	0.380
MOD_GlcNHglycan	364	367	PF01048	0.355
MOD_GlcNHglycan	372	375	PF01048	0.349
MOD_GlcNHglycan	38	42	PF01048	0.596
MOD_GlcNHglycan	45	48	PF01048	0.596
MOD_GlcNHglycan	50	53	PF01048	0.594
MOD_GlcNHglycan	74	78	PF01048	0.550
MOD_GSK3_1	147	154	PF00069	0.735
MOD_GSK3_1	158	165	PF00069	0.672
MOD_GSK3_1	205	212	PF00069	0.450
MOD_GSK3_1	33	40	PF00069	0.685
MOD_GSK3_1	358	365	PF00069	0.523
MOD_GSK3_1	369	376	PF00069	0.481
MOD_GSK3_1	43	50	PF00069	0.669
MOD_GSK3_1	591	598	PF00069	0.558
MOD_GSK3_1	7	14	PF00069	0.791
MOD_LATS_1	380	386	PF00433	0.561
MOD_LATS_1	546	552	PF00433	0.536
MOD_N-GLC_1	262	267	PF02516	0.183
MOD_N-GLC_1	556	561	PF02516	0.183
MOD_NEK2_1	163	168	PF00069	0.712
MOD_NEK2_1	280	285	PF00069	0.551
MOD_NEK2_1	370	375	PF00069	0.503
MOD_NEK2_1	392	397	PF00069	0.524
MOD_PIKK_1	163	169	PF00454	0.727
MOD_PIKK_1	193	199	PF00454	0.514
MOD_PIKK_1	303	309	PF00454	0.508
MOD_PK_1	28	34	PF00069	0.709
MOD_PK_1	522	528	PF00069	0.591
MOD_PKA_2	104	110	PF00069	0.753
MOD_PKA_2	18	24	PF00069	0.650
MOD_PKA_2	205	211	PF00069	0.432
MOD_PKA_2	252	258	PF00069	0.551
MOD_PKA_2	381	387	PF00069	0.490
MOD_Plk_1	33	39	PF00069	0.594
MOD_Plk_2-3	33	39	PF00069	0.693
MOD_Plk_4	232	238	PF00069	0.508
MOD_Plk_4	393	399	PF00069	0.490
MOD_Plk_4	56	62	PF00069	0.658
MOD_Plk_4	582	588	PF00069	0.394
MOD_ProDKin_1	145	151	PF00069	0.763
MOD_ProDKin_1	275	281	PF00069	0.536
MOD_ProDKin_1	592	598	PF00069	0.561
TRG_DiLeu_BaEn_3	581	587	PF01217	0.561
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.591
TRG_DiLeu_BaLyEn_6	446	451	PF01217	0.592
TRG_ENDOCYTIC_2	261	264	PF00928	0.452
TRG_ENDOCYTIC_2	311	314	PF00928	0.539
TRG_ENDOCYTIC_2	454	457	PF00928	0.511
TRG_ENDOCYTIC_2	86	89	PF00928	0.800
TRG_ER_diArg_1	123	125	PF00400	0.671
TRG_ER_diArg_1	187	190	PF00400	0.511
TRG_ER_diArg_1	204	207	PF00400	0.511
TRG_ER_diArg_1	587	589	PF00400	0.536
TRG_ER_diArg_1	84	86	PF00400	0.779
TRG_NLS_MonoExtN_4	545	551	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXQ4	Leptomonas seymouri	56%	100%
A0A3R7KZ00	Trypanosoma rangeli	41%	100%
A0A3S5H4W0	Leishmania donovani	88%	100%
A4H379	Leishmania braziliensis	76%	93%
A4HRH9	Leishmania infantum	88%	100%
C9ZXK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AC47	Leishmania major	86%	100%
V5BLJ6	Trypanosoma cruzi	40%	100%